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細胞系譜に依存した双方向性神経結合形成は胎生期の遺伝子発現制御により規定される

Establishment of high reciprocal connectivity between clonal cortical neurons is regulated by the Dnmt3b DNA methyltransferase and clustered protocadherins

The specificity of synaptic connections is fundamental for proper neural circuit function. Specific neuronal connections that underlie information processing in the sensory cortex are initially established without sensory experiences to a considerable extent, and then the connections are individually refined through sensory experiences.

December 8, 2016

大脳皮質視覚野の微小神経回路網の形成には生後の正常な視覚体験が必要である

Experience-dependent emergence of fine-scale networks in visual cortex

These results indicate that patterned vision is required for the emergence of the fine-scale network, whereas diffuse light stimulation is sufficient for the maturation of individual synapses.

September 11, 2014