業績 

2005年以前

  • Tsuchiya, N., Yamanaka, R., Yajima, N., Homma, J., Sano, M., Komata, T., Ikeda, T., Fujimoto, I., Takahashi, H., Tanaka, R. and Ikenaka, K. (2005) Isolation and characterization of an N-linked oligosaccharide that is increased in glioblastoma tissue and cell lines. International Journal of Oncology, 27,1231-1239. PubMed
  • Ding, L., Takebayashi, H., Watanabe, K., Ohtsuki, T., Tanaka, K. F., Nabeshima, Y., Chisaka, O., Ikenaka, K. and Ono, K. (2005) Short-term Lineage analysis of dorsally derived Olig3 cells in the developing spinal cord. Developmental Dynamics, 234, 622-632. PubMed
  • Eiraku, M., Tohgo, A., Ono, K., Kaneko, M., Fujishima, K., Hirano, T. and Kengaku, M. (2005) DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Nature Neuroscience, 8, 873-880. PubMed
  • Ogawa, Y., Takebayashi, H., Takahashi, M., Osumi, N., Iwasaki, Y. and Ikenaka, K. (2005) Gliogenic radial glial cells show heterogeneity in the developing mouse spinal cord. Developmental Neuroscience, 27, 364-377. PubMed
  • Tao, H., Shimizu, M., Kusumoto, R., Ono, K., Noji, S. and Ohuchi, H. (2005) A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge during mouse eyelid development. Development, 132, 3217-3230. PubMed
  • Nakakita, S., Natsuka, S., Okamoto, J., Ikenaka, K. and Hase, S. (2005) Alteration of brain type N-glycans in neurological mutant mouse brain. Journal of Biochemistry, 138, 277-283. PubMed
  • Shimizu,T., Kagawa,T., Wada,T., Muroyama, Y., Takada, S., and Ikenaka,K. (2005) Wnt signaling controls the timing of oligodendrocyte development in the spinal cord. Developmental Biology, 282, 397-410. PubMed
  • Menon, K.N., Ikeda, T., Fujimoto, I., Narimatsu, H., Nakakita, S., Has, S. and Ikenaka, K. (2005) Changes in N-linked sugar chain patterns induced by moderate-to-high expression of the galactosyltransferase I gene in a brain-derived cell Line, CG4. Journal of Neuroscience Research, 80, 29-36. PubMed
  • Kato, T., Ohtani-Kaneko, R., Ono, K., Okado, N. and Shiga, T. (2005) Developmental regulation of activated ERK expression in the spinal cord and dorsal root ganglion of the chick embryo. Neuroscience Research, 52, 11-19. PubMed
  • Shoji, H., Ikenaka, K., Nakakita, S Hayama, K., Hirabayashi, J., Arata I., Kasai, K., Nishi, N. and Nakamura, T. (2005) Xenopus galectin-VIIa binds N-glycans of members of the cortical granule lectin family (xCGL and xCGL2). Glycobiology, 15, 709-720. PubMed
  • Ohuchi, H., Yasue, A., Ono, K., Sasaoka, S., Tomonari, S., Takagi, A., Itakura, M., Moriyama, K., Noji, S., Nohno, T. (2005) Identification of Cis-Element Regulating Expression of the Mouse Fgf10 Gene during Inner Ear Development. Developmental Dynamics, 233, 177-187. PubMed
  • Masahira, N., Ding, L., Takebayashi, H., Shimizu, K., Ikenaka, K. and Ono, K. (2005) Improved preservation of X-gal reaction product for electron microscopy using hydroxypropyl methacrylate. Neuroscience Letters, 374, 17-20. PubMed
  • Prestoz, L., Chatzopoulou, E., Lemkine, G., Spassky, N., Lebras, B., Kagawa, T., Ikenaka, K., Zalc, B., and Thomas, J.L. (2004) Control of axonophilic migration of oligodendrocyte precursor cells by Eph-ephrin interaction. Neuron Glia Biology, 1, 73-83. Link
  • Hitoshi, S., Seaberg, R.M., Koscik, C., Alexson, T., Kusunoki, S., Kanazawa, I., Tsuji, S. and van der Kooy, D. (2004) Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling. Genes and Development, 18, 1806-1811. PubMed
  • Ono, K., Yasui, Y. and Ikenaka, K. (2004) Lower rhombic lip-derived cells undergo transmedian tangential migration followed by radial migration in the chick embryo brainstem. European Journal of Neuroscience, 20, 914-922. PubMed
  • Kumada, T., Hasegawa, A., Iwasaki, Y., Baba, H. and Ikenaka, K. (2004) Isolation of cystatin C via functional cloning of astrocyte differentiation factors. Developmental Neuroscience, 26, 68-76. PubMed
  • Jung, C., Hida, H., Nakahira, K., Ikenaka, K., Kim, H. and Nishino, H. (2004) Pleiotrophin mRNA is highly expressed in neural stem (progenitor) cells of mouse ventral mesencephalon and the product promotes production of dopaminergic neurons from ES cell-derived nestin-positive cells. FASEB Journal, 18, 1237-1239. PubMed
  • Tanaka, H., Ono, K., Shibasaki, H., Isa, T. and Ikenaka, K. (2004) Conduction properties of identified neural pathways in the central nervous system of mice in vivo. Neuroscience Research, 49, 113-122. PubMed
  • Shibasaki, K., Nakahira, K., Trimmer, J., Shibata, R., Akita, M., Watanabe, S. and Ikenaka, K. (2004) Mossy fiber contact triggers the targeting of Kv4.2 potassium channels to dendrites and synapses in developing cerebellar granule neurons. Journal of Neurochemistry, 89, 897-907. PubMed
  • Katakura, H., Harada, A., Kataoka, K., Furusho, M., Tanaka, F., Wada, H. and Ikenaka, K. (2004) Improvement of retroviral vectors by coating with poly(ethylene glycol)-poly(L-lysine) block copolymer (PEG-PLL). Journal of Gene Medicine, 6, 471-477. PubMed
  • Fukuda, S., Kondo, T., Takebayashi, H. and Taga, T. (2004)Negative regulatory effect of an oligodendrocytic bHLH factor OLIG2 on the astrocytic differentiation pathway. Cell Death and Differentiation 2004, 11, 196-202. PubMed
  • Yokoo, H., Nobusawa, N., Takebayashi, H., Ikenaka, K., Isoda, K., Kamiya, M., Sasaki, A., Hirato, J. and Nakazato, Y. (2004) Anti-human Olig2 antibody as a useful immunohistochemical marker of normal oligodendrocytes and gliomas. American Journal of Pathology 164 (5), 1717-1725. PubMed
  • Agius, E., Soukkarich, C., Danesin, C., Kan, P., Takebayashi, H., Soula, C. and Cochard, P. (2004) Converse control of oligodendrocyte and astrocyte lineage development by Sonic hedgehog in the chick spinal cord. Developmental Biology, 270, 308-321. PubMed
  • Hirahara, Y., Bansal, R., Honke, K., Ikenaka, K. and Wada, Y. (2004) Sulfatide is a negative regulator of oligodendrocyte differentiation: development in sulfatide-null mice. Glia, 45, 269-277. PubMed
  • Okumura, S., Baba, H., Kumada, T., Nanmoku, K., Nakajima, H., Nakane, Y., Koshiro H. and Ikenaka, K. (2004) Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells. Cancer Science, 95, 131-135. PubMed
  • Ishibashi, T., Ding, L., Ikenaka, K., Inoue, Y., Miyado, K., Mekada, E. and Baba, H. (2004) Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation. Journal of Neuroscience, 24, 96-102. PubMed
  • Iwasaki, Y., Hosoya, T., Takebayashi, H., Ogawa, Y., Hotta, Y. and Ikenaka, K. (2003) The potential to induce glial differentiation is conserved between Drosophila and mammalian glial cells missing (gcm) genes. Development, 130, 6027-6035. PubMed
  • Suzuki, R., Arata, S., Nakajo, S., Ikenaka, K., Kikuyama, S. and Shioda, S. (2003) Expression of the receptor for pituitary adenylate cyclase-activating polypeptide (PAC1-R) in reactive astrocytes. Molecular Brain Research, 115, 10-20. PubMed
  • Matsukawa, N., Ikenaka, K., Nanmoku, K., Yuasa, H., Hattori, M., Kawano, M., Nakazawa, H., Fujimori, O., Ueda, R. and Ojika, K. (2003) Brain malformations caused by retroviral vector-mediated gene transfer of hippocampal cholinergic neurostimulating peptide precursor protein into the CNS via embryonic mice ventricles. Developmental Neuroscience, 25, 349-356. PubMed
  • Ding, H., Shannon, P., Lau, N., Wu, X., Roncari, L., Baldwin, R.L., Takebayashi, H., Nagy, A., Gutmann, D.H. and Guha, A. (2003) Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model. Cancer Research, 63, 1106-1113. PubMed
  • Ivanova, A., Nakahira, E., Kagawa, T., Oba, A., Wada, T., Takebayashi, H., Spassky, N., Levine, J., Zalc, B. and Ikenaka, K. (2003) Evidence for a second wave of oligodendrogenesis in the postnatal cerebral cortex of the mouse. Journal of Neuroscience Research, 73, 581-592. PubMed
  • Nanmoku, K., Kawano, M., Iwasaki, Y. and Ikenaka K. (2003) Highly efficient gene transduction into the brain using high-titer retroviral vectors. Developmental Neuroscience, 25,152-161. PubMed
  • Nomoto, H., Yonezawa, T., Itoh, K., Ono, K., Yamamoto, K., Oohashi, T., Shiraga, F., Ohtsuki, H., and Ninomiya, Y. (2003) Molecular Cloning of a Novel Transmembrane Protein MOLT Expressed by Mature Oligodendrocytes. Journal of Biochemistry (Tokyo), 134, 231-238. PubMed
  • Rasband, M., Kagawa, T., Park, E., Ikenaka, K. and Trimmer, J. (2003) Dysregulation of axonal sodium channel isoforms After adult-onset chronic demyelination. Journal of Neuroscience Research, 73, 465-470. PubMed
  • Ohuchi, H., Tao, H., Ohara, K., Itoh, N., Kato, S., Noji, S. and Ono, K. (2003)　Fibroblast growth factor 10 is required for proper development of the mouse whiskers. Biochemical and Biophysical Research Communications, 302, 562-567. PubMed
  • Ishibashi, T., Ikenaka, K., Shimizu, T., Kagawa, T. and Baba, H. (2003) Initiation of sodium channel clustering at the node of Ranvier in the mouse optic nerve. Neurochemical Research, 28, 117-125. PubMed
  • Yamada, H., Fukushima, M., Koizumi, K., Katakura, H., Nakanishi, H., Teshima, S., Kamiyama, Y. and Ikenaka, K. (2003) Regulation of dihydropyrimidine dehydrogenase gene expression in regenerating mouse liver. International Journal of Oncology, 22, 359-364. PubMed
  • Ishibashi, T., Dupree, J. L., Ikenaka, K., Hirahara, Y., Honke, K., Peles, E., Popko, B., Suzuki, K., Nishino, H. and Baba, H. (2002) A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation. Journal of Neuroscience, 22, 6507-6514. PubMed
  • Fu, H., Qi, Y., Tan, M., Cai, J., Takebayashi, H., Nakafuku, M., Richardson, W. and Qiu, M. (2002) Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation. Development, 129, 681-693. PubMed
  • Takebayashi, H., Nabeshima, Y., Yoshida, S., Chisaka, O., Ikenaka, K. and Nabeshima, Y. (2002) The basic helix-loop-helix factor Olig2 is essential for development of motoneuron and oligodendrocyte lineages. Current Biology, 12, 1157-1163. PubMed
  • Takebayashi, H., Ohtsuki, T., Uchida, T., Kawamoto, S., Okubo K., Ikenaka, K., Takeichi, M., Chisaka, O. and Nabeshima Y. (2002) Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube. Mechanisms of Development, 113, 169-174. PubMed
  • Akahane, M., Kuriyama, S., Ohgushi, H., Akahane, T., Kawamura, K., Watanabe, S., Funakoshi, F., Yoshiji, H., Ikenaka, K. and Takakura Y. (2002) Enhancing and suppressing effects of dexamethasone on transgene expression in vitro. International Journal of Molecular Medicine, 10, 107-112. PubMed
  • Kawano, Y., Sasaki, M., Nakahira, K., Yoshimine, T., Shimizu, K., Wada, H. and Ikenaka, K. (2001) Structural characterization and chromosomal localization of the MAGE-E1 gene. Gene, 277, 129-137. PubMed
  • Yamada, M., Jung, M., Kagawa, T., Ivanova, A., Nave, K.-A. and Ikenaka, K. (2001) Mutant PLP/DM20 cannot be processed to secrete PLP-related oligodendrocyte differentiation/survival factor. Neurochemical Research, 26, 639-645. PubMed
  • Sasaki, M., Nakahira, K., Kawano, Y., Katakura, H., Yoshimine, T., Shimizu, K., Kim, S.U. and Ikenaka, K. (2001) MAGE-E1, a new member of the Melanoma-associated antigen gene family and its expression in human glioma. Cancer Research, 61, 4809-4814. PubMed
  • Espinosa de los Monteros, A., Baba, H., Zhao, P.M., Pan, T., Chang, R., de Vellis, J. and Ikenaka, K. (2001) Remyelination of the adult demyelinated mouse brain by grafted oligodendrocyte progenitors and the effect of B-104 cografts. Neurochemical Research, 26, 673-682. PubMed
  • Otake, Y., Fujimoto, I., Tanaka, F., Nakagawa, T., Ikeda, T., Menon, K.K., Hase, S., Wada, H. and Ikenaka, K. (2001) Isolation and characterization of an N-linked oligosaccharide that is significantly increased in sera from patients with non-small cell lung cancer. Journal of Biochemistry, 129, 537-542. PubMed
  • Tamura, K., Tamura, M., Ikenaka, K., Yoshimatsu, T., Miyao, Y., Nanmoku, K. and Shimizu, K. (2001) Eradication of murine brain tumors by direct inoculation of concentrated high titer-recombinant retrovirus harboring the herpes simplex virus thymidine kinase gene. Gene Therapy, 8, 215-222. PubMed
  • Tanaka, F., Otake, Y., Nakagawa, T., Kawano, Y., Miyahara, R., Li, M., Yanagihara, K., Inui, K., Oyanagi, H., Yamada, T., Nakayama, J., Fujimoto, I., Ikenaka, K. and Wada, H. (2001) Prognostic significance of polysialic acid expression in resected non-small cell lung cancer. Cancer Research, 61, 1666-1670. PubMed
  • Tsujinoue, H., Kuriyama, S., Nakatani, T., Yoshiji, H., Akahane T., Toyokawa, Y., Fukui, H., Yoshimatsu, T. and Ikenaka, K. (2001) Amelioration of retrovirus-mediated gene transfer into hepatocellular carcinoma cells. International Journal of Oncology, 18, 801-807. PubMed
  • Yoshida, S., Miyazaki, M., Zhang, Q-Z., Sakai, K., Fujimoto, I., Ikenaka, K., Ikemoto, A., Watanabe, S. and Okuyama, H. (2001) Change of Oligosaccharides of rat brain microsomes depending on dietary fatty acids and learning task. Journal of Neuroscience Research, 63, 185-195. PubMed
  • Ono, K., Kagawa, T., Yokota, S., Tsumori, T., and Yasui,Y. (2001) Morphological changes and cellular dynamics of oligodendrocyte lineage cells in the developing vertebrate central nervous system. Developmental Neuroscience, 23, 346-355. PubMed
  • Ikenaka, K., Sasaki, M., Tamura, K., Tamura, M., Miyao, Y., Nanmoku, K., Kawano, Y., Nakahira, K., Yoshimine, T. and Shimizu, K. (2001) Treatment of glioblastoma by direct inoculation of concentrated high titer-recombinant retrovirus carrying the herpes simplex virus thymidine kinase gene. Human Cell, 14, 49-58. PubMed
  • Tanaka, F., Otake, Y., Nakagawa, T., Kawano, Y., Miyahara, R., Li, M., Yanagihara, K., Nakayama, J., Fujimoto, I., Ikenaka, K. and Wada, H. (2000) Expression of polysialic acid and STX, a human polysialyltransferase, is correlated with tumor progression in non-small cell lung cancer. Cancer Research, 60, 3072-3080. PubMed
  • Wada, T., Kagawa, T., Ivanova, A., Zalc, B., Shirasaki, R., Murakami, F., Iemura, S., Ueno, N. and Ikenaka, K. (2000) Dorsal spinal cord inhibits oligodendrocyte development. Developmental Biology, 227, 42-55. PubMed
  • Shibata, R., Nakahira, K., Shibasaki, K., Wakazono, Y., Imoto, K. and Ikenaka, K. (2000) A-type K+ current mediated by the Kv4 channel regulates the generation of action potential in Developmentaleloping cerebellar granule cells. Journal of Neuroscience, 20, 4145-4155. PubMed
  • Yanagisawa, M. , Nakashima, K., Arakawa, H., Ikenaka, K., Yoshida, K., Kishimoto, T., Hisatsune, T. and Taga, T. (2000) Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3. Journal of Neurochemistry, 74, 1498-1504. PubMed
  • Yamada M, Ivanova A, Yamaguchi Y, Lees MB, Ikenaka K. (1999) Proteolipid protein gene product can be secreted and exhibit biological activity during early development. Journal of Neuroscience, 19, 2143-51. PubMed
  • Fujimoto I, Menon KK, Otake Y, Tanaka F, Wada H, Takahashi H, Tsuji S, Natsuka S, Nakakita S, Hase S, Ikenaka K. (1999) Systematic analysis of N-linked sugar chains from whole tissue employing partial automation. Analytical biochemistry, 267, 336-43. PubMed
  • Kagawa T, Ikenaka K, Inoue Y, Kuriyama S, Tsujii T, Nakao J, Nakajima K, Aruga J, Okano H, Mikoshiba K. (1994) Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene. Neuron. 13, 427-42. PubMed

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