所長招聘セミナー
| 日 時 | 2012年11月08日 16:00~17:30 |
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| 場 所 | 山手3号館2階西・共通セミナー室 |
| 演 者 | Professor Daniel Minor（Departments of Biochemistry and Biophysics & Cellular and Molecular Pharmacology, University of California San Francisco, USA） |
| 演 題 | Structural insights into ion channel function |
| 要 旨 | Ion channels are fundamental components of biological electrical signaling networks. These proteins control the passage of ions across the cell membrane and generate the bioelectricity that is essential for life. Much of the future of neuroscience, cardiovascular research, and design of biomimetic membrane systems lies in understanding the molecular details of how these protein machines function, how they are regulated, and how they are integrated into large, macromolecular complexes within the cell. My laboratory seeks to uncover the basic mechanisms by which ion channels act. We use a multidisciplinary approach that includes genetic selections, X-ray crystallography, solution biophysical methods, small molecule screening, and electrophysiology. We are interested in understanding the high-resolution structures of channel proteins, their regulatory factors, and the conformational changes that accompany channel action as well as in the development novel means to manipulate channel action in vivo. Recent progress from the laboratory's efforts in these areas will be presented. 参考文献 Multiple modalities converge on a common gate to control K2P channel function. EMBO Journal 30, 3594–3606 (2011)
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