|15:00 － 15:05||Opening Remarks and announcements|
|15:05 － 15:20||
Talk 1： Marino Kawamoto
|15:20 － 15:35||
Talk 2：Takumi Mitsuhashi
|15:35 － 16:20||
Lecture：Stephanie Forkel (Donders Research Institute)
（Chair： Ryuta Aoki）
Free discussion between speakers and attendees
Tokyo Medical and Dental University/Tamagawa University
Parental rejection in childhood is related to smaller hippocampal volume and low social cognitive abilities in healthy adults.
Childhood abuse reduces the hippocampus and amygdala volumes, and impairs social cognition, such as ability to recognize facial expressions. However, these associations have been studied primarily in individuals with a history of severe abuse and psychiatric symptoms, and thus, it is unclear whether it is also observed in healthy adults. We analyzed a dataset of 409 healthy adults collected at Tamagawa University. Parental rejection reflecting childhood abuse was assessed with the short form of Egna Minnen av Barndoms Uppfostran (s-EMBU), and social cognition was assessed with “Fake Smile Detection Task (FSDT)”. The hippocampus and amygdala volumes were extracted from T1-weighted MRI data using FreeSurfer. We found that greater parental rejection resulted in smaller hippocampal and amygdala volumes and lower performance on the FSDT. Hippocampal volume mediated the effect of maternal rejection on performance on the FSDT. These findings are in line with the facts that structural and functional connectivity is found between the hippocampus and amygdala, and that these brain regions jointly involve in social cognition. Our results suggest that parental rejection may affect hippocampal and amygdala volumes and social cognitive function even in adults without apparent psychiatric symptoms.
Dynamic tractography-based localization of spike sources and animation of spike
Intracranially-recorded spike discharges are suggested to have clinical utility. Previous intracranial electroencephalography (iEEG) studies reported that resection of electrode sites generating spikes frequently or those preceding others was predictive of successful seizure control. However, one cannot completely rule out the possibility that the true spike generator may have been unsampled by intracranial electrodes. In the present study of mono-synaptic spike propagations in patients with drug-resistant temporal lobe epilepsy (TLE), we identified the events of interictal spikes that propagated to other regions on iEEG recording and had a supporting white matter tract on diffusion-weighted imaging tractography. We estimated the source/origin of spike discharges using the tractography-based streamline length of white matter tracts from intracranial electrode sites and observed spike latencies at given sites. We then built a movie, named “dynamic tractography”, animating the spike propagating from the estimated source through the white matter. As result, the estimated spike sources in medial TLE patients with good seizure outcomes were more likely to be in the resected area and in the medial temporal lobe region than those associated with poor outcomes. The dynamic tractography successfully animated spike propagations.
Donders Research Institute for Brain, Cognition and Behaviour
Anatomical variability in cognitive and clinical neuroscience