Aoki I, Tateyama M, Shimomura T, Ihara K, Kubo Y, Nakano S, *Mori I.
SLO potassium channels antagonize premature decision making in C. elegans. Communications Biology 1: 123, 2018
Matsumoto H, Sugio S, Seghers F, Krizaj D, Akiyama H, Ishizaki Y, Gailly P, *Shibasaki K.
Retinal detachment-induced Müller glial cell swelling activates TRPV4 ion channels and triggers photoreceptor death at body temperature. J Neurosci. pii: 0897-18. 2018 PMID:30143574
Hiyama H, Yano Y, So K, Imai S, Nagayasu K, Shirakawa H, *Nakagawa T, Kaneko S.
TRPA1 sensitization during diabetic vascular impairment contributes to cold hypersensitivity in a mouse model of painful diabetic peripheral neuropathy. Mol Pain 14: 1-14, 2018. PMID:29968518
Ujisawa T, *Ohta A, Ii T, Minakuchi Y, Toyoda A, Ii M, *Kuhara A.
Endoribonuclease ENDU-2 regulates multiple traits including cold tolerance via cell autonomous and nonautonomous controls in Caenorhabditis elegans. PNAS.201808634;2018 PMID:30104389
Suito T, *Nagao K, *Umeda M.
Transport and Metabolism of Carotenoids in Drosophila melanogaster.
Carotenoid Science. in press.
Suito T, Nagao K, Hatano M, Kohashi K, Tanabe A, Ozaki H, Kawamoto J, Kurihara T, Mioka T, Tanaka K, Hara Y, *Umeda M.
Synthesis of omega-3 long-chain polyunsaturated fatty acid-rich triacylglycerols in an endemic goby, Gymnogobius isaza, from Lake Biwa, Japan. J Biochem. 164(2):127-140. 2018 PMID:29554278
Ohnishi K, Takagaki N, Okahata M, Fujita M, Ohta A, Kuhara A.
Molecular and Cellular Network Systems Underlying Cold Tolerance of Caenorhabditis elegans
Cryobiology and Cryotechnology, in press
Review
Kuhara A, Ohta A.
Temperature response in cold tolerance of C. elegans
IMPACT, in press
Review, 査読なし
*Kinbara K, Umetsu K. Sonobe H. Muraoka T. Shimokawa N. Takagi M.
Localization of transmembrane multiblock amphiphilic molecules in phase-separated vesicles. Faraday Discuss. inpress 2018 PMID:30015339
*Liu J, *Sokabe T, Montell C.
A Temperature Gradient Assay to Determine Thermal Preferences of Drosophila Larvae. J. Vis. Exp. (136), e57963 (2018).
*Equally contributed.
*Saito H , Morishita T, Mizukami T, Nishiyama K, Kawaguchi K, Nagao H.
Molecular dynamics study of binary POPC bilayers: molecular condensing
effects on membrane structure and dynamics.
J. Physics in press.
Hoshi T, Okabe K, Shibasaki K, Funatsu T, Matsuki N, Ikegaya Y, *Koyama R.
Ischemic brain injury leads to brain edema via hyperthermia-induced TRPV4 activation. J Neurosci. 38(25):5700-5709, 2018 PMID:29793978
*Furukawa K, Fukuda T, Yamashita SI, Saigusa T, Kurihara Y, Yoshida Y, Kirisako H, Nakatogawa H, *Kanki T.
The PP2A-like Protein Phosphatase Ppg1 and the Far Complex Cooperatively Counteract CK2-Mediated Phosphorylation of Atg32 to Inhibit Mitophagy. Cell Rep. 23(12):3579-3590. 2018 PMID:29925000
Suzuki Y, *Chitayat D, Sawada H, Deardorff MA, McLaughlin HM, Begtrup A, Millar K, Harrington J, Chong K, Roifman M, Grand K, Tominaga M, Takada F, Shuster S, Obara M, Mutoh H, Kushima R, Gen Nishimura G.
TRPV6 Variants Interfere with Maternal-Fetal Calcium Transport through the Placenta and Cause Transient Neonatal Hyperparathyroidism Am J Hum Genet. 102(6):1104-1114. 2018 PMID:29861107
＜プレスリリース＞
*Nakamura K, Nakamura Y.
Hunger and satiety signaling: Modeling two hypothalamomedullary pathways
for energy homeostasis. Bioessays. e1700252. 2018 PMID:29869415
Review
Ishii T, Uchida K, Hata S, Hatta M, Kita T, Miyake Y, Okamura K, Tamaoki S, Ishikawa H, *Yamazaki J.
TRPV2 channel inhibitors attenuate fibroblast differentiation and contraction mediated by keratinocyte-derived TGF-β1 in an in vitro wound healing model of rats J. Dermatological Sci. 90(3);332-342, 2018 PMID:29610016
Ohashi K, Deyashiki K, Miyake T, Nagayasu K, Shibasaki K, *Shirakawa H, Kaneko S.
TRPV4 is functionally expressed in oligodendrocyte precursor cells and increases their proliferation. Pflugers Arch. 470(5):705-716. 2018 PMID:29569183
*Miyake M, Kakizawa Y, Tobori N, Kurioka M, Tabuchi N, Kon R, Shimokawa N, Tsujino Y, Takagi M.
Membrane permeation of giant unilamellar vesicles and corneal epithelial cells with lipophilic vitamin nanoemulsions. Colloids Surf B Biointerfaces. 169:444-452. 2018 PMID:29852433
Tsuchiya M, *Hara Y, Okuda M, Itoh K, Nishioka R, Shiomi A, Nagao K, Mori M, Mori Y, Ikenouchi J, Suzuki R, Tanaka M, Ohwada T, Aoki J, Kanagawa M, Toda T, Nagata Y, Matsuda R, Takayama Y, Tominaga M, *Umeda M.
Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation. Nat Commun. 9(1):2049. 2018 PMID:29799007
Ichikawa S, Shimokawa N, Takagi M, Kitayama Y, *Takeuchi T .
Size-dependent uptake of electrically neutral amphipathic polymeric nanoparticles by cell-sized liposomes and an insight into their internalization mechanism in living cells. Chem Commun (Camb). 54(36):4557-4560. 2018 PMID:29662978
Phan H, Shimokawa N, Sharma N, Takagi M, *Vestergaad M.
Strikingly different effects of cholesterol and 7-ketocholesterol on lipid bilayer-mediated aggregation of amyloid beta (1-42). Biochem Biophys Rep. 14:98-103. 2018 PMID:29872741
#Abe Y, #Fujiwara Y, #Takahashi H, Matsumura Y, Sawada T, Jiang S, Nakaki R, Uchida A, Nagao N, Naito M, Kajimura S, Kimura H, Osborne TF, Aburatani H, Kodama T, *Inagaki T, *Sakai J.
Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch Nat Commun. 9(1):1566, 2018 PMID:29674659
#Goda T, #Doi M, Umezaki Y, Murai I, Shimatani H, Chu ML, Nguyen VH, *Okamura H, *Hamada FN.
Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals. Genes ＆ Development, 32(2):140-155, 2018 PMID:29440246
# These authors contributed equally to this work.
#Tainaka M, #*Doi M, Inoue Y, Murai I, *Okamura H.
Circadian PER2 protein oscillations do not persist in cycloheximide-treated mouse embryonic fibroblasts in culture. Chronobiol. Int. 35(1):132-136,2018 PMID:29283306
Fujita T, Liu Y, Higashitsuji H, Itoh K, Shibasaki K, *Fujita J, Nishiyama H.
Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins. Biochem Biophys Res Commun. 495(1):935-940,2018 PMID:29175331
*Inomata N, Toan NV, Ono T.
Piezoresistive property of an aluminum-doped zinc oxide thin film deposited via atomic-layer deposition for microelectromechanical system/nanoelectromenchanical system applications IEEJ Trans., 12(S2), S120-S124, 2017.
Murakami A, *Nagao K, Juni N, Hara Y, *Umeda M.
An N-terminal di-proline motif is essential for fatty acid-dependent degradation of Δ9-desaturase in Drosophila. J Biol Chem. 292(49):19976-19986, 2017 PMID:28972163
Mimura Y, Takemoto S, Tachibana T, Ogawa Y, Nishimura M, *Yokota H, *Imamoto N.
A statistical image analysis framework for pore-free islands derived from heterogeneity distribution of nuclear pore complexes. Sci Rep. 7(1):16315, 2017 PMID: 29176624
Oyama S, Dogishi K, Kodera M, Kakae M, Nagayasu K, Shirakawa H, *Nakagawa T, Kaneko S.
Pathophysiological Role of Transient Receptor Potential Ankyrin 1 in a Mouse Long-Lasting Cystitis Model Induced by an Intravesical Injection of Hydrogen Peroxide. Front Physiol. 8:877, 2017 PMID:29249972
Rahman K.M.Z., Kose S, *Imamoto N.
Effect of an inhibitor of HSP70, YM-1 on Hikeshi knockout cells.
Thermal Medicine 33, 129-134, 2017
Sukeishi A, Isami K, Hiyama H, Imai S, Nagayasu K, Shirakawa H, *Nakagawa T, Kaneko S.
Colchicine alleviates acute postoperative pain but delays wound repair in mice: roles of neutrophils and macrophages. Mol. Pain 13: 1-12, 2017 PMID: 29108466
Rahman KMZ, Mamada H, Takagi M, Kose S, *Imamoto N.
Hikeshi modulates the proteotoxic stress response in human cells: Implication for the importance of the nuclear function of HSP70s. Genes Cells. 22(11):968-976, 2017 PMID:28980748
Miyake T, Nakamura S, Meng Z, Hamano S, Inoue K, Numata T, Takahashi N, Nagayasu K, Shirakawa H, Mori Y, Nakagawa T, Kaneko S.
Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin. Front Physiol. 8:878, 2017 PMID:29163216
Jo A, Noel J, Lakk M, Yarishkin O, Ryskamp D, Shibasaki K, Maureen A McCall, *Krizaj D.
Mouse retinal ganglion cell signaling is dynamically modulated through parallel anterograde activation of cannabinoid and vanilloid pathways. J. Physiol.595(20):6499-6516, 2017 PMID:28766743
*Uchida K, Dezaki K, Yoneshiro T, Watanabe T, Yamazaki J, Saito M, Yada T, Tominaga M, *Iwasaki Y.
Involvement of thermosensitive TRP channels in energy metabolism. J Physiol Sci. 67(5):549-560, 2017 PMID:28656459
Review.
Yamashita W, Shimizu T, *Nomura T.
In Vitro and Ex Ovo Culture of Reptilian and Avian Neural Progenitor Cells. Methods Mol Biol.1650:259-265, 2017 PMID:28809027
Part of the Methods in Molecular Biology book series (MIMB, volume 1650)
Yahiro T, Kataoka N, Nakamura Y, *Nakamura K.
The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation. Sci. Rep. 7:5031, 2017 PMID:28694517
Sugahara K, *Shimokawa N, Takagi M.
Thermal Stability of Phase-Separated Domains in Multicomponent Lipid Membranes with Local Anesthetics. Membranes (Basel). 7(3),33, 2017 PMID:28661445
Deftu AF, Filippi A, Shibsaki K, Gheorghe RO, Chiritoiu M, Ristoiu V.
CXCL1 and CXCL2 chemokines modulate the activity of TRPV1+/IB4+ cultured rat dorsal ganglia neurons upon short-term and acute application. J. Physiol. Pharmacol. 68(3):385-395, 2017 PMID:28820395
Sharma N, Baek K, Phan H, Shimokawa N, *Takagi M.
Glycosyl chains and 25-hydroxycholesterol contribute to the intracellular transport of amyloid beta (Aβ-42) in Jurkat T cells. FEBS Open Bio. 18;7(6):865-876, 2017. PMID:28593141
Fujita T, Higashitsuji H, Higashitsuji H, Liu Y, Itoh K, Sakurai T, Kojima T, Kandori S, Nishiyama H, Fukumoto M, Fukumoto M, Shibasaki K, *Fujita J.
TRPV4-dependent induction of a novel mammalian cold-inducible protein SRSF5 as well as CIRP and RBM3. Sci. Rep. 7(1):2295, 2017. PMID:28536481
Kurganov E, Saito S, Saito CT, *Tominaga M.
Requirement of extracellular Ca2+ binding to specific amino acids for heat-evoked activation of TRPA1. J. Physiol. 595(8):2451-2463, 2017 PMID:28194754
Sugio S, Nagasawa M, Kojima I, Ishizaki Y, *Shibasaki K.
TRPV2 activation by focal mechanical stimulation requires interaction with the actin cytoskeleton and enhances growth cone motility. FASEB J. 31(4):1368-1381, 2017 PMID:28007781
Nakano M, Arai Y, Kotera I, Okabe K, Kamei Y, *Nagai T.
Genetically encoded ratiometric fluorescent thermometer with wide range and rapid response. PLoS ONE 12(2):e0172344, 2017 PMID:28212432
Nakamura Y, Yanagawa Y, Morrison SF, *Nakamura K.
Medullary reticular neurons mediate neuropeptide Y-induced metabolic inhibition and mastication. Cell Metab. 25(2):322-334, 2017 PMID:28065829
*Kimura M, Morinaka Y, Imai K, Kose S, Horton P, *Imamoto N.
Extensive cargo identification reveals distinct biological roles of the 12 importin pathways. eLife 6:e21184, 2017 PMID:28117667
*Sawamura S, Shirakawa H, Nakagawa T, Mori Y, Kaneko S.
Chapter 16. TRP Channels in the Brain: What Are They There For? Neurobiology of TRP Channels
(Frontiers in Neuroscience) (Edited by Tamara Luti Rosenbaum Emir), CRC press, 295-322, 2017
2016
Sohn J, Okamoto S, Kataoka N, Kaneko T, Nakamura K, *Hioki H.
Differential inputs to the perisomatic and distal-dendritic compartments of VIP-positive neurons in layer 2/3 of the mouse barrel cortex. Front Neuroanat. 10:124, 2016 PMID:28066195
Yamashita SI, Jin X, Furukawa K, Hamasaki M, Nezu A, Otera H, Saigusa T, Yoshimori T, Sakai Y, Mihara K, *Kanki T.
Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy. J. Cell Biol. 215(5):649-665, 2016 PMID:27903607
*Nishiyama KI, Tokuda H.
Novel translocation intermediate allows re-evaluation of roles of ATP, proton motive force and SecG at the late stage of preprotein translocation. Genes Cells 21(12):1353-1364, 2016 PMID:27813233
Kaneko T, Kaneda K, Ohno A, Takahashi D, Hara T, Amano T, Ide S, Yoshioka M, *Minami M.
Activation of adenylate cyclase-cyclic AMP-protein kinase A signaling by corticotropin-releasing factor within the dorsolateral bed nucleus of the stria terminalis is involved in pain-induced aversion. Eur. J. Neurosci. 44(11):2914-2924, 2016 PMID:27690274
#Okahata M, #*Ohta A, Mizutani H, Minakuchi Y, Toyoda A, *Kuhara A.
Natural variations of cold tolerance and temperature acclimation in Caenorhabditis elegans. J. Comp. Physiol. B 186(8):985-998. 2016 PMID:27318666
DOI:10.1007/s00360-016-1011-3
Miyake T, Nakamura S, Zhao M, So K, Inoue K, Numata T, Takahashi N, Shirakawa
H, Mori Y, *Nakagawa T, Kaneko S.
Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS. Nat. Commun. 7:12840, 2016 PMID:27628562
Sun W, *Uchida K, Takahashi N, Iwata Y, Wakabayashi S, Goto T, Kawada T, *Tominaga M.
Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes Pflugers Arch. 468(9):1527-1540, 2016 PMID:27318696
Ujisawa T, *Ohta A, Uda-Yagi M, *Kuhara A.
Diverse Regulation of Temperature Sensation by Trimeric G-Protein Signaling in Caenorhabditis elegans. PLoS One 11(10):e0165518, 2016 PMID:27788246
*Shimokawa N, Himeno H, Hamada T, Takagi M, Komura S, Andelman D.
Phase Diagrams and Ordering in Charged Membranes: Binary Mixtures of Charged and Neutral Lipids. J. Phys. Chem. B 120(26):6358-6367, 2016 PMID: 27141936
Sonoda S, *Ohta A, Maruo A, Ujisawa T, *Kuhara A.
Sperm affects head sensory neuron in temperature tolerance of Caenorhabditis elegans Cell Rep. 16(1):56-65, 2016 PMID:27320929
DOI:10.1016/j.celrep.2016.05.078.
*Saito S, Ohkita M, Saito CT, Takahashi K, Tominaga M, *Ohta T.
Evolution of Heat Sensors Drove Shifts in Thermosensation between Xenopus Species Adapted to Different Thermal Niches J. Biol. Chem. 291(21):11446-11459, 2016 PMID:27022021
Takaishi M, Uchida K, Suzuki Y, Matsui H, Shimada T, *Fujita F, *Tominaga M.
Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8. J. Physiol. Sci. 66(2):143-155, 2016 PMID:26645885
Chiba Y, *Yamada T, Tsukita S, Takahashi K, Munakata Y, Shirai Y, Kodama S, Asai Y, Sugisawa T, Uno K, Sawada S, Imai J, Nakamura K, Katagiri H,
Dapagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, Acutely Reduces Energy Expenditure in BAT via Neural Signals in Mice. PLoS One 11(3):e0150756, 2016 PMID:26963613
Sun W, *Uchida K, Suzuki Y, Zhou Y, Kim M, Takayama Y, Takahashi N, Goto T, Wakabayashi S, Kawada T, Iwata Y, *Tominaga M.
Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue. EMBO Rep. 17(3):383-399, 2016 PMID:26882545
*Uchida K, Demirkhanyan L, Asuthkar S, Cohen A, Tominaga M, *Zakharian E.
Stimulation dependent gating of TRPM3 channel in a planar lipid bilayer. FASEB J. 30(3):1306-1316, 2016 PMID:26655382
Himeno H, Ito H, Higuchi Y, Hamada T, *Shimokawa N, Takagi M.
Coupling between pore formation and phase separation in charged lipid membranes. Phys. Rev. E 92(6):062713, 2015 PMID:26764733
*Shibasaki K, Sugio S, Takao K, Yamanaka A, Miyakawa T, Tominaga M, Ishizaki Y.
TRPV4 activation at the physiological temperature is a critical determinant of neuronal excitability and behavior. Pflugers Arch. 467(12):2495-2507, 2015 PMID:26250433
Sugahara K, Shimokawa N, *Takagi M.
Destabilization of Phase-separated Structures in Local Anesthetic-containing Model Biomembranes. Chem. Lett. 44:1604-1606, 2015
