f

International collaboration

Research Project Collaborator Publication
Regulation of AMPA receptor function by LGI1 and ADAM22 Dr. Roger A Nicoll (UCSF, USA) Tomita S et al, Science 2004
Fukata M et al, Neuron 2004
Fukata Y et al, J Cell Biol 2005
Fukata Y et al, Science 2006
Fukata Y et al, PNAS 2010
Lovero KL et al, PNAS 2015
Regulation of AMPA receptor function by PSD-95 Dr. David S Bredt (Johnson & Johnson, USA) Fukata Y et al, Science 2006
Noritake J et al, J Cell Biol, 2009
Palmitoylation of GABAA receptor γ-subunit Dr. Bernhard Luscher (Penn State University, USA) Fang C et al, J Neurosci 2006
Palmitoylation of eNOS Dr. William Sessa (Yale University School of Medicine, USA Fernandez-Hernando C et al, J Cell Biol 2006
Palmitoylation of LAT Dr. Amnon Altman (La Jolla Institute for Allergy & Immunology, USA) Hundt M et al, Immunity 2006
Palmitoylation of NCAM Dr. Alexander Dityaetv (German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany)
Dr. Evgeni Ponimaskin (Hannover Medical School, Germany)
Ponimaskin E et al, J Neurosci 2008
Palmitoylation for SNAP-25 and CSP in exocytosis Dr. Luke Chamberlain (University of Strathclyde, UK) Greaves J et al, J Biol Chem 2008
Greaves J et al, Mol Biol Cell 2009
Palmitoylation for BACE1 in Aβ production Dr. Gopal Thinakaran (The University of Chicago, USA) Vetrivel KS et al, J Biol Chem 2009
Genetical study of DHHC21 Dr. Ian Jackson (MRC Human Genetics Unit, UK) Mill P et al, PLoS Genet 2009
Molecular mechanism for dynamic protein palmitoylation Dr. Franck Perez (Curie Institute, France) Tsutsumi R et al, Mol Cell Biol 2009
Fukata Y et al, J Cell Biol 2013
Supported by Human Frontier Science Program, Young Investigators Grant
Palmitoylation of Ndel1 and Nde1 Dr. Orly Reiner (Weismann Institure, Israel) Shmueli A et al, EMBO J 2010
Palmitoylation of Stathmin Dr. André Sobel (INSERM, France) Levy AD et al, Mol Biol Cell 2011
Genetical study of LGI2 Dr. Hannes Lohi (Folkhälsan Institute of Genetics, Finland) Seppala EH et al, PLoS Genet 2011
Palmitoylation of PI4 kinase Dr. Helen L Yin (Univ Texas Southwestern, USA) Lu D et al, J Biol Chem 2012
Development of activity-based probes for DHHC proteins Dr. Wu Xu (Harvard Med Sch, USA) Zheng B et al, J Am Chem Soc 2013
Palmitoylation of MAP6 Dr. Annie Andrieux (INSERM, France) Gory-Fauré S et al, PLoS One 2014
Functional analysis of BAI1 Dr. Erwin G Van Meir (Emory University, USA) Zhu D et al, J Clin Invest 2015
Patho-physiological analysis of ADAM22 knockout mouse Dr. Dies Meijer (University of Edinburgh, UK) Kegel L et al, Development 2014
Yokoi N et al, Nat Med 2015
Functional analysis of ADAM22 mutations in progressive encephalopathy Dr. Anna-Elina Lehesjoki (University of Helsinki, Finland) Muona M et al, Neurol Genet 2016

International collaboration (in progress)

USA France Germany UK Switzerland
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Internal Collaboration

Research Project Collaborator Publication
Production of antibodies by baculovirus display method Dr.Takao Hamakubo (Tokyo University) Noritake J et al, J Cell Biol, 2009
Biochemical analysis using baculovirus expression system Dr.Yoshiharu Matsuura (Osaka University Research Institute of Microbial Disease) Noritake J et al, J Cell Biol, 2009
Functional Proteomics Dr.Jun Watanabe (National Center for Geriatrics and Gerontology) Fukata Y et al, PNAS, 2010
Electron Microscopy analysis Dr.Ryuichi Shigemoto (Institute of Science and Technology (IST), Austria) Fukata Y et al, PNAS, 2010
Functional analysis of LGI1 Dr. Kazunori Nakajima(Keio University) Kusuzawa S et al, Eur J Neurosci 2012
Functional analysis of MHC1 in the synapse Dr. Isao Ito(Kyusyu University) Kawahara A et al, J Physiol 2013
Expression and functional analysis of LGI1/ADAM22 in the brain Dr. Masahiko Watanabe (Hokkaido University) Ohkawa et al, J Neurosci 2013
Yokoi N et al, Nat Med 2015
Identification and functional analysis of autoantibodies in the limbic encephalitis Dr. Osamu Watanabe(Kagoshima University) Ohkawa et al, J Neurosci 2013
Ohkawa et al, J Neurosci 2014
Mode of action of anti-GABAA receptor autoantibody Dr. Shin’Ichiro Satake (NIPS)、Dr. Gen Sobue(Nagoya University) Ohkawa et al, J Neurosci 2014
Palmitoylation of ELMOD2 Dr. Toyoshi Fujimoto(Nagoya University) Suzuki M et al, Mol Biol Cell 2015
Analysis of LGI1 knockout mouse Dr. Keiji Imoto (NIPS) Yokoi N et al, Nat Med 2015

Domestic collaboration(in progress)

17

Impact of our identified DHHC-palmitoylating enzymes

Distribute the DHHC-library to more than 100 Labs (2005.2 - 2017.10)

USA Germany France UK Canada 日本 Korea China Ireland Israel
54 12 9 9 7 7 4 2 2 2
Italy Spain Singapore Switzerland Sweden Argentine Taiwan Poland India Australia
2 3 1 1 1 1 1 2 1 1