6AGF

Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1


Experimental Data Snapshot

  • Method: ELECTRON MICROSCOPY
  • Resolution: 3.2 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 

wwPDB Validation 3D Report Full Report


This is version 1.0 of the entry. See complete history

Literature

Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta 1.

Pan, X.J.Li, Z.Q.Zhou, Q.Shen, H.Z.Wu, K.Huang, X.S.Chen, J.F.Zhang, J.R.Zhu, X.C.Lei, J.L.Xiong, W.Gong, H.P.Xiao, B.L.Yan, N.

(2018) Science --: --


Macromolecules

Find similar proteins by: Sequence  |  Structure

Entity ID: 1
MoleculeChainsSequence LengthOrganismDetails
Sodium channel protein type 4 subunit alpha
A
1879Homo sapiensMutation(s): 0 
Gene Names: SCN4A
Membrane protein
mpstruct
Group: 
TRANSMEMBRANE PROTEINS: ALPHA-HELICAL
Sub Group: 
Channels: Potassium, Sodium, & Proton Ion-Selective
Protein: 
NaV1.4-β1 complex
Find proteins for P35499 (Homo sapiens)
Go to Gene View: SCN4A
Go to UniProtKB:  P35499
Entity ID: 2
MoleculeChainsSequence LengthOrganismDetails
Sodium channel subunit beta-1
B
218Homo sapiensMutation(s): 0 
Gene Names: SCN1B
Membrane protein
mpstruct
Group: 
TRANSMEMBRANE PROTEINS: ALPHA-HELICAL
Sub Group: 
Channels: Potassium, Sodium, & Proton Ion-Selective
Protein: 
NaV1.4-β1 complex
Find proteins for Q07699 (Homo sapiens)
Go to Gene View: SCN1B
Go to UniProtKB:  Q07699
Small Molecules
Ligands 4 Unique
IDChainsName / Formula / InChI Key2D Diagram3D Interactions
6OU
Query on 6OU

Download SDF File 
Download CCD File 
A
[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
C39 H76 N O8 P
FHQVHHIBKUMWTI-OTMQOFQLSA-N
 Ligand Interaction
9Z9
Query on 9Z9

Download SDF File 
Download CCD File 
A
(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en
C34 H56 O5
CEEBZAXXSRFQIC-GZSGZGDASA-N
 Ligand Interaction
BMA
Query on BMA

Download SDF File 
Download CCD File 
A
BETA-D-MANNOSE
C6 H12 O6
WQZGKKKJIJFFOK-RWOPYEJCSA-N
 Ligand Interaction
NAG
Query on NAG

Download SDF File 
Download CCD File 
A, B
N-ACETYL-D-GLUCOSAMINE
C8 H15 N O6
OVRNDRQMDRJTHS-FMDGEEDCSA-N
 Ligand Interaction
Experimental Data & Validation

Experimental Data

  • Method: ELECTRON MICROSCOPY
  • Resolution: 3.2 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 
Software Package:
Software NamePurpose
PHENIXrefinement

Structure Validation

View Full Validation Report or Ramachandran Plots



Entry History & Funding Information

Deposition Data


Funding OrganizationLocationGrant Number
Ministry of Science and Technology (China)China2015CB910101
Ministry of Science and Technology (China)China2016YFA0501100
Ministry of Science and Technology (China)China2016YFA0500402
National Natural Science Foundation of ChinaChina31621092
National Natural Science Foundation of ChinaChina31630017
National Natural Science Foundation of ChinaChina81861138009

Revision History 

  • Version 1.0: 2018-10-10
    Type: Initial release