Welcome to HIRABAYASHI Lab！
Aim of Research
Genetically modified (GM) animals (transgenic animals with foreign genes
integrated into the genome / knock-out (KO) animals with disrupted specific
gene functions / knock-in (KI) animals with replaced specific genome sequence)
are indispensable tools in the research of life sciences. With the recent
development of gene editing technologies, it has become possible to generate
desired animals more quickly and efficiently. Routinely, we provide the
genetically modified rodents in responses to requests from research institutions.
Recently, we applied our laboratory skills to regenerative medical study.
“Blastocyst complementation”, that regenerates ES cell- or iPS cell-derived
organs in organ-deficient rodents, was significantly effective to regenerate
functional pancreas and kidneys in KO xenochimeras. In the future, our
activities will contribute to life science and medical development through
the controls of stem cell differentiation, early embryonic development,
and organogenesis, along with elucidation of underlying mechanisms.
