International collaboration
| Research Project | Collaborator | Publication |
|---|---|---|
| Regulation of AMPA receptor function by LGI1 and ADAM22 | Dr. Roger A Nicoll (UCSF, USA) |
Tomita S et al, Science 2004
Fukata M et al, Neuron 2004 Fukata Y et al, J Cell Biol 2005 Fukata Y et al, Science 2006 Fukata Y et al, PNAS 2010 Lovero KL et al, PNAS 2015 |
| Regulation of AMPA receptor function by PSD-95 | Dr. David S Bredt (Johnson & Johnson, USA) |
Fukata Y et al, Science 2006
Noritake J et al, J Cell Biol, 2009 |
| Palmitoylation of GABAA receptor γ-subunit | Dr. Bernhard Luscher (Penn State University, USA) | Fang C et al, J Neurosci 2006 |
| Palmitoylation of eNOS | Dr. William Sessa (Yale University School of Medicine, USA | Fernandez-Hernando C et al, J Cell Biol 2006 |
| Palmitoylation of LAT | Dr. Amnon Altman (La Jolla Institute for Allergy & Immunology, USA) | Hundt M et al, Immunity 2006 |
| Palmitoylation of NCAM | Dr. Alexander Dityaetv (German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany) Dr. Evgeni Ponimaskin (Hannover Medical School, Germany) | Ponimaskin E et al, J Neurosci 2008 |
| Palmitoylation for SNAP-25 and CSP in exocytosis | Dr. Luke Chamberlain (University of Strathclyde, UK) |
Greaves J et al, J Biol Chem 2008
Greaves J et al, Mol Biol Cell 2009 |
| Palmitoylation for BACE1 in Aβ production | Dr. Gopal Thinakaran (The University of Chicago, USA) | Vetrivel KS et al, J Biol Chem 2009 |
| Genetical study of DHHC21 | Dr. Ian Jackson (MRC Human Genetics Unit, UK) | Mill P et al, PLoS Genet 2009 |
| Molecular mechanism for dynamic protein palmitoylation | Dr. Franck Perez (Curie Institute, France) |
Tsutsumi R et al, Mol Cell Biol 2009
Fukata Y et al, J Cell Biol 2013 Supported by Human Frontier Science Program, Young Investigators Grant |
| Palmitoylation of Ndel1 and Nde1 | Dr. Orly Reiner (Weismann Institure, Israel) | Shmueli A et al, EMBO J 2010 |
| Palmitoylation of Stathmin | Dr. André Sobel (INSERM, France) | Levy AD et al, Mol Biol Cell 2011 |
| Genetical study of LGI2 | Dr. Hannes Lohi (Folkhälsan Institute of Genetics, Finland) | Seppala EH et al, PLoS Genet 2011 |
| Palmitoylation of PI4 kinase | Dr. Helen L Yin (Univ Texas Southwestern, USA) | Lu D et al, J Biol Chem 2012 |
| Development of activity-based probes for DHHC proteins | Dr. Wu Xu (Harvard Med Sch, USA) | Zheng B et al, J Am Chem Soc 2013 |
| Palmitoylation of MAP6 | Dr. Annie Andrieux (INSERM, France) | Gory-Fauré S et al, PLoS One 2014 |
| Functional analysis of BAI1 | Dr. Erwin G Van Meir (Emory University, USA) | Zhu D et al, J Clin Invest 2015 |
| Patho-physiological analysis of ADAM22 knockout mouse | Dr. Dies Meijer (University of Edinburgh, UK) |
Kegel L et al, Development 2014
Yokoi N et al, Nat Med 2015 |
| Functional analysis of ADAM22 mutations in progressive encephalopathy | Dr. Anna-Elina Lehesjoki (University of Helsinki, Finland) | Muona M et al, Neurol Genet 2016 |
International collaboration (in progress)
| USA | France | Germany | UK | Switzerland |
|---|---|---|---|---|
| 4 | 2 | 1 | 1 | 1 |
Internal Collaboration
| Research Project | Collaborator | Publication |
|---|---|---|
| Production of antibodies by baculovirus display method | Dr.Takao Hamakubo (Tokyo University) | Noritake J et al, J Cell Biol, 2009 |
| Biochemical analysis using baculovirus expression system | Dr.Yoshiharu Matsuura (Osaka University Research Institute of Microbial Disease) | Noritake J et al, J Cell Biol, 2009 |
| Functional Proteomics | Dr.Jun Watanabe (National Center for Geriatrics and Gerontology) | Fukata Y et al, PNAS, 2010 |
| Electron Microscopy analysis | Dr.Ryuichi Shigemoto (Institute of Science and Technology (IST), Austria) | Fukata Y et al, PNAS, 2010 |
| Functional analysis of LGI1 | Dr. Kazunori Nakajima (Keio University) | Kusuzawa S et al, Eur J Neurosci 2012 |
| Functional analysis of MHC1 in the synapse | Dr. Isao Ito (Kyusyu University) | Kawahara A et al, J Physiol 2013 |
| Expression and functional analysis of LGI1/ADAM22 in the brain | Dr. Masahiko Watanabe (Hokkaido University) | Ohkawa et al, J Neurosci 2013 Yokoi N et al, Nat Med 2015 |
| Identification and functional analysis of autoantibodies in the limbic encephalitis | Dr. Osamu Watanabe (Kagoshima University) | Ohkawa et al, J Neurosci 2013 Ohkawa et al, J Neurosci 2014 |
| Mode of action of anti-GABAA receptor autoantibody | Dr. Shin'Ichiro Satake (NIPS), Dr. Gen Sobue (Nagoya University) | Ohkawa et al, J Neurosci 2014 |
| Palmitoylation of ELMOD2 | Dr. Toyoshi Fujimoto (Nagoya University) | Suzuki M et al, Mol Biol Cell 2015 |
| Analysis of LGI1 knockout mouse | Dr. Keiji Imoto (NIPS) | Yokoi N et al, Nat Med 2015 |
Domestic collaboration（in progress）
| 17 |
Impact of our identified DHHC-palmitoylating enzymes
Distribute the DHHC-library to more than 100 Labs (2005.2 - 2017.10)
| USA | Germany | France | UK | Canada | Japan | Korea | China | Ireland | Israel |
|---|---|---|---|---|---|---|---|---|---|
| 54 | 12 | 9 | 9 | 7 | 7 | 4 | 2 | 2 | 2 |
| Italy | Spain | Singapore | Switzerland | Sweden | Argentine | Taiwan | Poland | India | Australia |
| 2 | 3 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 |