SWISS-MODEL Homology Modelling Report

Model Building Report

This document lists the results for the homology modelling project "Untitled Project" submitted to SWISS-MODEL workspace on Nov. 19, 2018, 5:36 a.m..The submitted primary amino acid sequence is given in Table T1.

If you use any results in your research, please cite the relevant publications:

Results

The SWISS-MODEL template library (SMTL version 2018-11-14, PDB release 2018-11-09) was searched with BLAST (Camacho et al.) and HHBlits (Remmert et al.) for evolutionary related structures matching the target sequence in Table T1. For details on the template search, see Materials and Methods. Overall 2638 templates were found (Table T2).

Models

The following models were built (see Materials and Methods "Model Building"):

Model #01

FileBuilt withOligo-StateLigandsGMQEQMEAN
PDB ProMod3 Version 1.2.0. monomer
3 x 6OU: [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate;
1 x 9Z9: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en;
0.54-5.52
QMEAN-5.52
-3.87
All Atom-1.98
Solvation0.38
Torsion-4.70
TemplateSeq IdentityOligo-stateFound byMethodResolutionSeq SimilarityRangeCoverageDescription
6agf.1.A70.78monomerHHblitsEMNA0.51114 - 17580.88Sodium channel protein type 4 subunit alpha

LigandAdded to ModelDescription
6OU
[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
6OU
[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
6OU
[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
9Z9
(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en
6OU✕ - Binding site not conserved.
[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
6OU✕ - Binding site not conserved.
[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
6OU✕ - Binding site not conserved.
[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
BMA✕ - Not in contact with model.
BETA-D-MANNOSE
NAG✕ - Binding site not conserved.
N-ACETYL-D-GLUCOSAMINE
NAG✕ - Binding site not conserved.
N-ACETYL-D-GLUCOSAMINE
NAG✕ - Binding site not conserved.
N-ACETYL-D-GLUCOSAMINE
NAG✕ - Not in contact with model.
N-ACETYL-D-GLUCOSAMINE
NAG✕ - Binding site not conserved.
N-ACETYL-D-GLUCOSAMINE
NAG✕ - Not in contact with model.
N-ACETYL-D-GLUCOSAMINE
NAG✕ - Binding site not conserved.
N-ACETYL-D-GLUCOSAMINE
NAG✕ - Not in contact with model.
N-ACETYL-D-GLUCOSAMINE

Target    MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDP
6agf.1.A --TLVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPMIYGDPPPEVIGIPLEDLDP

Target YYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFT
6agf.1.A YYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFT

Target GIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ
6agf.1.A GIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQ

Target SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLEN---------NETL--------------------ESIMN
6agf.1.A SVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWN

Target T------LE--SEEDFR---KYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQ
6agf.1.A SHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQ

Target DYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAI
6agf.1.A DYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKA

Target AAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEG
6agf.1.A KA-------------------------------------A----QALE-GGEADGDPA----------------------

Target HRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHRPQERRSS
6agf.1.A ------------------------------H-------------------------------------------------

Target NISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMS
6agf.1.A ---------------G-----KDCNGSLDTS-------------------------------------QGEKGAPRQSSS

Target RASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEE
6agf.1.A GDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEH

Target FKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPT
6agf.1.A FDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPT

Target LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIET
6agf.1.A LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIET

Target MWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFIL
6agf.1.A MWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLLH

Target KAFSKKPKIS-R--EIRQ------AEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHN
6agf.1.A GKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEE--DLKKDNHILNHMGLADGPPS------SLELDHLNFINN

Target PSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKV---RLNRSSSSECSTVDNPLPGEGEEAEAEPMNS---DEPEACFT
6agf.1.A PYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKPPEE--DPEEQAEENPEGEQPEECFT

Target DGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYI
6agf.1.A EACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYI

Target FILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIG
6agf.1.A FIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLG

Target AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGY
6agf.1.A AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMH-TGQVRWLNVKVNYDNVGLGY

Target LSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE
6agf.1.A LSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTE

Target EQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFII
6agf.1.A EQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFII

Target LFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFA
6agf.1.A IFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFA

Target LMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCD
6agf.1.A LMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCD

Target PKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQF
6agf.1.A PNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQF

Target IEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKVS
6agf.1.A IAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVS

Target YEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDD-DLLNKKDMAFDNVNENSSPEKTDAT------
6agf.1.A YEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDDAPEKEGLLANTMSKMYGHENGNSSSPSPEE

Target SSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDSKESKK
6agf.1.A KGEAGDAGPTMGLMPIS----------------------




Model #02

FileBuilt withOligo-StateLigandsGMQEQMEAN
PDB ProMod3 Version 1.2.0. monomer
None
0.54-5.97
QMEAN-5.97
-3.63
All Atom-2.08
Solvation0.12
Torsion-5.12
TemplateSeq IdentityOligo-stateFound byMethodResolutionSeq SimilarityRangeCoverageDescription
6a95.1.A40.99monomerHHblitsEM2.60Å0.4142 - 18640.77Sodium channel protein PaFPC1

LigandAdded to ModelDescription
9SR✕ - Binding site not conserved.
(1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name)
NA✕ - Not biologically relevant.
SODIUM ION
NAG✕ - Binding site not conserved.
N-ACETYL-D-GLUCOSAMINE
NAG✕ - Binding site not conserved.
N-ACETYL-D-GLUCOSAMINE
NAG✕ - Binding site not conserved.
N-ACETYL-D-GLUCOSAMINE
NAG✕ - Not in contact with model.
N-ACETYL-D-GLUCOSAMINE
NAG✕ - Not in contact with model.
N-ACETYL-D-GLUCOSAMINE
NAG✕ - Binding site not conserved.
N-ACETYL-D-GLUCOSAMINE
NAG✕ - Binding site not conserved.
N-ACETYL-D-GLUCOSAMINE

Target    MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKK--D-------DDEEAPKPSSDLEAGKQLP-FIYGDIPPGM
6a95.1.A --LIREERQRLFRPYTRAMLTAPSAQPAKENGKTEENKDNSRDKGRGANKDRDGSAHPDQALEQGSRLPARMRNIFPAEL

Target VSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPD
6a95.1.A ASTPLEDFDPFYKNKKTFVVVTKAGDIFRFSGEKSLWMLDPFTPIRRVAISTMVQPIFSYFIMITILIHCIFMIMPATQT

Target WTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPG
6a95.1.A -TYILELVFLSIYTIEVVVKVLARGFILHPFAYLRDPWNWLDFLVTLIGYITLVVDLGHLYALRAFRVLRSWRTVTIVPG

Target LKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFR---KYFYYLE
6a95.1.A WRTIVDALSLSITSLKDLVLLLLFSLFVFAVLGLQIYMGVLTQKCVKHF-PADGSW-GNFT-DERWFNYTSNSSHWYIPD

Target GSKDALLCGFSTDSGQCPEGYTCVKI-GRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVI
6a95.1.A DWIEYPLCGNSSGAGMCPPGYTCLQGYGGNPNYGYTSFDTFGWAFLSVFRLVTLDYWEDLYQLALRSAGPWHILFFIIVV

Target FLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETS
6a95.1.A FYGTFCFLNFILAVVVMSYTHMVKRADEEKAAERELKKEKKAASVANNT--A----------------------------

Target KLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSA
6a95.1.A -----------------------NGQEQ---TT--------I-------------------------------------E

Target RRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHRPQERRSSNISQASRSPPMLPVNGKMHSAVDCNG
6a95.1.A M--NG-----------------------------------------------D---------------------------

Target VVSLVDGRSALMLPNGQLLPEGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILTN-TVEELEESRQKCPPWWYR
6a95.1.A ----------------------------------------------------EAVVIDNNDQAARQQSDPETPAPSVTQR

Target FAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLI
6a95.1.A LTDFLCVWDCCVPWQKLQGAIGAVVLSPFFELFIAVIIVLNITFMALDHHDMNIEFERILRTGNYIFTSIYIVEAVLKII

Target AMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAII
6a95.1.A ALSPKFYFKDSWNVFDFIIVVFAILELGLEGVQGLSVFRSFRLLRVFRLAKFWPTLNNFMSVMTKSYGAFVNVMYVMFLL

Target VFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGN
6a95.1.A LFIFAIIGMQLFGMNYIDNMERFP-DGDLPRWNFTDFLHSFMIVFRALCGEWIESMWDCMLVGD-WSCIPFFVAVFFVGN

Target LVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLNTKKEN
6a95.1.A LVILNLLIALLLNNYGSFCTS-PTSDEEDSKDEDALAQIVRIFKRFKPNL---------------N-----AV-------

Target YISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSK
6a95.1.A ----KL----SPM------------------------------------------KPDSEDI------------------

Target VRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFES
6a95.1.A -----VESQEIQGNNIADAED--V---L--AGEFPPDCCCNAFYKCFPSRP-ARDSSVQRMWSNIRRVCFLLAKNKYFQK

Target FIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVAN
6a95.1.A FVTAVLVITSVLLALEDIYLPQRPVLVNITLYVDYVLTAFFVIEMIIMLFAVGFKKYFTSKWYWLDFIVVVAYLLNFVL-

Target TLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDG
6a95.1.A --MCAGIEALQTLRLLRVFRLFRPLSKVNGMQVVTSTLVEAVPHIFNVILVGIFFWLVFAIMGVQLFAGKFYKCVDENS-

Target SRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIY
6a95.1.A TVLSHEITMDRNDCLH-----ENYTWENSPMNFDHVGNAYLSLLQVATFKGWLQIMNDAIDSREVHKQPIRETNIYMYLY

Target FVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQA
6a95.1.A FIFFIVFGSFFILKLFVCILIDIFRQQRRKAEGLSATDSRTQLIYRRAVMRTMSAKPVKRIPKPTCHPQSLMYDISVNRK

Target FDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLA
6a95.1.A FEYTMMILIILNVAVMAIDHYGQSMEFSEVLDYLNLIFIIIFFVECVIKVSGLRHHYFKDPWNIIDFLYVVLAIAGLMLS

Target DLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGIN
6a95.1.A DVIEKYFISPTLLRILRILRVGRLLRYFQSARGMRLLLLALRKALRTLFNVSFLLFVIMFVYAVFGMEFFMHIRDAGAID

Target DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYI
6a95.1.A DVYNFKTFGQSIILLFQLATSAGWDGVYFAIANE--EDCRAP--DHELGYPGNCGSRALGIAYLVSYLIITCLVVINMYA

Target AVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRI
6a95.1.A AVILDYVLEVYEDSKEGLTDDDYDMFFEVWQQFDPEATQYIRYDQLSELLEALQPPLQVQKPNKYKILSMNIPICKDDHI

Target HCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIY
6a95.1.A FYKDVLEALVKDVFSRRG--SPVEAGDVQ---APNVDEAEYKPVSSTLQRQREEYCVRLIQNAWRKHKQQN---------

Target IKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDSKESKK
6a95.1.A ------------------------------------------------------------------------




Materials and Methods

Template Search

Template search with BLAST and HHBlits has been performed against the SWISS-MODEL template library (SMTL, last update: 2018-11-14, last included PDB release: 2018-11-09).

The target sequence was searched with BLAST against the primary amino acid sequence contained in the SMTL. A total of 221 templates were found.

An initial HHblits profile has been built using the procedure outlined in (Remmert et al.), followed by 1 iteration of HHblits against NR20. The obtained profile has then be searched against all profiles of the SMTL. A total of 2450 templates were found.

Template Selection

For each identified template, the template's quality has been predicted from features of the target-template alignment. The templates with the highest quality have then been selected for model building.

Model Building

Models are built based on the target-template alignment using ProMod3. Coordinates which are conserved between the target and the template are copied from the template to the model. Insertions and deletions are remodelled using a fragment library. Side chains are then rebuilt. Finally, the geometry of the resulting model is regularized by using a force field. In case loop modelling with ProMod3 fails, an alternative model is built with PROMOD-II (Guex et al.).

Model Quality Estimation

The global and per-residue model quality has been assessed using the QMEAN scoring function (Benkert et al.) . For improved performance, weights of the individual QMEAN terms have been trained specifically for SWISS-MODEL.

Ligand Modelling

Ligands present in the template structure are transferred by homology to the model when the following criteria are met: (a) The ligands are annotated as biologically relevant in the template library, (b) the ligand is in contact with the model, (c) the ligand is not clashing with the protein, (d) the residues in contact with the ligand are conserved between the target and the template. If any of these four criteria is not satisfied, a certain ligand will not be included in the model. The model summary includes information on why and which ligand has not been included.

Oligomeric State Conservation

The quaternary structure annotation of the template is used to model the target sequence in its oligomeric form. The method (Bertoni et al.) is based on a supervised machine learning algorithm, Support Vector Machines (SVM), which combines interface conservation, structural clustering, and other template features to provide a quaternary structure quality estimate (QSQE). The QSQE score is a number between 0 and 1, reflecting the expected accuracy of the interchain contacts for a model built based a given alignment and template. Higher numbers indicate higher reliability. This complements the GMQE score which estimates the accuracy of the tertiary structure of the resulting model.

References

Table T1:

Primary amino acid sequence for which templates were searched and models were built.

MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRF
NATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAY
LTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFR
KYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAV
VAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKL
SKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHRPQERRSS
NISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCP
PWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIF
DSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMN
DFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFIL
KAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSD
SEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAF
EDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVV
NALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTII
MYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDL
VTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRV
IRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSK
PPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDP
PLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKN
ISSIYIKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDSKESKK

Table T2:

TemplateSeq IdentityOligo-stateQSQEFound byMethodResolutionSeq SimilarityCoverageDescription
6agf.1.A70.78monomerHHblitsEMNA0.510.88Sodium channel protein type 4 subunit alpha
5xsy.1.A60.21monomerHHblitsEM4.00Å0.470.87Sodium channel protein
6a90.1.A40.99monomerHHblitsEM2.80Å0.410.77Sodium channel protein PaFPC1
6a91.1.A40.99monomerHHblitsEM3.20Å0.410.77Sodium channel protein PaFPC1
5x0m.1.A40.99monomerHHblitsEMNA0.410.77Sodium channel protein
6a95.1.A40.99monomerHHblitsEM2.60Å0.410.77Sodium channel protein PaFPC1
5gjw.1.A29.19monomerHHblitsEMNA0.350.72Voltage-dependent L-type calcium channel subunit alpha-1S
5gjv.1.A29.19monomerHHblitsEM3.60Å0.350.72Voltage-dependent L-type calcium channel subunit alpha-1S
6agf.1.A73.41monomerBLASTEMNA0.520.63Sodium channel protein type 4 subunit alpha
3jbr.1.A27.49monomerHHblitsEMNA0.330.72Voltage-dependent L-type calcium channel subunit alpha-1S
6byo.1.A30.16monomerHHblitsEMNA0.360.65Voltage-dependent L-type calcium channel subunit alpha-1S
5xsy.1.A61.87monomerBLASTEM4.00Å0.480.65Sodium channel protein
6a91.1.A43.44monomerBLASTEM3.20Å0.420.37Sodium channel protein PaFPC1
6a90.1.A43.44monomerBLASTEM2.80Å0.420.37Sodium channel protein PaFPC1
5x0m.1.A43.44monomerBLASTEMNA0.420.37Sodium channel protein
6a95.1.A43.44monomerBLASTEM2.60Å0.420.37Sodium channel protein PaFPC1
5x0m.1.A21.68monomerHHblitsEMNA0.320.44Sodium channel protein
6a91.1.A21.68monomerHHblitsEM3.20Å0.320.44Sodium channel protein PaFPC1
6a90.1.A21.68monomerHHblitsEM2.80Å0.320.44Sodium channel protein PaFPC1
6a95.1.A21.68monomerHHblitsEM2.60Å0.320.44Sodium channel protein PaFPC1
5gjv.1.A34.56monomerBLASTEM3.60Å0.380.33Voltage-dependent L-type calcium channel subunit alpha-1S
5gjw.1.A34.56monomerBLASTEMNA0.380.33Voltage-dependent L-type calcium channel subunit alpha-1S
5gjv.1.A27.66monomerHHblitsEM3.60Å0.340.29Voltage-dependent L-type calcium channel subunit alpha-1S
5gjw.1.A27.66monomerHHblitsEMNA0.340.29Voltage-dependent L-type calcium channel subunit alpha-1S
6byo.1.A27.43monomerHHblitsEMNA0.340.29Voltage-dependent L-type calcium channel subunit alpha-1S
3jbr.1.A35.73monomerBLASTEMNA0.380.29Voltage-dependent L-type calcium channel subunit alpha-1S
3jbr.1.A27.48monomerHHblitsEMNA0.340.29Voltage-dependent L-type calcium channel subunit alpha-1S
5gjw.1.A30.83monomerBLASTEMNA0.360.26Voltage-dependent L-type calcium channel subunit alpha-1S
5gjv.1.A30.83monomerBLASTEM3.60Å0.360.26Voltage-dependent L-type calcium channel subunit alpha-1S
3jbr.1.A30.83monomerBLASTEMNA0.360.26Voltage-dependent L-type calcium channel subunit alpha-1S
6a91.1.A28.57monomerBLASTEM3.20Å0.350.25Sodium channel protein PaFPC1
6byo.1.A31.03monomerBLASTEMNA0.360.26Voltage-dependent L-type calcium channel subunit alpha-1S
6a90.1.A28.57monomerBLASTEM2.80Å0.350.25Sodium channel protein PaFPC1
5x0m.1.A28.57monomerBLASTEMNA0.350.25Sodium channel protein
6a95.1.A28.57monomerBLASTEM2.60Å0.350.25Sodium channel protein PaFPC1
5dqq.1.A16.85homo-dimer0.15HHblitsX-ray2.87Å0.290.28Two pore calcium channel protein 1
6e1p.1.A16.67homo-dimer0.13HHblitsEMNA0.290.28Two pore calcium channel protein 1
5e1j.1.A17.00homo-dimer0.15HHblitsX-ray3.31Å0.290.28Two pore calcium channel protein 1
5tua.1.A16.30monomerHHblitsX-ray3.30Å0.290.28Two pore calcium channel protein 1
6e1n.1.A16.67homo-dimer0.14HHblitsEMNA0.290.28Two pore calcium channel protein 1
6cx0.1.A16.15homo-dimer0.12HHblitsX-ray3.50Å0.290.28Two pore calcium channel protein 1
5tua.1.A20.50monomerHHblitsX-ray3.30Å0.310.24Two pore calcium channel protein 1
5dqq.1.A20.55homo-dimer0.16HHblitsX-ray2.87Å0.310.24Two pore calcium channel protein 1
6e1p.1.A20.50homo-dimer0.20HHblitsEMNA0.310.24Two pore calcium channel protein 1
5e1j.1.A20.50homo-dimer0.20HHblitsX-ray3.31Å0.310.24Two pore calcium channel protein 1
6e1n.1.A20.50homo-dimer0.19HHblitsEMNA0.310.24Two pore calcium channel protein 1
5xsy.1.A67.02monomerBLASTEM4.00Å0.510.19Sodium channel protein
6agf.1.A72.92monomerBLASTEMNA0.520.22Sodium channel protein type 4 subunit alpha
6e1k.1.A16.67homo-dimer0.08HHblitsEMNA0.290.28Two pore calcium channel protein 1
6e1k.1.A20.50homo-dimer0.17HHblitsEMNA0.310.24Two pore calcium channel protein 1

The table above shows the top 50 filtered templates. A further 1,492 templates were found which were considered to be less suitable for modelling than the filtered list.
1yx7.1.A, 2m29.1.A, 2luc.1.A, 5g4p.1.A, 1a75.2.A, 3gk4.1.B, 5jqa.1.A, 4rjd.1.A, 6c1k.1.A, 4rjd.1.B, 3nxa.2.A, 1xfu.1.B, 4p2z.1.A, 3igo.1.A, 3zjz.1.A, 5dow.2.A, 2jtt.1.A, 2jtt.1.B, 5b7x.1.A, 2x0g.1.B, 2ggm.2.A, 5h53.1.B, 5h53.1.C, 3pat.1.A, 4i9w.1.A, 4i9w.1.B, 6bcj.1.A, 4by4.1.A, 4by4.1.B, 4bw7.2.A, 2n77.1.B, 2n77.1.A, 2jjz.4.A, 5hlo.1.A, 5hlo.1.B, 4l79.1.B, 2m0k.1.A, 5go9.1.A, 6dmu.1.D, 1nx1.1.A, 5zgm.1.A, 2ccm.1.A, 1dgv.1.A, 2b1u.1.A, 1scm.1.C, 1scm.1.B, 1a03.1.A, 1a03.1.B, 2col.1.B, 1wlz.1.A, 5lpu.1.C, 4aom.1.A, 1kso.1.B, 1kso.1.A, 2zrt.1.B, 2zrt.1.A, 5ibw.1.B, 5ibw.1.C, 1ytz.1.C, 5aan.1.A, 1lkj.1.A, 2pal.1.A, 1wrz.1.A, 3j41.1.F, 3g43.1.A, 1kfx.1.B, 4ekw.1.B, 4ekw.1.A, 5taz.1.E, 5jjg.1.A, 2w4t.2.A, 1cnp.1.B, 1cnp.1.A, 1qlk.1.A, 1odb.3.A, 4ehq.1.A, 3evv.1.A, 1tcf.1.A, 4lto.1.D, 4lto.1.B, 4lto.1.C, 4lto.1.A, 2jnx.1.A, 4drw.2.A, 2dfs.1.G, 2dfs.1.B, 2dfs.1.C, 1a4p.2.H, 1a4p.2.D, 3m0w.1.A, 6b8p.2.B, 5wcl.1.A, 1j7r.1.A, 1wrl.2.A, 4gow.1.A, 1xyd.1.A, 4d1e.1.A, 2pas.1.A, 3fwb.1.A, 1y1a.2.A, 2le9.1.C, 2le9.1.B, 6dqn.1.A, 4mzk.1.A, 6d7p.1.A, 6bpq.1.A, 5wpv.1.A, 1c7v.1.A, 6dae.1.A, 6dae.1.B, 3lle.2.D, 4yge.3.B, 6e2f.1.E, 4ds7.2.A, 1rwy.2.A, 6e2f.1.A, 1fpw.1.A, 6agf.1.A, 6b8q.1.B, 5h0p.1.A, 6b8q.3.B, 2y4v.1.A, 1oqp.1.A, 5klb.1.A, 2kz2.1.A, 3tuy.2.B, 6du8.1.A, 3gp2.1.A, 6b8l.4.B, 4i2y.2.A, 2bec.1.A, 2m3s.1.A, 6dqs.1.D, 6dqs.1.C, 3nxa.1.A, 6dqs.1.A, 4p5w.1.A, 1boc.1.A, 2k8m.1.C, 5va3.1.A, 2cxj.1.A, 3wxa.2.A, 2lv6.1.A, 2kyh.1.A, 3j04.1.B, 3j04.1.C, 3ox6.1.A, 3akb.1.A, 4byf.1.B, 1n0y.1.A, 2m5e.1.A, 2m5e.1.B, 1j1e.1.A, 3ewt.1.A, 5kmd.1.B, 2lls.1.A, 4ggn.3.A, 5kmd.1.A, 5kmd.1.D, 2mrd.1.A, 4ndb.2.A, 1kk7.1.C, 3dvm.1.A, 2jt0.1.A, 4jq0.1.B, 6bo8.1.A, 6daf.1.A, 5hj8.1.A, 5hj8.1.B, 5hj8.1.C, 5hj8.1.D, 2n7l.1.A, 1mq1.1.A, 1niw.5.E, 1dt7.1.A, 2pru.1.A, 1mf8.1.B, 6gdl.1.A, 6bbj.1.A, 1s6j.1.A, 3bya.1.A, 2bbn.1.A, 5w1a.1.B, 5joj.1.A, 5wsu.2.A, 2l0p.1.A, 3j5p.1.A, 1cdl.2.A, 2zrt.2.A, 2zrt.2.B, 2lan.1.A, 4by5.3.B, 4by5.3.A, 5klg.1.B, 5klg.1.C, 5klg.1.A, 1gjy.1.B, 3ko0.4.B, 5klg.1.D, 1gjy.1.A, 2hqw.1.A, 3h4s.1.B, 3ctn.1.A, 3beh.1.A, 3beh.1.C, 3beh.1.B, 3beh.1.D, 2opo.2.A, 2opo.2.B, 2qac.1.A, 5j03.1.B, 5h3o.1.A, 1s3p.1.A, 2f2o.1.B, 4by5.1.A, 4by5.1.B, 1dfk.1.C, 1dfk.1.B, 1irj.3.A, 1irj.3.B, 1dvi.1.A, 2be6.4.A, 1irj.1.B, 2be6.4.C, 3j8h.1.A, 2kay.1.B, 2kay.1.A, 1y6w.1.A, 5w3s.1.A, 5tp5.1.A, 1nx2.1.A, 2jpt.1.A, 1j7q.1.A, 3bxk.2.B, 2zn8.1.A, 3bxk.2.A, 5t7c.1.A, 1omr.1.A, 1kcy.1.A, 1cdp.1.A, 1smg.1.A, 4hex.1.B, 5tav.1.E, 4hex.1.A, 1blq.1.A, 6e2g.1.A, 5i2q.1.A, 1jfj.1.A, 2ju0.1.A, 6b5v.1.A, 2lvk.1.A, 4h33.1.A, 4gjg.1.A, 2f33.1.A, 4djc.1.A, 2k7d.1.A, 3dvk.1.B, 6mhs.1.A, 1c07.1.A, 3ucw.2.B, 4pcw.1.B, 1qiw.2.A, 3oxq.1.A, 1juo.1.A, 1juo.1.B, 3sg3.1.A, 3ifk.1.A, 2roa.1.A, 3lut.1.B, 3wlc.1.A, 1qx2.2.A, 2wcb.1.B, 2wcb.1.A, 1cff.1.A, 3ulg.1.A, 2lvi.1.A, 5ggm.1.A, 3nsl.2.A, 4pcw.1.A, 5klb.1.D, 5klb.1.C, 5klb.1.B, 1sy9.1.A, 5afp.1.A, 5hvx.1.A, 6fie.1.A, 4kfm.1.A, 1uwo.1.A, 1uwo.1.B, 3dtp.2.C, 2kqy.1.A, 5an8.1.A, 1prw.1.A, 2zne.1.A, 4aqj.1.A, 5gky.1.E, 1npq.1.A, 1k90.1.D, 1k90.1.B, 2r28.1.C, 2r28.1.A, 2lp3.1.A, 6dr2.1.A, 2na0.1.A, 2bki.1.C, 3gn4.1.C, 3gn4.1.B, 1dmo.1.A, 2m49.1.C, 4ovn.2.A, 1f4q.1.A, 4ovn.2.B, 5mkf.1.A, 4chv.1.A, 5hyd.2.B, 4zcu.1.A, 5hyd.2.A, 1jf0.1.A, 3tuy.1.B, 3tuy.1.C, 1wrl.1.A, 5kuk.1.A, 3czt.1.A, 3syq.1.A, 3syq.1.B, 2y5i.1.A, 5kmh.1.D, 5kmh.1.B, 5kmh.1.C, 5kmh.1.A, 3aaj.1.A, 3aaj.1.B, 6dr0.1.D, 1n2d.1.B, 1n2d.1.C, 6dr0.1.C, 1n2d.1.A, 4gft.1.A, 1mxe.1.A, 1c7w.1.A, 1xvj.1.A, 2kuh.1.A, 1cll.1.A, 2jnf.1.A, 5m6c.1.A, 2egd.1.A, 4y99.1.A, 1a2x.1.A, 6boa.1.A, 5jth.1.A, 3ko0.3.B, 1top.1.A, 2mg5.1.A, 1lvc.1.B, 3hr4.4.B, 1uhi.2.A, 2doq.1.B, 2doq.1.A, 5lpu.1.D, 3hr4.2.B, 5va2.1.A, 4yru.2.B, 5tj6.1.A, 5mra.1.A, 2f2p.1.B, 2f2p.1.A, 4v0c.1.D, 4v0c.1.C, 1k90.1.F, 5sve.1.B, 4zcv.1.A, 3mse.1.A, 5zab.2.A, 1yr5.1.A, 6ds2.1.B, 4n1f.1.A, 3ewv.1.A, 2n8z.1.A, 1vrk.1.A, 2joj.1.A, 5iwk.1.A, 5vms.1.A, 1qx7.4.A, 5tby.1.D, 1qx7.4.C, 1qx7.4.B, 3ek4.1.A, 5tby.1.C, 2mhh.1.A, 3bxk.1.A, 2kdh.1.A, 5tp6.1.A, 5gjv.1.A, 1la0.1.A, 4ndc.2.A, 3ko0.9.A, 5x0m.1.A, 6dah.1.A, 1s5g.1.B, 2nco.1.A, 2fcd.1.A, 2k7c.1.A, 5goa.1.A, 1aj5.2.A, 5tas.1.E, 3ucy.1.A, 2fot.1.A, 1y1x.1.A, 2a9h.1.A, 2a9h.1.C, 5kls.1.D, 6c1e.1.A, 5i0i.1.B, 2wcf.1.B, 2wcf.1.A, 5kmf.1.B, 5zbg.1.A, 5yua.1.A, 2be6.1.A, 2be6.1.B, 5va1.1.A, 3jbr.1.A, 4aqr.1.A, 4aqr.1.B, 2be6.3.B, 2zn9.1.B, 5n69.1.C, 1sr6.1.C, 2vtg.1.A, 1w7i.1.B, 3df0.1.B, 4bgn.1.A, 6c1g.1.B, 2kbm.1.D, 1s6i.1.A, 4chw.1.D, 1x02.1.A, 2kxw.1.B, 2kxw.1.A, 2w4u.1.D, 6d7l.1.A, 2r2i.1.A, 3lcp.1.B, 4ovn.1.B, 2l50.1.A, 4ovn.1.A, 4ovn.5.B, 5k47.1.A, 1f8h.1.A, 3spi.1.A, 4mvz.1.A, 6c96.1.A, 3um7.1.A, 3um7.1.B, 5vkq.1.A, 3dve.1.B, 2ec6.1.C, 2lvj.1.A, 2k0f.1.A, 2ami.1.A, 1lxf.1.A, 2cnp.1.B, 1zot.1.B, 5l1d.1.A, 5wie.2.B, 2lcp.1.A, 3d10.1.A, 2m97.1.A, 1alv.1.A, 3lnm.2.A, 4ygd.4.B, 4u8d.1.A, 6dqz.1.B, 3ek8.1.A, 4bya.1.A, 1alw.1.A, 4ftg.1.A, 1mxl.1.A, 5xop.1.C, 5xop.1.B, 5xop.1.A, 5xop.1.E, 5xop.1.D, 2kav.1.A, 3wht.1.B, 4fqo.1.A, 5t4d.1.A, 2llu.1.B, 2m3w.1.A, 2llu.1.A, 1g8i.1.A, 1m46.1.A, 3evr.1.A, 2k0e.1.A, 2v01.1.A, 3wfn.4.A, 1iwq.1.A, 3o78.2.A, 5sy1.1.A, 5x9a.1.A, 5x9a.1.B, 3psr.1.B, 1wrl.2.B, 5k7l.1.A, 2w4a.2.A, 2kyc.1.A, 5k7l.3.B, 3c1v.2.A, 5vb2.1.A, 1bjf.1.A, 2vay.1.B, 2vay.1.A, 2rob.1.A, 5ve9.1.C, 5ve9.1.A, 2g9b.1.A, 1kk7.1.B, 1avs.1.A, 5g58.1.A, 1mwn.1.A, 4j9y.1.D, 6d1w.1.A, 3khe.1.A, 5ye2.1.B, 3oxq.1.B, 3oxq.1.C, 2m9g.1.A, 1aj5.1.A, 5bpj.1.A, 6dvy.1.A, 1b8c.1.A, 1ckk.1.A, 2wce.1.A, 5tnc.1.A, 3zwh.1.A, 5hi9.1.A, 1fi6.1.A, 3k21.1.A, 6bnv.1.O, 5b8i.1.B, 2ll6.1.A, 5dow.1.A, 2n8j.1.A, 1ksm.1.A, 5dow.3.A, 6a70.1.C, 6a70.1.B, 6a70.1.A, 1ij5.1.A, 5gl1.1.A, 1tnp.1.A, 5zh6.1.A, 4ov2.3.A, 5ye5.1.A, 4ov2.1.A, 4mw8.1.A, 2m0r.1.A, 2m0r.1.B, 1k8u.1.A, 1dtl.1.A, 3sui.1.A, 1wlz.4.A, 1wlz.2.A, 3zwh.1.B, 2jjz.3.A, 1a29.1.A, 5j8h.1.A, 6cud.1.A, 2fce.1.A, 2k7b.1.A, 2n6a.1.A, 6bob.1.B, 5aer.1.A, 2m28.1.A, 2f8p.1.A, 5f6t.1.A, 3l9i.1.B, 5ek0.1.B, 5ek0.1.C, 5ek0.1.A, 1cfc.1.A, 5ek0.1.D, 2zrt.4.B, 2zrt.4.A, 5d67.1.A, 5aeq.1.A, 1jc2.1.A, 5u6o.1.A, 2auc.1.B, 2auc.1.C, 2auc.1.A, 2o60.1.A, 5g08.1.A, 2n8y.1.A, 4lzx.1.A, 5irz.1.A, 2w4t.3.A, 2l53.1.B, 2l53.1.A, 3l19.1.A, 4mn0.1.A, 1zmz.1.A, 1k95.1.A, 1sk6.2.B, 1nsh.1.A, 2bbm.1.A, 1b8r.1.A, 1v1g.1.A, 2rrt.1.A, 1sl7.1.A, 2vas.1.B, 1sl9.1.A, 2l51.1.A, 2l98.1.A, 1b9a.1.A, 6b8q.2.B, 1tiz.1.A, 1dgu.1.A, 3sg5.1.A, 1xk4.1.C, 6cx0.1.A, 1uhn.1.A, 4drw.1.A, 3evu.1.B, 1up5.1.A, 1cfp.1.A, 1m45.1.A, 6feg.1.B, 3sjs.1.A, 4n5x.1.A, 1f71.1.A, 1m39.1.A, 1rwy.1.A, 4phn.1.B, 4phn.1.A, 4okh.1.B, 4okh.1.A, 1rwy.3.A, 3sph.1.A, 6bco.1.A, 5jol.1.A, 1xa5.1.A, 5vt9.1.A, 2ctn.1.A, 1k96.1.A, 1zuz.2.C, 4ds7.1.A, 1ahr.1.A, 4tnc.1.A, 1g33.1.A, 3vou.1.D, 1clb.1.A, 4mvu.1.A, 3dtp.1.D, 2lp2.1.A, 1pon.1.A, 2l2e.1.A, 4g7y.1.C, 6dae.2.A, 4p60.1.B, 4p60.1.A, 4e50.1.A, 2w73.2.A, 2w73.2.B, 2a79.1.B, 1r6p.1.A, 6c8f.1.A, 5wp6.1.A, 5u6p.1.A, 1rec.1.A, 5vln.1.A, 2zrs.2.B, 2zrs.2.A, 4q5u.1.A, 3wxa.1.A, 2zrs.4.A, 2zrs.4.B, 1cfd.1.A, 1pva.1.A, 1ttx.1.A, 1ih0.1.A, 1n0y.2.A, 1np8.1.A, 1np8.1.B, 1ff1.1.A, 1rfj.1.A, 2os8.1.C, 2os8.1.B, 3qjk.1.A, 2obh.1.A, 2e6w.1.A, 2zne.2.A, 2lmt.1.A, 6cv9.1.A, 5z1w.1.A, 4umo.1.C, 4umo.1.D, 2a0l.1.A, 5w1a.2.B, 4mvf.1.A, 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