Original Papers

Oda M, Saito K, Hatta S, Kubo Y, Saitoh O.
Chemical and thermal sensitivity of medaka TRPA1 analyzed in heterologous expression system
Biochem Biophys Res Commun. (2017) [ PubMed ]
Chen IS, Tateyama M, Fukata Y, Uesugi M, Kubo Y.
Ivermectin activates GIRK channels in a PIP2 -dependent, GƒΐƒΑ-independent manner and an amino acid residue at the slide helix governs the activation
J Physiol. (2017) [ PubMed ]
Tsukamoto H, Chen IS, Kubo Y, Furutani Y.
A ciliary opsin in the brain of a marine annelid zooplankton is UV-sensitive and the sensitivity is tuned by a single amino acid residue
J Biol Chem. (2017) [ PubMed ]
Hirai S, Hotta K, Kubo Y, Nishino A, Okabe S, Okamura Y, Okado H.
AMPA glutamate receptors are required for sensory-organ formation and morphogenesis in the basal chordate
Proc Natl Acad Sci U S A. 114, 3939-3944 (2017) [ PubMed ]
Tateyama M, Kubo Y.
Stabilizing effects of G protein on the active conformation of adenosine A1 receptor differ depending on G protein type
Eur J Pharmacol. 788, 122-131 (2016) [ PubMed ]
Oda M, Kurogi M, Kubo Y, Saitoh O.
Sensitivities of Two Zebrafish TRPA1 Paralogs to Chemical and Thermal Stimuli Analyzed in Heterologous Expression Systems
Chemical Senses 41, 261-272 (2016) [ PubMed ]
Tsukamoto H, Kubo Y, Farrens DL, Koyanagi M, Terakita A, Furutani Y.
Retinal attachment instability is diversified among mammalian melanopsins
J Biol Chem. 290, 27176-27187 (2015) [ PubMed ]
Kitazawa M, Kubo Y, Nakajo K.
Kv4.2 and Accessory Dipeptidyl Peptidase-like Protein 10 (DPP10) Subunit Preferentially Form a 4:2 (Kv4.2:DPP10) Channel Complex
J Biol Chem. 290, 22724-22733 (2015) [ PubMed ]
Kubo Y, Okamura Y.@(preface)
NIPS-JP symposium: Cutting-edge approaches towards the functioning mechanisms of membrane proteins
J Physiol. 593, 2551-2552 (2015)
Nakajo K, Kubo Y.@(review article)
KCNQ1 channel modulation by KCNE proteins via the voltage-sensing domain
J Physiol. 593, 2617-2625 (2015) [ PubMed ]
Kurogi M, Kawai Y, Nagatomo K, Tateyama M, Kubo Y, Saitoh O.
Auto-oxidation Products of Epigallocatechin Gallate Activate TRPA1 and TRPV1 in Sensory Neurons
Chemical Senses 40, 27-46 (2015) [ PubMed ]
Keceli B, Kubo Y.
Voltage and ATP dependent structural rearrangements of the P2X2 receptor associated with the gating of the pore
J Physiol. 592, 4657-4676 (2014) [ PubMed ]
Nakajo K, Kubo Y.
Steric hindrance between S4 and S5 of the KCNQ1/KCNE1 channel hampers pore opening
Nature Communications 5:4100 (2014) [ PubMed ]
Kitazawa M, Kubo Y, Nakajo K.
The Stoichiometry and Biophysical Properties of the Kv4 Potassium Channel Complex with KChIP Subunits are Variable Depending on the Relative Expression Level
J Biol Chem. 289, 17597-17609 (2014) [ PubMed ]
Keceli B, Kubo Y.
Signal transmission within the P2X2 trimeric receptor
J. Gen. Physiol. 143, 761-782 (2014) [ PubMed ]
Nagase M, Takahashi Y, Watanabe AM, Kubo Y, Kato F.
On-Site Energy Supply at Synapses through Monocarboxylate Transporters Maintains Excitatory Synaptic Transmission
J. Neurosci. 34, 2605-2617 (2014) [ PubMed ]
Tateyama M, Kubo Y.
Analyses of the effects of Gq protein on the activated states of the muscarinic M3 receptor and the purinergic P2Y1 receptor
Physiological Reports 1, e00134 (2013) [ PubMed ]
Tateyama M, Kubo Y.
Binding of Gq protein stabilizes the activated state of the muscarinic receptor type 1
Neuropharmacology 65, 173-181 (2013) [ PubMed ]
Uchiyama M, Maejima S, Yoshie S, Kubo Y, Konno N, Joss JMP.
The epithelial sodium channel in the Australian lungfish, Neoceratodus forsteri (Osteichthyes: Dipnoi)
Proc. R. Soc. B 279, 4795-4802 (2012) [ PubMed ]
Kurogi M, Miyashita M, Emoto Y, Kubo Y, Saitoh O.
Green Tea Polyphenol Epigallocatechin Gallate Activates TRPA1 in an Intestinal Enteroendocrine Cell Line, STC-1.
Chem Senses. 37, 167-177 (2012) [ PubMed ]
Nakajo K, Nishino A, Okamura Y, Kubo Y.
KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 ortholog.
J. Gen. Physiol. 138, 521-535 (2011) [ PubMed ]
Tateyama M, Kubo Y.
The intra-molecular activation mechanisms of the dimeric metabotropic glutamate receptor 1 differ depending on the type of G proteins.
Neuropharmacology 61, 832-841 (2011) [ PubMed ]
Nakajo K, Kubo Y. (review article)
Nano-environmental changes by KCNE proteins modify KCNQ channel function.
Channels 5, 397-401 (2011) [ PubMed ]
Nagatomo K, Ishii H, Yamamoto T, Nakajo K, Kubo Y.
The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression.
Biophys. J. 99, 3609-3618 (2010) [ PubMed ]
Nakajo K, Ulbrich MH, Kubo Y, Isacoff EY.
Stoichiometry of the KCNQ1-KCNE1 ion channel complex.
Proc Natl Acad Sci U S A. 107, 18862-18867 (2010) [ PubMed ]
[ Commentary by Osteen et al. ]
Nakane Y, Ikegami K, Ono H, Yamamoto N, Yoshida S, Hirunagi K, Ebihara S, Kubo Y, Yoshimura T.
A mammalian neural tissue opsin (Opsin 5) is a deep brain photoreceptor in birds.
Proc Natl Acad Sci U S A. 107, 15264-15268 (2010) [ PubMed ]
Ishii H, Nakajo K, Yanagawa Y, Kubo Y.
Identification and characterization of Cs+-permeable K+ channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation.
Eur J Neurosci. 32, 736-748 (2010) [ PubMed ]
Matsushita S, Nakata H, Kubo Y, Tateyama M.
Ligand-induced rearrangements of the GABAB receptor revealed by fluorescence resonance energy transfer.
J Biol Chem. 285, 10291-10299 (2010) [ PubMed ]
Keceli B, Kubo Y.
Functional and structural identification of amino acid residues of the P2X2 receptor channel critical for the voltage- and [ATP]-dependent gating.
J Physiol. 587, 5801-5818 (2009) [ PubMed ]
Kubo Y, Fujiwara Y, Keceli B, Nakajo K.@(review article)
Dynamic aspects of functional regulation of the ATP receptor channel P2X2.
J Physiol. 587, 5317-5324 (2009) [ PubMed ]
Kurogi M, Nagatomo K, Kubo Y, Saitoh O.
Effects of spinophilin on the function of RGS8 regulating signals from M2 and M3-mAChRs.
Neuroreport. 20, 1134-1139 (2009) [ PubMed ]
Gleitsman KR, Tateyama M, Kubo Y.
Structural rearrangements of the motor protein prestin revealed by fluorescence resonance energy transfer.
Am J Physiol Cell Physiol. 297, C290-298 (2009) [ PubMed ]
Ishihara K, Yamamoto T, Kubo Y.
Heteromeric assembly of inward rectifier channel subunit Kir2.1 with Kir3.1 and with Kir3.4.
Biochem Biophys Res Commun. 380, 832-837 (2009) [ PubMed ]
Mio K, Ogura T, Yamamoto T, Hiroaki Y, Fujiyoshi Y, Kubo Y, Sato C.
Reconstruction of the P2X2 receptor reveals a vase-shaped structure with lateral tunnels above the membrane.
Structure. 17, 266-275 (2009) [ PubMed ]
Fujiwara, Y., Keceli, B., Nakajo, K., Kubo, Y.
Voltage- and [ATP]-dependent Gating of the P2X2 ATP Receptor Channel.
J. Gen. Physiol. 133, 93-109 (2009) [ PubMed ]
Nagatomo, K. and Kubo, Y.
Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels.
Proc Natl Acad Sci U S A. 105, 17373-17378 (2008) [ PubMed ]
Fujii S, Yamazoe G, Itoh M, Kubo Y, Saitoh O.
Spinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8.
Biochem Biophys Res Commun. 377, 200-204 (2008) [ PubMed ]
Tateyama, M. and Kubo, Y.
Regulatory role of C-terminus in the G protein coupling of the metabotropic glutamate receptor 1.
J. Neurochem. 107, 1036-1046 (2008) [ PubMed ]
Nakajo, K.and Kubo, Y.
Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks.
J. Physiol. 586, 2827-2840 (2008) [ PubMed ]
Mio, K., Kubo, Y., Ogura, T., Yamamoto, T., Arisaka, F. and Sato, C.
The motor protein prestin is a bullet-shaped molecule with inner cavities
J. Biol. Chem. 283, 1137-1145 (2008) [ PubMed ]
Nakajo K and Kubo Y
KCNE1 and KCNE3 Stabilize and/or Slow Voltage Sensing S4 Segment of KCNQ1 Channel
J. Gen. Physiol. 130, 269-281 (2007) [ PubMed ]
Tateyama M and Kubo Y
Coupling profile of the metabotropic glutamate receptor 1a is regulated by the C-terminal domain.
Mol. Cell. Neurosci 34, 445-452 (2007) [ PubMed ]
Itoh M, Nagatomo K, Kubo Y, Saitoh O.
Alternative splicing of RGS8 gene changes the binding property to the M1 muscarinic receptor to confer receptor type-specific Gq regulation.
J. Neurochem. 99, 1505-1516 (2006) [ PubMed ]
Fujiwara Y, Kubo Y.
Regulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides.
J. Physiol. 576, 135-149 (2006) [ PubMed ]
Fujiwara Y, Kubo Y.
Functional Roles of Charged Amino Acid Residues on the Wall of the Cytoplasmic Pore of Kir2.1.
J. Gen. Physiol. 127, 401-19 (2006) [ PubMed ]
Misaka T, Murate M, Fujimoto K, Kubo Y.
The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells.
Neurosci. Res. 55, 123-133 (2006) [ PubMed ]
Tateyama M, Kubo Y.
Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor 1a
Proc Natl Acad Sci U S A. 103, 1124-1128 (2006) [ PubMed ]
2005 - 2001
Nakajo K, Kubo Y.
Protein kinase C shifts the voltage-dependence of KCNQ/M channels expressed in Xenopus oocytes.
J. Physiol. 569, 59-74 (2005) [ PubMed ]
Mio K, Kubo Y, Ogura T, Yamamoto T, Sato C.
Visualization of the trimeric P2X2 receptor with a crown-capped extracellular domain.
Biochem Biophys Res Commun. 337, 998-1005 (2005) [ PubMed ]
Won-Kyu Ju, Takumi Misaka, Yulia Kushnareva, Saya Nakagomi, Neeraj Agarwal, Yoshihiro Kubo, Stuart A. Lipton, Ella Bossy-Wetzel
OPA1 expression in the normal rat retina and optic nerve.
J. Comp. Neurol. 488, 1-10 (2005) [ InterScience ]
Itoh M, Nagatomo K, Kubo Y, Sugimoto M, Saitoh O.
Molecular cloning and characterization of a new RGS protein of Medaka.
Gene. 345, 165-171 (2005) [ PubMed ]
Tateyama M, Abe H, Nakata H, Saito O, Kubo Y.
Ligand-induced rearrangement of the dimeric metabotropic glutamate receptor 1a.
Nat. Struct. Mol. Biol. 11, 637-642 (2004) [ PubMed ]
Fujiwara, Y. and Kubo, Y.
Density Dependent Changes of the Pore Properties of P2X2 Receptor Channel.
J. Physiol. 558, 31-43 (2004) [ PubMed ]
Abe, H., Tateyama, M. and Kubo, Y.
Functional identification of Gd3+ binding site of metabotropic glutamate receptor1a.
FEBS Lett. 545, 233-238 (2003) [ PubMed ]
Abe, H., Misaka, T., Tateyama, M. and Kubo, Y.
Effects of co-expression with Homer isoforms on the function of metabotropic glutamate receptor1a.
Mol. Cell Neurosci. 23, 157-168 (2003) [ PubMed ]
Fujiwara, Y. and Kubo, Y.
Ser 165 in the second transmembrane region of the Kir2.1 channel determines its susceptibility to blockade by intracellular Mg2+.
J. Gen. Physiol. 120, 677-692 (2002) [ PubMed ]
Murata, Y., Fujiwara, Y. and Kubo, Y.
Identification of a site involved in the block by extracellular Mg2+ and Ba2+ as well as permeation of K+ in Kir2.1 K+ channel.
J. Physiol. 544, 665-677 (2002) [ PubMed ]
Saitoh, O., Murata, Y., Odagiri, M., Itoh, M., Itoh, H., Misaka, T. and Kubo, Y.
Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling.
Proc. Natl. Acad. Sci. USA 99, 10138-10143 (2002) [ PubMed ]
Ai T., Fujiwara, Y., Tsuji, K., Otani, H., Nakano, S., Kubo, Y. and Horie, M.
Novel KCNJ2 mutation in familial periodic paralysis with ventricular dysrhythmia.
Circulation 105, 2592-2594 (2002) [ PubMed ]
Misaka, T., Miyashita, T. and Kubo, Y.
Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization and effect on mitochondrial morphology.
J. Biol. Chem. 277, 15834-15842 (2002) [ PubMed ]
Murata, Y., Okado, H., Katsuyama, Y., Okamura, Y. and Kubo, Y.
Primary structure, developmental expression and functional properties of an inward rectifier K+ channel of the tunicate.
Receptors Channels 7, 387-399 (2001) [ PubMed ]
Murata, Y., Okado, H. and Kubo, Y.
Characterization of heteromultimeric G protein-coupled inwardly rectifying potassium channels of the tunicate tadpole with a unique pore property.
J. Biol. Chem. 276, 18529-18539 (2001) [ PubMed ]
Soom, M., Schonherr, R., Kubo, Y., Kirsch, C., Klinger, R. and Heinemann, S. H.
Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium Channels
FEBS Lett. 490, 49-53 (2001) [ PubMed ]
Saitoh, O., Masuho, I., Terakawa, I., Nomoto, S., Asano, T. and Kubo, Y.
Regulator of G protein signaling 8 (RGS8) requires its NH2 terminus for subcellular localization and acute desensitization of G protein-gated K+ Channels.
J. Biol. Chem. 276, 5052-5058 (2001) [ PubMed ]
Kubo, Y. and Murata, Y.
Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel.
J. Physiol. 531, 645-660 (2001) [ PubMed ]
2000 - 1996
Miyashita, T. and Kubo, Y.
Extracellular Ca2+ sensitivity of mGluR1a induces an increase in the basal cAMP level by direct coupling with Gs protein in transfected CHO cells.
Receptors Channels 7, 77-91 (2000) [ PubMed ]
Miyashita, T. and Kubo, Y.
Extracellular Ca2+ sensitivity of mGluR1a associated with persistent glutamate response in transfected CHO cells.
Receptors Channels. 7, 25-40 (2000) [ PubMed ]
Saitoh, O., Kubo, Y., Odagiri, M., Ichikawa, M., Yamagata, K. and Sekine, T.
RGS7 and RGS8 Differentially Accelerate G Protein-mediated Modulation of K+ Currents.
J. Biol. Chem. 274(14), 9899-9904 (1999) [ PubMed ]
Kubokawa, K., Miyashita, T. and Kubo,Y.
Isolation of a cDNA for a novel 120-kDa GTP-binding protein expressed in motor neurons in the salmon brain.
FEBS Lett. 431, 231-235 (1998) [ PubMed ]
Kubo,Y., Murata, Y. and Heinemann, S. H.
Probing pore topology and conformational changes of Kir2.1 potassium channels by cysteine scanning mutagenesis.
FEBS Lett. 435, 69-73 (1998) [ PubMed ]
Nakamura, M., Watanabe, H., Kubo, Y., Yokoyama, M., Matsumoto, T., Sasai, H. and Nishi, Y.
KQT2, a new putative potassium channel family produced by alternative splicing.
Receptors Channels 5, 255-271 (1998) [ PubMed ]
Guo, L. and Kubo, Y.
Comparison of the open-close kinetics of the cloned inward rectifier K+ channel IRK1 and its point mutant (Q140E) in the pore region.
Receptors Channels 5, 273-289 (1998) [ PubMed ]
Chen, H., Kubo,Y., Hoshi, T. and Heinemann, S. H.
Cyclosporin A selectively reduces the functional expression of Kir2.1 potassium channels in Xenopus oocytes.
FEBS Lett. 422, 307-310 (1998) [ PubMed ]
Kubo,Y., Miyashita, T. and Murata, Y.
Structural basis for a Ca2+ - sensing function of the metabotropic glutamate receptors.
Science 279, 1722-1725 (1998) [ PubMed ]
Saitoh, O., Kubo, Y., Miyatani, T., Asano, T. and Nakata, H.
RGS8 accelerates G-protein-mediated modulation of K+ currents.
Nature 390, 525-529 (1997) [ PubMed ]
Miyashita, T. and Kubo, Y.
Localization and developmental changes of the expression of two inward rectifying K+ - channel proteins in the rat brain.
Brain Res. 750, 251-263 (1997) [ PubMed ]
Kubokawa, K. and Kubo, Y.
Functional Expression of GnRH Receptors in Xenopus Oocytes Injected with Salmon Brain RNA.
J. Reprod. Develop. 42, 283-289 (1996)
Kubo, Y. and Iizuka, M.
Identification of Domains of the Cardiac Inward Rectifying K+ Channel, CIR, Involved in the Heteromultimer Formation and in the G-Protein Gating.
Biochem. Biophys. Res. Commun. 227, 240-247 (1996) [ PubMed ]
Kubokawa, K., Miyashita, T., Nagasawa, H. and Kubo, Y.
Cloning and characterization of a bifunctional metabotropic receptoractivated by both exracellular calcium and glutamate.
FEBS Lett. 392, 71-76 (1996) [ PubMed ]
Kubo, Y., Miyashita, T. and Kubokawa, K.
A weakly inward rectifying potassium channel of the salmon brain. Glutamate 179 in the second transmembrane domain is insufficient for strong rectification.
J. Biol. Chem. 271, 1570-1573 (1996) [ PubMed ]
Kubo, Y.
Effects of Extracellular Cations and Mutations in the Pore Region on the Inward Rectifier K+ Channel IRK1.
Receptors Channels 4, 73-83 (1996) [ PubMed ]
1995 - 1986
Iizuka, M., Kubo, Y., Tsunenari, I., Pan, C. X., Akiba, I. and Kono, T.
Functional Characterization and Localization of a Cardiac-type Inwardly Rectifying K+ Channel.
Receptors Channels 3, 299-315 (1995) [ PubMed ]
Kubo, Y., Reuveny, E., Slesinger, P. A., Jan, Y. N. and Jan, L. Y.
Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel.
Nature 364, 802-806 (1993) [ PubMed ]
Kubo, Y., Baldwin, T. J., Jan, Y. N. and Jan, L. Y.
Primary structure and functional expression of a mouse inward rectifier potassium channel.
Nature 362, 127-133 (1993) [ PubMed ]
Kubo, Y.
Comparison of the initial stages of muscle differentiation in rat and mouse myoblastic and mouse mesodermal stem cell lines.
J. Physiol. 442, 743-759 (1991) [ PubMed ]
Kubo, Y.
Electrophysiological and immunohistochemical analysis of muscle differentiation in a mouse mesodermal stem cell line.
J. Physiol. 442, 711-741 (1991) [ PubMed ]
Kubo, Y.
Properties of ionic currents induced by external ATP in a mouse mesodermal stem cell line.
J. Physiol. 442, 691-710 (1991) [ PubMed ]
Takeuchi, K., Boonmar, S., Kubo, Y., Katayama, T., Harada, H., Ohbayashi,A., Choo, Q. - L., Kuo, G., Houghton, M., Saito, I. and Miyamura, T.
Hepatitis C viral cDNA clones isolated from a healthy carrier donor implicated in post-transfusion non-A,non-B hepatitis.
Gene 91, 287-291 (1990) [ PubMed ]
Takeuchi, K., Kubo, Y., Boonmar, S., Watanabe, Y., Katayama, T., Choo, Q. -L., Kuo, G., Houghton, M., Saito, I. and Miyamura, T.
The putative nucleocapsid and envelope protein genes of hepatitis C virus determined by comparison of the nucleotide sequences of two isolates derived from an experimentally infected chimpanzee and, healthy human carriers.
J. Gen. Virol. 71, 3027-3033 (1990) [ PubMed ]
Takeuchi, K., Kubo, Y., Boonmar, S., Watanabe, Y., Katayama, T., Choo, Q. -L., Kuo, G., Houghton, M., Saito, I. and Miyamura, T.
Nucleotide sequence of core and envelope genes of the hepatitis C virus genome derived directly from human healthy carriers.
Nucleic Acids Res. 18, 4626 (1990) [ PubMed ]
Kubo, Y., Takeuchi, K., Boonmar, S., Katayama, T., Choo, Q. -L., Kuo, G., Weiner, A. J., Bradley, D., Houghton, M., Saito, I. and Miyamura, T.
A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan.
Nucleic Acids Res. 17, 10367-10372 (1989) [ PubMed ]
Kubo, Y. and Kidokoro, Y.
Potassium currents induced by muscarinic receptor activation in the rat adrenal chromaffin cell.
Biomed. Res. 10, 71-81 (1989)
Kubo, Y.
Development of ion channels and neurofilaments during neuronal differentiation of mouse embryonal carcinoma cell lines.
J. Physiol. 409, 497-523 (1989) [ PubMed ]
Hirano, T., Kubo, Y. and Wu, M. M.
Cerebellar granule cells in culture: Monosynaptic connections with Purkinje cells and ionic currents.
Proc. Natl. Acad. Sci. USA 83, 4957-4961 (1986) [ PubMed ]
The 45th NIPS International symposium