$B!!(J$B@8M}3X8&5f=jG/Js(J$B!!Bh(J29$B4,(J
$B!!(J$B8&5f2qJs9p(J $BG/JsL\<!$XLa$k(J$B@8M}8&%[!<%`%Z!<%8$X(J

2$B!%%$%*%s%A%c%M%k!&%H%i%s%9%]!<%?!<$H?47l4I5!G=(J
$B!'3X:]E*

2007$BG/(J11$B7n(J13$BF|!](J11$B7n(J14$BF|(J
$BBeI=!&@$OC?M!'8E@nE/;K!JEl5~0e2J;u2JBg3XFq<#<@458&5f=j@8BN>pJsLtM}J,Ln!K(J
$B=jFbBP1~

$B!J#1!K(J
$B5u7l!]:F^uN.$K$h$k?46Z5!G=>c32!'(JNa+/Ca2+$B8r495!9=AK32Lt$rMQ$$$?2r@O(J
$B9TJ}0aM35*!$9b86!!>O!$EDCf!!8w!JElK.Bg3XLt3XItLtJ*3X!K(J
$B!J#2!K(J
$B%i%C%HF0L.4I$K$*$1$k(JT$B7?%+%k%7%&%`%A%c%s%M%k$NLr3d$N8!F$(J
$B@VCS!!E0(J$B#1(J$B!$2#;3!!;m;R(J$B#1(J$B!$A4!!9H(J$B#1(J$B!$@P@n!!5A90(J$B#1(J$B!$FnBt!!5}(J2
$B!J2#IM;TN)Bg3XBg3X1!0e3X8&5f2J=[4D@)8f0e3X(J
$B#1(J$BAa0pEDBg3X@h?JM}9)3XIt@8L?0e2J3X2J(J2$B!K(J
$B!J#3!K(J
Cav1.2$B%A%c%M%k$N%+%k%b%8%e%j%s$*$h$S(JCa2+ $B0MB8@-D4@a(J
$B55;3@5$B!JpJs@8M}3X!$(J
$BCf9q0e2JBg3XLt3X1!LtM}3X65<
$B!J#4!K(J
Structure of the CaV 2 IQ domain in complex with Ca2+ /calmodulin: High-resolution mechanistic implications for channel regulation by Ca2+
$B?9!!@?G7!$0f>eN4;J(J
$B!JJ!2,Bg3X0e3XIt0e3X2J@8M}3X!$(J
$BJ!2,Bg3XBg3X1!0e3X8&5f2J?MBN@8J*7O:YK&J,;R@)8f3X!K(J
$B!J#5!K(J
L$B7?(JCa2+$B%A%c%M%k(JCaV1.2$B$H(JCaV1.3$B$N?4B!%Z!<%9%a!<%+!<3hF0EE0L$K$*$1$kLr3d(J
$BCf@%8E42;R!$@V1)8gH~!JElK.Bg3X0e3XIt0e3X2JLtM}3X9V:B!K(J
$B!J#6!K(J
$BHnBg?4$K$*$1$kDcJ,;RNL(JG$BCAGr~$K$D$$$F(J
$BB$B#1(J$B!$LZB<;j(J2$B!$LpED9@?r(J$B#1(J$B!$J!ED7C0l(J$B#1(J
$B!J7DXf5A=NBg3X0e3XIt:F@80e3X9V:B(J$B#1(J$B!$(J
$BEl5~0eNE%;%s%?!<463P4o%;%s%?!2$B!K(J
$B!J#7!K(J
$B?4B!$NIBE*HnBg$K$*$1$k(JTRPC$B%A%c%M%k$NLr3d(J
$B@>ED!!4p9(!$9u@%!!Ey!J6e=#Bg3XBg3X1!Lt3X8&5f1!Lt8z0BA4@-3XJ,Ln!K(J
$B!J#8!K(J
LPA$B$B3h@-;@AG$r2p$7$?%7%0%J%kEAC#7PO)(J
$B0KP.EDBsLi(J1,2$B!$(JMei-Zhen Cui 1$B!$4dK\N49((J2
$B!J%F%M%7!1$B!$J!2,Bg0e3XItLtM}3X(J2$B!K(J
$B!J#9!K(J
$B%(%T%8%'%M%F%$%C%/0x;R72$H?4B!H/@8!$?4<@45(J
$BC]Fb!!=c!JEl5~9)6HBg3X%0%m!<%P%k%(%C%88&5f1!!K(J
$B!J(J10$B!K(J
$B?46Z$K$*$1$k8r46?@7P?-D9$H?@7P1IM\0x;R(J
$B;0NX2B;R(J1$B!$M{!!>a9q(J1$B!$9b4_K';R(J2$B!$>.C+!!7i(J3$B!$J?NS??@!(J4$B!$?@J]BYI'(J3$B!$;y6L0oM:(J$B#1(J
$B!JL>8E20Bg3X4D6-0e3X8&5f=j(J $B?4!&7l4IJ,Ln(J1$B!$(J
$BL>8E20Bg3X4D6-0e3X8&5f=j(J $BH/@8!&0dEAJ,Ln(J2$B!$(J
$BEl5~Bg3XBg3X1!?7NN0hAO@.2J3X8&5f2J?M4V4D6-3X@l96(J3$B!$(J
$B<+A32J3X8&5f5!9=(J $B@8M}3X8&5f=j9TF0!&Be4$B!K(J
$B!J(J11$B!K(J
G$BCAGr
$BB<>e?58c!$NkLZ?58g!$ARCR2E5W!JBg:eBg3X0e3XItLtM}3X9V:B!K(J
$B!J(J12$B!K(J
$B%l%H%m%&%#%k%9$K$h$k(JcDNA$BH/8=%i%$%V%i%j!<$rMQ$$$?GY4b860x0dEA;R$NH/8+(J
$B4VLnGn9T!J<+<#0e2JBg3X0e3XIt%2%N%`5!G=8&5f!K(J
$B!J(J13$B!K(J
$B%a%?%\%m!<%`2r@O$K$h$k%,%9J,;R$r2p$7$?@8BN@)8f5!9=$NC5:w$H0e3X1~MQ(J
$BKv>>!!@?!J7DXf5A=NBg3X0e3XIt0e2=3X!K(J
$B!J(J14$B!K(J
$BFb8~$-@0N.%+%j%&%`%A%c%M%k$NDc?FOB@-%9%Z%k%_%s%V%m%C%/(J
$B!':YK&FbNN0h%A%c%M%k%]%"$NLr3d(J
$B@P867=;R!$(JYan Ding-Hong$B!J:42lBg3X0e3XIt@8BN9=B$5!G=3X4o41:YK&@8M}J,Ln!K(J
$B!J(J15$B!K(J
$B?46ZEE5$3hF0$K$*$1$k(JKCNE$B%?%s%Q%/
$BK-ED!!B@!$Cz!!0]8w!$>>1:!!Gn!J<"2l0e2JBg3X@8M}3X9V:B:YK&5!G=@8M}3XItLg!K(J
$B!J(J16$B!K(J
$B7l4IJ?3j6Z$G$N(JCa2+$B%9%Q!<%/$K$h$kKlEE0LD4@a5!9=2rL@$N?7$?$J$kE83+(J
$B;3B<$B!JL>8E20;TN)Bg3XBg3X1!Lt3X8&5f2J:YK&J,;RLt8z2r@O3XJ,Ln!K(J
$B!J(J17$B!K(J
$B@-<~4|$K$h$k(JQT$B1dD9>I8u72IT@0L.%j%9%/JQF0$N%7%_%e%l!<%7%g%s(J
$B!=%W%m%2%9%F%m%s$K$h$k?46Z%$%*%s%A%c%M%k@)8f$N%G!<%?$r4p$K!=(J
$B9u@n^-;R!$8E@nE/;K!JEl5~0e2J;u2JBg3XFq<#<@458&5f=j@8BN>pJsLtM}3XJ,Ln!K(J

$B!Z;22C![(J
$BKv>>@?!J7DXf5A=NBg3X0e3XIt0e2=3X!K!$4VLnGn9T!J<+<#0e2JBg3X0e3XIt%2%N%`5!G=8&5fIt!K!$55;3@5pJs@8M}3X!K!$@>ED4p9(!J6e=#Bg3XBg3X1!Lt3X8&5f1!Lt8z0BA4@-3XJ,Ln!K!$B>1:Gn!$Cz0]8w!$K-EDB@!J<"2l0e2JBg3X@8M}3X9V:B:YK&5!G=@8M}3XItLg!K!$BkLn@?!J<+<#0e2JBg3X@8M}3X65<M;R!JEl5~0e2J;u2JBg3XFq<#<@458&5f=j@8BN>pJsLtM}J,Ln!K!$C]Fb=c!JEl5~9)6HBg3X%0%m!<%P%k%(%C%88&5f1!!K!$9TJ}0aM35*!JElK.Bg3XLt3XItLtJ*3X9V:B!K!$@V1)8gH~!$Cf@%8E42;R!$0KF#2mJ}!JElK.Bg3X0e3XIt0e3X2JLtM}3X9V:B!K!$EOn4BY=(!JIM>>0e2JBg3X0e3XIt4G8n3X2J7r9/2J3XNN0h0eNELtM}3XItLg!K!$?9@?G7!JJ!2,Bg3X0e3XIt0e3X2J@8M}3X!K!$4dK\N49(!$0KP.EDBsLi!JJ!2,Bg3X0e3XItLtM}3X9V:B!K!$FnBt5|!JAa0pEDBg3X@h?JM}9)3XIt@8L?0e2J3X2J!K!$@VCSE0!J2#IM;TN)Bg3XBg3X1!0e3X8&5f2J=[4D@)8f0e3X!K!$LZB<=c;R!$:dK\B?Jf!JJ!Eg8)N)0e2JBg3XLtM}3X!K!$;3B<8E20;TN)Bg3XBg3X1!Lt3X8&5f2J:YK&J,;RLt8z2r@O3XJ,Ln!K!$M{>b9q!$?9Eg44M:!JL>8E20Bg3X4D6-0e3X8&5f=j?4!&7l4IJ,Ln!K!$B<>e?58cL>!JBg:eBg3X0e3XItLtM}3X9V:B!K!$7,869(0lO:!J5~ETBg3X0e3XItFbJ,Hg!&Be8E20;TN)BgU\!K!$5WJ]5A90!$N);3=>2

$B!Z35MW![(J
$B!!J?@.(J19$BG/EY$O(J11$B7n(J13$BF|!J2P!K!](J14$BF|!J?e!K$N(J2$BF|4V!$2,:j%+%s%U%!%l%s%9%;%s%?!<(J2$B3,>.2q5D<<$G(J51$BL>$N;22C>@?65

$B!!3X:]E*$J%"%W%m!<%A$H$H$b$KK\G/EY$N8&5f2q$NBg$-$JL\E*$N0l$D$H$7$F!$$NBg3X1!@8$H(J1$BL>$N%]%9%I%/$,4^$^$l$$$i$C$7$c$C$?$3$H$bDI5-$7$?$$!#(J

$B!!0J>e!$?4B!EE5$@8M}8&5f$K$*$1$k3X:]E*$J

 

$B!J(J1$B!K!!5u7l!]:F^uN.$K$h$k?46Z5!G=>c32(J
$B!'(JNa+/Ca2+$B8r495!9=AK32Lt$rMQ$$$?2r(J

$B9TJ}0aM35*!$9b86>O!$EDCf8w!JElK.Bg3XLt3XItLtJ*3X!K(J

$B!!?46Z5u7l!]:F^uN.>c32$K$*$1$k(JNa+/Ca2+$B8r495!9=(J (NCX) $B$N4sM?$rFC0[E*AK32Lt(JSEA0400$B$rMQ$$$FAH?%$*$h$S:YK&%l%Y%k$GI>2A$7$?!#%b%k%b%C%H4'F0L.^uN.1&?4<o?46Z$N<}=L5!G=$*$h$S3hF0EE0LGH7A$K1F6A$rM?$($:!$:F^uN.8e$K4Q;!$5$l$k<}=LNODc2<$*$h$S3hF0EE0L;}B3;~4V$NC;=L$+$i$N2sI|$rB%?J$5$;$?!#$^$?:F^uN.;~$KH/@8$7$?IT@0L.$r(JSEA0400$B$OM^@)$7$?!#$5$i$K(JSEA0400$B$O5u7l$K$h$k?46ZAH?%Fb(JATP$BNL$N8:>/$rM^@)$7!$:F^uN.8e$N(JATP$BNL2sI|$rB%?J$5$;$?!#r7o$K$*$1$k%_%H%3%s%I%j%"5!G=$rC1N%?4<<6Z:YK&$rMQ$$$FI>2A$7$?$H$3$m!$:YK&2+$BG;EY$N>e>:$HF1;~$K%_%H%3%s%I%j%"$NKlEE0LDc2<$*$h$S(JCa2+$BG;EY>e>:$,4Q;!$5$l!$$3$l$i$N;~4V7P2a$O$$$:$l$b(JSEA0400$B$GCY1d$7$?!#$5$i$KF)2a@-:YK&$rMQ$$$F%_%H%3%s%I%j%"Fb$N(JCa2+$BF0BV$r8!F$$7$?7k2L!$%_%H%3%s%I%j%">e$N(JNCX$B$O(JCa2+$B$/$_=P$7$K4sM?$7$F$$$?$,(JSEA0400$B$O$3$N5!9=$K$OL51F6A$G$"$C$?!#0J>e$N7k2L$h$j?46Z5u7l!]:F^uN.;~$K$O:YK&Kl>e$N(JNCX$B$+$iN.F~$7$?(JCa2+$B$K$h$C$F(JCa2+overload$B$,@8$8!$%_%H%3%s%I%j%"$N(JCa2+$BG;EY$,>e>:$7!$IT2D5UE*$J?46Z5!G=>c32$K;j$C$?$H9M$($i$l$?!#:YK&Kl>e$N(JNCX$B$rAK32$9$k$3$H$O?4M^@)$rH<$o$:$K5u7l!]:F^uN.>c32$r7Z8:$9$k?46ZJ]8n<#NE@oN,$NM-8z$J

 

$B!J(J2$B!K!!%i%C%HF0L.4I$K$*$1$k(JT$B7?%+%k%7%&%`%A%c%s%M%k$NLr3d$N8!F$(J

$B@VCSE0(J$B#1(J$B!$2#;3;m;R(J$B#1(J$B!$A49H(J$B#1(J$B!$@P@n5A90(J$B#1(J$B!$FnBt5}(J2
$B!J2#IM;TN)Bg3XBg3X1!0e3X8&5f2J=[4D@)8f0e3X(J
$B#1(J$BAa0pEDBg3X@h?JM}9)3XIt@8L?0e2J3X2J(J2$B!K(J

$B!ZGX7J![J?3j6Z<}=L$O(JVoltage-dependent Ca2+ channel (VDCC) $B$r2p$7$?:YK&Fb(JCa2+$B$N>e>:$K$h$j@8$8$k$?$a!$(JVDCC$B$OF0L.4I$NJD:?$K$b=EMW$JLr3d$rC4$C$F$$$k$H9M$($i$l$k!#2f!9$O@h9T8&5f$G(JT$B7?(JVDCC$B$NH/8=$,=P@8A08e$K>e>:$9$k$3$H$rJs9p$7$?!#(J

$B!ZL\E*![F0L.4I<}=L5Z$S%j%b%G%j%s%0$K$*$1$k(JT$B7?(JVDCC$B$NLr3d$r2rL@$9$k$3$H!#(J

$B!ZJ}K!![A4$F$Na1GmRNA$B$NH/8=$K5Z$\$91F6A$r(JRT-PCR$BK!$G8!F$$7$?!#(J2) a1G$B$N(JsiRNA$B$H(Jplasmid$B$rMQ$$!$J?3j6Z:YK&M7AvG=$r8!F$$7$?!#(J3) $BA*BrE*(JT$B7?(JVDCC$BAK32Lt(J(R(-)-efonidipine)$B$rMQ$$!$;@AG$K$h$kF0L.4I<}=L$X$N(JT$B7?(JVDCC$B$N4XM?$r8!F$$7$?!#(J

$B!Z7k2L![(J1) $BDc;@AGJ,05$+$i@5>o;@AGJ,05$X$NJQ2=$K$h$C$F!$(Ja1GmRNA$B$NH/8=$O(J1.5$BG\$KA}2C$7$?!#(J2) a1GsiRNA$B$G(Ja1G$B$NH/8=$rM^@)$9$k$HM7AvG=$OBP>H$KHf$Y(J53%$B$^$GDc2<$7$?(J(p<0.05)$B!#(Ja1Gplasmid$B$r2aBgH/8=$5$;$k$H!$M7AvG=$O(J60%$BP6?J$7$?(J(p<0.01)$B!#(J3) $B;@AG$K$h$kF0L.4I<}=L$r!$(JR(-)-efonidipine$B$OG;EY0MB8>I$KM^@)$7!$(J10-6M$B$G:GBgD%NO$N(J74%$B$^$G3HD%$7$?(J(p<0.01)$B!#(J

$B!Z7kO@![(JT$B7?(JVDCC$B$r2p$9$k(JCa2+ $BN.F~$O!$=P@88e$NF0L.4I$N7l4I<}=L$d%j%b%G%j%s%0$rB%?J$9$k$H9M$($i$l$?!#(J

 

$B!J(J3$B!K!!(JCav1.2$B%A%c%M%k$N%+%k%b%8%e%j%s$*$h$S(JCa2+$B0MB8@-D4@a(J

$B55;3@5$B!JpJs@8M}3X!$(J
$BCf9q0e2JBg3XLt3X1!LtM}3X65<

$B!!?46Z(JL$B7?(JCa2+$B%A%c%M%k(J (Cav1.2) $B$O!$(JCa2+$B0MB8@-B%DL(J(CDF) $B$HIT3h@-2=(J(CDI)$B$r<($7!$%+%k%b%8%e%j%s(J (CaM) $B$N4XM?$,Js9p$5$l$F$$$k$,!$$=$N5!9=$K$D$$$F$OITL@$JE@$,B?$$!#K\8&5f$G$O!$(JCDF$B$H(JCDI$B$N5!9=$r2rL@$9$kL\E*$G!$Ev8&5f<<$N$3$lKx$N@.2L$r4p$K2>@bE*%b%G%k$r9M$(!$%b%k%b%C%H?4<<6Z:YK&$rMQ$$$?Z$9$k$3$H$r;n$_$?!#(J

$B!Z2>@b![(JCav1.2$B%A%c%M%k$K$O!$(J2$B%+=j$N(JCaM$B7k9gIt0L(J (A$B%5%$%H5Z$S(JI$B%5%$%H$H$9$k!K$,B8:_$7!$(JCaM$B$,(JA$B%5%$%H$K7k9g$9$k$H(JCDF$B$,5/$3$j!$(JI$B%5%$%H$K7k9g$9$k$H(JA$B%5%$%H$N>u67$K94$o$i$:(JCDI$B$,5/$3$k!#(J

$B!Z7k2L![(JInsdie-out$B%Q%C%A$G!$2+$BG;EY(J ( [Ca2+]i ) $B>r7o$N22+]i <100 nM$B$N>r7o2<$G!$(J0.15-2 mM CaM (+2.4 mM ATP) $B$O(JCav1.2$B%A%c%M%k$N3+8}3NN($rG;EY0MB8E*$KA}2C$5$;$?$,!$$h$j9bG;EY$G$OM^@)$r<($7!$G;EY!]H?1~6J@~$O(Jbell$B7?$H$J$C$?!#$3$N6J@~$O!$(J[Ca2+]i$B$rA}2C$5$;$k$H:8J}$K%7%U%H$7$?!#(JCa2+$B7k9gG=$NL5$$(JCaM$BJQ0[BN$b(Jbell$B7?$NG;EY!]H?1~6J@~$r<($7$?$,!$(J[Ca2+]i$B$K$h$k%7%U%H$O8+$i$l$J$+$C$?!#$3$l$i$N7k2L$O!$(J1) A$B5Z$S(JI$B$NN>%5%$%H$O6&$K(JCa2+ -free CaM (apoCaM)$B$H(JCa2+/CaM$B$NN>%5%$%H6&$K(JapoCaM<Ca2+/CaM$B$G$"$k$3$H!$$J$I$rAH$_F~$l$k$3$H$G%b%G%k$H@09g$7$?!#(J

$B!Z7k8l![0J>e$N7k2L$+$i!$(J2$B%+=j$N(JCaM$B7k9gIt0L$r;}$D%b%G%k$O!$(JCDF$B$H(JCDI$B$N5!9=$r$&$^$/@bL@$G$-$k$3$H$,<($5$l$?!#$^$?!$=>Mh$N9M$($H$O0[$J$j!$(JCa2+-free$B>r7o2<$G$b(J CaM (apoCaM) $B$O(JCDF$B$*$h$S(JCDI$BMM$ND4@a:nMQ$r5/$3$7$&$k$3$H$,<(:6$5$l$?!#(J

 

$B!J(J4$B!K!!(JStructure of the CaV 2 IQ domain in complex with Ca2+ /calmodulin: High-resolution mechanistic implications for channel regulation by Ca2+

$B?9@?G7!$0f>eN4;J(J
$B!JJ!2,Bg3X0e3XIt0e3X2J@8M}3X!$(J
$BJ!2,Bg3XBg3X1!0e3X8&5f2J?MBN@8J*7O:YK&J,;R@)8f3X!K(J

$B!!(JP/Q$B7?%+%k%7%&%`%A%c%M%k$K$O(JCa2+-dependent facilitation (CDF) $B$H8F$P$l$k%A%c%M%k3h@-2=IQEY$N>e>:$KH<$$!$%+%k%7%&%`N.F~$rB%?J$9$k%]%8%F%#%V%U%#!<%I%P%C%/@)8f$,4Q;!$5$l$k!#$3$N(JCDF$B$N7k2L!$EAC#J*2+ $BCg2pJ,;R!$%+%k%b%8%e%j%s(J(CaM) $B$N7k>=J#9gBN9=B$2r@O$r9T$C$?!#6=L#?<$$$3$H$K!$$3$N9=B$$O5!G=E*$K$O5U$N(JCa2+-dependent inactivation$B$r0z$-5/$3$9(JCav1.2 (L$B7?(J) $B%A%c%M%k(JIQ$B$H(JCa2+CaM$B$NJ#9gBN9=B$$HHs>o$K;w$?9=B$$G$"$k$3$H$,L@$i$+$H$J$C$?!#$7$+$7$J$,$i!$EE5$@8M}3XE*$K%7%9%F%`E*%"%i%K%s%9%-%c%K%s%0$J$I$rMQ$$$F8!F$$7$?7k2L!$(J(1) IQ$B%b%A!<%U$N>eN.0h$K=EMW$J7k9gIt0L$,B8:_$9$k!$J,;R%7%e%_%l!<%7%g%s$K$h$k7k9g%(%M%k%.!<$H$NAj4X$+$i!$(J(2) CaM N-lobe$B$N7k9g$,=EMW$G$"$k$3$H!$(J(3) C-lobe$B$H(JIQ$B%I%a%$%s$N

 

$B!J(J5$B!K!!(JL$B7?(JCa2+$B%A%c%M%k(JCaV1.2$B$H(JCaV1.3$B$N(J
$B?4B!%Z!<%9%a!<%+!<3hF0EE0L$K$*$1$kLr3d(J

$BCf@%8E42;R!$@V1)8gH~!JElK.Bg3X0e3XIt0e3X2JLtM}3X9V:B!K(J

$B!!F6K<7k@a$K$O(JL$B7?(JCa2+$B%A%c%M%k(Ja1$B%5%V%f%K%C%H$N(JCaV1.2$B$H(JCaV1.3$B$,H/8=$7$F$*$j!$(JCaV1.3$B$O3h@-2=$HIT3h@-2=$NEE0L0MB8@-$,(JCaV1.2$B$KHf$Y2aJ,6KB&$X%7%U%H$7$F$$$k$3$H$,Js9p$5$l$F$$$k!#K\8&5f$G$O(JCaV1.3$B$NEE5$@8M}3XE*FCD'$r(JCaV1.2$B$HHf3S$7!$F6K<7k@a$N%Z!<%9%a!<%+!<3hF0EE0L$K$*$1$kLr3d$r8!F$$7$?!#(J

$B!!EE0L0MB8@-IT3h@-2=(J (VDI) $B%-%M%F%#%/%9$r2r@O$7$?$H$3$m!$(JCaV1.3$B$O(JCaV1.2$B$KHf3S$7$F(JVDI$B$,CY$/!$Dj>oE*$JIT3h@-2=$+$i$N2sI|B.EY$,B.$$$3$H$r8+=P$7$?!#:YK&Fb%+%k%\%-%7%kKvCV1.2$B$N(JC$BKvCV1.3$B7?$KCV49$7$?%-%a%i%A%c%M%k(JCTD$B$r:n@.$72r@O$r9T$C$?!#$=$N7k2L!$(JCTD$B$O(JCaV1.3$B7?$NCY$$(JVDI$B$r<($7!$(JC$BKvCV1.2$B$H(JCaV1.3$B$N(JVDI$BB.EY$N:90[$rC4$&$3$H$,<(:6$5$l$?!#F6K<7k@a$N3hF0EE0LGH7A$GEE0L8GDj$r9T$$(JCa2+$B%A%c%M%kEEN.$r2r@O$7$?$H$3$m!$(JCaV1.3$B$O4K=yC&J,6KAj$+$i3h@-2=$7;O$a!$:FJ,6KAj$G:F3h@-2=$,8+$i$l!$I}9-$$EE0L$G3h@-2=$7$F$$$?!#$5$i$KH?I|C&J,6K2<$K$*$$$F!$(JCaV1.2$B$KHf3S$7$F(JCaV1.3$B$H(JCTD$B$G$O(JCa2+$B%A%c%M%kEEN.NL$,9b$$%l%Y%k$G0];}$5$l$F$$$?!#(J

$B!!0J>e$h$j!$(JCaV1.3$B$O3h@-2=EE0L$,?<$/$+$D(JVDI$B$,CY$$$H$$$&FCD'$rM-$7!$F6K<7k@a$N%Z!<%9%a!<%+!<3hF0EE0L$K$*$$$F4K=yC&J,6KAj$*$h$S3hF0EE0LI}$N0];}$K=EMW$JLr3d$rC4$&$3$H$rL@$i$+$K$7$?!#(J

 

$B!J(J6$B!K!!HnBg?4$K$*$1$kDcJ,;RNL(JG$BCAGrL$B7?%+%k%7%&%`%A%c%M%k=$>~$K$D$$$F(J

$BB$B#1(J$B!$LZB<(J $B;j(J2$B!$LpED9@?r(J$B#1(J$B!$J!ED7C0l(J$B#1(J
$B!J7DXf5A=NBg3X0e3XIt:F@80e3X9V:B(J$B#1(J$B!$(J
$BEl5~0eNE%;%s%?!<463P4o%;%s%?!2$B!K(J

$B!!DcJ,;RNL(JRas$B4XO"(JG$BCAGr(JRGK$B%U%!%_%j!<(J(Rad, Gem, Rem) $B$,(JL$B7?(JCa2+$B%A%c%M%k(Jb$B%5%V%f%K%C%H$H7k9g$7(JL$B7?(JCa2+$BEEN.(J(ICa,L) $B$rM^@)$9$k$3$H$,CN$i$l$F$$$k!#:G6a2f!9$O!$?4B!$K$*$$$FFb0x@-(JRad$B$,?46Z(JL$B7?(JCa2+ $BEEN.$rD4@a$9$k$3$H$K$h$jIT@0L.$NH/@8$K4X$o$C$F$$$k$3$H$rJs9p$7$?!#$5$i$K(JRad$B$N%W%m%b!<%?!<3h@-$,!$%+%k%7%K%e!<%j%s(J/NFAT$B7O$K$h$C$F3h@-2=$9$k$3$H$,Js9p$5$l$F$*$j!$?4HnBg$K$*$$$F(JRad$B$,=EMW$JF/$-$r$7$F$$$k2DG=@-$,<(:6$5$l$k!#$=$3$GK\8&5f$G$OHnBg?4$K$*$1$k(JRad$B$N0U5A$K$D$$$F8!F$$7$?!#?7@8;y%i%C%HG]M\:YK&$r%"%s%8%*%F%s%7%s(JII (AngII) $B$G;I7c$7?4HnBg$re>:$rG'$a$?!#$3$N(JAngII$B;I7c$K$h$k(JRad$B0dEA;R$NA}2C$O%+%k%7%K%e!<%j%sAK32:^$G$"$k%7%/%m%9%]%j%s(JA (CysA) $B$K$h$jM^@)$5$l$?!#$^$?!$(JI Ca,L$B$O(JAngII$B;I7c(J1$BF|8e$G$O%3%s%H%m!<%k$HHf3S$7JQ2=$rG'$a$J$+$C$?$,!$;I7c(J3$BF|8e$K$OM-0U$K8:>/$7$F$$$?!#0lJ}!$%I%_%J%s%H%M%,%F%#%V(JRad$B$r6/H/8=$7$?:YK&$G$O!$(JAngII$B$K$h$k(JI Ca,L$BM^@):nMQ$N8:e$N7k2L$h$j!$(JRad$B$O(JL$B7?%+%k%7%&%`EEN.NL$rD4@a$9$k$3$H$K$h$jHnBg?4$K$*$1$k<}=L5!G=>c32$NH/>I$H$+$+$o$C$F$$$k2DG=@-$,$"$k!#(J

 

$B!J(J7$B!K!!?4B!$NIBE*HnBg$K$*$1$k(JTRPC$B%A%c%M%k$NLr3d(J

$B@>ED4p9(!$9u@%(J $BEy!J6e=#Bg3XBg3X1!Lt3X8&5f1!Lt8z0BA4@-3XJ,Ln!K(J

$B!!?4B!$NIBE*HnBg$K$O!$%"%s%8%*%F%s%7%s(J(Ang)$B$d%(%s%I%;%j%s(J (ET) $B$K$h$jM6H/$5$l$k:YK&Fb(JCa2+$BG;EY(J ([Ca2+]i)$B>e>:$H$=$l$KB3$/E>2+]i$B>e>:$N%a%+%K%:%`$rD4$Y$?7k2L!$2f!9$O%8%"%7%k%0%j%;%m!<%k(J (DAG) $B462+$B%A%c%M%k$N3h@-2=$,4XM?$7$F$$$?!#0lJ}!$(JET-1$B;I7c$K$h$kD94|E*$J(JNFAT$B3h@-2=$K(JTRPC6$B%?%s%Q%/$NH/8=A}2C$,4XM?$9$k$3$H$bL@$i$+$K$7$?!#$3$N%a%+%K%:%`$K$O!$;0NLBN(JG12$B%U%!%_%j!12/13) $B$r2p$7$?%7%0%J%j%s%07PO)$,4XM?$7$F$$$?!#0J>e$N7k2L$+$i!$?@7PBN1U@-0x;R$K$h$j

 

$B!J(J8$B!K!!(JLPA$B$B3h@-;@AG$r2p$7$?%7%0%J%kEAC#7PO)(J

$B0KP.EDBsLi(J1,2$B!$(JMei-Zhen Cui 1$B!$4dK\N49((J2
$B!J%F%M%7!1$B!$J!2,Bg0e3XItLtM}3X(J2$B!K(J

$B!!(JLysophosphatidic Acid (LPA) $B$O(JoxLDL$B$r9=@.$9$kJ,;R$N(J1$B$D$G$"$j!$4!>uF0L.9E2=NN0h$X$N=8@Q$,G'$a$i$l$k!#(JLPA$B$O7l4IJ?3j6Z:YK&$K:nMQ$7$F!$(JEgr-1$BH/8=$r2p$7$?6E7l0x;R(JTissue Factor (TF) $B$NH/8=$rM6F3$9$k!#$3$N(JTF$B$K$h$C$F3h@-2=$5$l$?7l>.HD$b(JLPA$B%=!<%9$N(J1$B$D$G$"$k$3$H$+$i!$$3$NJ,;R$,%(%s%I%l%9$J7l1U6E8G%5%$%/%k$rM6F3$7$F$$$k2DG=@-$,$"$k!#:#2s!$G]M\7l4IJ?3j6Z:YK&$rMQ$$!$$3$N(JEgr-1$BH/8=$N5!=x$K$D$$$F8!F$$7$?!#(JLPA$B;I7c$O(JERK$B!$(JJNK$B!$(Jp38$BA4$F$N%j%s;@2=$rM6F3$7$?$,!$$3$N;~(JERK$BAK32:^$,(JJNK$B$N3h@-2=$rAK32$7$?!#$5$i$K(JLPA$B$,F1:YK&$K$*$$$F3h@-;@AG(J (ROS) $B;:@8$rM6F3$9$kCN8+$r4{$KF@$F$$$?$,!$(JERK$BAK32:^$,(JROS$B;:@8$rM^@)$7!$$5$i$K93;@2=:^$,(JJNK$B$N3h@-2=$rAK32$7$?$3$H$+$i!$(JERK$B$H(JJNK$B$,(JROS$B$r64$s$G=D$KJB$s$G$$$k$H?dB,$5$l$?!#(JROS$B;:@8@)8f0x;R$H$7$F$O(JPKC$B$,CN$i$l$F$$$k$,!$:#2s$N7O$G$O(JPKCd$B$,(JERK$B$N3h@-2=$r@)8f$7$F$$$?!#$^$?!$(JEgr-1$BH/8=$r8!F$$7$?$H$3$m!$>e5-$GAK328z2L$NG'$a$i$l$?AK32:^$d93;@2=:^$J$I$,(JEgr-1$BH/8=$rM^@)$7$?!#:G8e$K$3$N1~Ez$K4XM?$9$k(JLPA$B

 

$B!J(J9$B!K!!%(%T%8%'%M%F%$%C%/0x;R72$H?4B!H/@8!$?4<@45(J

$BC]Fb(J $B=c!JEl5~9)6HBg3X%0%m!<%P%k%(%C%88&5f1!!K(J

$B!!?4B!uBV$K$"$k$H9M$(!$@w?'BN:F9=@.0x;R72$G$"$k(JSWI/SNF$BJ#9gBN$KCeL\$72r@O$r9T$C$F$-$?!#(J

$B!!%^%&%9(JKO$B$N7k2L!$(JSWI/SNF$BJ#9gBN$O?4B!H/@8$K$*$$$F=EMW$J5!G=$r;}$A9g$o$;$F$$$k$3$H$,L@$i$+$H$J$j!$(Jin vivo transfection assay$BK!$K$h$j!$?4B!

$B!!$5$i$K!$(JSWI/SNF$BJ#9gBN$KJQ0[$,5/$3$k$H:8?4<<3HD%5!G=>c32$r0z$-5/$3$7!$(JTbx$B0dEA;R$H6/8G$K2q9g$7$F!$(JCa2+$B7O%$%*%s%A%c%M%k72$NH/8=@)8f$7$F$$$k$3$H$bL@$i$+$H$J$C$F$-$?!#:#2s!$?4B!

 

$B!J(J10$B!K!!?46Z$K$*$1$k8r46?@7P?-D9$H?@7P1IM\0x;R(J

$B;0NX2B;R(J1$B!$M{>a9q(J1$B!$9b4_K';R(J2$B!$>.C+7i(J3$B!$J?NS??@!(J4$B!$?@J]BYI'(J3$B!$;y6L0oM:(J$B#1(J
$B!JL>8E20Bg3X4D6-0e3X8&5f=j(J $B?4!&7l4IJ,Ln(J1$B!$(J
$BL>8E20Bg3X4D6-0e3X8&5f=j(J $BH/@8!&0dEAJ,Ln(J2$B!$(J
$BEl5~Bg3XBg3X1!?7NN0hAO@.2J3X8&5f2J?M4V4D6-3X@l96(J3$B!$(J
$B<+A32J3X8&5f5!9=(J $B@8M}3X8&5f=j9TF0!&Be4$B!K(J

$B!ZL\E*![?46Z$K$*$1$k8r46?@7P$N?-D9$H?@7P(J-$B?46Z@\9g7A@.$NJ,;R5!9=$rD4$Y$kL\E*$G!$?@7P1IM\0x;R$N8z2L$r8!F$$7$?!#(J

$B!ZJ}K!![%i%C%H?7@8;FM3Mh?4<<6Z:YK&$H>ept?@7P@a8r46?@7P:YK&$r6a@\G]M\$7!J4V3V(J1 mm$B!K!$?@7P?-D9!$?@7P!]6Z@\9gIt7A@.$KBP$9$k(Jnerve growth factor (NGF: 50 ng/mL)$B!$(Jglial cell line-derived neurotrophic factor (GDNF: 10 ng/mL) $B$N8z2L$r!$LH1V@w?'K!!$EE;R82Hy6@

$B!Z7k2L![?46Z:YK&$X$N8r46?@7P$N?-D9$O!$(JNGF$B!$(JGDNF$BE:2C$$$:$l$N72$K$*$$$F$b!$(JControl$B72$h$jB%?J$7$F$$$?!#?46Z:YK&$K$*$1$k(Jsynapsin$B$H(Jb1-adrenergic receptor$BH/8=$O!$(JNGF$BE:2C72$h$j$b(JGDNF$BE:2C72$GP6?J$7$F$$$?!#EE82$G$O!$%7%J%W%9>.K&$rM-$9$k?@7P=*Kv$,?46Z:YK&$KJ,I[$7$F$$$?!#:YK&30EE0L5-O?$G$O!$?46Z:YK&<+8JGoF0$N$f$i$.$rH?1G$9$k(JFractal$B;X?t(J(Lorenz plot)$B$,!$(JGDNF$BB8:_2<$GM-0U$KA}2C$7$?(J (GDNF vs Control 1.5 ± 0.02 vs 1.3 ± 0.08, p<0.05, n=3)$B!#(J

$B!Z7kO@![(JNGF$B!$(JGDNF$B$O?46ZFb$G$N8r46?@7P$N?-D9$rB%$7!$(JGDNF$B$O$5$i$K?@7P!]?46Z$N@\9g7A@.$rB%?J$9$k8z2L$,$"$k$3$H$,<(:6$5$l$?!#(J

 

$B!J(J11$B!K!!(JG$BCAGr

$BB<>e?58c!$NkLZ?58g!$ARCR2E5W!JBg:eBg3X0e3XItLtM}3X9V:B!K(J

$B!!?4B!$N5!G=$O@8M}E*?4M}E*MW5a$K1~$8!$8r46?@7P$HI{8r46?@7P$+$i$J$k<+N'?@7P$K$h$C$FD4@0$5$l$k!#$3$N@)8f$O!$pJsEAC#7O$K$h$C$Fb g $B%5%V%f%K%C%H$K$h$C$F3h@-2=$5$l$k!#:#2s@=:n$7$?%b%G%k$G$O!$$3$N>pJsEAC#7O$r(J2$B$D$N9=@.MWAG$KJ,$1$?!#0l$D$O(Jbg$B%5%V%f%K%C%H$H(JG $BCAGr

 

$B!J(J12$B!K(J $B%l%H%m%&%#%k%9$K$h$k(JcDNA$BH/8=%i%$%V%i%j!<$rMQ$$$?(J
$BGY4b860x0dEA;R$NH/8+(J

$B4VLnGn9T!J<+<#0e2JBg3X0e3XIt%2%N%`5!G=8&5f!K(J

$B!!GY4b$O2f$,9q$*$h$S2$JF$N4b;`$NBh0l0L$r@j$a$kM=8eITNI$N<@45$G$"$j!$H/4b5!9=$N2rL@$K4p$E$/?7$?$J<#NEK!$N3+H/$,BT$?$l$F$$$?!#2f!9$OHyNL$NNW>28!BN$+$i8zN(NI$/(JcDNA$B$rH/8=$5$;$k%l%H%m%&%#%k%9%i%$%V%i%j!<9=C[K!$r3+H/$7!$$=$l$rMQ$$$FGY4b$N860x0dEA;R$r%9%/%j!<%K%s%0$7$?!#6qBNE*$K$O5J1lNr$rM-$9$k(J62$B:MCK@-$K@8$8$?GYA#4b302J@Z=|I8K\$+$i(JcDNA$BH/8=%i%$%V%i%j!<$r9=C[$7!$$=$l$r%^%&%9(J3T3$BA!0]30:YK&$K46@w$5$;$?!#$=$N7k2L@8$8$?7A49%U%)!<%+%9$+$i46@w%l%H%m%&%#%k%9$N(JcDNA$B$r2s<}$7$?$H$3$m!$Hy>/4I2q9g%?%s%Q%/(JEML4$B$HoE*$KFsNLBN2=$7$?!$3h@-7?%A%m%7%s%-%J!<%<$G$"$j!$(J3T3$BA!0]2j:YK&$K7A49%U%)!<%+%9$r:n$k$H6&$K%L!<%I%^%&%9$KHi2<.:YK&4b45INc$G(JEML4-ALK$B$,B8:_$9$k$3$H$,<($5$l$?!#$3$l$i(JEML4-ALK$BM[@-GY4b$O>-Mh$K$*$$$F(JALK$B%A%m%7%s%-%J!<%]$H$J$k$H4|BT$5$l$k!#(J

 

$B!J(J13$B!K!!%a%?%\%m!<%`2r@O$K$h$k%,%9J,;R$r2p$7$?(J
$B@8BN@)8f5!9=$NC5:w$H0e3X1~MQ(J

$BKv>>@?!J7DXf5A=NBg3X0e3XIt0e2=3X!K(J

$B!!%,%9>u%a%G%#%(!<%?$O@8BNFb$G@8@.$5$l$kDcJ,;R$G@8BN9bJ,;R$N!V7d4V!W$KF~$j9~$_!$It0LFC0[E*$K7k9g$7$F$=$N5!G=$rD4@a$9$kFCD'$r;}$D!#2f!9$O(J1994$BG/$K%9%H%l%9M6F39ZAG$G$"$k(Jheme oxygenase (HO) $B$+$i@8@.$5$l$k0l;@2=C:AG(J (CO) $B$,4NB!$NN`F67l4I$r91>oE*$KCP4K$5$;!$7lN.0];}:nMQ$r$b$?$i$9$3$H$rJs9p$7$?!#$3$l$r7@5!$H$7$F@8BNFb$G$N(JCO$B$,(JNO$B$HN`;w$N7l4I3HD%J*ZL@$7$F$-$?!#%,%9J,;R$N:nMQE@$d%l%;%W%?J,;R$rC5:w$9$k$3$H$O:$Fq$r6K$a$k$,!$%a%?%\%m!<%`2r@O5;=Q$r3hMQ$9$k$3$H$K$h$j@oN,E*$KFCDj$N%,%9J,;R$N:nMQE@$rF1Dj$7!$$=$N@8J*3XE*9M;!$r?d?J$9$k$3$H$,2DG=$K$J$C$?!#(J $B$=$N7k2LDc;@AG1~Ez$GM6F3$5$l$kBeI=E*$J9ZAG$G$"$k(JHO-1$BM3Mh$N(JCO$B$K$h$j!$(Jmethionine$B$+$i(Jcysteine$B$r@8@.$9$k9ZAG$G$"$k(Jcystathionine beta synthase$B$,AK32$5$l!$(Jthiol$BBe]$O$H$b$K(JCO$B$,%X%`$K7k9g$9$k$H(J6$BG[0L!$(JNO$B$,7k9g$9$k$H(J5$BG[0L$r$H$k$H$$$&CAGr$N%3%s%U%)%a!<%7%g%sJQ2=$N0c$$$K$h$k$b$N$G$"$k!#(JCO$B$K$h$kK\9ZAG$N3h@-@)8f$OE|Be

 

$B!J(J14$B!K!!Fb8~$-@0N.%+%j%&%`%A%c%M%k$NDc?FOB@-%9%Z%k%_%s%V%m%C%/(J
$B!':YK&FbNN0h%A%c%M%k%]%"$NLr3d(J

$B@P867=;R!$(JYan Ding-Hong$B!J:42lBg3X0e3XIt@8BN9=B$5!G=3X4o41:YK&@8M}J,Ln!K(J

$B!!(JKir2$BFb8~$-@0N.%+%j%&%`%A%c%M%k$rN.$l$k308~$-EEN.$O!$:n6H?46Z!J?4<<6Z!&?4K<6Z!K$d%W%k%-%s%(@~0]$N@E;_EE0L0];}$d:FJ,6KAj7A@.$K=EMW$JLr3d$rC4$$!$:YK&Fb$N%9%Z%k%_%sEy$NM[%$%*%s$K$h$k%A%c%M%k!&%V%m%C%/$K$h$jD4@a$5$l$F$$$k!#(JKir2.1$B%A%c%M%k$N%3%s%@%/%?%s%9$K$O%V%m%C%/$KBP$9$k46.$5$J%3%s%@%/%?%s%9@.J,$rN.$l$k;v$r;d$?$A$O0JA0$KJs9p$7$?(J (Ishihara & Ehara, 2004; Yan & Ishihara, 2005)$B!#:#2s$O(JKir2.1$B%A%c%M%kJQ0[BN$N%9%Z%k%_%s$K$h$k%V%m%C%/$r2r@O$7$?!#$=$N7k2L!$Kl4SDLNN0h%]%"FbLL$K0LCV$9$k(JAsp172$BB&:?$NIiEE2Y$rCfOB$9$kJQ0[BN(J (D172N) $B$O!$Ln@87?%A%c%M%k$N%V%m%C%/Dc46uBV$,$"$k$H$$$&2>@b$r;Y;}$7!$(JKir2$B%A%c%M%k$N:YK&FbNN0h%]%"FbLL$NIiEE2Y$O9b?FOB@-%V%m%C%/$N:]$K%]%j%"%_%s$,7k9g$9$kIt0L$G$OL5$$$,!$Dc?FOB@-%V%m%C%/$,5/$-$k:]$N7k9gIt0L$G$"$k;v$,<(:6$5$l$?!#(J

 

$B!J(J15$B!K!!?46ZEE5$3hF0$K$*$1$k(JKCNE$B%?%s%Q%/

$BK-EDB@!$Cz0]8w!$>>1:Gn!J<"2l0e2JBg3X@8M}3X9V:B:YK&5!G=@8M}3XItLg!K(J

$B!!?46Z(JK+$B%A%c%M%k$N(JKCNQ1 (Q1) $B$O(Jb$B%5%V%f%K%C%H$N(JKCNE1 (E1) $B$H2q9g$7(JIKs$B$r9=@.$9$k!#0lJ}!$?4B!$K$OB>$N(JKCNE$B%?%s%Q%/+$B%A%c%M%k$r9=C[$7$F$$$k2DG=@-$,$"$k!#K\8&5f$O!$(JKCNE2 (E2) $B$*$h$S(JKCNE3 (E3) $B$K$h$k(JQ1$B$N5!G=D4@a$r8!F$$7$?!#(JQ1$B$r0BDjH/8=$7$?(JCHO$B:YK&$K(JE1$B$rF3F~$9$k$H(JIKs$BMM$NEEN.$,F@$i$l!$(JE2$B$d(JE3$B$rF3F~$9$k$H>o;~3h@-2=7?$N(JK+$BEEN.$,M6H/$7$?!#$=$3$G(JE1$B$H(JE2$B$rF1;~$KF3F~$9$k$H(JIKs$B$HN`;w$N;~4V0MB8@-EEN.$N$_$,5-O?$5$l$?$,!$(JQ1/E1$BEEN.$H$O@-DK!$rE,MQ$7(JKCNE$B%?%s%Q%/Ks$B$,(J50-70%$BM^@)$5$l$?!#(J

$B!!0lJ}!$(JE3$B$N%N%C%/%@%&%s$O(J IKs$B$K1F6A$r$*$h$\$9$3$H$J$/3hF0EE0L$N1dD9$r0z$-5/$3$7$?!#%b%k%b%C%H?46Z:FJ,6K2aDx$K(JE1$B$N$_$J$i$:(JE2$B$d(JE3$B$b4sM?$9$k2DG=@-$,<(:6$5$l$?!#(J

 

$B!J(J16$B!K7l4IJ?3j6Z$G$N(JCa2+$B%9%Q!<%/$K$h$k(J
$BKlEE0LD4@a5!9=2rL@$N?7$?$J$kE83+(J

$B;3B<$B!JL>8E20;TN)Bg3XBg3X1!Lt3X8&5f2J:YK&J,;RLt8z2r@O3XJ,Ln!K(J

$B!!J?3j6Z$G$O!$6Z>.K&BN$+$i$N<+H/@-(JCa2+$BM7N%$K$h$C$F!$6I=j(JCa2+$BG;EY>e>:!J(JCa2+$B%9%Q!<%/!K$,@8$8$k7k2L!$Bg%3%s%@%/%?%s%9(JCa2+$B3h@-2=(JK+ (BK) $B%A%c%M%k$N3h@-2=$r2p$7$F!$6Z6[D%EY$,D4@a$5$l$F$$$k!#K\8&5f$G$O!$%&%5%.LgL.J?3j6Z:YK&$K6&>GE@7V8w82Hy6@$b$7$/$OA4H?2+ $BG;EYJQ2=$H(JBK$B%A%c%M%k3h@-$rF1;~5-O?$7$?!#$=$N7k2L!$:YK&KlD>2<$GH/@8$7$?(JCa2+$B%9%Q!<%/$@$1$,<+H/0l2a@-308~$-EEN.(J (STOC) $B$HF14|$7$?!#(JCa2+$B%9%Q!<%/$HF14|$7$?<+H/0l2a@-2aJ,6K(J (STH) $B$b4Q;!$G$-$?!#(JCa2+$B%9%Q!<%/$H$=$l$KBP1~$9$k(JSTOC$B$d(JSTH$B$N>e>:;~4V$dH>CMI}$O!$$=$l$>$lNI$/Aj4X$7$?!#$5$i$K!$:YK&KlI=LL$K8B6I$7$?(JTIRF$BNN0h!J%,%i%9@\CeLL$h$j(J200 nm$B0JFb!K$K$*$$$F!$(JCa2+$B%9%Q!<%/$r8zN($h$/8!=P$9$k$3$H$,=PMh$?!#0J>e$h$j!$7l4IJ?3j6Z:YK&$N6I=jIt0L$GH/@8$9$k(JCa2+$B%9%Q!<%/$N$h$j>\:Y$J2r@O$H$=$N6aK5$KB8:_$9$k(JBK$B%A%c%M%k$N@8M}E*0U5A$N2rL@$K!$(JTIRF$B82Hy6@$rMQ$$$?2D;k2=2hA|2r@O$,M-MQ$G$"$k$3$H$,J,$+$C$?!#(J

 

$B!J(J17$B!K!!@-<~4|$K$h$k(JQT$B1dD9>I8u72IT@0L.%j%9%/JQF0$N%7%_%e%l!<%7%g%s(J
$B!=%W%m%2%9%F%m%s$K$h$k?46Z%$%*%s%A%c%M%k@)8f$N%G!<%?$r4p$K!=(J

$B9u@n^-;R!$8E@nE/;K!JEl5~0e2J;u2JBg3XFq<#<@458&5f=j@8BN>pJsLtM}3XJ,Ln!K(J

$B!!(JQT$B1dD9>I8u72$K$*$1$kIT@0L.%j%9%/$O=w@-$K$*$$$FM-0U$K9b$/!$@-<~4|$d<~;:4|$K$h$jJQF0$9$k!#NW>2E*$K$O!$9b%W%m%2%9%F%m%s%l%Y%k>uBV$G$O(JQT$B4V3V$,C;$/IT@0L.%j%9%/$,8:>/$9$k798~$,Js9p$5$l$F$$$k$,!$%a%+%K%:%`$O$$$^$@2rL@$5$l$F$$$J$$!#2f!9$OKl$K8B6I$7$?H?1~$G$"$kHs%2%N%`:nMQ$KCmL\$7!$EE5$@8M}3XE*4)$B$N?46Z:FJ,6KAj$X$N:nMQ$rDjNLE*$K2r@O$7!$7k2L$r3hF0EE0L%7%_%e%l!<%7%g%s!J(JLuo-Rudy$B%b%G%k!K$KF3F~$7$FIT@0L.%j%9%/$X$N1F6A$rE}9gE*$KD4$Y$?!#@8M}E*G;EYHO0O$N(JP4$B$O!$(JP4$B2+ $BEEN.$r8:>/$7$?!#%7%0%J%kJ,;R$O%+%Y%*%i$K6I:_2=$7$F$*$j!$Hs%2%N%`7PO)$rC4$&(JP4$B4$BG;EY$N:G9bCM(J40.6 nM$B$H:GDcCM(J2.5 nM$B$K$*$1$k4$B$OJ]8nE*:nMQ$r;}$A!$2+BN4|$KJ]8nE*:nMQ$,A}6/$5$l$k$3$H$,M=B,$5$l$?!#(JP4$B$N%G!<%?$r4p$K$7$?%7%_%e%l!<%7%g%s%b%G%k$O!$=w@-$N@-<~4|$K$h$j%@%$%J%_%C%/$KJQF0$9$kIT@0L.%j%9%/$rM=B,$9$k$H$$$&1~MQ$,>-MhE*$K4|BT$5$l$k!#(J

 


$B$3$N%Z!<%8$N@hF,$X(J$BG/JsL\<!$XLa$k(J$B@8M}8&%[!<%`%Z!<%8$X(J
Copyright(C) 2008 National Institute for Physiological Sciences