National Institutes of Natural Sciences, National Institute for Physiological Sciences, Department of Homeostatic Regulation
SERVICE&PROD
Yasuhiko Minokoshi
Professor
Yasuhiko Minokoshi, M.D., Ph.D.
1983 Graduated from Ehime University School of Medicine.
1987 Completed the doctoral course in Science in Ehime University.
1987 Research Associate in Ehime University.
1993 Lecturer in Ehime University School of Medicine.
1997 Associate Professor in Ehime University School of Medicine.
2003 Lecturer in Harvard Medical School.
2003 Professor, NIPS.
e-mail: minokosh(at)nips.ac.jp
Speciality:
Endocrinology and metabolism
Selected Publications:
Miki T, Liss B, Minami K, Shiuchi T, Saraya A, Kashima Y, Horiuchi M, Ashcroft F, Minokoshi Y, Roeper J, Seino S. ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nature Neuroscience 4: 507-512 (2001)
Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, Carling D, Kahn BB.
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase.
Nature. 415:339-343 (2002)
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T.
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase.
Nat Med. 11:1288-1295 (2002)
Minokoshi Y, Alquier T, Furukawa N, Kim Y-B, Lee A, Xue B, Mu J, Foufelle F, Ferré P, Birnbaum MJ, Stuck BJ, Kahn BB. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428: 569-574 (2004)
Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, Kaneko K, Ishihara H, Niijima A, Nakazato M, Asano T, Minokoshi Y, Oka Y. Regulation of pancreatic β cell mass by neuronal signals from the liver. Science 322: 1250-1254 (2008)
Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, Toda C, Suzuki A, Eric S. Bachman ES, Kim Y-B, Sakurai T, Yanagisawa M, Shioda S, Imoto K, Minokoshi Y. Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system. Cell Metabolism 10: 466-480 (2009)
Toda C, Shiuchi T, Lee S, Yamato-Esaki M, Fujino Y, Suzuki A, Okamoto S, Minokoshi Y.
Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues.
Diabetes. 58(12):2757-2765 (2009)
Toda C, Shiuchi T, Kageyama H, Okamoto S, Coutinho EA, Sato T, Okamatsu-Ogura Y, Yokota S, Takagi K, Tang L, Saito K, Shioda S, Minokoshi Y. Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptin-induced glucose uptake in red-type skeletal muscle. Diabetes 62: 2295-2307 (2013).
Kahn BB, Minokoshi Y
Leptin, GABA, and glucose control
Cell Metab. 18(3) :304-306 (2013) [Preview]
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