The cortex processes information through intricate circuitry and outputs to multiple brain areas by different sets of pyramidal cells (PCs). We have shown that PCs form intra- and inter-laminar subnetworks, depending on PC projection subtypes. However, it remains unknown how individual PC subtypes are involved in cortical network activity and, thereby, in distinct brain functions. Here, we examined the effects of optogenetic manipulations of specific PC subtypes on network activity in the motor cortical slices. In layer V, the beta/gamma frequency band (30~35 Hz) of oscillation was evoked by photostimulation, depending on PC subtypes. Our experimental and simulation results suggest that oscillatory activity is generated in reciprocal connections between pyramidal tract (PT) and fast-spiking cells. Moreover, a similar frequency band was also observed in local field potentials during a pattern learning task. Manipulation of PT cell activity affected beta/gamma band power and learning. Our results suggest that PT cell-dependent oscillations play important roles in motor learning.

Funding

KAKENHI

Journal article

Title: Pyramidal cell subtype-dependent cortical oscillatory activity regulates motor learning

Authors: Takeshi Otsuka and Yasuo Kawaguchi
Journal: Communications biology
Issue: 22;4(1)
Date: 22 April 2021
URL (abstract):
DOI: 10.1038/s42003-021-02010-7