部門公開セミナー
日 時 | 2012年03月27日 17:00~18:00 |
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場 所 | 山手3号館2階 大会議室 |
演 者 | Prof. Karl Peter Giese (Institute of Psychiatry, King's College London, UK) |
演 題 | Mechanisms of memory formation: fast tracks and slow routes |
要 旨 | We have used mouse molecular genetic approaches to study memory mechanisms. We found that the autophosphorylation of alphaCaMKII (alpha-isoform of calcium/calmodulin-dependent kinase II), a major kinase in the excitatory post-synapse, is essential for NMDA receptor-dependent LTP (long-term potentiation) in hippocampal area CA1. This LTP deficit correlates with impaired one-trial learning in aversive conditioning tasks, suggesting that LTP is required for rapid, one-trial learning. However, despite impaired CA1 LTP, memory can be formed in aversive conditioning tasks after multiple training trials. We found evidence that this memory is dependent on increased PSD-95 expression followed by the generation of multi-innervated spines, a type of synapse where a dendritic spine receives more than one presynaptic input. We suggest that generation of multi-innervated spines is a slow learning mechanism when LTP is impaired. |
連絡先 | 山肩葉子(神経シグナル研究部門、内線5887) |