National Institute for Physiological Sciences Takemura Lab Sensory & Cognitive Brain Mapping
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Seminars

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Takemura Lab Seminar: Aviv Mezer (Hebrew University of Jerusalem, Israel)

Date and Time

Februrary 19th (Wed), 2025, 10:30AM-11:30AM

Format

Onsite/Hybrid

Onsite Venue

Main Conference Room, 1st floor, National Institute for Physiological Sciences

Co-Host

Frontiers of Life Sciences [Spin-L]

Registration

Onsite participants do not need to register for this seminar. For online participants, please register using the URL (registration form) below. Zoom URL will be only announced for registered attendees.

Registration Form (Deadline: Feb 13th)

Language

English

Speaker

Aviv Mezer

Professor

The Edmond and Lily Safra Center for Brain Sciences (ELSC)

The Hebrew University of Jerusalem, Israel

Title and Abstract

Title: Spatial Changes in Basal Ganglia Microstructure in Parkinson's Disease


Abstract: Mapping structural changes in subcortical brain regions is crucial for understanding their functions in both health and disease. We developed a method to quantify microstructure profiles in vivo within a single human brain. Our findings show that spatial profiles in the putamen, caudate, and globus pallidus are consistently reproducible across individuals, clinical conditions, and datasets. Using multiparametric quantitative MRI, we identified distinct, spatially dependent, aging-related changes in water content and iron concentration. In Parkinson's disease (PD) patients, we observed abnormal profiles in the putamen, particularly in the posterior putamen, which correlate with patients' dopaminergic loss and motor dysfunction.