Original Papers
2021-
Chang L, Chen IS, Tateyama M, Kubo Y.
Structural determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist
J Biol Chem. 107219 (2024) Online ahead of print [
PubMed ]
Tateyama M, Kubo Y.
Regulation of the two-pore domain potassium channel, THIK-1 and THIK-2, by G protein coupled receptors
PLoS One. 18, e0284962 (2023) [
PubMed ]
Tsukamoto H, Kubo Y.
A self-inactivating invertebrate opsin optically drives biased signaling toward Gβγ-dependent ion channel modulation
Proc Natl Acad Sci U S A. 120, e2301269120 (2023) [
PubMed ]
Hori S, Tateyama M, Shirai T, Kubo Y, Saitoh O.
Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1
Nature Communications. 14, 2415 (2023) [
PubMed ]
Shimomura T, Hirazawa K, Kubo Y.
Conformational rearrangements in the second voltage sensor domain switch PIP2- and voltage-gating modes in two-pore channels
Proc Natl Acad Sci U S A. 120, e2209569120 (2023) [
PubMed ]
Tsuboi D, Otsuka T, Shimomura T, Faruk MO, Yamahashi Y, Amano M, Funahashi Y, Kuroda K, Nishioka T, Kobayashi K, Sano H, Nagai T, Yamada K, Tzingounis AV, Nambu A, Kubo Y, Kawaguchi Y, Kaibuchi K.
Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior
Cell Rep. 40, 111309 (2022) [
PubMed ]
Brake N, Mancino AS, Yan Y, Shimomura T, Kubo Y, Khadra A, Bowie D.
Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific
J Gen Physiol. 154, e202112921 (2022) [
PubMed ]
Chen IS, Eldstrom J, Fedida D, Kubo Y.
A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K+ channel
J Physiol. 600, 603-622 (2022) [
PubMed ]
Hirazawa K, Tateyama M, Kubo Y, Shimomura T.
Phosphoinositide regulates dynamic movement of the S4 voltage sensor in the 2 nd repeat in Two-pore channel 3
J Biol Chem. 297, 101425 (2021) [
PubMed ]
Andriani R, Kubo Y.
Voltage-clamp fluorometry analysis of structural rearrangements of ATP-gated channel P2X2 upon hyperpolarization
Elife. 10, e65822 (2021) [
PubMed ]
Matsumura K, Shimomura T, Kubo Y, Oka T, Kobayashi N, Imai S, Yanase N, Akimoto M, Fukuda M, Yokogawa M, Ikeda K, Kurita J, Nishimura Y, Shimada I, Osawa M.
Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization
BMC Mol Cell Biol. 22, 3 (2021) [
PubMed ]
2020-2016
Kubo Y. (commentary)
A new world of heme function
Pflugers Arch. 472, 547-548 (2020) [
PubMed ]
Akiyama S, Aoki K, Kubo Y. (review article)
Biophysical research in Okazaki, Japan
Biophys Rev. 12, 237-243 (2020) [
PubMed ]
Shimomura T, Yonekawa Y, Nagura H, Tateyama M, Fujiyoshi Y, Irie K.
A native prokaryotic voltage-dependent calcium channel with a novel selectivity filter sequence
Elife. 9:e52828 (2020) [
PubMed ]
Ishii J, Suzuki A, Kimura T, Tateyama M, Tanaka T, Yazawa T, Arimasu Y, Chen IS, Aoyama K, Kubo Y, Saitoh S, Mizuno H, Kamma H.
Congenital goitrous hypothyroidism is caused by dysfunction of the iodide transporter SLC26A7
Commun Biol. 2, 270 (2019) [
PubMed ]
Shimomura T, Kubo Y.
Phosphoinositides modulate the voltage dependence of two-pore channel 3
J Gen Physiol. 151, 986-1006 (2019) [
PubMed ]
Chen IS, Liu C, Tateyama M, Karbat I, Uesugi M, Reuveny E, Kubo Y.
Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels
Br J Pharmacol. 176, 3161-3179 (2019) [
PubMed ]
Oda M, Ogino H, Kubo Y, Saitoh O.
Functional properties of axolotl transient receptor potential ankyrin 1 revealed by the heterologous expression system
Neuroreport. 30, 323-330 (2019) [
PubMed ]
Tateyama M, Kubo Y.
Gi/o-coupled muscarinic receptors co-localize with GIRK channel for efficient channel activation
PLoS One. 13, e0204447 (2018) [
PubMed ]
Aoki I, Tateyama M, Shimomura T, Ihara K, Kubo Y, Nakano S, Mori I.
SLO potassium channels antagonize premature decision making in C. elegans
Commun Biol. 1, 123 (2018) [
PubMed ]
Kume S, Shimomura T, Tateyama M, Kubo Y.
Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain
J Physiol. 596, 4629-4650 (2018) [
PubMed ]
Tsukamoto H, Higashi M, Motoki H, Watanabe H, Ganser C, Nakajo K, Kubo Y, Uchihashi T, Furutani Y.
Structural properties determining low K+ affinity of the selectivity filter in the TWIK1 K+ channel
J Biol Chem. 293, 6969-6984 (2018) [
PubMed ]
Oda M, Kubo Y, Saitoh O.
Sensitivity of Takifugu TRPA1 to thermal stimulations analyzed in oocytes expression system
Neuroreport. 29, 280-285 (2018) [
PubMed ]
Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferré P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y.
Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat
Cell Rep. 22, 706-721 (2018) [
PubMed ]
Chen IS, Kubo Y.
Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin
J Physiol. 596, 1833-1845 (2018) [
PubMed ]
Oda M, Saito K, Hatta S, Kubo Y, Saitoh O.
Chemical and thermal sensitivity of medaka TRPA1 analyzed in heterologous expression system
Biochem Biophys Res Commun. 494, 194-201 (2017) [
PubMed ]
Chen IS, Tateyama M, Fukata Y, Uesugi M, Kubo Y.
Ivermectin activates GIRK channels in a PIP2 -dependent, Gβγ-independent manner and an amino acid residue at the slide helix governs the activation
J Physiol. 595, 5895-5912 (2017) [
PubMed ]
Tsukamoto H, Chen IS, Kubo Y, Furutani Y.
A ciliary opsin in the brain of a marine annelid zooplankton is UV-sensitive and the sensitivity is tuned by a single amino acid residue
J Biol Chem. 292, 12971-12980 (2017) [
PubMed ]
Hirai S, Hotta K, Kubo Y, Nishino A, Okabe S, Okamura Y, Okado H.
AMPA glutamate receptors are required for sensory-organ formation and morphogenesis in the basal chordate
Proc Natl Acad Sci U S A. 114, 3939-3944 (2017) [
PubMed ]
Tateyama M, Kubo Y.
Stabilizing effects of G protein on the active conformation of adenosine A1 receptor differ depending on G protein type
Eur J Pharmacol. 788, 122-131 (2016) [
PubMed ]
Oda M, Kurogi M, Kubo Y, Saitoh O.
Sensitivities of Two Zebrafish TRPA1 Paralogs to Chemical and Thermal Stimuli Analyzed in Heterologous Expression Systems
Chemical Senses 41, 261-272 (2016) [
PubMed ]
2015-2011
Tsukamoto H, Kubo Y, Farrens DL, Koyanagi M, Terakita A, Furutani Y.
Retinal attachment instability is diversified among mammalian melanopsins
J Biol Chem. 290, 27176-27187 (2015) [
PubMed ]
Kitazawa M, Kubo Y, Nakajo K.
Kv4.2 and Accessory Dipeptidyl Peptidase-like Protein 10 (DPP10) Subunit Preferentially Form a 4:2 (Kv4.2:DPP10) Channel Complex
J Biol Chem. 290, 22724-22733 (2015) [
PubMed ]
Kubo Y, Okamura Y. (preface)
NIPS-JP symposium: Cutting-edge approaches towards the functioning mechanisms of membrane proteins
J Physiol. 593, 2551-2552 (2015)
Nakajo K, Kubo Y. (review article)
KCNQ1 channel modulation by KCNE proteins via the voltage-sensing domain
J Physiol. 593, 2617-2625 (2015) [
PubMed ]
Kurogi M, Kawai Y, Nagatomo K, Tateyama M, Kubo Y, Saitoh O.
Auto-oxidation Products of Epigallocatechin Gallate Activate TRPA1 and TRPV1 in Sensory Neurons
Chemical Senses 40, 27-46 (2015) [
PubMed ]
Keceli B, Kubo Y.
Voltage and ATP dependent structural rearrangements of the P2X2 receptor associated with the gating of the pore
J Physiol. 592, 4657-4676 (2014) [
PubMed ]
Nakajo K, Kubo Y.
Steric hindrance between S4 and S5 of the KCNQ1/KCNE1 channel hampers pore opening
Nature Communications 5:4100 (2014) [
PubMed ]
Kitazawa M, Kubo Y, Nakajo K.
The Stoichiometry and Biophysical Properties of the Kv4 Potassium Channel Complex with KChIP Subunits are Variable Depending on the Relative Expression Level
J Biol Chem. 289, 17597-17609 (2014) [
PubMed ]
Keceli B, Kubo Y.
Signal transmission within the P2X2 trimeric receptor
J. Gen. Physiol. 143, 761-782 (2014) [
PubMed ]
Nagase M, Takahashi Y, Watanabe AM, Kubo Y, Kato F.
On-Site Energy Supply at Synapses through Monocarboxylate Transporters Maintains Excitatory Synaptic Transmission
J. Neurosci. 34, 2605-2617 (2014) [
PubMed ]
Tateyama M, Kubo Y.
Analyses of the effects of Gq protein on the activated states of the muscarinic M3 receptor and the purinergic P2Y1 receptor
Physiological Reports 1, e00134 (2013) [
PubMed ]
Tateyama M, Kubo Y.
Binding of Gq protein stabilizes the activated state of the muscarinic receptor type 1
Neuropharmacology 65, 173-181 (2013) [
PubMed ]
Uchiyama M, Maejima S, Yoshie S, Kubo Y, Konno N, Joss JMP.
The epithelial sodium channel in the Australian lungfish, Neoceratodus forsteri (Osteichthyes: Dipnoi)
Proc. R. Soc. B 279, 4795-4802 (2012) [
PubMed ]
Kurogi M, Miyashita M, Emoto Y, Kubo Y, Saitoh O.
Green Tea Polyphenol Epigallocatechin Gallate Activates TRPA1 in an Intestinal Enteroendocrine Cell Line, STC-1.
Chem Senses. 37, 167-177 (2012) [
PubMed ]
Nakajo K, Nishino A, Okamura Y, Kubo Y.
KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 ortholog.
J. Gen. Physiol. 138, 521-535 (2011) [
PubMed ]
Tateyama M, Kubo Y.
The intra-molecular activation mechanisms of the dimeric metabotropic glutamate receptor 1 differ depending on the type of G proteins.
Neuropharmacology 61, 832-841 (2011) [
PubMed ]
Nakajo K, Kubo Y. (review article)
Nano-environmental changes by KCNE proteins modify KCNQ channel function.
Channels 5, 397-401 (2011) [
PubMed ]
2010-2006
Nagatomo K, Ishii H, Yamamoto T, Nakajo K, Kubo Y.
The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression.
Biophys. J. 99, 3609-3618 (2010) [
PubMed ]
Nakajo K, Ulbrich MH, Kubo Y, Isacoff EY.
Stoichiometry of the KCNQ1-KCNE1 ion channel complex.
Nakane Y, Ikegami K, Ono H, Yamamoto N, Yoshida S, Hirunagi K, Ebihara S, Kubo Y, Yoshimura T.
A mammalian neural tissue opsin (Opsin 5) is a deep brain photoreceptor in birds.
Proc Natl Acad Sci U S A. 107, 15264-15268 (2010) [
PubMed ]
Ishii H, Nakajo K, Yanagawa Y, Kubo Y.
Identification and characterization of Cs+-permeable K+ channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation.
Eur J Neurosci. 32, 736-748 (2010) [
PubMed ]
Matsushita S, Nakata H, Kubo Y, Tateyama M.
Ligand-induced rearrangements of the GABAB receptor revealed by fluorescence resonance energy transfer.
J Biol Chem. 285, 10291-10299 (2010) [
PubMed ]
Keceli B, Kubo Y.
Functional and structural identification of amino acid residues of the P2X2 receptor channel critical for the voltage- and [ATP]-dependent gating.
J Physiol. 587, 5801-5818 (2009) [
PubMed ]
Kubo Y, Fujiwara Y, Keceli B, Nakajo K. (review article)
Dynamic aspects of functional regulation of the ATP receptor channel P2X2.
J Physiol. 587, 5317-5324 (2009) [
PubMed ]
Kurogi M, Nagatomo K, Kubo Y, Saitoh O.
Effects of spinophilin on the function of RGS8 regulating signals from M2 and M3-mAChRs.
Neuroreport. 20, 1134-1139 (2009) [
PubMed ]
Gleitsman KR, Tateyama M, Kubo Y.
Structural rearrangements of the motor protein prestin revealed by fluorescence resonance energy transfer.
Am J Physiol Cell Physiol. 297, C290-298 (2009) [
PubMed ]
Ishihara K, Yamamoto T, Kubo Y.
Heteromeric assembly of inward rectifier channel subunit Kir2.1 with Kir3.1 and with Kir3.4.
Biochem Biophys Res Commun. 380, 832-837 (2009) [
PubMed ]
Mio K, Ogura T, Yamamoto T, Hiroaki Y, Fujiyoshi Y, Kubo Y, Sato C.
Reconstruction of the P2X2 receptor reveals a vase-shaped structure with lateral tunnels above the membrane.
Structure. 17, 266-275 (2009) [
PubMed ]
Fujiwara, Y., Keceli, B., Nakajo, K., Kubo, Y.
Voltage- and [ATP]-dependent Gating of the P2X2 ATP Receptor Channel.
J. Gen. Physiol. 133, 93-109 (2009) [
PubMed ]
Nagatomo, K. and Kubo, Y.
Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels.
Proc Natl Acad Sci U S A. 105, 17373-17378 (2008) [
PubMed ]
Fujii S, Yamazoe G, Itoh M, Kubo Y, Saitoh O.
Spinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8.
Biochem Biophys Res Commun. 377, 200-204 (2008) [
PubMed ]
Tateyama, M. and Kubo, Y.
Regulatory role of C-terminus in the G protein coupling of the metabotropic glutamate receptor 1.
J. Neurochem. 107, 1036-1046 (2008) [
PubMed ]
Nakajo, K.and Kubo, Y.
Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks.
J. Physiol. 586, 2827-2840 (2008) [
PubMed ]
Mio, K., Kubo, Y., Ogura, T., Yamamoto, T., Arisaka, F. and Sato, C.
The motor protein prestin is a bullet-shaped molecule with inner cavities
J. Biol. Chem. 283, 1137-1145 (2008) [
PubMed ]
Nakajo K and Kubo Y
KCNE1 and KCNE3 Stabilize and/or Slow Voltage Sensing S4 Segment of KCNQ1 Channel
J. Gen. Physiol. 130, 269-281 (2007) [
PubMed ]
Tateyama M and Kubo Y
Coupling profile of the metabotropic glutamate receptor 1a is regulated by the C-terminal domain.
Mol. Cell. Neurosci 34, 445-452 (2007) [
PubMed ]
Itoh M, Nagatomo K, Kubo Y, Saitoh O.
Alternative splicing of RGS8 gene changes the binding property to the M1 muscarinic receptor to confer receptor type-specific Gq regulation.
J. Neurochem. 99, 1505-1516 (2006) [
PubMed ]
Fujiwara Y, Kubo Y.
Regulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides.
J. Physiol. 576, 135-149 (2006) [
PubMed ]
Fujiwara Y, Kubo Y.
Functional Roles of Charged Amino Acid Residues on the Wall of the Cytoplasmic Pore of Kir2.1.
J. Gen. Physiol. 127, 401-19 (2006) [
PubMed ]
Misaka T, Murate M, Fujimoto K, Kubo Y.
The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells.
Neurosci. Res. 55, 123-133 (2006) [
PubMed ]
Tateyama M, Kubo Y.
Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor 1a
Proc Natl Acad Sci U S A. 103, 1124-1128 (2006) [
PubMed ]
2005 - 2001
Nakajo K, Kubo Y.
Protein kinase C shifts the voltage-dependence of KCNQ/M channels expressed in Xenopus oocytes.
J. Physiol. 569, 59-74 (2005) [
PubMed ]
Mio K, Kubo Y, Ogura T, Yamamoto T, Sato C.
Visualization of the trimeric P2X2 receptor with a crown-capped extracellular domain.
Biochem Biophys Res Commun. 337, 998-1005 (2005) [
PubMed ]
Won-Kyu Ju, Takumi Misaka, Yulia Kushnareva, Saya Nakagomi, Neeraj Agarwal, Yoshihiro Kubo, Stuart A. Lipton, Ella Bossy-Wetzel
OPA1 expression in the normal rat retina and optic nerve.
Itoh M, Nagatomo K, Kubo Y, Sugimoto M, Saitoh O.
Molecular cloning and characterization of a new RGS protein of Medaka.
Gene. 345, 165-171 (2005) [
PubMed ]
Tateyama M, Abe H, Nakata H, Saito O, Kubo Y.
Ligand-induced rearrangement of the dimeric metabotropic glutamate receptor 1a.
Nat. Struct. Mol. Biol. 11, 637-642 (2004) [
PubMed ]
Fujiwara, Y. and Kubo, Y.
Density Dependent Changes of the Pore Properties of P2X2 Receptor Channel.
J. Physiol. 558, 31-43 (2004) [
PubMed ]
Abe, H., Tateyama, M. and Kubo, Y.
Functional identification of Gd3+ binding site of metabotropic glutamate receptor1a.
FEBS Lett. 545, 233-238 (2003) [
PubMed ]
Abe, H., Misaka, T., Tateyama, M. and Kubo, Y.
Effects of co-expression with Homer isoforms on the function of metabotropic glutamate receptor1a.
Mol. Cell Neurosci. 23, 157-168 (2003) [
PubMed ]
Fujiwara, Y. and Kubo, Y.
Ser 165 in the second transmembrane region of the Kir2.1 channel determines its susceptibility to blockade by intracellular Mg2+.
J. Gen. Physiol. 120, 677-692 (2002) [
PubMed ]
Murata, Y., Fujiwara, Y. and Kubo, Y.
Identification of a site involved in the block by extracellular Mg2+ and Ba2+ as well as permeation of K+ in Kir2.1 K+ channel.
J. Physiol. 544, 665-677 (2002) [
PubMed ]
Saitoh, O., Murata, Y., Odagiri, M., Itoh, M., Itoh, H., Misaka, T. and Kubo, Y.
Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling.
Proc. Natl. Acad. Sci. USA 99, 10138-10143 (2002) [
PubMed ]
Ai T., Fujiwara, Y., Tsuji, K., Otani, H., Nakano, S., Kubo, Y. and Horie, M.
Novel KCNJ2 mutation in familial periodic paralysis with ventricular dysrhythmia.
Circulation 105, 2592-2594 (2002) [
PubMed ]
Misaka, T., Miyashita, T. and Kubo, Y.
Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization and effect on mitochondrial morphology.
J. Biol. Chem. 277, 15834-15842 (2002) [
PubMed ]
Murata, Y., Okado, H., Katsuyama, Y., Okamura, Y. and Kubo, Y.
Primary structure, developmental expression and functional properties of an inward rectifier K+ channel of the tunicate.
Receptors Channels 7, 387-399 (2001) [
PubMed ]
Murata, Y., Okado, H. and Kubo, Y.
Characterization of heteromultimeric G protein-coupled inwardly rectifying potassium channels of the tunicate tadpole with a unique pore property.
J. Biol. Chem. 276, 18529-18539 (2001) [
PubMed ]
Soom, M., Schonherr, R., Kubo, Y., Kirsch, C., Klinger, R. and Heinemann, S. H.
Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium Channels
FEBS Lett. 490, 49-53 (2001) [
PubMed ]
Saitoh, O., Masuho, I., Terakawa, I., Nomoto, S., Asano, T. and Kubo, Y.
Regulator of G protein signaling 8 (RGS8) requires its NH2 terminus for subcellular localization and acute desensitization of G protein-gated K+ Channels.
J. Biol. Chem. 276, 5052-5058 (2001) [
PubMed ]
Kubo, Y. and Murata, Y.
Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel.
J. Physiol. 531, 645-660 (2001) [
PubMed ]
2000 - 1996
Miyashita, T. and Kubo, Y.
Extracellular Ca2+ sensitivity of mGluR1a induces an increase in the basal cAMP level by direct coupling with Gs protein in transfected CHO cells.
Receptors Channels 7, 77-91 (2000) [
PubMed ]
Miyashita, T. and Kubo, Y.
Extracellular Ca2+ sensitivity of mGluR1a associated with persistent glutamate response in transfected CHO cells.
Receptors Channels.
7, 25-40 (2000) [
PubMed ]
Saitoh, O., Kubo, Y., Odagiri, M., Ichikawa, M., Yamagata, K. and Sekine, T.
RGS7 and RGS8 Differentially Accelerate G Protein-mediated Modulation of K+ Currents.
J. Biol. Chem. 274(14), 9899-9904 (1999) [
PubMed ]
Kubokawa, K., Miyashita, T. and Kubo,Y.
Isolation of a cDNA for a novel 120-kDa GTP-binding protein expressed in motor neurons in the salmon brain.
FEBS Lett. 431, 231-235 (1998) [
PubMed ]
Kubo,Y., Murata, Y. and Heinemann, S. H.
Probing pore topology and conformational changes of Kir2.1 potassium channels by cysteine scanning mutagenesis.
FEBS Lett. 435, 69-73 (1998) [
PubMed ]
Nakamura, M., Watanabe, H., Kubo, Y., Yokoyama, M., Matsumoto, T., Sasai, H. and Nishi, Y.
KQT2, a new putative potassium channel family produced by alternative splicing.
Receptors Channels 5, 255-271 (1998) [
PubMed ]
Guo, L. and Kubo, Y.
Comparison of the open-close kinetics of the cloned inward rectifier K+ channel IRK1 and its point mutant (Q140E) in the pore region.
Receptors Channels 5, 273-289 (1998) [
PubMed ]
Chen, H., Kubo,Y., Hoshi, T. and Heinemann, S. H.
Cyclosporin A selectively reduces the functional expression of Kir2.1 potassium channels in Xenopus oocytes.
FEBS Lett. 422, 307-310 (1998) [
PubMed ]
Kubo,Y., Miyashita, T. and Murata, Y.
Structural basis for a Ca2+ - sensing function of the metabotropic glutamate receptors.
Science 279, 1722-1725 (1998) [
PubMed ]
Saitoh, O., Kubo, Y., Miyatani, T., Asano, T. and Nakata, H.
RGS8 accelerates G-protein-mediated modulation of K+ currents.
Nature 390, 525-529 (1997) [
PubMed ]
Miyashita, T. and Kubo, Y.
Localization and developmental changes of the expression of two inward rectifying K+ - channel proteins in the rat brain.
Brain Res. 750, 251-263 (1997) [
PubMed ]
Kubokawa, K. and Kubo, Y.
Functional Expression of GnRH Receptors in Xenopus Oocytes Injected with Salmon Brain RNA.
J. Reprod. Develop. 42, 283-289 (1996)
Kubo, Y. and Iizuka, M.
Identification of Domains of the Cardiac Inward Rectifying K+ Channel, CIR, Involved in the Heteromultimer Formation and in the G-Protein Gating.
Biochem. Biophys. Res. Commun. 227, 240-247 (1996) [
PubMed ]
Kubokawa, K., Miyashita, T., Nagasawa, H. and Kubo, Y.
Cloning and characterization of a bifunctional metabotropic receptoractivated by both exracellular calcium and glutamate.
FEBS Lett. 392, 71-76 (1996) [
PubMed ]
Kubo, Y., Miyashita, T. and Kubokawa, K.
A weakly inward rectifying potassium channel of the salmon brain. Glutamate 179 in the second transmembrane domain is insufficient for strong rectification.
J. Biol. Chem. 271, 1570-1573 (1996) [
PubMed ]
Kubo, Y.
Effects of Extracellular Cations and Mutations in the Pore Region on the Inward Rectifier K+ Channel IRK1.
Receptors Channels 4, 73-83 (1996) [
PubMed ]
1995 - 1986
Iizuka, M., Kubo, Y., Tsunenari, I., Pan, C. X., Akiba, I. and Kono, T.
Functional Characterization and Localization of a Cardiac-type Inwardly Rectifying K+ Channel.
Receptors Channels 3, 299-315 (1995) [
PubMed ]
Kubo, Y., Reuveny, E., Slesinger, P. A., Jan, Y. N. and Jan, L. Y.
Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel.
Nature 364, 802-806 (1993) [
PubMed ]
Kubo, Y., Baldwin, T. J., Jan, Y. N. and Jan, L. Y.
Primary structure and functional expression of a mouse inward rectifier potassium channel.
Nature 362, 127-133 (1993) [
PubMed ]
Kubo, Y.
Comparison of the initial stages of muscle differentiation in rat and mouse myoblastic and mouse mesodermal stem cell lines.
J. Physiol. 442, 743-759 (1991) [
PubMed ]
Kubo, Y.
Electrophysiological and immunohistochemical analysis of muscle differentiation in a mouse mesodermal stem cell line.
J. Physiol. 442, 711-741 (1991) [
PubMed ]
Kubo, Y.
Properties of ionic currents induced by external ATP in a mouse mesodermal stem cell line.
J. Physiol. 442, 691-710 (1991) [
PubMed ]
Takeuchi, K., Boonmar, S., Kubo, Y., Katayama, T., Harada, H., Ohbayashi,A., Choo, Q. - L., Kuo, G., Houghton, M., Saito, I. and Miyamura, T.
Hepatitis C viral cDNA clones isolated from a healthy carrier donor implicated
in post-transfusion non-A,non-B hepatitis.
Gene 91, 287-291 (1990) [
PubMed ]
Takeuchi, K., Kubo, Y., Boonmar, S., Watanabe, Y., Katayama, T., Choo, Q. -L., Kuo, G., Houghton, M., Saito, I. and Miyamura, T.
The putative nucleocapsid and envelope protein genes of hepatitis C virus determined by comparison of the nucleotide sequences of two isolates derived from an experimentally infected chimpanzee and, healthy human carriers.
J. Gen. Virol. 71, 3027-3033 (1990) [
PubMed ]
Takeuchi, K., Kubo, Y., Boonmar, S., Watanabe, Y., Katayama, T., Choo, Q. -L., Kuo, G., Houghton, M., Saito, I. and Miyamura, T.
Nucleotide sequence of core and envelope genes of the hepatitis C virus genome derived directly from human healthy carriers.
Nucleic Acids Res. 18, 4626 (1990) [
PubMed ]
Kubo, Y., Takeuchi, K., Boonmar, S., Katayama, T., Choo, Q. -L., Kuo, G., Weiner, A. J., Bradley, D., Houghton, M., Saito, I. and Miyamura, T.
A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan.
Nucleic Acids Res. 17, 10367-10372 (1989) [
PubMed ]
Kubo, Y. and Kidokoro, Y.
Potassium currents induced by muscarinic receptor activation in the rat adrenal chromaffin cell.
Biomed. Res. 10, 71-81 (1989)
Kubo, Y.
Development of ion channels and neurofilaments during neuronal differentiation of mouse embryonal carcinoma cell lines.
J. Physiol. 409, 497-523 (1989) [
PubMed ]
Hirano, T., Kubo, Y. and Wu, M. M.
Cerebellar granule cells in culture: Monosynaptic connections with Purkinje cells and ionic currents.
Proc. Natl. Acad. Sci. USA 83, 4957-4961 (1986) [
PubMed ]