| Our main interest lies in elucidation of the mechanism of transduction and integration of neural information in the nervous system. More specifically, we are trying to understand the basic properties of neural information processing between neurons or among a group of neurons constituting a local network. We are also interested in the pathophysiological mechanism how a single gene mutation leads to a symptom (such as ataxia, epilepsy and learning and memory deficits), particularly in Ca2+ channel mutant and Ca2+/calmodulin-dependent protein kinase IIα mutant mice. Additionally, we have recently started to make a computational approach, incorporating computer-based neurons into brain slice measurements (dynamic clamp), together with computational simulation of network functions. The following are currently ongoing major projects. | |
| 1. Neurological disorders caused by calcium channel mutations | 2. In vivo nociceptive synaptic transmission and its plastic change |
 |
 |
| 3. Transmitter diffusion-mediated crosstalk between heterologous neurons | 4．Role of protein phosphorylation in neuronal functions |
 |
 |
Update 12-May-2010