目次｜次へ

1 分子生理研究系

1.1 神経機能素子研究部門

A. 英文原著
  1. Mio K, Kubo Y, Ogura T, Yamamoto T, Arisaka F & Sato C (2008) The motor protein prestin is a bullet-shaped molecule with inner cavities. J Biol Chem 283: 1137-1145.
  2. Nakajo K & Kubo Y (2008) Second ciled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks. J Physiol 586: 2827-2840.
  3. Tateyama M & Kubo Y (2008) Regulatory role of C-terminus in the G protein coupling of the metabotropic glutamate receptor1. J Neurochem 107: 1036-1046.
  4. Fujii S, Yamazoe G, Itoh M, Kubo Y & Saitoh O (2008) Sphinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8. Biochem Biophys Res Commun 377: 200-204.
  5. Nagatomo K & Kubo Y (2008) Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels. Proc Natl Acad Sci USA 105: 17373-17378.
  6. Fujiwara Y & Kubo Y (2008) Voltage- and [ATP]- dependent gating of the P2X2 ATP receptor channel. J Gen Physiol (in press).
  7. Hill AS, Nishino A, Nakajo K, Zhang G, Fineman JR, Selzer ME, Okamura Y, Cooper EC (2008) Ion channel clustering at the axon initial segment and node of ranvier evolved sequentially in early chordates. PLoS Genet 4:e1000317.

1.2 分子神経生理研究部門

A. 英文原著
  1. Sasaki N, Okishio K, Ui- Tei K, Saigo K, Kinoshita-Toyoda A, Toyoda H, Nishimura T, Suda Y, Hayasaka M, Hanaoka K, Hitoshi S, Ikenaka K & Nishihara S (2008) Heparan sulfate regulates self-renewal and pluripotency of embryonic stem cells. J Biol Chem 283:3594-3606.
  2. Higashi M, Maruta N, Bernstein A, Ikenaka K & Hitoshi S (2008) Mood stabilizing drugs expand the neural stem cell pool in the adult brain through activation of Notch signaling. Stem Cells 26:1758-1768.
  3. Masuda M, Tanaka KF, Kanazaki S, Wakabayashi K, Oishi N, Suzuki T, Ikenaka K & Ogawa K (2008) GFAP aggregates in the cochlear nerve increase the noise vulnerability of sensory cells in the organ of Corti in the murine model of Alexander disease. Neurosci Res 62:15-24.
  4. Ono K, Takebayashi H, Ikeda K, Furusho M, Nishizawa T, Watanabe K & Ikenaka K(2008) Regional- and Temporal-dependent changes in the differentiation of Olig2 progenitors in the forebrain, and the impact on astrocyte　development in the dorsal pallium. Dev Biol 320:456-468.
  5. Masuda T, Watanabe K, Sakuma C, Ikenaka K, Ono K & Yaginuma H (2008) Netrin-1 acts as a repulsive guidance cue for sensory axonal projections toward the spinal cord. J Neurosci 28 : 10380-10385.
  6. Dimou L, Simon C, Kirchhoff F, Takebayashi H & Gotz M (2008) Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex. J Neurosci 28:10434-10442.
  7. Tatsumi K, Takebayashi H, Manabe T, TanakaKF, Makinodan M, Yamauchi T, Makinodan E, Matsuyoshi H, Okuda H, Ikenaka K & Wanaka A (2008) Genetic fate mapping of Olig2 progenitors in the injured adult cerebral cortex reveals preferential differentiation into astrocytes. J Neurosci Res (in press).
  8. Gotoh H, Okumura A, Nagai K & Okumura N (2008) Localization of phospho-tyrosine489-beta-adducin -immunoreactivity in the hypothalamic tanycytes and its involvement in energy homeostasis. Brain Res (in press).
  9. Ema M, Mori D, Niwa H, Hasegawa Y, Yamanaka Y, Hitoshi S, Mimura J, Kawabe Y, Hosoya T, Morita M, Shimosato D, Uchida K, Suzuki N, Yanagisawa J, Sogawa K, Rossant J, Yamamoto M, Takahashi S & Fujii-Kuriyama Y (2008) Kruppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ES cells. Cell Stem Cell (in press).
  10. Toda T, Hayakawa I, Matsubayashi Y, Tanaka K, Ikenaka K, Lu QR & Kawasaki H (2008) Termination of lesion-induced plasticity in the mouse barrel cortex in the absence of oligodendrocytes. Molecular and Cellular Neuroscience (in press).
  11. Takebayashi H, Usui N, Ono K & Ikenaka K (2008) Tamoxifen modulates apoptosis in multiple modes of action in CreER mice. Genesis (in press).

D. 研究関係著作

  1. 後藤仁志、池中一裕 (2008) グリア細胞の発生・分化・機能。神経の分化，回路形成，機能発現特集号　蛋白質核酸酵素　53:400-405.
  2. 竹林浩秀 (2008) グリア発生の研究を起点とした脳研究 神経化学 47:10-18.

E. その他（学会報告、人物紹介、随筆など）

  1. 田中謙二 (2008)（海外留学便り）ニューヨーク　コロンビア大学に留学して、財団法人　細胞科学研究財団 財団年報　20:27-29.

1.3 細胞内代謝研究部門

A. 英文原著

  1. Cai W, Zhu Y, Furuya K, Li Z, Sokabe M & Chen L (2008) Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damage. Neuropharmacol 55:127-138.
  2. Mohri T, Sokabe M & Kyozuka K (2008) Nitric oxide (NO) increase at fertilization in sea urchin eggs upregulates fertilization envelope hardening. Dev Biol 322:251-262.
  3. Zhao H & Sokabe M (2008) Tuning the Mechanosensitivity of BK Channels by Changing the Linker length. Cell Res 18:871-878.
  4. Hirata H, Tatsumi H & Sokabe M (2008) Mechanical Forces Facilitate Actin Polymerization at Focal Adhesions in a Zyxin-Dependent Manner. J Cell Sci 121:2795-2804.
  5. Hayakawa K, Tatsumi H & Sokabe M (2008) Actin stress fibers transmit and focus force to activate mechanosensitive channels. J Cell Sci 121:496-503.
  6. Ito S, Kume H, Naruse K, Kondo M, Takeda N, Iwata S, Hasegawa Y & Sokabe M (2008) A novel Ca2+ influx pathway activated by mechanical stretch in human airway smooth muscle cells. Am J Respir Cell Mol Biol 38:407-413.
  7. Yoshimura K, Usukura J & Sokabe M (2008) Gating-associated conformational changes in the mechanosensitive channel, MscL. Proc Natl Acad Sci USA 105:4033-4038.
  8. Nomura T, Sokabe M & Yoshimura K (2008) Interaction between the cytoplasmic and transmembrane domains of the mechanosensitive channel, MscS. Biophys J 94:1638-1645.
  9. Toyota M, Furuichi T, Tatsumi H & Sokabe M (2008) Cytoplasmic calcium increases in response to changes in the gravity vector in hypocotyls and petioles of Arabidopsis seedling. Plant Physiol 146:505-514.
  10. Furuichi T, Tatsumi H & Sokabe M (2008) Mechano-sensitive Channels regulate the stomatal aperture in Vicia faba. Biochem Biophys Res Com 366:758-762.
  11. Hirano Y, Ishiguro N, Sokabe M, Takigawa M & Naruse K (2008) Effects of tensile and compressive strains on response of a chondrocytic cell line embedded in type I collagen gel. J Biotechnol 133:245-252
  12. Morihata H, Kawawaki J, Okina M, Sakai H, Notomi T, Sawada M & Kuno M (2008) Early and late activation of the voltage-gated proton channel during lactic acidosis through pH-dependent and -independent mechanisms. Pflügers Arhciv 455:829-838.

D. 研究関係著作

  1. Hirata H, Tatsumi H & Sokabe M (2008) Zyxin emerges as a key player in the mechanotransduction at cell adhesive structures (mini-review). Commun Integr Biol 1:1-4.
  2. Toyota M, Furuichi T, Tatsumi H & Sokabe M (2008) Critical Consideration on the Relationship between Auxin Transport and Calcium Increase in Gravity Perception of Arabidopsis Seedlings (mini-review). Plant Signal Behav 3-8:521-524.
  3. 曽我部正博 (2008) 細胞膜の透過性と物質輸送. “標準細胞生物学”, 医学書院, 東京 (in press).
  4. 曽我部正博 (2008) 動物は何を考えているのか？ “学習と記憶の比較生物学” (曽我部正博 編), 共立出版, 東京 (in press).
  5. 辰巳仁史, 早川公英, 曽我部正博 (2008) 細胞科学における光測定の展開：近接場光、光ピンセットを用いた細胞の力応答の研究の紹介. 日本基礎耳科学会誌 (in press).
  6. 古家喜四男, 曽我部正博 (2008) メカニカルストレスと細胞応答：メカノセンサーとメッセンジャー. Clinical Calcium 18:63-71.
  7. 曽我部正博 (2008) 細胞力学研究の最前線；MSチャネルとアクチン線維. 診療と新薬 45:19-22.

1.4 ナノ形態生理研究部門

A. 英文原著
  1. Danev R & Nagayama K (2008) Single Particle Analysis Based on Zernike Phase Contrast Microscopy. J Struct Biol 161:211-218.
  2. Furuhata M, Danev R, Nagayama K, Yamada Y, Kawakami H, Toma K, Hattori Y and Mitani Y (2008) Decaarginine-PEG-Artificial Lipid/DNA Complex for Gene Delivery: Nanostructure and Transfection Efficiency. J Nanosci Nanotechnol 8:2308-2315.
  3. Yui H, Minamikawa H, Danev R, Nagayama K, Kamiya S & Shimizu T (2008) Growth Process and Molecular Packing of a Self-assembled Lipid Nanotube: Phase-contrast Transmission Electron Microscopy and XRD Analyses. Langmuir 24:709-713.
  4. Yamaguchi M, Danev R, Nishiyama K, Sugawara K & Nagayama K (2008) Zernike phase contrast electron microscopy of ice-embedded influenza A virus. J Struct Biol 162:271-276.
  5. Minkov D & Nagayama K (2008) Chemical Changes of Evaporated a-C Films upon UV Ashing, Hydration, and Drying. Z Phys Chem 12:1-2.
  6. Sasaki K, Kogure K, Chiaki S, Nakamura Y, Moriguchi R, Hamada H, Danev R, Nagayama K, Futaki S & Harashima H (2008) An artificial virus-like nano carrier system: enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives. Anal Bioanal Chem 391:2717-2727.
  7. Hossain I, Iwasaki H, Okochi Y, Chahine M, Higashijima S, Nagayama K & Okamura Y (2008) Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish VSPs. J Biol Chem 283:18248-18259.
  8. Takahashi S, Iwamoto N, Sasaki H, Ohashi M, Oda Y, Tsukita S & Furuse M (2008) The E3 ubiquitin ligase LNX1p80 downregulates claudins from tight junctions in MDCK cells. J Cell Sci (in press).
  9. Nitta K, Nagayama K & Kaneko Y (2008) Visualization of BrdU incorporating DNA in cyanobacterial cells by Hilbert Differential Contrast Transmission Electron Microscopy. J Miroscopy (in press).

C.英文総説(査読あり)

  1. Nagayama K (2008) Develoment of Phase Plates for Electron Microscopes and their Biological Application. Euro Biophys J 37:345-358.
  2. Nagayama K & Danev R (2008) Phase contrast electron microscopy development of thin-fim phase plates and biological applications. Phil Trans R Soc B 363:2153-2162.

D. 研究関係著作

  1. 山口正視, 岡田仁, ダネフ ラドスティン, 西山清人, 菅原敬信, 永山國昭 (2008) 位相差電子顕微鏡によるウィルス観察. 顕微鏡 43:115-120.
  2. 嶋田睦, 末次志郎, 白水美香子, 永山國昭,横山茂之 (2008) EFC/F-BARドメインの構造機能解析－エンドサイト―シスにおける細胞膜陥入機構－.日本結晶学会誌 50:161-168.
  3. 永山國昭, ラドスチン ダネフ (2008) 位相差電子顕微鏡－問題解決のヒントは論文のなかにあった！. 化学（化学同人) 63:48-50.
  4. 永山國昭 (2008) ナノバイオロジーを切り拓く位相差電子顕微鏡. パリテ 23:30-40.