$B@8M}3X8&5f=jG/Js(B $BG/JsL\<!$XLa$k(B$B@8M}8&%[!<%`%Z!<%8$X(B

$B5;=Q2](B

$BBgDmL@@8(B

1$B!%35MW(B

$B!!:#G/EY$N?M;v$O!$J?@.(B15$BG/(B3$B7n$KF0J*-9@780w$rH/C#@8M}3X8&5f7O!$8M@n?9M:pJs8&5f7O!$C]Eg9/9T780w$r@8BND4@a8&5f7O!$;3ED85780w$rJ,;R@8M}8&5f7O$XG[CV49$7$?!#(B7$B7n$K@8BND4@a8&5f7O5;=Q78!&9b?\@i;|;R780w$NB`?&$,$"$C$?!#(B9$B7n$KBgG>Hi<8w78D9$rG[CV49$($7$?!#0i;y5Y6H$K$"$C$?J!EDD>H~780w$N?&>lI|5"!J(B9$B7n!K$,$"$C$?!#(B

$B!!Bh(B3$B4|5;=QIt2q!J%(%l%/%H%m%K%/%99):nIt2q!$5!3#9):nIt2q!$E`7k5;K!It2q!$%P%$%*%$%s%U%)%^%F%#%/%9It2q!$0BA44IM}It2q!$2J3X1Q8l2qOCIt2q!$5;=Q;N!&FC5vIt2q!$Hs?/=15;=QIt2q!K$N3hF0$r0z$-B3$-9T$C$?!#$^$?K\G/EY$b8&5f3hF0$X$N9W8%$r0lAX?J$a$k$?$a$K2<5-$N;v6H$r0z$-B3$-

$B!R(B1$B!S@8M}2J3X

$B!!K\G/!J(B7$B7n(B26$BF|!](B7$B7n(B30$BF|!K$bI85-$N(B1$B%3!<%9!X@8M}3X

$B!R(B2$B!S2J3X8&5fHqJd=u6b!J>)Ne8&5f!K?=@A$N?d?J(B

$B!!6HL3$rE83+$7$F$$$/$?$a$NLdBj0U<1$NM\@.$H$=$N2r7h$N$?$a$N6qBNE*$JE83+7W2h!$J}K!$NN)0FG=NO$NM\@.$*$h$S$=$N$?$a$NI=8=NO$H@bL@NO$NM\@.$rDL$8!$6HL3>e$N5;=QNO$NAm9gE*$J8~>e$r?^$k$3$H$rL\E*$K9T$C$F$$$kI85-$N?=@A$O!$(B20$B2]Bj$r?=@A$7!$(B2$B2]Bj$N:NBr$rF@$?!#:NBr $B!!(B(1)$B1JED<#5;=Q78D9!'G>9b $B!!(B(2)$B@FF#5WH~;R5;=Q780w!'(BIn vivo$B$K$*$1$k3FAH?%$N%0%k%3!<%9$H;iKC;@

$B!R(B3$B!S2]BjJs9p7?5;=Q%7%s%]%8%&%`$N3+:E(B

$B!!8&5f$N9bEY2=$HB?MM2=$O5;=Q?&0w$N%9%-%k$KBg$-$JJQ3W$rGw$C$F$$$k!#;~BeMW@A$KBP1~$7$?%9%-%kG'<1$H8~>e$rL\;X$7$??7$7$$4pHW$KN)$D8&5f2q$NN)$A>e$2$K$h$k5;=Q7O?&0w$N6HL3$N)Ne8&5f!K$N:NBr

$B!R(B4$B!S@.LP?@7P2J3X8&5f=u@.4p6b?=@A$N?d?J(B

$B!!2]0w$N8&5f;Y1gNO$N6/2=$H8~>e$5$i$KAH?%$N<+N)$N$?$a$K$OB?MM$J;q6b$N3NJ]$,:#8e=EMW$J2]Bj$H$J$k!#:#2s>.LZA>>:5;=Q

$B!R(B5$B!SJ|AwBg3XMxMQ$K$h$k?&0w8&=$$N3+9V(B

$B!!J|AwBg3XMxMQ$K$h$k@lLg8&=$$r9T$C$?!#8&=$2JL\$O!XG'CN2J3X!Y$H!X%Y%s%A%c!<4k6HO@!Y$rA*$S!$3F(B5$BL>$,

$B!R(B6$B!SBh(B4$B2s5!3#9):n4pAC9V:B$N

$B!!@8M}3Xl$G3hMQ$G$-$k$3$H$rL\E*$K!$Bh(B4$B2s5!3#9):n4pAC9V:B$r3+9V$7$?!J6&DL8&5f;\@_!&5!4o8&5f;n:n<!$Bj:`$O0l<4<04J0W7?%^%K%e%W%l!<%?$G$"$k!#(B

$B!R(B7$B!S@8M}3X5;=Q8&5f2q$N3+:E(B

$B!!Bh(B26$B2s$r4pAC@8J*3X8&5f=j5;=Q2]$H9gF13+:E$7$?!JJ?@.(B16$BG/(B2$B7n(B19$BF|!](B20$BF|!K!#2q$G$O!$8}1iH/I=$,(B30$BBj!$%]%9%?!49K!$H6/NO$J%]%8%F%#%V!&%M%,%F%#%VA*H4K!$r4pHW$H$7$?%$%M$N0dEA;R%?!<%2%F%#%s%0K!$N3+H/!Y!J;{EDM};^!$4pAC@8J*3X8&5f=j!K$r9T$C$?!#$3$l$i$NJs9p$O!X@8M}3X5;=Q8&5f2qJs9p!Y$K$^$H$a$?!#(B

$B!R(B8$B!S5!9=D9>7f[;05;=Q2]9gF1%;%_%J!<$N3+:E(B

$B!!Bh(B5$B2s$r3+:E$7$?!JJ?@.(B15$BG/(B12$B7n(B9$BF|!K!#3+:E%F!<%^$O!X%P%$%*%F%/%N%m%8!<$H;:3XO"7H!Y$G!$(B4$BBj$N8&=$9V1i$r9T$C$?!#:#2s$bEl3$CO6hBg3X$X$N0FFb$H2,:j>&9)2q5D=j$rDL$8$F$NL14V4k6H$X$N0FFb$r9T$$!$2q$N3H=<$r?J$a$?!#2q$N9V1iFbMF$O!X5!9=D9>7f[;05;=Q2]9gF1%;%_%J!

 

$B!!(B2$B!%;\@_$N1?1D>u67(B

$B!R(B1$B!S@8BN<'5$7WB,AuCV<<(B

$B1JED!!<#!$C]Eg9/9T(B

$B!Z35MW![(B

$B!!K\G/EY$O!$A4F,7?@8BN<'5$7WB,AuCV$ND4@0$,=*N;$75l(BBTi$B%7%9%F%`$+$i$N0\9T:n6H$b$[$\40N;$7$?!#F1;~$K;I7c%7%9%F%`$K$*$$$F$bM=HwD4@0:n6H$,=*N;$7E,59K\l9g$K$h$C$F$O(B1$B;~4V$[$II,MW$G$"$k!#$^$?!$(BLHe$B$N= $B!!;HMQ>u67$O!$B?$/$,:B0L$K$h$k7WB,$G$"$k$?$a;k3P;I7c$N>l9gF)2a%9%/%j!<%s$K$h$k;I7c2hA|I=<($r;HMQ$7$F$$$k$,!$Iz2i0L$K$*$$$F$O%7!<%k%I%k!<%`E7>eLL$X$NEj1F$,I,MW$H$J$k$?$a?7$?$J5!:`$r8!F$$7$J$1$l$P$J$i$J$$!#DK3P$O%l!<%6$rC:;@%,%9$+$i(BYAG$B%l!<%6$KJQ99$7$?$3$H$G!$%S!<%`$NM6F3$,8w%U%!%$%P$K$h$jMF0W$K2DG=$H$J$C$?$?$a!$$h$j=@Fp$JBP1~$,$G$-$k!#$?$@$7!$%l%Y%k(B4$B%/%i%9$N%l!<%6$G$"$k$?$a:Y?4$NCm0U$rMW$7!$Ho83

 

$B!R(B2$B!SG>5!G=7WB,%;%s%?!<(B

$B!J(B1$B!K7ABV>pJs2r@O<<(B

$B;38}!!EP(B

$B!Z35MW![(B

$B!!:#G/EY$K$*$1$kD69b05EE;R82Hy6@6&F1MxMQO$K>\=R$5$l$F$$$k!#D69b05EE;R82Hy6@$NG/4V$NMxMQ>u67$rI=$K$^$H$a$?$N$G2<5-$K<($9!#2TF0N($O!$MxMQF|?t$H;HMQ2DG=F|?t$h$j5a$a$F$$$k!#K\G/EY$N

$B!!(B2003$BG/EY!!D69b05EE827nJL2TF0N((B

$BG/(B  $B7n(B

$BAmF|?t(B

$B5YF|(B

$BD4@0F|(B

$B;HMQ2DG=F|!!!!?t(B

$B=jFbMxMQ(B

$B=j30MxMQ(B

$B7W(B

$B2TF/N((B

$BHw(B  $B9M(B

2003$BG/(B4$B7n(B

30

9

4

17

4

0

4

24%

 

5$B7n(B

31

10

4

17

2

2

4

24%

 

6$B7n(B

30

9

11

10

4

0

4

40%

$B=$M}!!(B8$BF|(B

7$B7n(B

31

9

1

21

8

13

21

100%

$B=$M}!!(B1$BF|(B

8$B7n(B

31

10

4

17

9

4

13

76%

 

9$B7n(B

30

10

5

15

8

2

10

67%

 

10$B7n(B

31

9

9

13

13

0

13

100%

$B=$M}!!(B6$BF|(B

11$B7n(B

30

12

4

14

9

3

12

86%

 

12$B7n(B

31

12

4

15

6

6

12

80%

 

2004$BG/(B1$B7n(B

31

12

4

15

3

11

14

93%

 

2$B7n(B

29

10

1

18

1

17

18

100%

 

3$B7n(B

31

8

4

19

8

2

10

53%

 

$B7W(B

366

120

55

191

75

60

135

71%

 

$B%U%#%i%a%s%HE@Et;~4V!!!!(B417.8$B;~4V(B

$B;HMQ%U%#%k%`Kg?t!!!!!!!!(B5,068$BKg(B

 

$B!J(B2$B!K5!G=>pJs2r@O<<(B

$B:4F#LP4p(B

$B!Z35MW![(B

$B!!:#G/EY$K$*$1$k%j%"%k%?%$%`AuCV$NMxMQ>u67$O!$:NBr8&5f2]Bj?t(B4$BBj$G!$A4$F$N8&5f2]Bj$O

$B!!:#G/EY$NAuCV@0Hw>u67$O!$c$O5/$-$:!$Hf3SE*0BDj$7$?2TF/>uBV$G$"$C$?!#(B9$B7n$K%G!<%?2r@OMQ%3%s%T%e!<%?$N%O!<%I%G%#%9%/$,8N>c$7=$M}8r49$r9T$C$?!#(B11$B7n$K$O2hA|0u:~MQ%+%i!<%S%G%*%W%j%s%?!<$,8N>c$7$?0Y!$=$M}$r9T$$BP1~$7$?!#(B

$B!!6&DL5!4o$G$"$k%U%#%k%`<+F08=A|5!$N@0HwE@8!$r9T$C$?!#(B

$B!!J?@.(B15$BG/EY$N(BMR$BAuCVMxMQ

 

$B!Z5!4oMxMQN(![(B

$BJ?@.(B15$BG/EY%j%"%k%?%$%`AuCV7nJL2TF/N((B

$BG/7n(B

$BAmF|?t(B

$BJ]

$B;HMQ2DG=(B

$B=jFbMxMQ(B

$B=j30MxMQ(B

$B7W(B

$BMxMQN((B

$BHw9M(B

2003$BG/(B4$B7n(B

30

1

29

0

11

11

38%

 

5$B7n(B

31

1

30

0

5

5

17%

 

6$B7n(B

30

1

29

0

8

8

28%

 

7$B7n(B

31

1

30

0

4

4

13%

 

8$B7n(B

31

1

30

0

5

5

17%

 

9$B7n(B

30

3

27

0

6

6

22%

$B%O!<%I8N>c!$DdEE(B

10$B7n(B

31

3

28

0

5

5

18%

$BDdEE(B

11$B7n(B

30

1

29

0

5

5

17%

$B%W%j%s%?!<8N>c(B

12$B7n(B

31

1

30

0

5

5

17%

 

2004$BG/!!(B1$B7n(B

31

1

30

0

7

7

23%

 

2$B7n(B

29

1

28

0

7

7

25%

 

3$B7n(B

31

3

28

0

5

5

18%

$BDj4|E@8!(B

$B7W(B

366

18

348

0

73

73

21%

 

*$BJ]

 

$B!J(B3$B!K@8BN>pJs=hM}<<(B

$B5HB

$B!Z35MW![(B

$B!!@8M}3X8&5f=j$K$*$1$kEv;\@_$NMxMQ7ABV$O!$@8BN>pJs2r@O%7%9%F%`!J9b5!G=%o!<%/%9%F!<%7%g%s!\%"%W%j%1!<%7%g%s!$9b2hpJs%5!<%S%9!J(Be-mail$B!$(BWWW$BEy!K!$%W%m%0%i%`3+H/5Z$S%a%G%#%"JQ49$J$I$KJ,N`$9$k$3$H$,$G$-$k!#$^$?!$$3$l$i$r1_3j$K1?MQ$7$F$$$/$?$a$K$O!$=jFb(BLAN$B$N4IM}!$@0Hw$d>pJs%;%-%e%j%F%#$N0];}$b=EMW$G$"$k!#$3$N$h$&$J8=>u$r$U$^$($?$&$($G!$>pJs%M%C%H%o!<%/4IM}<<$H$bO"7H$7$J$,$i!$;\@_@0Hw$r?J$a$F$$$k!#(B

$B!!@8BN>pJs2r@O%7%9%F%`$O!$%G!<%?2r@O!&2D;k2=!$?.9f=hM}!$2hA|=hM}!$?t<01i;;!$E}7W=hM}!$EE;R2sO)@_7W$J$I$NB?$/$N%"%W%j%1!<%7%g%s$rHw$(!$$3$l$i$O9b5!G=%o!<%/%9%F!<%7%g%s>e$G$NMxMQ$N$_$J$i$:!$3FItLg;\@_$N(BPC$B$KD>@\F3F~$7!$%i%$%;%s%9%5!<%P$GG'>Z$r9T$&$3$H$G$NMxMQ$b2DG=$G$"$k!#EPO?$G!$8&5f?d?J$N$?$a$N@Q6KE*$JMxMQ$,$"$k!#(B

$B!!K\G/EY$O!V2,:j9qN)6&F18&5f5!9=>pJs%;%-%e%j%F%#%]%j%7!pJs%M%C%H%o!<%/MxMQ

$B!!@8M}3X8&5f=j$N%M%C%H%o!<%/MxMQ>u67$O!$%a!<%kEPO?!#(BWWW$BEPO?!#(BLAN$B$NC

$B!!(BWWW$B$O0lG/4V$K(B17$BK|Bf$NC

 

$B!!!R(B3$B!SF0J*

$B:4<#=S9,!$>.LZA>>:!$W"9>LT!$NkLZ@i9a(B

$B!Z35MW![(B

$B!!J?@.(B13$BG/EY(B3$B7nKv$K=W9)$7$?;3

$B!!;3

 

$B!ZL@Bg;{CO6h!!N&@8F0J*<

$B!!J?@.(B15$BG/EY$N;t0i<

$B!!F0J*;t0i?t$NA}2C798~$OF,BG$A$N798~$r<($7$F$$$k$,;3

$B!!;3

$B!!F0J*$N?t$G$"$j!$;D$j$O%/%j!<%s%"%C%WEy$N:n6H$,I,MW$H$J$C$?!#(B

$B!!@_Hw5!4o$N8N>c$,L\N)$A!$(BEOG$BLG6]4o$N8N>c$G$O!$D94|4V$K$o$?$j%,%9LG6]$,9T$($J$$>uBV$,B3$$$?!#:#8e$b5!4o$NO75`2=$K$h$k8N>c$OB?H/$9$k$H;W$o$l$k!#(B

 

$B!ZN>CO6h!!?e@8F0J*<

$B!!J?@.(B15$BG/EY$N?e@8F0J*<u67$O!$@8M}8&!&4p@88&N>8&5f=j$"$o$;$F(B6$BItLg!&;\@_!$(B36$B7o$NMxMQ$,$"$C$?!#(B

$B!!

$B!!L@Bg;{CO6h?e@8F0J*<$,$"$j!$;HMQItLgM=;;$K$F@_CV$r$7$?!#$3$N@_CV$KH<$$!$(B5$B4p$N?eAe$N0\@_$r9T$C$?!#Fb(B3$B4p$O!$;3

$B!!;3$,=P$5$l!$E}9g%P%$%*%5%$%(%s%9%;%s%?!<$NM=;;$K$F@_CV$7$?!#(B

 

$B!Z;3

$B!!J?@.(B15$BG/EY$NMxMQItLg?t$O(B14$B8&5fItLg!J5!9=(B1$B;\@_!$@8M}8&(B6$BItLg!$4p@88&(B2$BItLg!$E}9g%P%$%*%5%$%(%s%9%;%s%?!<(B5$BItLg!K$GMxMQ$G$"$C$?!#(B

$B!!%^%&%9$N(BSPF$B2=$K$O!$

$B!!(BSPF$B6h0h$G;t0iCf$N%^%&%9$K$D$$$F$O!$Dj4|Hy@8J*%b%K%?%j%s%0$r9T$$!$A4<<$GIB86@-Hy@8J*$,%M%,%F%#%V$G$"$k$3$H$r3NG'$7$?!#(B

$B!!%;%s%?!<$h$j8&5f<<$X;}$A=P$7$?F0J*$r:FHBF~$9$k;t0i<<$H$7$F!$(B1F$B$K%^%&%9!$%i%C%HMQ;t0i<<3F(B1$B<<$rMQ0U$7$?!#(B

 

$B!Z$=$NB>![(B

$B!!J?@.(B16$BG/EY$+$i$NK!?M2=$,7hDj$5$l!$O+F/0BA41R@8$K4X$9$k=j3m$,?M;v1!$+$iO+F/4p=`4FFD=p$X0\9T$9$k!#$3$N$?$a$KI,MW$J5!4o$NE@8!2~=$Ey$,9T$o$l$?!#(B
$B!!!&L@Bg;{CO6h%(%A%l%s%*%-%5%$%IG[4I$N2~=$(B
$B!!!&L@Bg;{CO6h!!!!!7!!!!2030%\%s%Y8K$N@_CV(B
$B!!!&L@Bg;{CO6h!!8!::<<%I%i%U%H%A%c%s%P$N@_CV(B
$B!!!&%*!<%H%/%l!<%V!JBh0l $B!!!&8~@:?@Lt;n838&5f;\@_@_CVZ$NJQ99(B
$B!!!&%5%k!!;tM\EPO?I<$NJQ99(B
$B!!$=$NB>!$I,MW$H;W$o$l$kFCDj2=3XJ*

 

$BN&@8F0J*!!!!ItLgJL!&F0J*

$BItLg!!!!!!!!!!!!F0J*

$B%^%&%9(B

$B%i%C%H(B

$B%b%k%b%C%H(B

$B%&%5%.(B

$B%5%k(B

$B?@7P2=3X(B

363

 

 

 

 

$BD6Hy>.7ABV@8M}(B

 

14

 

 

 

$B:YK&FbBe

132

 

 

 

 

$B@8BNKl(B

240

124

79

 

 

$B5!G=6(4X(B

745

254

5

 

 

$BJ,;R?@7P@8M}(B

2,864

2

 

 

 

$B1U@->pJs(B

173

86

 

 

 

$B9b

3,875

14

 

 

 

$B463PG'CN>pJs(B

 

 

 

 

5

$B@8BN%7%9%F%`(B

 

2

 

 

9

$BG'CN9TF0H/C#5!9=(B

87

66

 

 

10

$BG>7ABV2r@O(B

284

290

44

 

3

$BBgG>?@7P2sO)O@(B

4

59

 

 

 

$B7ABV>pJs2r@O<<(B

4

2

 

 

 

$B@8BN>pJs=hM}<<(B

39

9

 

 

 

$B@8?#FbJ,Hg7O(B

 

5

 

 

 

 

 

 

 

 

 

$BF0J*

1,586

 

4

 

 

 

 

 

 

 

$B:YK&5!9=(B

40

 

 

3

 

$B:YK&Fb%(%M%k%.!

140

 

 

 

 

$B:YK&J,2=(B

84

 

 

 

 

$B463P>pJs(B

881

5

 

6

 

$B

240

31

 

 

2

$B:YK&4o41G]M\(B

93

 

 

 

 

$B7A49@8J*(B

44

 

 

 

 

 

 

 

 

 

$BJ,;RH/@8(B

1,566

 

 

 

 

$B?@7PJ,2=(B

754

23

 

 

 

$B%J%N7ABV@8M}(B

20

207

 

 

 

$B@8L?4D6-(B

2,276

 

 

 

 

$B:YK&@8M}(B

343

 

 

 

 

$BG>5!G=J,;R2r@O<<(B

81

831

 

 

 

7,742

1,125

132

9

29

 

$B?e@8F0J*!!7nJL!&F0J*

$B

$B#47n(B

$B#57n(B

$B#67n(B

$B#77n(B

$B#87n(B

$B#97n(B

$B#1#07n(B

$B#1#17n(B

$B#1#27n(B

$B#17n(B

$B#27n(B

$B#37n(B

$B9g7W(B

$B%3%$(B

 

8

6

 

 

 

 

 

 

 

 

 

14

$B%a%@%+(B

500

 

 

 

 

 

 

1,000

 

1,000

 

500

3,000

$B%-%s%.%g(B

50

 

50

100

 

 

 

 

 

 

 

 

200

$B%O%<(B

 

 

 

 

 

 

 

 

 

 

3

 

3

$B%<%N%Q%9(B

 

 

 

 

 

 

 

 

 

40

 

 

40

$B%&%K(B

57

 

 

 

 

 

 

 

 

 

 

 

57

$B%R%H%G(B

 

180

 

 

 

 

 

130

 

60

100

 

470

$B%[%d(B

 

 

 

150

 

 

 

 

 

 

 

90

240

 

 

 

 

 

 

 

 

 

 

 

 

 

0

$B3$?e!J#t!K(B

 

10

12

 

8

8

8

 

8

 

 

8

62

 

 

 

 

 

 

 

 

 

 

 

 

 

0

 

$B!R(B4$B!S6&DL8&5f;\@_(B

$B!J(B1$B!KEE;R82Hy6@<<(B

$BA066!!42(B

$B!Z35MW![(B

$B!!J?@.(B15$BG/Kv$K;34[$,7z@_$5$l!$$=$N(B3$B3,$KEE;R82Hy6@<<$,A}@_$5$l$?!#$=$l$K$H$b$J$$!$F)2a7?EE;R82Hy6@$,(B3$BBf0\E>$5$l!$J?@.(B16$BG/(B1$B7nKv$KF|N)(BH-7000$B!J(B125kv$B!$J?@.(B13$BG/(B10$B7n$KM}2=3X8&5f=j$+$i0\@_!K(B2$B7n$K%U%#%j%C%W(BTecnai 12(120kV)$B$HF|K\EE;R(BJEM-1010$B!J(B100kV$B!$J?@.(B12$BG/(B2$B7n!$El5~Bg3X0e3XIt$h$j0\@_!K$,0\E>$5$l$?!#;3e5-(B3$BBf$NB>$K!$?7$?$K(B3$BBf$NF)2a7?EE;R82Hy6@!J%U%#%j%C%W%9(BEM208S$B!$(BTecnai10$B!$F|N)(BH-7000$B!K$,@_CV$5$l$?!#(B

$B!!:#G/EY!$EE;R82Hy6@9V=,2q$O(B1$BF|%3!<%9!VEE;R82Hy6@$N;22C!K$H(B3$BF|%3!<%9!JJ?@.(B16$BG/(B1$B7n(B20$B!A(B22$BF|!$(B3$BL>;22C!K$,<65;22C!$9V;U(BRadostin Danev$B;a!K$,$"$C$?!#(B

 

$B!!!Z8&5fFbMF0lMwI=![(B

$B!!K\G/EY!$Ev<<$rMxMQ$7$F$J$5$l$?8&5f$NAm7o?t$O(B40$B7o$G$"$C$?!#5!9=Fb$G$O(B30$B7o$"$j!$5!9=30$O!$9qFb$G(B7$B7o!$9q30$G$O%$%.%j%9!$%I%$%D!$Cf9q$N8&5f

 

$B!!MxMQFbMF0lMwI=(B
$B!!Fs8&5f=j(B

$B8&5f=j(B

$BItLg!&;\@_(B

$B8&5fFbMF(B


$B@8M}8&(B

$B1U@->pJs(B
  • $B%$%*%s%A%c%M%k!J(BNa$B%A%c%M%k!K$NKlM"Aw2r@O(B

$BJ,;R?@7P@8M}(B
  • $B7V8wLH1V@w?'$r9T$C$?%^%&%9@T?q$N<4:w>e$G$N%$%*%s%A%c%M%k$NJ,I[2r@O5Z$S%^%&%9@T?q$G$N?q>d!&<4:w$N7ABV2r@O(B
  • $B%K%o%H%jfu$NG>$K$*$1$k?@7PA06n:YK&$N0\F0$N2r@O(B
  • $B%M%H%j%s7gB;%^%&%9$rMQ$$$?%*%j%4%G%s%I%m%5%$%H$NH/@8$N2r@O(B

$BBgG>?@7P2sO)O@(B
  • $BBgG>Hi
  • $BHiuBN!&;k>2Ej
  • $B$2$C;uN`BgG>Hi

$BG>7ABV2r@O(B
  • NMDA$BFb$G$NJ,I[!!:81&HsBP>N@-(B
  • AMPA$B
  • NMDA$B.G>JRMU$N%7%J%W%97ABVJQ2=$NF1Dj(B

$BE}9g%P%$%*%;%s%?!<(B
$B%J%N7ABV@8M}(B
  • $B:YK&!$(BDNA$B%?%s%Q%/
  • $B%?%s%Q%/
  • $B%(%s%I%5%$%H!<%7%97PO)$N@8M}5!G=$H%a%+%K%:%`(B

$B5!G=6(4X(B
  • $B1?F0?@7P:YK&$N@8B85!G=0];}5!9=$N7ABV3XE*8&5f(B

$B7ABV>pJs2r@O<<(B
  • $B>C2=4I$K$*$1$k?e%A%c%M%k$NJ,I[$K4X$9$k8&5f(B

$B5;=Q2](B
  • $B%3%a%D%-%`%7$NAv::A|Hy:Y9=B$4Q;!(B
  • $B@T?qA03Q%K%e!<%m%s:YK&BN$N(B3$B


$B4p@88&(B

$B@8?#(B
  • $B@8?#:YK&$NJ,2=$NJ,;R5!9=$N2r@O(B

$B:YK&5!9=(B
  • $B9bEy?"J*$N0dEA;R;:J*$N:YK&Fb6I:_@-$N2r@O(B

$B
  • $B?"J*:YK&$K$*$1$kI=AXHy>.4I$N9=C[5!9=(B
  • $BCO0aN`$NHy:Y9=B$4Q;!(B
  • $B%R%a%D%j%,%M%4%1$N%W%m%H%W%i%9%H:F@8;~$K$*$1$k:YK&Fb$N6K@-4Q;!(B

$B:YK&A}?#(B
  • $B%7%g%&%8%g%&%P%(G>$K$*$1$k?@7P:YK&$NHy:Y7ABV$N4Q;!(B

$B7W;~5!9=(B
  • $B@8BNKl!$FC$KMuAtN`$N8w9g@.Kl$NH/C#$NHy:Y9=B$E*8&5f(B

$B>pJs@)8f(B
  • $B%7%m%$%L%J%:%J$K$*$1$kMUNPBN8wDj0L1?F0$N2r@O(B

$B463P>pJs=hM}(B
  • $B0dEA;R2~JQ%^%&%9$rMQ$$$?LVKl5Z$S?@7P7O$NH/@8$K4X$9$k7ABV3XE*8&5f(B

$B:YK&Fb%(%M%k%.!]JQ495!9=(B
  • $B9ZJl%*!<%H%U%!%8!<5!9=$N2rL@(B

$BH/@8@8J*7O8DJL8&5f(B
  • $BF0J*AH?%:YK&$ND6Hy7ABV4Q;!(B

 

$B=j30!J9qFb!K(B

$BBg3X!&8&5f=j(B

$B8&5fBeI=(B

$B8&5fFbMF(B

$BN05eBg3X(B

$BCfB

$B5{N`@8?#A#J,2=2aDx$N4Q;!5Z$S%&%K@:;R$N4Q;!(B

$BEl5~Bg3X(B

$BC*66!!5.;R(B

$B%R%a%D%j%,%M%4%1(BFLO/LFY$BAjF10dEA;R(BPPLFY1$B!$(BPPLFY2$B$N5!G=2r@O(B

$BEl5~Bg3X(B

$B0f@n!!0<;R(B

$B%R%a%D%j%,%M%4%1$N(BPIN$B%?%s%Q%/

$BElKLBg3X(B

$B0pMU0lCK(B

$B@:;R$Y$sLS%?%s%Q%/

$BBg:eI\N)Bg3X(B

$B2CF#!!44CK(B

$B1v4pG[Ns0MB8$N(BDNA$B9b

$BEl5~;u2JBg3X(B

$B66K\Dg8w(B

$BBC1UA#K5:YK&M"Aw7PO)$N8!F$!!(B

$B`W6(0e2JBg3X(B

$BCf4[OBI'(B

$B>.G>JRMU$K$*$1$kJ?9T@~0]%7%J%W%9$ND6Hy7ABV3XE*2r@O!!(B

 

$B=j30!J9q30!K(B

$B9qL>!$Bg3X!$8&5f=j(B

$B8&5f(B

$B8&5fFbMF(B

$B%$%.%j%9%*%C%/%9%U%)!<%IBg3X(B

SOMOGYI,Peter

$B%l%W%j%+$N4Q;!(B

$B%$%.%j%9%*%C%/%9%U%)!<%IBg3X(B

ROBERTS,David

$B%l%W%j%+$N4Q;!(B

$B%I%$%D%U%i%$%V%k%/Bg3X(B

KULIK, Akos

$BKl>e5!G=J,;R$N6I:_2r@O(B

$BCf9q(BK.Kleung Brain Research Centre

WEN ,Wang

$B%0%k%?%_%s;@.G>$H3$GO$NJ,I[$N2r@O(B

 

$B!J(B2$B!K5!4o8&5f;n:n<<(B

$B2CF#>!L&(B

$B!Z35MW![(B

$B!!5!4o8&5f;n:n<<$OB?/$J$/$J$j!$?7$7$$8&5f$K$O?7$7$$8&5f5!4o$r:n$k$H$$$&!X$b$N$E$/$j!Y$,4uGv$K$J$j!$0lJ}$G!$:G6a$N8&5f$NB?MM2=$O<<$K?7$?$JLr3d$NLO:w$rGw$C$F$$$k!#$=$&$7$?G'<1$N$b$H!$!X$b$N$E$/$j!YG=NO$N=EMW@-$NM}2r$H5!3#9):n%K!<%:$N?7$?$JH/7!$HE83+$rL\;X$9$?$a$K!$<<$G$O!$(B2000$BG/EY$+$i!$0e3X!&@8J*3X$N!$4p@88&(B2$BL>$G!$%,%$%@%s%9$N8e!$%^%s%D!<%^%s$G(B3$B!A(B4$B2s$N9V=,$r9T$$!$0l?M$N$1$,?M$bL5$/L5;v$K9V=,$r=*N;$9$k;v$,=PMh$?!#(B

$B!!$J$*!$5!4o8&5f;n:n<<$NJ?@.(B15$BG/EY$NMxMQ>u67$O!$0J2<$NDL$j$G$"$k!#(B

 

$B!!5!4o8&5f;n:n<

$B7n(B

$B%\!<%kHW(B

$B%U%i%$%9HW(B

$B%3%s%?!<%^%7%s(B

$B@{HW(B

$B2#@ZHW(B

$B%0%i%$%s%@!<(B

$B@ZCG5!(B

NC$B%U%i%$%9HW(B

$B$=$NB>(B

$B7W(B

4

22

6

19

4

20

18

12

0

32

133

5

15

13

14

6

8

3

0

0

22

81

6

17

12

14

18

4

2

3

1

29

100

7

31

35

25

16

14

4

16

2

42

185

8

17

12

9

10

6

7

2

1

13

77

9

12

18

16

20

6

8

0

0

25

105

10

20

22

22

9

9

8

3

1

18

112

11

19

25

16

8

4

8

1

0

22

103

12

11

10

10

7

5

3

1

0

13

60

1

14

13

15

4

5

9

0

2

12

74

2

8

5

9

3

7

4

3

0

18

57

3

8

6

4

3

11

3

0

2

9

46

$B9g7W(B

194

177

173

108

99

77

44

9

255

1133

 

$B5!4o8&5f;n:n<

$B7n(B

$B@8M}8&(B

$B4p@88&(B

$B$=$NB>(B

$B9g7W(B

$B1d$Y;~4V(B

4

67

8

0

75

69

5

41

1

0

42

81

6

50

5

0

55

75

7

100

1

4

105

221

8

35

5

3

43

88

9

48

1

3

52

96

10

43

3

0

46

95

11

49

2

1

52

86

12

24

6

2

32

56

1

36

0

0

36

57

2

36

1

1

38

35

3

34

3

0

37

78

$B9g7W(B

563

36

14

613

1037

 

$BG'CN9TF0H/C#5!9=(B 110$BL>(B $B!!(B $B463PG'CN>pJs(B 100$BL>(B $B!!(B $B%J%N7ABV@8M}(B 83$BL>(B
$B@8BN%7%9%F%`(B 51$BL>(B $B!!(B $B?4M}@8M}3X(B 43$BL>(B $B!!(B $B@8BNKl(B 29$BL>(B
$B5!G=>pJs2r@O<<(B 29$BL>(B $B!!(B $BF0J* 28$BL>(B $B!!(B $BG>7ABV2r@O(B 25$BL>(B
$BBgG>?@7P2sO)O@(B 15$BL>(B $B!!(B $B1U@->pJs(B 14$BL>(B $B!!(B $B463P1?F0D4@a(B 10$BL>(B
$B?@7PJ,2=(B 10$BL>(B $B!!(B $B7ABV>pJs2r@O<<(B 9$BL>(B $B!!(B $B?@7P2=3X(B 5$BL>(B
$B5!G=6(4X(B 2$BL>(B $B!!(B $B9b 2$BL>(B $B!!(B $BL>M@65 2$BL>(B
$B@8BN>pJs=hM}<<(B 1$BL>(B $B!!(B $B@8?#!&(B
$BFbJ,Hg7OH/C#5!9=(B		 1$BL>(B $B!!(B $B9>668&5f<<(B 1$BL>(B
$B463P>pJs=hM}(B 9$BL>(B $B!!(B $B5;=Q2](B 5$BL>(B $B!!(B $B?"J*H/@8(B 3$BL>(B
RI$B 3$BL>(B $B!!(B $BJ,@O<<(B 3$BL>(B $B!!(B $B0dEA;RH/8=E}8fBh0l(B 2$BL>(B
$B:YK&5!9=(B 2$BL>(B $B!!(B $B@8?#(B 1$BL>(B $B!!(B $BBg7?%9%Z%/%H%m(B 2$BL>(B
$B=jD9< 2$BL>(B $B!!(B $B%(%M%k%.! 1$BL>(B $B!!(B $B7ABV7A@.(B 1$BL>(B
$B7W;~5!9=(B 1$BL>(B $B!!(B     $B!!(B    
$BJ,;R8&$=$NB>(B 14$BL>(B

 
$B$3$N%Z!<%8$N@hF,$X(B$BG/JsL\<!$XLa$k(B$B@8M}8&%[!<%`%Z!<%8$X(B
Copyright(C) 2004 National Institute for Physiological Sciences