Ivermectin activates GIRK channels in a PIP2 -dependent, GΐΑ-independent manner and an amino acid residue at the slide helix governs the activation
A ciliary opsin in the brain of a marine annelid zooplankton is UV-sensitive and the sensitivity is tuned by a single amino acid residue
J Biol Chem.
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AMPA glutamate receptors are required for sensory-organ formation and morphogenesis in the basal chordate
Proc Natl Acad Sci U S A. 114
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Stabilizing effects of G protein on the active conformation of adenosine A1 receptor differ depending on G protein type
Eur J Pharmacol. 788
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Sensitivities of Two Zebrafish TRPA1 Paralogs to Chemical and Thermal Stimuli Analyzed in Heterologous Expression Systems
Chemical Senses 41
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Retinal attachment instability is diversified among mammalian melanopsins
J Biol Chem. 290
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Kv4.2 and Accessory Dipeptidyl Peptidase-like Protein 10 (DPP10) Subunit Preferentially Form a 4:2 (Kv4.2:DPP10) Channel Complex
J Biol Chem. 290
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NIPS-JP symposium: Cutting-edge approaches towards the functioning mechanisms of membrane proteins
J Physiol. 593, 2551-2552 (2015)
KCNQ1 channel modulation by KCNE proteins via the voltage-sensing domain
J Physiol. 593
, 2617-2625 (2015) [ PubMed
Auto-oxidation Products of Epigallocatechin Gallate Activate TRPA1 and TRPV1 in Sensory Neurons
Chemical Senses 40
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Voltage and ATP dependent structural rearrangements of the P2X2 receptor associated with the gating of the pore
J Physiol. 592
, 4657-4676 (2014) [ PubMed
Steric hindrance between S4 and S5 of the KCNQ1/KCNE1 channel hampers pore opening
5:4100 (2014) [ PubMed
The Stoichiometry and Biophysical Properties of the Kv4 Potassium Channel Complex with KChIP Subunits are Variable Depending on the Relative Expression Level
J Biol Chem. 289
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Signal transmission within the P2X2 trimeric receptor
J. Gen. Physiol. 143
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On-Site Energy Supply at Synapses through Monocarboxylate Transporters Maintains Excitatory Synaptic Transmission
J. Neurosci. 34
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Analyses of the effects of Gq protein on the activated states of the muscarinic M3 receptor and the purinergic P2Y1 receptor
Physiological Reports 1
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Binding of Gq protein stabilizes the activated state of the muscarinic receptor type 1
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The epithelial sodium channel in the Australian lungfish, Neoceratodus forsteri (Osteichthyes: Dipnoi)
Proc. R. Soc. B 279
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Green Tea Polyphenol Epigallocatechin Gallate Activates TRPA1 in an Intestinal Enteroendocrine Cell Line, STC-1.
Chem Senses. 37
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KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 ortholog.
J. Gen. Physiol. 138
, 521-535 (2011) [ PubMed
The intra-molecular activation mechanisms of the dimeric metabotropic glutamate receptor 1 differ depending on the type of G proteins.
, 832-841 (2011) [ PubMed
Nano-environmental changes by KCNE proteins modify KCNQ channel function.
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The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression.
Biophys. J. 99
, 3609-3618 (2010) [ PubMed
Stoichiometry of the KCNQ1-KCNE1 ion channel complex.
A mammalian neural tissue opsin (Opsin 5) is a deep brain photoreceptor in birds.
Proc Natl Acad Sci U S A. 107
, 15264-15268 (2010) [ PubMed
Identification and characterization of Cs+-permeable K+ channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation.
Eur J Neurosci. 32
, 736-748 (2010) [ PubMed
Ligand-induced rearrangements of the GABAB receptor revealed by fluorescence resonance energy transfer.
J Biol Chem. 285
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Functional and structural identification of amino acid residues of the P2X2 receptor channel critical for the voltage- and [ATP]-dependent gating.
J Physiol. 587
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Dynamic aspects of functional regulation of the ATP receptor channel P2X2.
J Physiol. 587
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Effects of spinophilin on the function of RGS8 regulating signals from M2 and M3-mAChRs.
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Structural rearrangements of the motor protein prestin revealed by fluorescence resonance energy transfer.
Am J Physiol Cell Physiol. 297
, C290-298 (2009) [ PubMed
Heteromeric assembly of inward rectifier channel subunit Kir2.1 with Kir3.1 and with Kir3.4.
Biochem Biophys Res Commun. 380
, 832-837 (2009) [ PubMed
Reconstruction of the P2X2 receptor reveals a vase-shaped structure with lateral tunnels above the membrane.
, 266-275 (2009) [ PubMed
Voltage- and [ATP]-dependent Gating of the P2X2 ATP Receptor Channel.
J. Gen. Physiol. 133
, 93-109 (2009) [ PubMed
Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels.
Proc Natl Acad Sci U S A. 105
, 17373-17378 (2008) [ PubMed
Spinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8.
Biochem Biophys Res Commun. 377
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Regulatory role of C-terminus in the G protein coupling of the metabotropic glutamate receptor 1.
J. Neurochem. 107
, 1036-1046 (2008) [ PubMed
Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks.
J. Physiol. 586
, 2827-2840 (2008) [ PubMed
The motor protein prestin is a bullet-shaped molecule with inner cavities
J. Biol. Chem. 283
, 1137-1145 (2008) [ PubMed
KCNE1 and KCNE3 Stabilize and/or Slow Voltage Sensing S4 Segment of KCNQ1 Channel
J. Gen. Physiol. 130
, 269-281 (2007) [ PubMed
Coupling profile of the metabotropic glutamate receptor 1a is regulated by the C-terminal domain.
Mol. Cell. Neurosci 34
, 445-452 (2007) [ PubMed
Alternative splicing of RGS8 gene changes the binding property to the M1 muscarinic receptor to confer receptor type-specific Gq regulation.
J. Neurochem. 99
, 1505-1516 (2006) [ PubMed
Regulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides.
J. Physiol. 576
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Functional Roles of Charged Amino Acid Residues on the Wall of the Cytoplasmic Pore of Kir2.1.
J. Gen. Physiol. 127
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The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells.
Neurosci. Res. 55
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Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor 1a
Proc Natl Acad Sci U S A. 103
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2005 - 2001
Protein kinase C shifts the voltage-dependence of KCNQ/M channels expressed in Xenopus oocytes.
J. Physiol. 569
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Visualization of the trimeric P2X2 receptor with a crown-capped extracellular domain.
Biochem Biophys Res Commun. 337
, 998-1005 (2005) [ PubMed
OPA1 expression in the normal rat retina and optic nerve.
Molecular cloning and characterization of a new RGS protein of Medaka.
, 165-171 (2005) [ PubMed
Ligand-induced rearrangement of the dimeric metabotropic glutamate receptor 1a.
Nat. Struct. Mol. Biol. 11
, 637-642 (2004) [ PubMed
Density Dependent Changes of the Pore Properties of P2X2 Receptor Channel.
J. Physiol. 558
, 31-43 (2004) [ PubMed
Functional identification of Gd3+ binding site of metabotropic glutamate receptor1a.
FEBS Lett. 545
, 233-238 (2003) [ PubMed
Effects of co-expression with Homer isoforms on the function of metabotropic glutamate receptor1a.
Mol. Cell Neurosci. 23
, 157-168 (2003) [ PubMed
Ser 165 in the second transmembrane region of the Kir2.1 channel determines its susceptibility to blockade by intracellular Mg2+.
J. Gen. Physiol. 120
, 677-692 (2002) [ PubMed
Identification of a site involved in the block by extracellular Mg2+ and Ba2+ as well as permeation of K+ in Kir2.1 K+ channel.
J. Physiol. 544
, 665-677 (2002) [ PubMed
Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling.
Proc. Natl. Acad. Sci. USA 99
, 10138-10143 (2002) [ PubMed
Novel KCNJ2 mutation in familial periodic paralysis with ventricular dysrhythmia.
, 2592-2594 (2002) [ PubMed
Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization and effect on mitochondrial morphology.
J. Biol. Chem. 277
, 15834-15842 (2002) [ PubMed
Primary structure, developmental expression and functional properties of an inward rectifier K+ channel of the tunicate.
Receptors Channels 7
, 387-399 (2001) [ PubMed
Characterization of heteromultimeric G protein-coupled inwardly rectifying potassium channels of the tunicate tadpole with a unique pore property.
J. Biol. Chem. 276
, 18529-18539 (2001) [ PubMed
Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium Channels
FEBS Lett. 490
, 49-53 (2001) [ PubMed
Regulator of G protein signaling 8 (RGS8) requires its NH2 terminus for subcellular localization and acute desensitization of G protein-gated K+ Channels.
J. Biol. Chem. 276
, 5052-5058 (2001) [ PubMed
Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel.
J. Physiol. 531
, 645-660 (2001) [ PubMed
2000 - 1996
Extracellular Ca2+ sensitivity of mGluR1a induces an increase in the basal cAMP level by direct coupling with Gs protein in transfected CHO cells.
Receptors Channels 7
, 77-91 (2000) [ PubMed
Extracellular Ca2+ sensitivity of mGluR1a associated with persistent glutamate response in transfected CHO cells.
, 25-40 (2000) [ PubMed
RGS7 and RGS8 Differentially Accelerate G Protein-mediated Modulation of K+ Currents.
J. Biol. Chem. 274
(14), 9899-9904 (1999) [ PubMed
Isolation of a cDNA for a novel 120-kDa GTP-binding protein expressed in motor neurons in the salmon brain.
FEBS Lett. 431
, 231-235 (1998) [ PubMed
Probing pore topology and conformational changes of Kir2.1 potassium channels by cysteine scanning mutagenesis.
FEBS Lett. 435
, 69-73 (1998) [ PubMed
KQT2, a new putative potassium channel family produced by alternative splicing.
Receptors Channels 5
, 255-271 (1998) [ PubMed
Comparison of the open-close kinetics of the cloned inward rectifier K+ channel IRK1 and its point mutant (Q140E) in the pore region.
Receptors Channels 5
, 273-289 (1998) [ PubMed
Cyclosporin A selectively reduces the functional expression of Kir2.1 potassium channels in Xenopus oocytes.
FEBS Lett. 422
, 307-310 (1998) [ PubMed
Structural basis for a Ca2+ - sensing function of the metabotropic glutamate receptors.
, 1722-1725 (1998) [ PubMed
RGS8 accelerates G-protein-mediated modulation of K+ currents.
, 525-529 (1997) [ PubMed
Localization and developmental changes of the expression of two inward rectifying K+ - channel proteins in the rat brain.
Brain Res. 750
, 251-263 (1997) [ PubMed
Functional Expression of GnRH Receptors in Xenopus Oocytes Injected with Salmon Brain RNA.
J. Reprod. Develop. 42, 283-289 (1996)
Identification of Domains of the Cardiac Inward Rectifying K+ Channel, CIR, Involved in the Heteromultimer Formation and in the G-Protein Gating.
Biochem. Biophys. Res. Commun. 227
, 240-247 (1996) [ PubMed
Cloning and characterization of a bifunctional metabotropic receptoractivated by both exracellular calcium and glutamate.
FEBS Lett. 392
, 71-76 (1996) [ PubMed
A weakly inward rectifying potassium channel of the salmon brain. Glutamate 179 in the second transmembrane domain is insufficient for strong rectification.
J. Biol. Chem. 271
, 1570-1573 (1996) [ PubMed
Effects of Extracellular Cations and Mutations in the Pore Region on the Inward Rectifier K+ Channel IRK1.
Receptors Channels 4
, 73-83 (1996) [ PubMed
1995 - 1986
Functional Characterization and Localization of a Cardiac-type Inwardly Rectifying K+ Channel.
Receptors Channels 3
, 299-315 (1995) [ PubMed
Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel.
, 802-806 (1993) [ PubMed
Primary structure and functional expression of a mouse inward rectifier potassium channel.
, 127-133 (1993) [ PubMed
Comparison of the initial stages of muscle differentiation in rat and mouse myoblastic and mouse mesodermal stem cell lines.
J. Physiol. 442
, 743-759 (1991) [ PubMed
Electrophysiological and immunohistochemical analysis of muscle differentiation in a mouse mesodermal stem cell line.
J. Physiol. 442
, 711-741 (1991) [ PubMed
Properties of ionic currents induced by external ATP in a mouse mesodermal stem cell line.
J. Physiol. 442
, 691-710 (1991) [ PubMed
Hepatitis C viral cDNA clones isolated from a healthy carrier donor implicated
in post-transfusion non-A,non-B hepatitis.
, 287-291 (1990) [ PubMed
The putative nucleocapsid and envelope protein genes of hepatitis C virus determined by comparison of the nucleotide sequences of two isolates derived from an experimentally infected chimpanzee and, healthy human carriers.
J. Gen. Virol. 71
, 3027-3033 (1990) [ PubMed
Nucleotide sequence of core and envelope genes of the hepatitis C virus genome derived directly from human healthy carriers.
Nucleic Acids Res. 18
, 4626 (1990) [ PubMed
A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan.
Nucleic Acids Res. 17
, 10367-10372 (1989) [ PubMed
Potassium currents induced by muscarinic receptor activation in the rat adrenal chromaffin cell.
Biomed. Res. 10, 71-81 (1989)
Development of ion channels and neurofilaments during neuronal differentiation of mouse embryonal carcinoma cell lines.
J. Physiol. 409
, 497-523 (1989) [ PubMed
Cerebellar granule cells in culture: Monosynaptic connections with Purkinje cells and ionic currents.
Proc. Natl. Acad. Sci. USA 83
, 4957-4961 (1986) [ PubMed