前へ｜目次｜次へ

2 細胞器官研究系

2.1 生体膜研究部門

A. 英文原著
  1. Tsutsumi R, Fukata Y, Noritake J, Iwanaga T, Perez F, Fukata M (2009) Identification of G-protein alpha subunit palmitoylating enzyme. Mol Cell Biol 29:435-447.
  2. Noritake J, Fukata Y, Iwanaga T, Hosomi N, Tsutsumi R, Matsuda N, Tani H, Iwanari H, Mochizuki Y, Kodama T, Matsuura Y, Bredt DS, Hamakubo T, Fukata M (2009) Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. J Cell Biol 186:147-160.
  3. Matsuda N, Lu H, Fukata Y, Noritake J, Gao H, Mukherjee S, Nemoto T, Fukata M, Poo MM (2009) Differential activity-dependent secretion of brain-derived neurotrophic factor from axon and dendrite. J Neurosci 29:14185-14198.
  4. Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G (2009) Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J Biol Chem 284:3793-3803.
  5. Greaves J, Prescott GR, Fukata Y, Fukata M, Salaun C, Chamberlain LH (2009) The Hydrophobic cysteine-rich domain of SNAP25 couples with downstream residues to mediated membrane interactions and recognitions by DHHC palmitoyl transferases. Mol Biol Cell 20:1845-1854.
  6. Mill P, Lee AWS, Fukata Y, Tsutsumi R, Fukata M, Keighren M, Porter RM, McKie L, Smyth I, Jackson IJ (2009) Palmitoylation Regulates Epidermal Homeostasis and Hair Follicle Differentiation. PLoS Genetics 11:e1000748.
  7. Shmueli A, Segal M, Sapir T, Tsutsumi R, Noritake J, Bar A, Sapoznik S, Fukata Y, Orr Y, Fukata M, Reiner O (2009) Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity. EMBO J (in press).
C. 英文総説（査読あり）
  1. Iwanaga T, Tsutsumi R, Noritake J, Fukata Y, Fukata M (2009) Dynamic protein palmitoylation in cellular signaling. Prog Lipid Res 48:117-127.
  2. Fukata Y, Fukata M (2009) Protein palmitoylation in neuronal development and synaptic plasticity. Nat Rev Neurosci (in press).

2.2 機能協関研究部門

A. 英文原著
  1. Liu H-T, Akita T, Shimizu T, Sabirov RZ, Okada Y (2009) Bradykinin-induced astrocyte-neuron signaling: glutamate release is mediated by ROS-activated volume-sensitive outwardly rectifying anion channels. J Physiol 587:2197-2209.
  2. Toychiev AH, Sabirov RZ, Takahashi N, Ando-Akatsuka Y, Liu H-T, Shintani T, Noda M, Okada Y (2009) Activation of the maxi-anion channel by protein tyrosine dephosphorylation. Am J Physiol Cell Physiol 297:C990-C1000.
  3. James AF, Sabirov RZ, Okada Y (2009) Clustering of protein kinase A-dependent CFTR chloride channels in the sarcolemma of guinea-pig ventricular myocytes. Biochem Biophys Res Commun (in press).
  4. Subramanyam M, Takahashi N, Hasegawa Y, Mohri T, Okada Y (2009) Inhibition of a protein kinase Akt1 by apoptosis signal-regulating kinase-1 (ASK1) is involved in apoptotic inhibition of regulatory volume increase. J Biol Chem (in press).
C.英文総説 (査読あり)
  1. Okada Y, Sato K, Numata T (2009) Pathophysiology and puzzles of the volume-sensitive outwardly rectifying anion channel. J Physiol 587:2141-2149.
  2. Sabirov RZ, Okada Y (2009) The maxi-anion channel: A classical channel playing novel roles through an unidentified molecular entity. J Physiol Sci 59:3-21.
D. 研究関係著作
  1. Okada Y, Sato K, Toychiev AH, Suzuki M, Dutta AK, Inoue H, Sabirov RZ (2009) The puzzles of volume-activated anion channels. “Physiology and Pathology of Chloride Transporters and Channels in the Nervous System. From Molecules to Diseases” (Eds. Alvarez-Leefmans FJ, Delpire E), Elsevier, San Diego, pp 283-306.
  2. 岡田泰伸 (2009) 第一章 細胞の一般生理. “標準生理学 (第7版)” (小澤瀞司, 福田康一郎 総編集), 医学書院, 東京, pp 10-46.
E. その他
  1. 岡田泰伸 (2009) 生理学と脳科学--「統合生物学」から「統合生理学」へ. 日本生理学雑誌 71:1-2.
  2. 立花隆, 岡田泰伸 (2009) 脳科学の未来. “解き明かされる脳の不思議” (立花隆 編), クバプロ, 東京, pp 180-192.
  3. 岡田泰伸 (2009) 基礎医学研究・教育の危機に緊急の対策を. 総合臨床 6月号 “論壇”.
  4. 岡田泰伸 (2009) 教育とその条件に思う. 月報 岡崎の教育 10月号 “教育随想”.

2.3 細胞生理研究部門

A. 英文原著
  1. Iwasaki Y, Tanabe M, Kayama Y, Abe M, Kashio M, Koizumi K, Okumura Y, Morimitsu Y, Tominaga M, Ozawa Y, Watanabe T (2009) Miogadial and miogatrial with alpha,beta-unsaturated 1,4-dialdehyde moieties-novel and potent TRPA1 agonists. Life Sci 85:60-69.
  2. Mochizuki T, Sokabe T, Araki I, Fujishita K, Shibasaki K, Uchida K, Naruse K, Koizumi S, Takeda M, Tominaga M (2009) The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures. J Biol Chem. 284:21257-21264.
  3. Mandadi S, Sokabe T, Shibasaki K, Katanosaka K, Mizuno A, Moqrich A, Patapoutian A, Fukumi-Tominaga T, Mizumura K, Tominaga M (2009) TRPV3 in keratinocytes transmits temperatutre information to sensory neurons via ATP. Pfluger Archiv Eur J Physiol 458:1093-1102.
  4. Adachi E, Kazoe Y, Sato Y, Suzuki Y, Urano T, Ueyama T, Saito N, Nikolaev VO, Lohse MJ, Tominaga M, Mogami H (2009) A technique for monitoring multiple signals with a combination of prism-based total internal reflection fluorescence microscopy and epifluorescence microscopy. Pfluger Archiv Eur J Physiol 459:227-234.
  5. Fukumi-Tominaga T, Mori Y, Matsuura A, Kaneko K, Matsui M, Ogata M, Tominaga M (2009) DIP/WISH-Deficient Mice Reveal Dia- and N-WASP-interacting Protein (DIP/WISH) as a regulator of cytoskeletal dynamics in embryonic fibroblasts. Genes to Cells 14 (10):1197-1207.
  6. Matsuura H, Sokabe T, Kohno K, Tominaga M, Kadowaki T (2009) Evolutionary conservation and changes in insect TRP channels. BMC Evolutionary Biology 9 (1):228.
  7. Fujita F, Azuma T, Tajiri M, Okamoto H, Sano M, Tominaga M (2009) Significance of hair-dye base-induced sensory irritation. International J Cosmetic Sci (in press).
D. 研究関係著作
  1. 富永真琴 (2009) カプサイシン受容体と痛み. Anesthesia network 13 (1):19-22.
  2. 富永真琴 (2009) TRPチャネルの機能とアレルギー. アレルギーと神経ペプチド 5: 4-10.
  3. 曽我部隆彰、富永真琴 (2009) 哺乳類における温度受容の分子機構. BRAIN and NERVE 61 (7): 867-873.
  4. 富永真琴 (2009) カプサイシン受容体. 生体の科学 60 (5):470-471.