Publication list of Keiji Imoto


December 2002

I. 原著論文
  1. Imoto K, Saida K, Iwamura K, Saida T, Nishitani H. Amyotrophic lateral sclerosis: A double-blind crossover trial of thyrotropine-releasing hormone. J Neurol Neurosurg Psychiat 47:1332-1334, 1984.

  2. Ozawa K, Saida K, Saida T, Imoto K, Nishitani H. Familial neuropathy with dementia, retinitis pigmentosa, and dysautonomia. Neurology 35:1184-1187, 1985.

  3. Mishina M, Tobimatsu T, Imoto K, Tanaka K, Fujita Y, Fukuda K, Kurasaki M, Takahashi H, Morimoto Y, Hirose T, Inayama S, Takahashi T, Kuno M, Numa S. Location of functional regions of acetylcholine receptor a-subunit by site-directed mutagenesis. Nature 313:364-369, 1985.

  4. Mishina M, Takai T, Imoto K, Noda M, Takahashi T, Numa S, Methfessel C, Sakmann B. Molecular distinction between fetal and adult forms of muscle acetylcholine receptor. Nature 321:406-411, 1986.

  5. Imoto K, Methfessel C, Sakmann B, Mishina M, Mori Y, Konno Y, Fukuda K, Kurasaki M, Bujo H, Fujita Y, Numa S. Location of a d-subunit region determining ion transport through the acetylcholine receptor channel. Nature 324:670-674, 1986.

  6. Imoto K, Busch C, Sakmann B, Mishina M, Konno T, Nakai J, Bujo H, Mori Y, Fukuda K, Numa S. Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance. Nature 335:645-648, 1988.

  7. Mikami A, Imoto K, Tanabe T, Niidome T, Mori Y, Takeshima H, Narumiya S, Numa S. Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature 340:230-233, 1989.

  8. Yokoyama S, Imoto K, Kawamura T, Higashida H, Iwabe N, Miyata T, Numa S. Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells: Primary structure and functional expression from cDNAs. FEBS Lett 259:37-42, 1989.

  9. Jackson MB, Imoto K, Mishina M, Konno T, Numa S, Sakmann B. Spontaneous and agonist-induced openings of an acetylcholine receptor channel composed of bovine muscle a-, b- and d-subunits. Pflugers Arch 417:129-135, 1990.

  10. Mori Y, Friedrich T, Kim M-S, Mikami A, Nakai J, Ruth P, Bosse E, Hofmann F, Flockerzi V, Furuichi T, Mikoshiba K, Imoto K, Tanabe T, Numa S. Primary structure and functional expression from complementary DNA of a brain calcium channel. Nature 350:398-402, 1991.

  11. Konno T, Busch C, von Kitzing E, Imoto K, Wang F, Nakai J, Mishina M, Numa S, Sakmann B. Rings of anionic amino acids as structural determinants of ion selectivity in the acetylcholine receptor channel. Proc R Soc Lond B 244:69-79, 1991.

  12. Imoto K, Konno T, Nakai J, Wang F, Mishina M, Numa S. A ring of uncharged polar amino acids as a component of channel constriction in the nicotinic acetylcholine receptor. FEBS Lett 289:193-200, 1991.

  13. Terlau H, Heinemann SH, Stuhmer W, Pusch M, Conti F, Imoto K, Numa S. Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II. FEBS Lett 293:93-96, 1991.

  14. Heinemann SH, Terlau H, Stuhmer W, Imoto K, Numa S. Calcium channel characteristics conferred on the sodium channel by single mutations. Nature 356:441-443, 1992.

  15. Heinemann SH, Terlau H, Imoto K. Molecular basis for pharmacological differences between brain and cardiac sodium channels. Pflugers Arch 422:90-92, 1992.

  16. Wang F, Imoto K. Pore and negative charge as structural determinants of permeability in the Torpedo nicotinic acetylcholine receptor channel. Proc R Soc Lond B 250:11-17, 1992.

  17. Hakamata Y, Nakai J, Takeshima H, Imoto K. Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brain. FEBS Lett 312:229-235, 1992.

  18. Kim M-S, Morii T, Sun L-X, Imoto K, Mori Y. Structural determinants of ion selectivity in brain calcium channel. FEBS Lett 318:145-148, 1993.

  19. Nishimura S, Takeshima H, Hofmann F, Flockerzi V, Imoto K. Requirement of the calcium channel b subunit for functional conformation. FEBS Lett 324:283-286. 1993.

  20. Nakai J, Adams BA, Imoto K, Beam KG. Critical roles of the S3 segment and S3-S4 linker of repeat I in activation of L-type calcium channels. Proc Natl Acad Sci USA 91:1014-1018, 1994.

  21. Moran O, Gheri A, Zegarra-Moran O, Imoto K, Conti F. Proline mutations on the S4 segment of rat brain sodium channel II. Biochem Biophys Res Comm 202:1438-1444, 1994.

  22. Hakamata Y, Nishimura S, Nakai J, Nakashima Y, Kita T, Imoto K. Involvement of the brain type of ryanodine receptor in T-cell proliferation. FEBS Lett 352:206-210, 1994.

  23. Heinemann SH, Schlief T, Mori Y, Imoto K. Molecular pore structure of voltage-gated sodium and calcium channels. Brazilian J Med Biol Res 27:2781-2802, 1994.

  24. Helmchen F, Imoto K, Sakmann B. Ca2+ buffering and action potential evoked Ca2+ signaling in dendrites of pyramidal neurons. Biophys J 70:1069-1081, 1996.

  25. Schlief T, Schonherr R, Imoto K, Heinemann SH. Pore properties of rat brain II sodium channels mutated in the selectivity filter domain. Eur Biophys J 25:75-91, 1996.

  26. Garcia J, Nakai J, Imoto K, Beam K. Role of S4 segments and the leucine heptad motif in the activation of an L-type calcium channel. Biophys J 72:2515-2523, 1997.

  27. Dirksen RT, Nakai J, Gonzalez A, Imoto K, Beam K. The S5-S6 linker of Repeat I is a critical determinant of L-type Ca2+ channel conductance. Biophys J 73:1402-1409, 1997.

  28. Nakashima Y, Nishimura S, Maeda A, Barsoumian EL, Hakamata Y, Nakai J, Allen PD, Imoto K, Kita T. Molecular cloning and characterization of a human brain ryanodine receptor. FEBS Lett 417:157-162, 1997.

  29. Wakamori M, Strobeck M, Niidome T, Teramoto T, Imoto K, Mori Y. Functional characterization of ion permeation pathway in the N-type Ca2+ channel. J Neurophysiol 79:622-634. 1998.

  30. Mori Y, Takada Y, Okada T, Wakamori M, Imoto K, Wanifuchi H, Oka H, Oba A, Ikenaka K, Kurosaki K. Differential distribution of TRP Ca2+ channel isoforms in mouse brain. NeuroReport 9:507-515, 1998.

  31. Okada T, Shimizu S, Wakamori M, Maeda A, Kurosaki T, Takada N, Imoto K, Mori Y. Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. J Biol Chem 273:10279-10287, 1998.

  32. Wakamori M, Yamazaki K, Matsunodaira H, Teramoto T, Tanaka I, Niidome T, Sawada K, Nishizawa Y, Sekiguchi N, Mori E, Mori Y, Imoto K. Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel. J Biol Chem 273:34857-34867, 1998.

  33. Aizawa Y, Sugiura Y, Ueno M, Mori Y, Imoto K, Makino K, Morii T. Stability of the dimerization domain effects the cooperative DNA binding of short peptides. Biochemistry 38:4008-4017, 1999.

  34. Matsuyama Z, Wakamori M, Mori Y, Kawakami H, Nakamura S, Imoto K. Direct alteration of the P/Q type Ca2+ channel property by polyglutamine expansion in spinocerebellar ataxia 6 (SCA6). J Neurosci 19:RC14, 1999.

  35. Boccaccio A, Moran O, Imoto K, Conti F. Tonic and phasic TTX-block of sodium channels with point mutations in the outer pore region. Biophys J 77:229-40, 1999.

  36. Okada T, Inoue R, Yamazaki K, Maeda A, Kurosaki T, Yamakuni T, Tanaka I, Shimizu S, Ikenaka K, Imoto K, Mori Y. Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca2+-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem 274:27359-27370 , 1999.

  37. Ishii H, Kinoshita E, Kimura T, Yakehiro M, Yamaoka K, Imoto K, Mori Y, Seyama I. Point-mutations related to the loss of batrachotoxin binding abolish the gryanotoxin effect in Na+ channel isoforms. Jpn J Physiol 49:457-461, 1999.

  38. Yamazaki Y, Yagi T, Ozaki T, Imoto K. In vivo gene transfer to mouse spermatogenic cells using green fluorescent protein as a marker. J Exp Zool 286:212-218, 2000.

  39. Mori M, Konno T, Ozawa T, Murata M, Imoto K, Nagayama K. Novel interaction of the voltage-dependent sodium channel (VDSC) with calmodulin: Does VDSC acquire calmodulin-mediated Ca2+-sensitivity? Biochemistry 39:316-1323, 2000.

  40. Yamada H, Wakamori M, Hara Y, Takahashi Y, Konishi K, Imoto K, Mori Y. Spontaneous single-channel activity of neuronal TRP5 channel recombinantly expressed in HEK293 cells. Neurosci Lett 285:111-114, 2000.

  41. Shibata R, Nakahira K, Shibasaki K, Wakazono Y, Imoto K, Ikenaka K. A-type K+ current mediated by the Kv4 channel regulates the generation of action potential in developing cerebellar granule cells. J Neurosci 20:4145-4155, 2000.

  42. Mori Y, Wakamori M, Oda Si, Fletcher CF, Sekiguchi N, Mori E, Copeland NG, Jenkins NA, Matsushita K, Matsuyama Z, Imoto K. Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling nagoya. J Neurosci 20:5654-62, 2000.

  43. Nishimura S, Iizuka M, Akiba I, Wakamori M, Imoto K, Barsoumian EL. Stable expression of human homomeric and heteromeric AMPA receptor subunits in HEK293 cells. Receptors Channels 7:139-150, 2000.

  44. Yakehiro M, Yuki T, Yamaoka K, Furue T, Mori Y, Imoto K, Seyama I. An analysis of the variations in potency of grayanotoxin analogs in modifying frog sodium channels of differing subtypes. Mol Pharmacol 58:692-700,2000.

  45. Iizuka M, Nishimura S, Wakamori M, Akiba I, Imoto K, Barsoumian EL. The lethal expression of the GluR2flip/GluR4flip AMPA receptor in HEK293 cells. Eur J Neurosci 12:3900-3908, 2000.

  46. Nakai J, Ohkura M, Imoto K. A high signal-to-noise Ca2+ probe composed of a single green fluorescent protein. Nat Biotechnol 19:137-141, 2001.

  47. Ino M, Yoshinaga T, Wakamori M, Miyamoto N, Takahashi E, Sonoda J, Kagaya T, Oki T, Nagasu T, Nishizawa Y, Tanaka I, Imoto K, Aizawa S, Koch S, Schwartz A, Niidome T, Sawada K, Mori Y. Functional disorder of sympathetic nervous system in mice lacking a1B subunit (Cav 2.2) of N-type calcium channel. Proc Natl Acad Sci USA 98:5323-5328, 2001.

  48. Sugawara T, Tsurubuchi Y, Agarwala KL, Ito M, Fukuma G, Mazaki-Miyazaki E, Nagafuji H, Noda M, Imoto K, Wada K, Mitsudome A, Kaneko S, Montal M, Nagata K, Hirose S, Yamakawa K. A missense mutation of the Na+ channel alphaII subunit gene Nav1.2 in a patient with febrile and afebrile seizures causes channel dysfunction. Proc Natl Acad Sci USA 98:6384-6389, 2001.

  49. Hatakeyama S, Wakamori M, Ino M, Miyamoto N, Takahashi E, Yoshinaga T, Sawada K, Imoto K, Tanaka I, Yoshizawa T, Nishizawa Y, Mori Y, Niidome T, Shoji S. Differential nociceptive responses in mice lacking the alpha-1B subunit of N-type Ca2+ channels. NeuroReport 12:2423-2427, 2001.

  50. Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T. Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K, Mori Y. LTRPC2 Ca2-permeable channel activated by changes in redox status confers susceptibility to cell death. Molecular Cell 9:163-173, 2002.

  51. Morii T, Sato S, Hagihara M, Mori Y, Imoto K, Makino K. Structure-based design of a leucine zipper protein with new DNA contacting region. Biochemistry 41:2177-2183, 2002.

  52. Morii T, Sugimoto K, Makino K, Otsuka M, Imoto K, Mori Y. A new fluorescent biosensor for inositol trisphosphate. J Am Chem Soc 124:1138-1139, 2002.

  53. Matsushita K, Wakamori M, Rhyu I.-J, Arii T, Oda S, Mori Y, Imoto K. Bidirectional alterations in cerebellar synaptic transmission of tottering and rolling Ca2+ channel mutant mice. J Neurosci 22:4388-4398,2002.

  54. Kato K, Wakamori M, Mori Y, Imoto K, Kitamura K. Inhibitory effects of cilnidipine on peripheral and brain N-type Ca2+ channels expressed in BHK cells. Neuropharmacology 42:1099-1108, 2002.

  55. Akiba I, Seki T, Mori M, Iizuka M, Nishimura S, Sasaki S, Imoto K, Barsoumian EL. Stable expression and characterization of human PN1 and PN3 sodium channels. Receptors Channels (in press)

II 原著(和文)
  1. 杉之下 俊彦、井本 敬二、熊谷 俊一. シェーグレン症候群患者の乾燥症状に対するbromhexineの効果. 医療 36,419-423,1982

  2. 井本 敬二、小西 哲郎、西谷 裕. D-ペニシラミンによる重症筋無力症. 医療 38,916-919,1984

III 総説(欧文)
  1. Imoto K. Ion channels: molecular basis of ion selectivity (Minireview). FEBS Lett 325, 100-103, 1993.

  2. Imoto K. Molecular aspects of ion permeation through channels. Annals NY Acad Sci 707, 38-50, 1993.

  3. Imoto K. Structure and function of voltage-dependent Na+ channel. in "Handbook of Experimental Pharmacology", Volume 147, Pharmacology of ionic channel functions: activatiors and inhibitors (ed. Endo M, Kurachi Y, Mishina M), pp. 3-26, Springer-Verlag,Heidelberg, 2000.

  4. Mori Y, Inoue R, Ishii M, Hara Y, Imoto K. Dissecting receptor-mediated Ca2+ influx pathways: TRP channels and their native counterparts. Jpn J Pharmacol 87:245-252, 2001.

  5. Imoto K. Voltage-dependent Na+ channel. in "Encyclopedic Reference of Molecular Pharmacology" (ed. Offermanns S, Rosenthal W), Springer-Verlag,Heidelberg. (in press).

IV 和文総説
  1. 西谷 裕、久野 貞子、井本 敬二、太田 光熙、 倉田 昌彦. 自己免疫性筋無力症. 臨床医 7,2405-2409,1981.

  2. 西谷 裕、井本 敬二. Morvan症候群. 日本臨床 40, 726-727, 1982.

  3. 西谷 裕、斉田 孝彦、井本 敬二、人見 英子、 石田 収. スモン. 治療 65,897-902,1983.

  4. 井本 敬二、西谷 裕. 重症筋無力症. 臨床免疫 15,790-795,1983.

  5. 井本 敬二、西谷 裕. D-Penicillamine-induced Myasthenia Gravis. 神経研究の進歩 30,139-145,1986.

  6. 井本 敬二 電位依存性Na+チャネルの構造と機能. 実験医学 12,1311,1316, 1994.

  7. 井本 敬二 Ca2+チャネルの構造と機能. Clinical Neuroscience 14,143-146,1996.

  8. 月田 承一郎、井本 敬二、高井 義美、大橋 正人. 細胞の構造と機能 −総説−. 月田 承一郎 編 ”分子医科学シリーズ 2 細胞:構造と機能” pp 1-42, メジカルビュー社、1996.

  9. 井本 敬二 神経系とカルシウム --分子生物学的研究の成果と今後の問題点-- 小児神経学の進歩 26, 129-138, 1997.

  10. 井本 敬二 分子生物学的実験のための準備と基礎技術 日本生理学会誌 59, 271-278, 1997.

  11. 森島 繁、森 泰生、井本 敬二. 電位依存性カチオンチャネルと神経・筋・心疾患. 岡田泰伸、清野 進 編 ”チャネルとトランスポーター: その働きと病気 分子医科学で病気を識るシリーズ 5” pp 78-100 メジカルビュー社、 1997.

  12. 井本 敬二 Na+チャネル. 御子柴 克彦 編 ”実験医学 Bio Science用語ライブラリー” pp 80-81 羊土社 1997.

  13. 井本 敬二 受容体システム イオンチャネル. 現代医療 30, 59-63, 1998.

  14. 森 泰生、井本 敬二. 受容体活性化されるCa2+流入機構 容量性 Ca2+流入とTRP蛋白質. 蛋白質核酸酵素 43,1567-1576, 1998.

  15. 井本 敬二 神経から筋肉への興奮伝達. 久野 宗、三品 昌美 編 ”岩波講座 現代医学の基礎 6 脳・神経の科学 I ニューロン” pp25-42 岩波書店1998.

  16. 井本 敬二 電位依存性Na+チャネル. 現代医療 31, 905-911,1999.

  17. 井本 敬二 電位依存性ナトリウムチャネル. Clinical Neuroscience 18, 274-277,2000.

  18. 森 泰生、井本 敬二、井上 隆司. カルシウムチャネルの構造と機能.Clinical Calcium 11:9-16, 2001.

  19. 井本 敬二、松下 かおり. 電位依存性Na+チャネル・Ca2+チャネルと神経疾患. 医学のあゆみ 201:1128-1132, 2002.

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