Integrative understanding of biological phenomena with temperature as a key theme(Thermal Biology)




  • #Abe Y, #Fujiwara Y, #Takahashi H, Matsumura Y, Sawada T, Jiang S, Nakaki R, Uchida A, Nagao N, Naito M, Kajimura S, Kimura H, Osborne TF, Aburatani H, Kodama T, *Inagaki T, *Sakai J.
    Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch
    Nat. Commun. inpress
  • Ohnishi K., Takagaki N., Okahata M., Fujita M., Ohta A., *Kuhara A.
    Molecular and Cellular Network Systems Underlying Cold Tolerance of Caenorhabditis elegans
    Cryobiology and Cryotechnology inpress
  • *Saito H , Morishita T, Mizukami T, Nishiyama K, Kawaguchi K, Nagao H.
    Molecular dynamics study of binary POPC bilayers: molecular condensing effects on membrane structure and dynamics.
    J. Physics in press.
  • Nakamura Y, *Nakamura K.
    Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability.
    Pflügers Arch. - Eur. J. Physiol. in press.
    PMID: 29209779
  • *Nomura T, Yamashita W, Gotoh H, Ono K.
    Species-specific mechanisms of neuron subtype specification reveal evolutionary plasticity of amniote brain development.
    Cell Reports 22(12): 3142-3151, 2018
  • #Goda T, #Doi M, Umezaki Y, Murai I, Shimatani H, Chu ML, Nguyen VH, *Okamura H, *Hamada FN.
    Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals.
    Genes & Development, 32(2):140-155, 2018
    #These authors contributed equally to this work, *Corresponding authors .
  • *Karasawa T, Kawashima A, Usui-Kawanishi F, Watanabe S, Kimura H, Kamata R, Shirasuna K, Koyama Y, Sato-Tomita A, Matsuzaka T, Tomoda H, Park SY, Shibayama N, Shimano H, Kasahara T, *Takahashi M.
    Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages.
    Arterioscler Thromb Vasc Biol. inpress
  • *Derouiche S, Takayama Y, Murakami M, *Tominaga M.
    TRPV4 heats up ANO1-dependent exocrine gland fluid secretion.
    FASEB J. inpress
  • *Okabe K, Sakaguchi R, Shi B, *Kiyonaka S.
    Intracellular thermometry with fluorescent sensors for thermal biology.
    Pflugers Arch. inpress
  • Nakamura S, Suzuki S, Saito H, *Nishiyama KI.
    Cholesterol blocks spontaneous insertion of membrane proteins into liposomes of phosphatidylcholine.
    J Biochem. inpress
  • *Fukuda T, *Kanki T.
    Mechanisms and Physiological Roles of Mitophagy in Yeast.
    Mol Cells. 41(1):35-44, 2018
    PMID: 29370687
  • *Nomura T, Gotoh H, Ono K.
    The Future Vocation of Neural Stem Cells: Lineage Commitment in Brain Development and Evolution.
    Neurochem Res. 43(1):153-156, 2018
  • Eto K, Kim SK, Takeda I, *Nabekura J.
    The roles of cortical astrocytes in chronic pain and other brain pathologies.
    Neurosci Res. 126:3-8, 2018
  • #Tainaka M, #*Doi M, Inoue Y, Murai I, *Okamura H.
    Circadian PER2 protein oscillations do not persist in cycloheximide-treated mouse embryonic fibroblasts in culture.
    Chronobiol. Int. 35(1):132-136,2018
  • Fujita T, Liu Y, Higashitsuji H, Itoh K, Shibasaki K, *Fujita J, Nishiyama H.
    Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins.
    Biochem Biophys Res Commun. 495(1):935-940,2018
  • *Inomata N, Toda M, Ono T.
    Microfabricated Temperature-Sensing Devices Using a Microfluidic Chip for Biological Applications
    Int. J. of Automation Technology, 12(1), 15-23, 2018
  • *Imamoto N.
    Regulating β-catenin nuclear import with the small GTPase Rap.
    Developmental Cell 44, 135-136, 2018.


  • *Inomata N, Toan NV, Ono T.
    Piezoresistive property of an aluminum-doped zinc oxide thin film deposited via atomic-layer deposition for microelectromechanical system/nanoelectromenchanical system applications
    IEEJ Trans., 12(S2), S120-S124, 2017.
  • Murakami A, *Nagao K, Juni N, Hara Y, *Umeda M.
    An N-terminal di-proline motif is essential for fatty acid-dependent degradation of Δ9-desaturase in Drosophila.
    J Biol Chem. 292(49):19976-19986, 2017
  • Mimura Y, Takemoto S, Tachibana T, Ogawa Y, Nishimura M, *Yokota H, *Imamoto N.
    A statistical image analysis framework for pore-free islands derived from heterogeneity distribution of nuclear pore complexes.
    Sci Rep. 7(1):16315, 2017
    PMID: 29176624
  • Oyama S, Dogishi K, Kodera M, Kakae M, Nagayasu K, Shirakawa H, *Nakagawa T, Kaneko S.
    Pathophysiological Role of Transient Receptor Potential Ankyrin 1 in a Mouse Long-Lasting Cystitis Model Induced by an Intravesical Injection of Hydrogen Peroxide.
    Front Physiol. 8:877, 2017
  • Rahman K.M.Z., Kose S, *Imamoto N.
    Effect of an inhibitor of HSP70, YM-1 on Hikeshi knockout cells.
    Thermal Medicine 33, 129-134, 2017
  • Sukeishi A, Isami K, Hiyama H, Imai S, Nagayasu K, Shirakawa H, *Nakagawa T, Kaneko S.
    Colchicine alleviates acute postoperative pain but delays wound repair in mice: roles of neutrophils and macrophages.
    Mol. Pain 13: 1-12, 2017
    PMID: 29108466
  • Rahman KMZ, Mamada H, Takagi M, Kose S, *Imamoto N.
    Hikeshi modulates the proteotoxic stress response in human cells: Implication for the importance of the nuclear function of HSP70s.
    Genes Cells. 22(11):968-976, 2017
  • Miyake T, Nakamura S, Meng Z, Hamano S, Inoue K, Numata T, Takahashi N, Nagayasu K, Shirakawa H, Mori Y, Nakagawa T, Kaneko S.
    Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin.
    Front Physiol. 8:878, 2017
  • Jo A, Noel J, Lakk M, Yarishkin O, Ryskamp D, Shibasaki K, Maureen A McCall, *Krizaj D.
    Mouse retinal ganglion cell signaling is dynamically modulated through parallel anterograde activation of cannabinoid and vanilloid pathways.
    J. Physiol.595(20):6499-6516, 2017
  • *Uchida K, Dezaki K, Yoneshiro T, Watanabe T, Yamazaki J, Saito M, Yada T, Tominaga M, *Iwasaki Y.
    Involvement of thermosensitive TRP channels in energy metabolism.
    J Physiol Sci. 67(5):549-560, 2017
  • Yamashita W, Shimizu T, *Nomura T.
    In Vitro and Ex Ovo Culture of Reptilian and Avian Neural Progenitor Cells.
    Methods Mol Biol.1650:259-265, 2017
    Part of the Methods in Molecular Biology book series (MIMB, volume 1650)
  • Yahiro T, Kataoka N, Nakamura Y, *Nakamura K.
    The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation.
    Sci. Rep. 7:5031, 2017
  • Yamashita SI, *Kanki T.
    Detection of Hypoxia-Induced and Iron Depletion-Induced Mitophagy in Mammalian Cells.
    Methods Mol. Biol. in press.
  • Furukawa K, *Kanki T.
    Mitophagy in Yeast: A Screen of Mitophagy-Deficient Mutants.
    Methods Mol. Biol. in press.
  • *Inomata N, Ono T.
    Geometry dependence of temperature coefficient of resonant frequency in highly sensitive resonant thermal sensors.
    Japanese Journal of Applied Physics 56, 087201, 2017
  • *Nakagawa T, Kaneko S.
    Roles of transient receptor potential ankyrin 1 in oxaliplatin-induced peripheral neuropathy.
    Biol. Pharm. Bull. 40(7):947-953, 2017.
  • Sugahara K, *Shimokawa N, Takagi M.
    Thermal Stability of Phase-Separated Domains in Multicomponent Lipid Membranes with Local Anesthetics.
    Membranes (Basel). 7(3),33, 2017
  • Deftu AF, Filippi A, Shibsaki K, Gheorghe RO, Chiritoiu M, Ristoiu V.
    CXCL1 and CXCL2 chemokines modulate the activity of TRPV1+/IB4+ cultured rat dorsal ganglia neurons upon short-term and acute application.
    J. Physiol. Pharmacol. 68(3):385-395, 2017
  • Sharma N, Baek K, Phan H, Shimokawa N, *Takagi M.
    Glycosyl chains and 25-hydroxycholesterol contribute to the intracellular transport of amyloid beta (Aβ-42) in Jurkat T cells.
    FEBS Open Bio. 18;7(6):865-876, 2017.
  • *Yamashita SI, *Kanki T.
    How autophagy eats large mitochondria: Autophagosome formation coupled with mitochondrial fragmentation.
    Autophagy. 13(5):980-981, 2017
    PMID: 28521613
  • *Nomura T. *Izawa E-I.
    Avian brains: insights from development, behaviors and evolution.
    Dev. Growth Differ. 59(4):244-257, 2017.
  • Fujita T, Higashitsuji H, Higashitsuji H, Liu Y, Itoh K, Sakurai T, Kojima T, Kandori S, Nishiyama H, Fukumoto M, Fukumoto M, Shibasaki K, *Fujita J.
    TRPV4-dependent induction of a novel mammalian cold-inducible protein SRSF5 as well as CIRP and RBM3.
    Sci. Rep. 7(1):2295, 2017.
  • Shimokawa N, Mukai R, Nagata M, *Takagi M.
    Formation Q1 of modulated phases and domain rigidification in fatty acid-containing lipid membranes.
    Phys. Chem. Chem. Phys. 19(20):13252-13263, 2017
  • Kurganov E, Saito S, Saito CT, *Tominaga M.
    Requirement of extracellular Ca2+ binding to specific amino acids for heat-evoked activation of TRPA1.
    J. Physiol. 595(8):2451-2463, 2017
  • Nishikawa H, Sasaki M, *Nishiyama KI.
    Membrane insertion of F0c subunit of F0F1 ATPase depends on glycolipozyme MPIase and is stimulated by YidC.
    Biochem. Biophys. Res. Commun. 487(2):477-482, 2017
  • Sugio S, Nagasawa M, Kojima I, Ishizaki Y, *Shibasaki K.
    TRPV2 activation by focal mechanical stimulation requires interaction with the actin cytoskeleton and enhances growth cone motility.
    FASEB J. 31(4):1368-1381, 2017
  • Nakano M, Arai Y, Kotera I, Okabe K, Kamei Y, *Nagai T.
    Genetically encoded ratiometric fluorescent thermometer with wide range and rapid response.
    PLoS ONE 12(2):e0172344, 2017
  • Nakamura Y, Yanagawa Y, Morrison SF, *Nakamura K.
    Medullary reticular neurons mediate neuropeptide Y-induced metabolic inhibition and mastication.
    Cell Metab. 25(2):322-334, 2017
  • *Shibasaki K, Hosoi N, Kaneko R, Tominaga M, Yamada K.
    Glycine release from astrocytes via functional reversal of GlyT1.
    J. Neurochem. 140:395-403, 2017
  • *Kimura M, Morinaka Y, Imai K, Kose S, Horton P, *Imamoto N.
    Extensive cargo identification reveals distinct biological roles of the 12 importin pathways.
    eLife 6:e21184, 2017
  • *Sawamura S, Shirakawa H, Nakagawa T, Mori Y, Kaneko S.
    Chapter 16. TRP Channels in the Brain: What Are They There For? Neurobiology of TRP Channels
    (Frontiers in Neuroscience) (Edited by Tamara Luti Rosenbaum Emir), CRC press, 295-322, 2017


  • Sohn J, Okamoto S, Kataoka N, Kaneko T, Nakamura K, *Hioki H.
    Differential inputs to the perisomatic and distal-dendritic compartments of VIP-positive neurons in layer 2/3 of the mouse barrel cortex.
    Front Neuroanat. 10:124, 2016
  • Yamashita SI, Jin X, Furukawa K, Hamasaki M, Nezu A, Otera H, Saigusa T, Yoshimori T, Sakai Y, Mihara K, *Kanki T.
    Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy.
    J. Cell Biol. 215(5):649-665, 2016
  • *Nishiyama KI, Tokuda H.
    Novel translocation intermediate allows re-evaluation of roles of ATP, proton motive force and SecG at the late stage of preprotein translocation.
    Genes Cells 21(12):1353-1364, 2016
  • Kaneko T, Kaneda K, Ohno A, Takahashi D, Hara T, Amano T, Ide S, Yoshioka M, *Minami M.
    Activation of adenylate cyclase-cyclic AMP-protein kinase A signaling by corticotropin-releasing factor within the dorsolateral bed nucleus of the stria terminalis is involved in pain-induced aversion.
    Eur. J. Neurosci. 44(11):2914-2924, 2016
  • #Okahata M, #*Ohta A, Mizutani H, Minakuchi Y, Toyoda A, *Kuhara A.
    Natural variations of cold tolerance and temperature acclimation in Caenorhabditis elegans.
    J. Comp. Physiol. B 186(8):985-998. 2016
  • Miyake T, Nakamura S, Zhao M, So K, Inoue K, Numata T, Takahashi N, Shirakawa H, Mori Y, *Nakagawa T, Kaneko S.
    Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS.
    Nat. Commun. 7:12840, 2016
  • Sun W, *Uchida K, Takahashi N, Iwata Y, Wakabayashi S, Goto T, Kawada T, *Tominaga M.
    Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes
    Pflugers Arch. 468(9):1527-1540, 2016
  • Ujisawa T, *Ohta A, Uda-Yagi M, *Kuhara A.
    Diverse Regulation of Temperature Sensation by Trimeric G-Protein Signaling in Caenorhabditis elegans.
    PLoS One 11(10):e0165518, 2016
  • *Shimokawa N, Himeno H, Hamada T, Takagi M, Komura S, Andelman D.
    Phase Diagrams and Ordering in Charged Membranes: Binary Mixtures of Charged and Neutral Lipids.
    J. Phys. Chem. B 120(26):6358-6367, 2016
    PMID: 27141936
  • Sonoda S, *Ohta A, Maruo A, Ujisawa T, *Kuhara A.
    Sperm affects head sensory neuron in temperature tolerance of Caenorhabditis elegans
    Cell Rep. 16(1):56-65, 2016
  • *Saito S, Ohkita M, Saito CT, Takahashi K, Tominaga M, *Ohta T.
    Evolution of Heat Sensors Drove Shifts in Thermosensation between Xenopus Species Adapted to Different Thermal Niches
    J. Biol. Chem. 291(21):11446-11459, 2016
  • Takaishi M, Uchida K, Suzuki Y, Matsui H, Shimada T, *Fujita F, *Tominaga M.
    Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8.
    J. Physiol. Sci. 66(2):143-155, 2016
  • Chiba Y, *Yamada T, Tsukita S, Takahashi K, Munakata Y, Shirai Y, Kodama S, Asai Y, Sugisawa T, Uno K, Sawada S, Imai J, Nakamura K, Katagiri H,
    Dapagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, Acutely Reduces Energy Expenditure in BAT via Neural Signals in Mice.
    PLoS One 11(3):e0150756, 2016
  • Sun W, *Uchida K, Suzuki Y, Zhou Y, Kim M, Takayama Y, Takahashi N, Goto T, Wakabayashi S, Kawada T, Iwata Y, *Tominaga M.
    Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue.
    EMBO Rep. 17(3):383-399, 2016
  • *Uchida K, Demirkhanyan L, Asuthkar S, Cohen A, Tominaga M, *Zakharian E.
    Stimulation dependent gating of TRPM3 channel in a planar lipid bilayer.
    FASEB J. 30(3):1306-1316, 2016
  • Himeno H, Ito H, Higuchi Y, Hamada T, *Shimokawa N, Takagi M.
    Coupling between pore formation and phase separation in charged lipid membranes.
    Phys. Rev. E 92(6):062713, 2015
  • *Shibasaki K, Sugio S, Takao K, Yamanaka A, Miyakawa T, Tominaga M, Ishizaki Y.
    TRPV4 activation at the physiological temperature is a critical determinant of neuronal excitability and behavior.
    Pflugers Arch. 467(12):2495-2507, 2015
  • Sugahara K, Shimokawa N, *Takagi M.
    Destabilization of Phase-separated Structures in Local Anesthetic-containing Model Biomembranes.
    Chem. Lett. 44:1604-1606, 2015
  • Shimokawa N, Nagata M, *Takagi M.
    Physical properties of the hybrid lipid POPC on micrometer-sized domains in mixed lipid membranes.
    Phys. Chem. Chem. Phys. 17:20882-20888, 2015