Takemura Lab Seminar: Aviv Mezer (Hebrew University of Jerusalem, Israel)
Date and Time
Februrary 19th (Wed), 2025, 10:30AM-11:30AM
Format
Onsite/Hybrid
Onsite Venue
Main Conference Room, 1st floor, National Institute for Physiological Sciences
Co-Host
Frontiers of Life Sciences [Spin-L]
Registration
Onsite participants do not need to register for this seminar. For online participants, please register using the URL (registration form) below. Zoom URL will be only announced for registered attendees.
Registration Form (Deadline: Feb 13th)
Language
English
Speaker
Aviv Mezer
Professor
The Edmond and Lily Safra Center for Brain Sciences (ELSC)
The Hebrew University of Jerusalem, Israel
Title and Abstract
Title: Spatial Changes in Basal Ganglia Microstructure in Parkinson's Disease
Abstract: Mapping structural changes in subcortical brain regions is crucial for understanding their functions in both health and disease. We developed a method to quantify microstructure profiles in vivo within a single human brain. Our findings show that spatial profiles in the putamen, caudate, and globus pallidus are consistently reproducible across individuals, clinical conditions, and datasets. Using multiparametric quantitative MRI, we identified distinct, spatially dependent, aging-related changes in water content and iron concentration. In Parkinson's disease (PD) patients, we observed abnormal profiles in the putamen, particularly in the posterior putamen, which correlate with patients' dopaminergic loss and motor dysfunction.