National Institutes of Natural Sciences, National Institute for Physiological Sciences, Department of Homeostatic Regulation

Publication List

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Nakajima KI
Neural insights into sweet taste transduction and hunger-induced taste modification in mice.
Biosci Biotechnol Biochem. 2022 Oct 20;86(11):1485-1489.doi: 10.1093/bbb/zbac142.

Izawa S, Yoneshiro T, Kondoh K, Nakagiri S, Okamatsu-Ogura Y, Terao A, Minokoshi Y, Yamanaka A, Kimura K
Melanin-concentrating hormone-producing neurons in the hypothalamus regulate brown adipose tissue and thus contribute to energy expenditure.
J Physiol. 2022 Feb;600(4):815-827. doi: 10.1113/JP281241. Epub 2021 May 13. PMID: 33899241

Fu O, Minokoshi Y, Nakajima KI
Recent Advances in Neural Circuits for Taste Perception in Hunger.
Front Neural Circuits. 2021 Feb 2;15:609824.doi: 10.3389/fncir.2021.609824. eCollection 2021.

Minokoshi Y, Nakajima KI, Okamoto S.
Homeostatic versus hedonic control of carbohydrate selection.
J Physiol. 2020 Jul 9.doi: 10.1113/JP280066. Online ahead of print.

Guo T, Tanaka T, Matsumoto M, Kaneko K, Unzai T, Ogino Y, Aotani D, Kusakabe T, Iwakura H, Miyazawa T, Sawamoto K, Minokoshi Y, Masuzaki H, Inagaki N, Nakao K.
A combination of dietary fat intake and nicotine exposure enhances CB1 endocannabinoid receptor expression in hypothalamic nuclei in male mice.
Neurosci Lett. 2020 Jan 1;714:134550. doi: 10.1016/j.neulet.2019.134550. Epub 2019 Oct 18.

Fu O, Iwai Y, Narukawa M, Ishikawa AW, Ishii KK, Murata K, Yoshimura Y, Touhara K, Misaka T, Minokoshi Y, Nakajima KI.
Hypothalamic neuronal circuits regulating hunger-induced taste modification.
Nat Commun. 2019 Oct 8;10(1):4560. doi: 10.1038/s41467-019-12478-x.

Fu O, Iwai Y, Kondoh K, Misaka T, Minokoshi Y, Nakajima KI.
SatB2-Expressing Neurons in the Parabrachial Nucleus Encode Sweet Taste.
Cell Rep. 2019 May 7;27(6):1650-1656.e4. doi: 10.1016/j.celrep.2019.04.040.

Hirata Y, Nomura K, Senga Y, Okada Y, Kobayashi K, Okamoto S, Minokoshi Y, Imamura M, Takeda S, Hosooka T, Ogawa W.
Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis.
JCI Insight. 2019 Feb 21;4(4). pii: 124952. doi: 10.1172/jci.insight.124952. eCollection 2019 Feb 21.

Okamoto S, Asgar NF, Yokota S, Saito K, Minokoshi Y.
Role of the α2 subunit of AMP-activated protein kinase and its nuclear localization in mitochondria and energy metabolism-related gene expressions in C2C12 cells.
Metabolism. 2019 Jan;90:52-68. doi: 10.1016/j.metabol.2018.10.003. Epub 2018 Oct 23.

Ikegami R, Shimizu I, Sato T, Yoshida Y, Hayashi Y, Suda M, Katsuumi G, Li J, Wakasugi T, Minokoshi Y, Okamoto S, Hinoi E, Nielsen S, Jespersen NZ, Scheele C, Soga T, Minamino T.
Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity.
Cell Rep. 2018 Sep 11;24(11):2827-2837.e5. doi: 10.1016/j.celrep.2018.08.024.

Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S,
Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F,
Ferre P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y.
Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat.
Cell Rep. (2018) Jan 16;22(3):706-721. doi: 10.1016/j.celrep.2017.11.102.

Shiuchi T, Toda C, Okamoto S, Coutinho EA, Saito K, Miura S, Ezaki O, Minokoshi Y.
Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β2-adrenergic receptor but not by AMPK.
Sci Rep. (2017) Nov 9;7(1):15141.

Iwakoshi-Ukena E, Shikano K, Kondo K, Taniuchi S, Furumitsu M, Ochi Y, Sasaki T, Okamoto S, Bentley GE, Kriegsfeld LJ, Minokoshi Y, Ukena K.
Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity.
eLIFE. (2017) Aug 11;6. pii: e28527.

Coutinho EA, Okamoto S, Ishikawa AW, Yokota S, Wada N, Hirabayashi T, Saito K, Sato T, Takagi K, Wang CC, Kobayashi K, Ogawa Y, Shioda S, Yoshimura Y, Minokoshi Y.
Activation of SF1 Neurons in the Ventromedial Hypothalamus by DREADD Technology Increases Insulin Sensitivity in Peripheral Tissues.
Diabetes Sep;66(9):2372-2386. (2017)

Miyatake Y, Shiuchi T, Mawatari K, Toda S, Taniguchi Y, Futami A, Sato F, Kuroda M, Sebe M, Tsutsumi R, Harada N, Minokoshi Y, Kitamura T, Gotoh K, Ueno M, Nakaya Y, Sakaue H.
Intracerebroventricular injection of ghrelin decreases wheel running activity in rats.
Peptides 87:12-19. (2017)

Inagaki-Ohara K, Okamoto S, Takagi K, Saito K, Arita S, Tang L, Hori T, Kataoka H, Matsumoto S, Minokoshi Y.
Leptin receptor signaling is required for high-fat diet-induced atrophic gastritis in mice.
Nutr Metab (Lond). 13:7. (2016)

Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T.
Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet.
Sci. Rep. 5:17565. (2015)

Hirono S, Lee EY, Kuribayashi S, Fukuda T, Saeki N, Minokoshi Y, Iwanaga T, Miki T.
Importance of Adult Dmbx1 in Long-Lasting Orexigenic Effect of Agouti-Related Peptide.
Endocrinology 157(1):245-57. (2015)

Tang L, Okamoto S, Shiuchi T, Toda C, Takagi K, Sato T, Saito K, Yokota S, Minokoshi Y.
Sympathetic Nerve Activity Maintains an Anti-Inflammatory State in Adipose Tissue in Male Mice by Inhibiting TNF-α Gene Expression in Macrophages.
Endocrinology 156(10):3680-94. (2015)

Tabuchi S, Tsunematsu T, Black SW, Tominaga M, Maruyama M, Takagi K, Minokoshi Y, Sakurai T, Kilduff TS, Yamanaka A.
Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function.
J Neurosci. 34(19):6495-6509 (2014)

Sasaki T, Kikuchi O, Shimpuku M, Susanti VY, Yokota-Hashimoto H, Taguchi R, Shibusawa N, Sato T, Tang L, Amano K, Kitazumi T, Kuroko M, FujitaY, Maruyama J, Lee YS, Kobayashi M, Nakagawa T, Minokoshi Y, Harada A, Yamada M, Kitamura T.
Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice.
Diabetologia. 57(4):819-831 (2014)

Inagaki-Ohara K, Mayuzumi H, Kato S, Minokoshi Y, Otsubo T, Kawamura YI, Dohi T, Matsuzaki G, Yoshimura A. Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice. Oncogene. 33(1):74-84 (2014)

Kahn BB, Minokoshi Y
Leptin, GABA, and glucose control
Cell Metab. 18(3) :304-306 (2013) [Preview]

Toda C, Shiuchi T, Kageyama H, Okamoto S, Coutinho EA, Sato T, Okamatsu-Ogura Y, Yokota S, Takagi K, Tang L, Saito K, Shioda S, Minokoshi Y.
Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptin-induced glucose uptake in red-type skeletal muscle.
Diabetes. 62(7):2295-2307 (2013)

Rodriguez-Araujo G, Nakagami H, Hayashi H, Mori M, Shiuchi T, Minokoshi Y, Takami Y, Komuro I, Morishita R, Kaneda Y
Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/P13K/Akt transduction pathway. Cell Mol Life Sci. 70(6):1123-1133 (2013)

Minokoshi Y, Toda C, Okamoto S.
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
Indian J Endocrinol Metab. 16(Suppl 3):S562-568 (2012)

Inagaki-Ohara K, Mayuzumi H, Kato S, Minokoshi Y, Otsubo T, Kawamura YI, Dohi T, Matsuzaki G, Yoshimura A.
Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice.
Oncogene. Nov 26 (2012)

Ogawa N, Ito M, Yamaguchi H, Shiuchi T, Okamoto S, Wakitani K, Minokoshi Y, Nakazato M.
Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats.
Metabolism. 61(9):1312-1320 (2012)

Kukimoto-Niino M, Yoshikawa S, Takagi T, Tomabechi Y, Terada T, Shirouzu M, Suzuki A, Lee S, Kadowaki T, Minokoshi Y, Yokoyama S.
Crystal structure of the Ca2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem 286: 22570-22579 (2011)

Cao Y, Nakata M, Okamoto S, Takano E, Yada T, Minokoshi Y, Hirata Y, Nakajima K, Iskandar K, Hayashi Y, Ogawa W, Barsh GS, Hosoda H, Kangawa K, Itoh H, Noda T, Kasuga M, Nakae J.
PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure. PLoS One. 6(4):e18324. Epub (2011) 

Tanaka M, Suganami T, Kim-Saijo M, Toda C, Tsuiji M, Ochi K, Kamei Y, Minokoshi Y, Ogawa Y.
Role of central leptin signaling in the starvation-induced alteration of B-cell development.
J Neurosci. 31(23):8373-8380 (2011)

Handa N, Takagi T, Saijo S, Kishishita S, Takaya D, Toyama M, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T, Okada-Iwabu M, Iwabu M, Kadowaki T, Minokoshi Y, Yokoyama S.
Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain.
Acta Crystallogr D Biol Crystallogr. 67(Pt 5):480-487 (2011)

Hoivik EA, Bjanesoy TE, Mai O, Okamoto S, Minokoshi Y, Shima Y, Morohashi KI, Boehm U, Bakke M.
DNA methylation of intronic enhancers directs tissue-specific expression of steroidogenic factor 1/Adrenal 4 binding protein (SF-1/Ad4BP).
Endocrinology. 152(5):2100-2112 (2011)

Saito K, Lee S, Shiuchi T, Toda C, Kamijo M, Inagaki-Ohara K, Okamoto S, Minokoshi Y.
An enzymatic photometric assay for 2-deoxyglucose uptake in insulin-responsive tissues and 3T3-L1 adipocytes.
Anal Biochem. 412(1):9-17 (2011)

Matsuo E, Mochizuki A, Nakayama K, Nakamura S, Yamamoto T, Shioda S, Sakurai T, Yanagisawa M, Shiuchi T, Minokoshi Y, Inoue T.
Decreased intake of sucrose solutions in orexin knockout mice.
J Mol Neurosci. 43(2):217-224 (2011)

Uchida K, Dezaki K, Damdindorj B, Inada H, Shiuchi T, Mori Y, Yada T, Minokoshi Y, Tominaga M.
Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes. 60(1):119-126 (2011)

Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim H-J, Lee I-K, Minokoshi Y, Saito Y, Takahashi K, Yamada Y, Takakura N, Kaneko S.
A liver-derived secretory protein, Selenoprotein P, causes insulin resistance. Cell Metab. 12(5): 483-495 (2010)

Uchida K, Dezaki K, Damdindorj B, Inada H, Shiuchi T, Mori Y, Yada T, Minokoshi Y, Tominaga M.
Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice.
Diabetes. 60(1):119-126 (2010)

Tanegashima K, Okamoto S, Nakayama Y, Taya C, Shitara H, Ishii R, Yonekawa H, Minokoshi Y, Hara T.
CXCL14 deficiency in mice attenuates obesity and inhibits feeding behavior in a novel environment.
PLoS One. 5(4):e10321 (2010)

Sasaki T, Kim HJ, Kobayashi M, Kitamura YI, Yokota-Hashimoto H, Shiuchi T, Minokoshi Y, Kitamura T.
Induction of hypothalamic sirt1 leads to cessation of feeding via agouti-related peptide.
Endocrinology. 151(6):2556-2566 (2010)

Uchida K, Shiuchi T, Inada H, Minokoshi Y, Tominaga M.
Metabolic adaptation of mice in a cool environment.
Pflugers Arch. 459(5):765-774. Epub (2010)

Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, Toda C, Suzuki A, Bachman ES, Kim YB, Sakurai T, Yanagisawa M, Shioda S, Imoto K, Minokoshi Y.
Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system.
Cell Metab. 10(6):466-480 (2009)

Toda C, Shiuchi T, Lee S, Yamato-Esaki M, Fujino Y, Suzuki A, Okamoto S, Minokoshi Y.
Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues.
Diabetes. 58(12):2757-2765 (2009)

Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB.
Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.
Molecular and Cellular Biology. 29(16): 4563-4573 (2009)

Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, Kaneko K, Ishihara H, Niijima A, Nakazato M, Asano T, Minokoshi Y, Oka Y.
Regulation of pancreatic beta cell mass by neuronal signals from the liver.
Science. 322(5905):1250-1254 (2008)

Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S.
Role of hypothalamic AMP-kinase in food intake regulation.
Nutrition. 24(9):786-790 (2008)

Kohno D, Sone H, Minokoshi Y, Yada T.
Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons.
Biochem Biophys Res Commun. 366(2):388-392 (2008)

Arai N, Masuzaki H, Tanaka T, Ishii T, Yasue S, Kobayashi N, Tomita T, Noguchi M, Kusakabe T, Fujikura J, Ebihara K, Hirata M, Hosoda K, Hayashi T, Sawai H, Minokoshi Y, Nakao K.
Ceramide and adenosine 5'-monophosphate-activated protein kinase are two novel regulators of 11beta-hydroxysteroid dehydrogenase type 1 expression and activity in cultured preadipocytes.
Endocrinology. 148(11):5268-5277 (2007)

Fujimoto W, Shiuchi T, Miki T, Minokoshi Y, Takahashi Y, Takeuchi A, Kimura K, Saito M, Iwanaga T, Seino S.
Dmbx1 is essential in agouti-related protein action.
Proc. Natl. Acad. Sci. U S A. 104(39):15514-15519 (2007)

Nara N, Nakayama Y, Okamoto S, Tamura H, Kiyono M, Muraoka M, Tanaka K, Taya C, Shitara H, Ishii R, Yonekawa H, Minokoshi Y, Hara T.
Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance.
J. Biol. Chem. 282(42):30794-30803 (2007)

Suzuki A, Okamoto S, Lee S, Saito K, Shiuchi T, Minokoshi Y.
Leptin stimulates fatty acid oxidation and PPARalpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase.
Mol. Cell. Biol. 27(12):4317-4327 (2007)

Kubota N, Yano W, Kubota T, Yamauchi T, Itoh S, Kumagai H, Kozono H, Takamoto I, Okamoto S, Shiuchi T, Suzuki R, Satoh H, Tsuchida A, Moroi M, Sugi K, Noda T, Ebinuma H, Ueta Y, Kondo T, Araki E, Ezaki O, Nagai R, Tobe K, Terauchi Y, Ueki K, Minokoshi Y, Kadowaki T.
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake.
Cell Metab. 6(1):55-68 (2007)

Tanaka T, Masuzaki H, Yasue S, Ishii T, Arai N, Kobayashi N, Tomita T, Kusakabe T, Noguchi M, Fujikura J, Miyanaga F, Ebihara K, Hirata M, Hosoda K, Shiuchi T, Yamamoto H, Hayashi T, Minokoshi Y, Nakao K.
Activation of the central melanocortin system mediates the restoration of skeletal muscle AMP-activated protein kinase phosphorylation in mice fed high fat diet.
Cell Metab. 5(5):395-402 (2007)

Miura S, Kawanaka K, Kai Y, Tamura M, Goto M, Shiuchi T, Minokoshi Y, Ezaki O.
An increase in murine skeletal muscle PGC-1alpha mRNA in response to exercise is mediated by beta-adrenergic receptor activation.
Endocrinology. 148(7):3441-3448 (2007)

Maeda T*, Cao H*, Kono K, Gorgun CZ, Furuhashi M, Uysa K, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS (*equally contributed)
Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.
Cell Metab. 1(2):107-119 (2005)

Kim YB, Peroni O, Aschenbach WG, Minokoshi Y, Kotani K, Zisman A, Kahn CR, Goodyear LJ, Kahn BB.
Deletion of the Glut4 glucose transporter in muscle results in increased levels of glycogen-targeting subunits and glycogen content.
Mol. Cell. Biol. 25(21):9713-9723 (2005)

Tanaka T, Hidaka S, Masuzaki H, Yasue S, Minokoshi Y, Ebihara K, Chusho H, Ogawa Y, Toyoda T, Sato K, Miyanaga F, Fujimoto M, Tomita T, Kusakabe T, Kobayashi N, Tanioka H, Hayashi T, Hosoda K, Yoshimatsu H, Sakata T, Nakao K.
Skeletal muscle AMP-activated protein kinase phosphorylation parallels metabolic phenotype in leptin transgenic mice under dietary modification.
Diabetes. 54(8):2365-2374 (2005)

Shima Y, Zubair M, Ishihara S, Shinohara Y, Oka S, Kimura S, Okamoto S, Minokoshi Y, Suita S, Morohashi K.
Ventromedial hypothalamic nucleus-specific enhancer of Ad4BP/SF-1 gene.
Mol. Endocrinol. 19(11):2812-2823 (2005)

Guo F, Bakal K, Minokoshi Y, Hollenberg AN.
Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo.
Endocrinology. 145(5):2221-2227 (2004)

Minokoshi Y, Alquier T, Furukawa N, Kim Y-B, Lee A, Xue B, Mu J, Foufelle F, Ferr? P, Birnbaum MJ, Stuck BJ, Kahn BB.
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.
Nature. 428(6982):569-574 (2004)

Kotani K, Peroni OD*, Minokoshi Y *, Boss O, Kahn BB. (*Contributed equally)
GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.
J. Clin. Invest. 114(11):1666-1675 (2004)

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