National Institute for Physiological Sciences


Division of Cardiocirculatory Signaling
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 Publications
  Original Papers
  2017
Oda S., Numaga-Tomita T., Kitajima N., Toyama T., Harada E., Shimauchi T., Nishimura A., Ishikawa T., Kumagai Y., Birnbaumer L. and Nishida M.
TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice.
Sci. Rep.
Aug 8;7(1):7511 (2017). doi: 10.1038/s41598-017-07903-4.


Phosri S., Arieyawong A., Boonrukchai K., Parichatikanond W., Nishimura A., Nishida M. and Mangmool S.
Stimulation of adenosine A2B receptor inhibits endothelin-1-induced cardiac fibroblast proliferation and α-smooth muscle actin synthesis through the cAMP/Epac/PI3K/Akt-signaling pathway.
Front. Pharmacol. Jun 30;8:428 (2017). doi: 10.3389/fphar.2017.00428.

Shimauchi T., Numaga-Tomita T., Ito T., Nishimura A., Matsukane R., Oda S, Hoka S., Ide T., Koitabashi N., Uchida K., Sumimoto H., Mori Y. and Nishida M.
TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.
JCI Insight.
Aug 3;2(15). pii: 93358 (2017). doi: 10.1172/jci.insight.93358.

Nakagawa Y, Nishikimi T, Kuwahara K, Fujishima A, Oka S, Tsutamoto T, Kinoshita H, Nakao K, Cho K, Inazumi H, Okamoto H, Nishida M, Kato T, Fukushima H, Yamashita JK, Wijnen WJ, Creemers EE, Kangawa K, Minamino N, Nakao K, Kimura T.
MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts.
J Am Heart Assoc.
Feb 10;6(2), pii: e003601 (2017). doi: 10.1161/JAHA.116.003601.

Yamaguchi Y, Iribe G, Kaneko T, Takahashi K, Numaga-Tomita T, Nishida M, Birnbaumer L, Naruse K.
TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes.
J. Physiol. Sci.
Jan 19 (2017). doi: 10.1007/s12576-016-0519-3.
  2016
Numaga-Tomita T., Kitajima N., Kuroda T., Nishimura A., Miyano K., Yasuda S., Kuwahara K., Sato Y., Ide T., Birnbaumer L., Sumimoto H., Mori Y. and Nishida M.
TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.
Sci. Rep. 6, 39383 (2016); doi: 10.1038/srep39383.


Kitajima N., Numaga-Tomita T., Watanabe M., Kuroda T., Nishimura A., Miyano K., Yasuda S., Kuwahara K., Sato Y., Ide T., Birnbaumer L., Sumimoto H., Mori Y. and Nishida M.
TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.
Sci. Rep.
6, 37001 (2016). doi: 10.1038/srep37001.


Unoki T, Abiko Y, Toyama T, Uehara T, Tsuboi K, Nishida M, Kaji T, Kumagai Y.
Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells.
Sci Rep.
, Jun 30;6:28944 (2016). doi: 10.1038/srep28944.


Hagimori M, Murakami T, Shimizu K, Nishida M, Ohshima T, Mukai T.
Synthesis of radioiodinated probes to evaluate the biodistribution of a potent TRPC3 inhibitor.
Med. Chem. Comm.
7(5), 1003-1006 (2016). doi: 10.1039/c6md00023a.


Nishimura A, Sunggip C, Tozaki-Saitoh H, Shimauchi T, Numaga-Tomita T, Hirano K, Ide T, Boeynaems J-M, Kurose H, Tsuda M, Robaye B, Inoue K,Nishida M*.
The purinergic P2Y6 receptor heterodimerizes with the angiotensin AT1 receptor to promote angiotensin II-induced hypertension.
Sci. Signal. 9(411), ra7 (2016). doi: 10.1126/scisignal.aac9187.


Sawamura S, Hatano M, Takada Y, Hino K, Kawamura T, Tanikawa J, Nakagawa H, Hase H, Nakao A, Hirano M, Rotrattanadumrong R, Kiyonaka S, Mori MX, Nishida M, Hu Y, Inoue R, Nagata R, Mori Y.
Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds.
Mol Pharmacol.
89(3), 348-363 (2016). doi: 10.1124/mol.115.102863.

Mangmool S, Denkaew T, Phosri S, Pinthong D, Parichatikanond W, Shimauchi T, Nishida M.
Sustained βAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner.
Mol Endocrinol. 30(1), 118-132 (2016). doi: 10.1210/me.2015-1201.


Numaga-Tomita T, Nishida M*, Putney JW Jr. and Mori Y*.
TRPC3 amplifies B cell receptor-induced ERK signaling via protein kinase D-dependent Rap1activation.
Biochem J. Jan 15;473(2):201-10 (2016). doi: 10.1042/BJ20150596. (*corresponding author)

  2015
Gentry LR, Nishimura A, Cox AD, Martin TD, Tsygankov D, Nishida M, Elston TC, Der CJ.
Divergent Roles of CAAX Motif-signaled Posttranslational Modifications in the Regulation and Subcellular Localization of Ral GTPases.
J Biol Chem. 290(37), 22851-22861 (2015). doi: 10.1074/jbc.M115.656710.


Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y.
Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress.
Chem Res Toxicol.
28(5), 838-847 (2015). doi: 10.1021/tx500416y.

  2014
Yamada Y, Kinoshita H, Kuwahara K, Nakagawa Y, Kuwabara Y, Minami T, Yamada C, Shibata J, Nakao K, Cho K, Arai Y, Yasuno S, Nishikimi T, Ueshima K, Kamakura S, Nishida M, Kiyonaka S, Mori Y, Kimura T, Kangawa K, Nakao K.
Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure.
Cardiovasc. Res.
104(1):183-93 (2014). doi: 10.1093/cvr/cvu185.

  2013
Watari K, Nakaya M, Nishida M, Kim KM, Kurose H. 
β-arrestin2 in infiltrated macrophages inhibits excessive inflammation after myocardial infarction. 
PLoS One. 8(7):e68351 (2013). doi: 10.1371/journal.pone.0068351.

Nakaya M, Tajima M, Kosako H, Nakaya T, Hashimoto A, Watari K, Nishihara H, Ohba M, Komiya S, Tani N, Nishida M, Taniguchi H, Sato Y, Matsumoto M, Tsuda M, Kuroda M, Inoue K, Kurose H.  GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance.
 Nature Commun. 4, 1532 (2013). doi: 10.1038/ncomms2540.

Nishida M, Ishikawa T, Saiki S, Sunggip C, Aritomi S, Harada E, Kuwahara K, Hirano K, Mori Y, Kim-Mitsuyama S. 
Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice. 
Biochem. Biophys. Res. Commun. 434(2), 210-216 (2013). doi: 10.1016/j.bbrc.2013.03.040.

Chen W, Oberwinkler H, Werner F, Gasner B, Nakagawa H, Feil R, Hofmann F, Schlossmann J, Dietrich A, Gudermann T, Nishida M, Del Galdo S, Wieland T, Kuhn M. 
Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels.
Arterioscler. Thromb. Vasc. Biol. 33(9), 2121-2129 (2013). doi: 10.1161/ATVBAHA.113.001974.

  2012
Nakaya M, Chikura S, Watari K, Mizuno N, Mochinaga K, Mangmool S, Koyanagi S, Ohdo S, Sato Y, Ide T, Nishida M, Kurose H.

Induction of cardiac fibrosis by β-blocker in G protein-independent and GRK5/β-arrestin2-dependent signaling pathways.
J. Biol. Chem. 2012 Oct 12;287(42):35669-35677. doi: 10.1074/jbc.M112.357871.

Kan-o M, Takeya R, Abe T, Kitajima N, Nishida M, Tominaga R, Kurose H and Sumimoto H.
Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis. 
Biol Open. 2012 Sep 15;1(9):889-896.
doi: 10.1242/bio.20121370.

Fujino T, Ide T, Yoshida M, Onitsuka K, Tanaka A, Hata Y, Nishida M, Takehara T, Kanemaru T, Kitajima N, Takazaki S, Kurose H, Kang D, Sunagawa K.

Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes.
Mitochondrion. 12:449-458(2012). Epub 2012 Jun 16. doi: 10.1016/j.mito.2012.06.002

Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, Akaike T.

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration.
Nature Chem Biol. 8: 714-724 (2012) doi: 10.1038/nchembio.1018. [Epub ahead of print]


  English Reviews
Yamaguchi Y, Iribe G, Nishida M and Naruse K.
Role of TRPC3 and TRPC6 channels in the myocardial response to stretch: Linking physiology and pathophysiology.
Prog Biophys Mol Biol. Jun 20. pii: S0079-6107(17)30023-8 (2017).
doi: 10.1016/j.pbiomolbio.2017.06.010. [Epub ahead of print] Review.


Nishimura A, Sunggip C, Oda S, Numaga-Tomita T, Tsuda M and Nishida M.
Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases. Pharmacol Ther. Jun 22. pii: S0163-7258(17)30158-4 (2017). doi: 10.1016/j.pharmthera.2017.06.010. [Epub ahead of print] Review.


Sunggip C, Nishimura A, Shimoda K, Numaga-Tomita T, Tsuda M and Nishida M.
Purinergic P2Y6 receptors: A new therapeutic target of age-dependent hypertension.
Pharmacol Res. 2017 Jun;120:51-59. doi: 10.1016/j.phrs.2017.03.013. Epub 2017 Mar 20. Review.


Nishida M, Nishimura A, Matsunaga T, Motohashi H, Kasamatsu S and Akaike T.
Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells.
Free Radic Biol Med. pii: S0891-5849(17)30033-3, 2017. doi: 10.1016/j.freeradbiomed.2017.01.024.


Fujii S, Sawa T, Nishida M, Ihara H, Ida T, Motohashi H, and Akaike T.
Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides.
Arch Biochem Biophys.;595:140-146 (2016). doi: 10.1016/j.abb.2015.11.008

Nishida M, Kumagai Y, Ihara H, Fujii S, Motohashi H, Akaike T.
Redox signaling regulated by electrophiles and reactive sulfur species.

J. Clin. Biochem. Nutr. 58(2):91-98 (2016). doi: 10.3164/jcbn.15-111.

Nishida M*, Toyama T, Akaike T. 
Role of 8-nitro-cGMP and its redox regulation in cardiovascular electrophilic signaling.
J Mol Cell Cardiol. 73, 10-7 (2014). doi: 10.1016/j.yjmcc.2014.02.003.

Sawa T, Ihara H, Ida T, Fujii S, Nishida M, Akaike T. 
Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide. 
Nitric Oxide 34, 10-18 (2013). doi: 10.1016/j.niox.2013.04.004.

Akaike T, Nishida M, Fujii S. 
Regulation of redox signalling by an electrophilic cyclic nucleotide. 
J. Biochem. 153(2), 131-138 (2013). doi: 10.1093/jb/mvs145.

Sunggip C, Kitajima N, Nishida M
Redox control of cardiovascular homeostasis by angiotensin II. 
Curr Pharm Des. 19(17), 3022-3032 (2013) 

Akaike T, Nishida M, Fujii S. 
Regulation of redox signaling by an electrophilic cyclic nucleotide. 
J Biochem. 153(2), 131-138 (2013). doi: 10.1093/jb/mvs145.

Nishida M, Sunggip C, Kitajima N & Kurose H
Redox regulation of angiotensin receptor signaling in the heart.
Angiotensin: New Research, NOVA Publishers (New York) (2012).


 
  English Books
Nishida M, Kuwahara K, Kozai D, Sakaguchi R, Mori Y.
TRP Channels: Their Function and Potentiality as Drug Targets.
Innovative Medicine: Basic Research and Development (Springer Open, edited by Nakao K, Minato N and Uemoto S), ISBN 978-4-431-55651-0 (eBook) 195-218 (2015). DOI 10.1007/978-4-431-5561-0_17.


Nishida M*, Sunggip C, Kitajima N & Kurose H 
Redox regulation of angiotensin receptor signaling in the heart.
Angiotensin: New Research, NOVA Publishers (New York), Edited by Harada S and Moi I. 165-179 (2012).



  和文総説・著書Japanese Reviews and Books
島内司西村明幸、石川達也、西田基宏 
ミトコンドリア分裂を主眼とした既承認薬のエコファーマ 
日本薬理学雑誌 149, 269-273, 2017. 


西村明幸西田基宏 
プリン作動性P2Y6受容体はアンジオテンシンAT1受容体とヘテロ二量体化を形成してアンジオテンシンII誘発性高血圧を促進する 
Japanese Scientists in Science Signaling 2016「シグナリングに載った日本人研究者」 2017 Issue (Science Signaling AAAS, Cosmo Bio Co. Inc.).


西村明幸西田基宏 
プリン作動性シグナルの心血管系における役割 
日本薬理学雑誌 149, 84−90, 2017.


西田基宏島内司 
ガス様シグナルの破綻と疾患 
医学のあゆみ(2015年8月号)

西田基宏西村明幸 
酸素シグナル 
実験医学(2015年6月増刊号)

西田基宏、森泰生 
Gタンパク質、TRPシグナルと活性イオウ分子 
細胞工学(2015年4月特集号)

森泰生、森誠之、西田基宏 
カルシウムシグナルの基本機構とその可能性 Clin Calcium. 25(1):47-58. doi: CliCa15014758. Review. Japanese.(2015年1月).

Nishida M, Toyama T, Kumagai Y, Numaga-Tomita T.
Establishment of a novel therapeutic strategy for heart failure based on the mechanism underlying maintenance of redox homeostasis by reactive sulfur species.
Yakugaku Zasshi. 134(12):1239-1243 (2014).

北島直幸西田基宏 
心臓におけるTRPチャネルの多様な役割 
実験医学 Vol.32, No.4, 527-533 (2014).

西田基宏
酸化ストレスによるレドックス恒常性異常と心筋リモデリング 
医学のあゆみ Vol. 247, No. 9, 875-878 (2013).

西田基宏,角田将明,北島直幸 
TRPチャネルの生理機能と病態生理 
Clinical Calcium  23(4), 561-568 (2013).
北島直幸西田基宏  
硫化水素のケミカルバイオロジー  
日薬理誌 Vol. 141, 350-351 (2013).

西田基宏,澤智裕 
硫化水素アニオンによるレドックス恒常性制御とその臨床応用 
生化学 みにれびゅー Vol. 85, No. 11, 996-999 (2013)

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