業績 

2006-2010年

  • Moritoh S, Tanaka KF, Jouhou H, Ikenaka K, Koizumi A.(2010) Organotypic tissue culture of adult rodent retina followed by particle-mediated acute gene transfer in vitro. PLoS One. 5(9):e12917.
  • Tanaka KF, Ahmari SE, Leonardo ED, Richardson-Jones JW, Budreck EC, Scheiffele P, Sugio S, Inamura N, Ikenaka K, Hen R., (2010) Flexible accelerated STOP tetracycline operator-knockin(FAST):A versatile and efficient new gene modulating system.Biol Psychiatry 67:770-773
  • Bao GM, Tanaka K, Ikenaka K, Fukase K.,(2010) Probe design and synthesis of Galbeta(1-->3)[NeuAcalpha(2-->6)]GlcNAcbeta(1-->2)Man motif of N-glycan.Bioorg Med Chem. Jun 1;18(11):3760-6.
  • Murakami S, Ohki-Hamazaki H, Watanabe K, Ikenaka K, Ono K.,(2010) Netrin 1 provides a chemoattractive cue for the ventral migration of GnRH neurons in the chick forebrain., J Comp Neurol. Jun 1;518(11):2019-34.
  • Espinosa-Jeffrey A, Hitoshi S, Zhao P, Awosika O, Agbo C, Olaniyan E, Garcia J, Valera R, Thomassian A, Chang-Wei R, Yamaguchi M, de Vellis J, Ikenaka K.,(2010) Functional central nervous system myelin repair in an adult mouse model of demyelination caused by proteolipid protein overexpression.,J Neurosci Res. Jun;88(8):1682-94.
  • Shimono C, Manabe R, Yamada T, Fukuda S, Kawai J, Furutani Y, Tsutsui K, Ikenaka K, Hayashizaki Y, Sekiguchi K.,(2010) Identification and characterization of nCLP2, a novel C1q family protein expressed in the central nervous system.,J Biochem. Apr;147(4):565-79
  • Piao H, Minohara M, Kawamura N, Li W, Mizunoe Y, Umehara F, Goto Y, Kusunoki S, Matsushita T, Ikenaka K, Maejima T, Nabekura J, Yamasaki R, Kira J.(2010) Probe design and synthesis of Galbeta(1-->3)[NeuAcalpha(2-->6)]GlcNAcbeta(1-->2)Man motif of N-glycan.Induction of paranodal myelin detachment and sodium channel loss in vivo by Campylobacter jejuni DNA-binding protein from starved cells (C-Dps) in myelinated nerve fibers. J Neurol Sci. Jan 15;288(1-2):54-62.
  • Toda T, Nakamura M, Yamada M, Nishine T, Torii T, Ikenaka K, Hashimoto R, Mori M., (2009) Glycoproteomic analysis of abnormal N-glycosylation on the kappa chain of cryocrystalglobulin in a patient of multiple myeloma.J Electrophoresis 53:1-6
  • Ono K, Takebayashi H, Ikenaka K, (2009) Olig2 transcription factor in the developing and injured forebrain; Cell lineage and glial development.Mol Cells 27:397-401
  • Tanaka H, Ma J, Tanaka KF, Takao K, Komada M, Tanda K, Suzuki A, Ishibashi T, Baba H, Isa T, Shigemoto R, Ono K, Miyakawa T, Ikenaka K., (2009) Mice with altered myelin proteolipid protein gene expression display cognitive deficits accompanied by abnormal neuron-glia interactions and decreased conduction velocities.J Neurosci. 29(26):8363-8371
  • Deltheil T, Tanaka K, Reperant C, Hen R, David DJ, Gardier AM., (2009) Synergistic neurochemical and behavioural effects of acute intrahippocampal injection of brain-derived neurotrophic factor and antidepressants in adult mice. Int J Neuropsychopharmacol.23:1-11
  • Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF, Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL, Karsenty G.(2009) A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure.Cell.138(5):976-989.
  • Yadav VK, Ryu JH, Suda N, Tanaka KF, Gingrich JA, Schütz G, Glorieux FH, Chiang CY, Zajac JD, Insogna KL, Mann JJ, Hen R, Ducy P, Karsenty G.(2008)Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum.Cell. 135(5):825-837.
  • Deltheil T, Guiard BP, Cerdan J, David DJ, Tanaka KF, Repérant C, Guilloux JP, Coudoré F, Hen R, Gardier AM. (2008)Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice.Neuropharmacology. 55(6):1006-1014.
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  • Masuda M, Tanaka KF, Kanzaki S, Wakabayashi K, Oishi N, Suzuki T, Ikenaka K, Ogawa K.(2008)GFAP aggregates in the cochlear nerve increase the noise vulnerability of sensory cells in the organ of Corti in the murine model of Alexander disease.Neurosci Res, 62:15-24.
  • Toda T, Hayakawa I, Matsubayashi Y, Tanaka K, Ikenaka K, Lu QR, Kawasaki H. (2008)Termination of lesion-induced plasticity in the mouse barrel cortex in the absence of oligodendrocytes.Mol Cell Neurosci. 39 :40-49
  • Tatsumi K, Takebayashi H, Manabe T, Tanaka KF, Makinodan M, Yamauchi T,Makinodan E, Matsuyoshi H, Okuda H, Ikenaka K, Wanaka A. (2008) Genetic fate mapping of Olig2 progenitors in the injured adult cerebral cortex revealed preferential differentiation into astrocytes. J Neurosci Res 86:3494-3502. PubMed
  • Takebayashi H, Usui N, Ono K, Ikenaka K. (2008) Tamoxifen modulates apoptosis in multiple modes of action in CreER mice. Genesis 46:775-781. PubMed
  • Masuda T, Watanabe K, Sakuma C, Ikenaka K, Ono K, Yaginuma H. (2008) Netrin-1 acts as a repulsive guidance cue for sensory axonal projections toward the spinal cord. J Neurosci 28:10380-10385. PubMed
  • Gotoh H, Okumura A, Nagai K, Okumura N. (2008) Localization of phospho-tyrosine489-beta-adducin -immunoreactivity in the hypothalamic tanycytes and its involvement in energy homeostasis. Brain Res 1228:97-106. PubMed
  • Ono K, Takebayashi H, Ikeda K, Furusho M, Nishizawa T, Watanabe K, Ikenaka K (2008) Regional- and Temporal-dependent changes in the differentiation of Olig2 progenitors in the forebrain, and the impact on astrocyte development in the dorsal pallium. Dev Biol 320:456-468. PubMed
  • Higashi M, Maruta N, Bernstein A, Ikenaka K & Hitoshi S (2008) Mood Stabilizing Drugs Expand the Neural Stem Cell Pool in the Adult Brain Through Activation of Notch Signaling. Stem Cells 26:1758-1767. PubMed
  • Matsushita Y, Nakajima K, Tohyama Y, Kurihara T, Kohsaka S (2008) Activation of microglia by endotoxin suppresses the secretion of glial cell line-derived neurotrophic factor (GDNF) through the action of protein kinase Calpha (PKCalpha) and mitogen-activated protein kinases (MAPKS). J Neurosci Res 86:1959-1971. PubMed
  • Sasaki N, Okishio K, Ui-Tei K, Saigo K, Kinoshita-Toyoda A, Toyoda H, Nishimura T, Suda Y, Hayasaka M, Hanaoka K, Hitoshi S, Ikenaka K & Nishihara S (2008) Heparan sulfate regulates self-renewal and pluripotency of embryonic stem cells. J Biol Chem 283:3594-3606. PubMed
  • Hitoshi S, Maruta N, Higashi M, Kumar A, Kato N & Ikenaka K (2007) Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress. J Neurosci Res 85:3574-3585. PubMed
  • Ishii A, Ikenaka K & Pfeiffer SE (2007) The N-glycan profile of mouse myelin, a specialized central nervous system membrane. J Neurochem 103:25-31. PubMed
  • Tanaka KF, Lee HU & Ikenaka K (2007) Generation of mice with glial cell dysfunction. Brain Nerve 59:747-753. PubMed
  • Karpowicz P, Inoue T, Runciman S, Deveale B, Seaberg R, Gertsenstein M, Byers L, Yamanaka Y, Tondat S, Slevin J, Hitoshi S, Rossant J & van der Kooy D (2007) Adhesion is prerequisite, but alone insufficient, to elicit stem cell pluripotency. J Neurosci 27:5437-5447. PubMed
  • Miyoshi G, Butt SJ, Takebayashi H & Fishell G (2007) Physiologically Distinct Temporal Cohorts of Cortical Interneurons Arise from Telencephalic Olig2-Expressing Precursors. J Neurosci 27:7786-7798. PubMed
  • Mo Z, Moore A, Filipovic R, Ogawa Y, Ikenaka K, Antic S & Zecevic N (2007) Human cortical neurons originate from radial glia and neuron-restricted progenitors. J Neurosci 27:4132-4145. PubMed
  • Tanaka KF, Takebayashi H, Yamazaki Y, Ono K, Naruse M, Iwasato T, Itohara S, Kato H & Ikenaka K (2007) Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance. Glia 55:617-631. PubMed
  • Dromard C, Bartolami S, Deleyrolle L, Takebayashi H, Ripoll C, Simonneau L, Prome S, Puech S, Tran VB, Duperray C, Valmier J, Privat A & Hugnot JP (2007) NG2 and Olig2 expression provides evidence for phenotypic deregulation of cultured central nervous system and peripheral nervous system neural precursor cells. Stem Cells 25:340-353. PubMed
  • Ishii A, Ikeda T, Hitoshi S, Fujimoto I, Torii T, Sakuma K, Nakakita SI, Hase S & Ikenaka K (2007) Developmental Changes in the Expression of Glycogenes and the Content of N-glycans in the Mouse Cerebral Cortex. Glycobiology 17:261-276. PubMed
  • Ma J, Tanaka KF, Yamada G & Ikenaka K (2007) Induced Expression of Cathepsins and Cystatin C in a Murine Model of Demyelination. Neurochem Res 32:311-320. PubMed
  • Hasegawa A, Naruse M, Hitoshi S, Iwasaki Y, Takebayashi H & Ikenaka K (2007) Regulation of glial development by cystatin C. J Neurochem 100:12-22. PubMed
  • Shibasaki K, Takebayashi H, Ikenaka K, Feng L & Gan L (2007) Expression of the basic helix-loop-factor Olig2 in the developing retina: Olig2 as a new marker for retinal progenitors and late-born cells. Gene Expr Patterns 7:57-65. PubMed
  • Tanaka, K.F., Ochi, N., Hayashi, T., Ikeda, E. and Ikenaka, K. (2006) Fluoro-Jade: New fluorescent marker of Rosenthal fibers. Neuroscience Letters, 407, 127-130. PubMed
  • Tanaka, H., Ikenaka, K. and Isa, T. (2006) Electrophysiological abnormalityprecedes apparent histological demyelination in the CNS of mice over-expressingproteolipid protein. Journal of Neuroscience Research, 84, 1206-1216. PubMed
  • Nagata, I., Ono, K., Kawana, A. and Kimura-Kuroda, J. (2006) Aligned neurite bundles of granule cells regulate orientation of Purukinje cell dendrites by perpendicular contact guidance in two-dimensional and three-dimensional mouse cerebellar cultures. Journal of Comparative Neurology, 499, 274-289. PubMed
  • Naruse, M., Nakahira, E., Miyata, T., Hitoshi, S., Ikenaka, K. and Bansal, R. (2006) Induction of oligodendrocyte progenitors in dorsal forebrain by intraventricular microinjection of FGF-2. Developmental Biology, 297, 262-273. PubMed
  • Masahira, N., Takebayashi, H., Ono, K., Watanabe, K., Ding, L., Furusho, M., Ogawa, Y., Nabeshima, Y., Alvarez-Buylla, A., Shimizu, K. and Ikenaka, K. (2006) Olig2 positive progenitors in the embryonic spinal cord give rise to not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells. Developmental Biology, 293, 358-369. PubMed
  • Furusho, M., Ono, K., Takebayashi, H., Masahira, N., Kagawa, T., Ikeda, K. and Ikenaka, K. (2006) Involvement of the Olig2 transcription factor in cholinergic neuron development of the basal forebrain. Developmental Biology, 293, 348-357. PubMed
  • Watanabe, K., Tamamaki, N., Furuta, T., Ackerman, S.L., Ikenaka, K. and Ono, K. (2006) Dorsally derived netrin-1 provides an Inhibitory cue and elaborates the “waiting period” for primary sensory axons in the developing spinal cord. Development, 133, 1379-1386. PubMed
  • Nakahira, E., Kagawa, T., Shimizu, T., Goulding, M.D. and Ikenaka, K. (2006) Direct evidence that ventral forebrain cells migrate to the cortex and contribute to the generation of cortical myelinating oligdendrocytes. Developmental Biology, 291,123-131. PubMed
  • Tao, H., Ono, K., Kurose, H., Noji, S. and Ohuchi, H. (2006) Exogenous FGF10 can rescue an eye-open at birth phenotype of FGF10-null mice by activating activin and TGFa-EGFR signaling. Development Growth & Differentiation, 48, 339-346. PubMed
  • Alexson, T.O., Hitoshi, S., Coles, B.L., Bernstein, A. and van der Kooy, D. (2006) Notch signaling is required to maintain all neural stem cell populations--irrespective of spatial or temporal niche. Developmental Neuroscience, 28, 34-48. PubMed
  • Abematsu M., Kagawa T., Fukuda S., Inoue T., Takebayashi H., Komiya S. and Taga T. (2006) bFGF endows dorsal telencephalic neural progenitors with ability to differentiate into oligodendrocytes but not GABAergic neurons. Journal of Neuroscience Research, 83, 731-743. PubMed
  • Ma, J., Matsumoto, M., Tanaka K.F., Takebayashi H. and Ikenaka K. (2006) An animal model for late onset chronic demyelination disease caused by failed terminal differentiation of oligodendrocytes. Neuron Glia Biology, 2, 81-91. Link
  • Sakuma, K., Fujimoto, I., Hitoshi, S., Tanaka, F., Ikeda, T., Tanabe, K., Toyokuni, S., Wada, H., Mio, T., Mishima, M. and Ikenaka, K., (2006) An N-glycan structure correlates with pulmonary metastatic ability of cancer cells. Biochemical and Biophysical Research Communications, 340, 829-835. PubMed
  • Tanabe, K. and Ikenaka, K. (2006) In-column removal of hydrazine and N-acetylation of oligosaccharides released by hydrazinolysis. Analytical Biochemistry, 348, 324-326. PubMed
  • Lim, D.A., Suarez-Farinas, M., Naef, F., Hacker, C., Menn, B., Takebayashi, H., Magnasco, M., Patil, N. and Alvarez-Buylla, A. (2006) In vivo transcriptional profile analysis reveals RNA processing and chromatin remodeling as prominent processes for adult neurogenesis. Molecular and Cellular Neuroscience, 31, 131-148. PubMed
  • Ito, S., Kawano, Y., Katakura, H., Takenaka, K., Adachi M., Sasaki, M., Shimizu, K., Ikenaka, K., Wada, H. and Tanaka, F. (2006) Expression of MAGE-D4, A novel MAGE family antigen, is correlated with tumor-cell proliferation of non-small cell lung cancer. Lung Cancer, 51, 79-88. PubMed

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