index
*基礎生物学研究所 論文2021年度発表 Papers 2021 from NIBB
*生理学研究所 論文2021年度発表 Papers 2021 from NIPS
*基礎生物学研究所 論文2020年度発表 Papers 2020 from NIBB
*生理学研究所 論文2020年度発表 Papers 2020 from NIPS
基礎生物学研究所 NIBB 2021
1. Yuji Nishiike, Daichi Miyazoe, Rie Togawa, Keiko Yokoyama, Kiyoshi Nakasone, Masayoshi Miyata,
Yukiko Kikuchi, Yasuhiro Kamei, Takeshi Todo, Tomoko Ishikawa-Fujiwara, Kaoru Ohno, Takeshi Usami,
Yoshitaka Nagahama, Kataaki Okubo (2021) Estrogen receptor 2b is the major determinant of sex-typical mating
behavior and sexual preference in medaka. Current biology CB 31(8):1699-1710. doi: 10.1016/j.cub.2021.01.089.
2. Di Feng, Jin Wang, Wei Yang, Jingyu Li, Xiaochen Lin, Fangzi Zha, Xiaolu Wang, Luyao Ma,
Nga Ting Choi, Yusuke Mii, Shinji Takada, Michael S. Y. Huen, Yusong Guo, Liang Zhang, Bo Gao (2021)
Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7–mediated Vangl ubiquitination and
endoplasmic reticulum–associated degradation. Science Advances 7(20): eabg2099. doi: 10.1126/sciadv.abg2099.
3. Okubo T, Hara K, Azuma S, Takada S (2021) Effect of retinoic acid signaling on Ripply3 expression
and pharyngeal arch morphogenesis in mouse embryos. Developmental Dynamics. doi: 10.1002/dvdy.301.
4. Noriyuki Kinoshita, Takamasa S. Yamamoto, Naoko Yasue, Chiyo Takagi, Toshihiko Fujimori, Naoto Ueno (2021)
Force-dependent remodeling of cytoplasmic ZO-1 condensates contributes to cell-cell adhesion
through enhancing tight junctions. iScience 25(2): 103846. doi:10.1016/j.isci.2022.103846.
5. Kei Yamamoto, Haruko Miura, Motohiko Ishida, Yusuke Mii, Noriyuki Kinoshita, Shinji Takada,
Naoto Ueno, Satoshi Sawai, Yohei Kondo, Kazuhiro Aoki (2021) Optogenetic relaxation of
actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis.
Nature Communications 12(1):7145. doi: 10.1038/s41467-021-27458-3.
6. Toshinori Nakagawa, David J Jörg, Hitomi Watanabe, Seiya Mizuno, Seungmin Han, Tatsuro Ikeda, Yoshiki Omatsu,
Keiko Nishimura, Miyako Fujita, Satoru Takahashi, Gen Kondoh, Benjamin D Simons, Shosei Yoshida,
Takashi Nagasawa (2021) A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis.
Cell reports 37(3):109875. doi: 10.1016/j.celrep.2021.109875.
7. Yuki Osawa, Kazuya Murata, Miho Usui, Yumeno Kuba, Hoai Thu Le, Natsuki Mikami, Toshinori Nakagawa,
Yoko Daitoku, Kanako Kato, Hossam Hassan Shawki, Yoshihisa Ikeda, Akihiro Kuno, Kento Morimoto, Yoko Tanimoto,
Tra Thi Huong Dinh, Ken-ichi Yagami, Masatsugu Ema, Shosei Yoshida, Satoru Takahashi, Seiya Mizuno,
Fumihiro Sugiyama (2021) EXOC1 plays an integral role in spermatogonia pseudopod elongation
and spermatocyte stable syncytium formation in mice. eLife 10. doi: 10.7554/elife.59759.
8. Yoshiaki Nakamura, David J. Jörg, Yayoi Kon, Benjamin D. Simons, Shosei Yoshida (2021)
Transient suppression of transplanted spermatogonial stem cell differentiation restores fertility in mice.
Cell Stem Cell. doi: 10.1016/j.stem.2021.03.016.
9. Takashi Takeuchi, Haruka Matsubara, Fumina Minamitani, Yukio Satoh, Sayo Tozawa, Tomoki Moriyama,
Kohei Maruyama, Ken-Ichi T Suzuki, Shuji Shigenobu, Takeshi Inoue, Koji Tamura, Kiyokazu Agata, Toshinori Hayashi
(2021) Newt Hoxa13 has an essential and predominant role in digit formation during development and regeneration.
Development (Cambridge, England) 149(5). doi: 10.1242/dev.200282.
10. Kanae Kishi, Hiroshi Koyama, Sanae Oka, Azusa Kato, Moritoshi Sato, Toshihiko Fujimori (2021)
Repetitive short‐pulsed illumination efficiently activates photoactivatable-Cre as continuous illumination
in embryonic stem cells and pre‐implantation embryos of transgenic mouse. genesis. doi: 10.1002/dvg.23457.
11. Toshihiko Fujimori (2021) Tracheal motile cilia in mice require CAMSAP3 for the formation of central microtubule
pair and coordinated beating. Molecular biology of the cell. doi: 10.1091/mbc.e21-06-0303,10.1091/mbc.E21-06-0303.
12. Tatsumi Hirata, Yukako Tohsato, Hiroya Itoga, Go Shioi, Hiroshi Kiyonari, Sanae Oka, Toshihiko Fujimori,
Shuichi Onami (2021) NeuroGT: A brain atlas of neurogenic tagging CreER drivers for birthdate-based classification
and manipulation of mouse neurons. Cell Reports Methods :100012. doi: 10.1016/j.crmeth.2021.100012 .
13. Kohei Kawano, Kagayaki Kato, Takumi Sugioka, Yukiko Kimura, Masashi Tanimoto, Shin-Ichi Higashijima (2021)
Long descending commissural V0v neurons ensure coordinated swimming movements along the body axis in larval zebrafish.
Scientific reports 12(1):4348. doi: 10.1038/s41598-022-08283-0.
14. Urs L Böhm, Yukiko Kimura, Takashi Kawashima, Misha B Ahrens, Shin-Ichi Higashijima, Florian Engert, Adam E Cohen
(2021) Voltage imaging identifies spinal circuits that modulate locomotor adaptation in zebrafish.
Neuron. doi: 10.1016/j.neuron.2022.01.001.
15. Toshinori Nakagawa, David J Jörg, Hitomi Watanabe, Seiya Mizuno, Seungmin Han, Tatsuro Ikeda,
Omatsu, Keiko Nishimura, Miyako Fujita, Satoru Takahashi, Gen Kondoh, Benjamin D Simons, Shosei Yoshida,
Takashi Nagasawa (2021) A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis.
Cell reports 37(3): 109875. doi: 10.1016/j.celrep.2021.109875.
16. Daichi G Suzuki, Hiroshi Wada, Osawa Y, Murata K, Usui M, Kuba Y, Le H, Mikami N, Nakagawa T, Daitoku Y,
Kato K, Shawki H, Ikeda Y, Kuno A, Morimoto K, Tanimoto Y, Dinh T, Yagami K, Ema M, Yoshida S, Takahashi S,
Mizuno S, Sugiyama F (2021) EXOC1 plays an integral role in spermatogonia pseudopod elongation and
spermatocyte stable syncytium formation in mice. eLife 10. doi: 10.7554/eLife.59759.
17. Shin-Ichi Higashijima (2021) Generation of knock-in lampreys by CRISPR-Cas9-mediated genome engineering.
Scientific reports 11(1): 19836. doi: 10.1038/s41598-021-99338-1.
18. Di Wu, Hiromu Arakawa, Akiko Fujita, Hisashi Hashimoto, Masahiko Hibi, Kiyoshi Naruse, Yasuhiro Kamei,
Chihiro Sato, Ken Kitajima (2021) A point-mutation in the C-domain of CMP-sialic acid synthetase leads
to lethality of medaka due to protein insolubility. Scientific Reports 11(1) doi: 10.1038/s41598-021-01715-3.
19. Megumi Matsuo, Yasuhiro Kamei, Shoji Fukamachi (2021) Behavioural red-light sensitivity in fish
according to the optomotor response. Royal Society Open Science 8(8):210415. doi: 10.1098/rsos.210415.
20. Yudai Hatakeyama, Nen Saito, Yusuke Mii, Takuma Shinozuka, Tatsuya Takemoto, Honda Naoki, Shinji Takada
(2021) Intercellular exchange of Wnt ligands reduces cell population heterogeneity in embryogenesis.
Research Square (preprint) doi: 10.21203/rs.3.rs-1271602/v1.
21. Kei Yamamoto, Haruko Miura, Motohiko Ishida, Yusuke Mii, Noriyuki Kinoshita, Shinji Takada, Naoto Ueno,
Satoshi Sawai, Yohei Kondo, Kazuhiro Aoki (2021) Optogenetic relaxation of actomyosin contractility uncovers
mechanistic roles of cortical tension during cytokinesis. Nature Communications 12(1) doi: 10.1038/s41467-021-27458-3.
22. Yusuke Mii, Kenichi Nakazato, Chan-Gi Pack, Takafumi Ikeda, Yasushi Sako, Atsushi Mochizuki, Masanori Taira,
Shinji Takada (2021) Quantitative analyses reveal extracellular dynamics of Wnt ligands in Xenopus embryos.
eLife (10) doi: 10.7554/elife.55108.
23. Tsubouchi T., Pereira C.-F. (2021) Reprogramming Stars #1: Genome Programming through the Cell Cycle
- An Interview with Dr. Tomomi Tsubouchi. Cellular Reprogramming 23(3) doi: 10.1089/cell.2021.29039.tt.
24. Yu Kitadate, Shosei Yoshida (2021) Regulation of spermatogenic stem cell homeostasis by mitogen competition
in an open niche microenvironment. Genes & Genetic Systems doi: 10.1266/ggs.21-00062.
25. Hiroshi Koyama, Makoto Suzuki, Naoko Yasue, Hiroshi Sasaki, Naoto Ueno, Toshihiko Fujimori (2021)
Differential Cellular Stiffness Contributes to Tissue Elongation on an Expanding Surface.
Frontiers in Cell and Developmental Biology (10) doi: 10.3389/fcell.2022.864135.
26. Shinnosuke Suzuki, John R. McCarrey, Brian P Hermann (2021) Differential RA responsiveness
among subsets of mouse late progenitor spermatogonia. Reproduction. doi: 10.1530/rep-21-0031.
27. Yuta Tanizaki, Hongen Zhang, Yuki Shibata, Yun-Bo Shi (2021) Thyroid hormone receptor α controls
larval intestinal epithelial cell death by regulating the CDK1 pathway.
Communications Biology 5(1) doi: 10.1038/s42003-022-03061-0.
28. Yuta Tanizaki, Yuki Shibata, Hongen Zhang, Yun-Bo Shi (2021) Thyroid Hormone Receptor α Controls
the Hind Limb Metamorphosis by Regulating Cell Proliferation and Wnt Signaling Pathways in Xenopus tropicalis.
International Journal of Molecular Sciences 23(3):1223. doi: 10.3390/ijms23031223.
29. Anna Trofka, Bau-Lin Huang, Jianjian Zhu, William F. Heinz, Valentin Magidson, Yuki Shibata,
Yun-Bo Shi, Basile Tarchini, H. Scott Stadler, Mirindi Kabangu, Nour W. Al Haj Baddar, S. Randal Voss,
Susan Mackem (2021) Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity
in non-urodele vertebrates. Current Biology doi: 10.1016/j.cub.2021.09.010.
30. Yun-Bo Shi, Yuki Shibata, Yuta Tanizaki, Liezhen Fu (2021) The development of adult intestinal stem cells:
Insights from studies on thyroid hormone-dependent anuran metamorphosis.
Vitamins and hormones 116:269-293 doi: 10.1016/bs.vh.2021.02.010.
生理学研究所 NIPS 2021
1. Chen IS, Eldstrom J, Fedida D, Kubo Y (2021) A novel ion conducting route besides the central pore
in an inherited mutant of G-protein-gated inwardly rectifying K
+ channel. J Physiol (epub Dec 8). doi: 10.1113/JP282430.
2. Hirazawa K, Tateyama M, Kubo Y, Shimomura T (2021) Phosphoinositide regulates dynamic movement
of the S4 voltage sensor in the second repeat in two-pore channel 3.
J Biol Chem 297(6):101425. doi: 10.1016/j.jbc.2021.101425.
3. Andriani RT, Kubo Y (2021) Voltage-clamp fluorometry analysis of structural rearrangements of ATP-gated
channel P2X2 upon hyperpolarization. Elife 10:e65822. doi: 10.7554/eLife.65822.
4. Matsumura K, Shimomura T, Kubo Y, Oka T, Kobayashi N, Imai S, Yanase N, Akimoto M, Fukuda M, Yokogawa M,
Ikeda K, Kurita J, Nishimura Y, Shimada I, Osawa M (2021) Mechanism of hERG inhibition by gating-modifier toxin,
APETx1, deduced by functional characterization. BMC Mol Cell Biol 22(1):3. doi: 10.1186/s12860-020-00337-3.
5. Fukata Y, Chen X, Chiken S, Hirano Y, Yamagata A, Inahashi H, Sanbo M, Sano H, Goto T, Hirabayashi M,
Kornau HC, Prüss H, Nambu A, Fukai S, Nicoll RA, Fukata M (2021) LGI1-ADAM22-MAGUK configures trans-synaptic
nanoalignment for synaptic transmission and epilepsy prevention.
Proc Natl Acad Sci USA 118:e2022580118. doi: 10.1073/pnas.2022580118.
6. Nakamoto C, Goto Y, Tomizawa Y, Fukata Y, Fukata M, Harpsøe K, Gloriam DE, Aoki K, Takeuchi T (2021)
A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro.
Mol Brain 14:173. doi.org/10.1186/s13041-021-00882-8.
7. Yokoi N, Fukata Y, Okatsu K, Yamagata A, Liu Y, Sanbo M, Miyazaki Y, Goto T, Abe M, Kassai H, Sakimura K,
Meijer D, Hirabayashi M, Fukai S, Fukata M (2021) 14-3-3 proteins stabilize LGI1-ADAM22 levels to
regulate seizure thresholds in mice. Cell Rep 37:110107. doi.org/10.1016/j.celrep.2021.110107.
8. Haga K, Takai-Todaka R, Matsumura Y, Song C, Takano T, Tojo T, Nagami A, Ishida Y, Masaki H, Tsuchiya M,
Ebisudani T, Sugimoto S, Sato T, Yasuda H, Fukunaga K, Sawada A, Nemoto N, Murata K, Morimoto T, Katayama K.(2021)
Nasal delivery of single-domain antibody improves symptoms of SARS-CoV-2 infection in an animal model.
PLoS Pathog 17(10): e1009542. doi: 10.1371/journal.ppat.1009542.
9. Koyanagi I, Sonomura K, Naoi T, Ohnishi T, Kaneko N, Sawamoto K, Sato T, Sakaguchi M (2021)
Metabolic fingerprints of fear memory consolidation during sleep. Mol Brain 14(1): 30. doi: 10.1186/s13041-021-00733-6.
10. Ito N, Riyadh MA, Ahmad SAI, Hattori S, Kanemura Y, Kiyonari H, Abe T, Furuta Y, Shinmyo Y, Kaneko N,
Hirota Y, Lupo G, Hatakeyama J, Abdulhaleem MFA, Anam MB, Yamaguchi M, Takeo T, Takebayashi H, Takebayashi M,
Oike Y, Nakagata N, Shimamura K, Holtzman MJ, Takahashi Y, Guillemot F, Miyakawa T, Sawamoto K, Ohta K (2021)
Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis
in the subventricular zone in mice. Sci Transl Med 13: 587. doi: 10.1126/scitranslmed.aay7896.
11. Okada M, Kawagoe Y, Sato Y, Nozumi M, Ishikawa Y, Tamada A, Yamazaki H, Sekino Y, Kanemura Y, Shinmyo Y,
Kawasaki H, Kaneko N, Sawamoto K, Fujii Y, Igarashi M (2021)
Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates.
Mol Brain 14 (1): 66. doi: 10.1186/s13041- 021-00755-0.
12. Yaguchi A, Oshikawa M, Watanabe G, Hiramatsu H, Uchida N, Hara C, Kaneko N, Sawamoto K, Muraoka T, Ajioka I (2021)
Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel
for injured brain regeneration. Nat Commun 12: 6623. doi: 10.1038/s41467-021-26896-3.
13. Ota Y, Kubota Y, Hotta Y, Matsumoto M, Matsuyama N, Kato T, Hamakawa T, Kataoka T, Kimura K, Sawamoto K,
Yasui T (2021) Change in the central control of the bladder function of rats with focal cerebral infarction
induced by photochemically-induced thrombosis. PLoS ONE 16(11): e0255200. doi: 10.1371/journal.pone.0255200.
14. Kurematsu C, Sawada M, Ohmuraya M, Tanaka M, Kuboyama K, Ogino T, Matsumoto M, Oishi H, Inada H, Ishido Y,
Sakakibara Y, Nguyen HB, Thai TQ, Kohsaka Sh, Ohno N, Yamada MK, Asai M, Sokabe M, Nabekura J, Asano K, Tanaka M,
Sawamoto K (2021) Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine.
J Exp Med (in press).doi: 10.1084/jem.20202304.
15. 宮本拓哉, 金子奈穂子，澤本和延 (2021) 成体脳における新生ニューロンの移動メカニズムと治療応用. BIO Clinica 36(4月号):192-196.
16. 中嶋智佳子，澤本和延 (2021) シングルセル解析技術を用いたニューロン移動・再生機構の解明. Precision Medicine (7 月臨時増刊号):60-63.
17. Sugawara T, Furuse K, Otani T, Wakayama T, Furuse M (2021) Angulin-1 seals tricellular contacts
independently of tricellulin and claudins. J Cell Biol 220(9): e202005062. doi: 10.1083/jcb.202005062.
18. Baier FA, Sanchez-Taltavull D, Yarahmadov T, Castella CG, Jebbawi F, Keogh A, Tombolini R, Odriozola A, Dias MC,
Deutsch U, Furuse M, Engelhardt B, Zuber B, Odermatt A, Candinas D, Stroka D (2021)
Loss of Claudin- 3 Impairs Hepatic Metabolism, Biliary Barrier Function, and Cell Proliferation in the Murine Liver.
Cell Mol Gastroenterol Hepatol 12(2): 745-767. doi: 10.1016/j.jcmgh.2021.04.003.
19. Nishimoto R, Derouiche S, Eto K, Deveci A, Kashio M, Kimori Y, Matsuoka Y, Morimatsu H, Nabekura J, Tominaga
M. Thermosensitive TRPV4 channels mediate temperature-dependent microglia movement.
Proc. Natl. Acad. Sci. USA 118 (17): e2012894118, 2021. doi: 10.1073/pnas.2012894118.
20. Matsui T, Kadono-Maekubo N, Suzuki Y, Furuichi Y1, Shiraga K, Sasaki H, Ishida A, Takahashi S, Okada T,
Toyooka K, Sharif J, Furuya Y, Abe T, Tominaga M, Miyawaki A, Amagai M. Unique cell death of keratinocytes,
corneoptosis, requires Ca2+ elevation and acidification.
Proc. Natl. Acad. Sci. USA 118 (17): e2020722118, 2021. doi: 10.1073/pnas.2020722118.
21. Derouiche S, Li T, Sakai Y, Uta D, Aoyagi S, Tominaga M. Inhibition of TRPV1 and TRPA1 by mosquito
and mouse saliva. Pain (in press; epub May 10).doi: 10.1097/j.pain.0000000000002337.
22. Izawa S, Yoneshiro T, Kondoh K, Nakagiri S, Okamatsu-Ogura Y, Terao A, Minokoshi Y, Yamanaka A, Kimura K (2021)
Melanin-concentrating hormone-producing neurons in the hypothalamus regulate brown adipose tissue and
thus contribute to energy expenditure. J Physiol (epub Apr 26). doi: 10.1113/JP281241.
23. Ryuge A, Kosugi T, Maeda K, Banno R, Gou Y, Zaitsu K, Ito T, Sato Y, Hirayama A, Tsubota S, Honda T,
Nakajima K, Ozaki T, Kondoh K, Takahashi K, Kato N, Ishimoto T, Soga T, Nakagawa T, Koike T, Arima H, Yuzawa Y,
Minokoshi Y, Maruyama S, Kadomatsu K (2021) Basigin deficiency prevents anaplerosis and ameliorates
insulin resistance and hepatosteatosis. JCI Insight 6(20):e142464. doi: 10.1172/jci.insight.142464.
24. Fu O, Minokoshi Y, Nakajima KI (2021) Recent advances in neural circuits for taste perception in hunger.
Front Neural Circuits 15:609824. doi: 10.3389/fncir.2021.609824.
25. 箕越靖彦 (2021) 摂食と食物嗜好性の調節 -恒常性と快楽的調節. 実験医学 39(5):676-687.
26. 岡本士毅, 箕越靖彦, 益崎裕章 (2021) ストレスによる食行動の変容メカニズム. “食と栄養のサイエンス 食行動を司る生体恒常性維持システム”,
実験医学別冊 (佐々木努 編), 羊土社, pp. 187-198.
27. 箕越靖彦 (2021) 糖尿病における脳の代謝変化. “糖尿病と食 (シリーズ <栄養と疾病の化学> 3), 第12 章” (植木浩⼆郎 編),朝倉書店, pp. 213-237.
28. Shiizaki K, Tsubouchi A, Miura Y, Seo K, Kuchimaru T, Hayashi H, Iwazu Y, Miura M, Battulga B, Ohno N, Hara T,
Kunishige R, Masutani M, Negishi K, Kario K, Kotani K, Yamada T, Nagata D, Komuro I, Itoh H, Kurosu H, Murata M,
Kuro-O M (2021) Calcium phosphate microcrystals in the renal tubular fluid accelerate chronic kidney disease progression.
J Clin Invest 131:e145693. doi: 10.1172/JCI145693.
29. Simankova A, Bizen N, Saitoh S, Shibata S, Ohno N, Abe M, Sakimura K, Takebayashi H (2021) Ddx20,
DEAD box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression.
Glia 69:2559-2574. doi: 10.1002/glia.24058.
30. Hamada K, Shinozaki Y, Namekata K, Matsumoto M, Ohno N, Segawa T, Kashiwagi K, Harada T, Koizumi S (2021)
Loss of P2Y1 receptors triggers glaucoma-like pathology in mice. Br J Pharmacol 178:4552-4571. doi: 10.1111/bph.15637.
31. Kuroda R, Tominaga K, Kasashima K, Kuroiwa K, Sakashita E, Hayakawa H, Kouki T, Ohno N, Kawai K, Endo H (2021)
Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers
the activation of the integral stress response in vivo. PLoS One 16:e0255355. doi: 10.1371/journal.pone.0255355.
32. Yamazaki R, Osanai Y, Kouki T, Shinohara Y, Huang JK, Ohno N (2021) Macroscopic detection of demyelinated lesions
in mouse PNS with neutral red dye. Sci Rep 11:16906. doi: 10.1038/s41598-021-96395-4.
33. Komuro Y, Galas L, Morozov YM, Fahrion JK, Raoult E, Lebon A, Tilot AK, Kikuchi S, Ohno N, Vaudry D,
Rakic P, Komuro H (2021) The Role of Galanin in Cerebellar Granule Cell Migration in the Early Postnatal Mouse
during Normal Development and after Injury. J Neurosci 41:8725-8741. doi: 10.1523/JNEUROSCI.0900-15.2021.
34. Hosotani M, Kametani K, Ohno N, Hiramatsu K, Kawasaki T, Hasegawa Y, Iwasaki T, Watanabe T (2021)
The unique physiological features of the broiler pectoralis major muscle as suggested by the three-dimensional
ultrastruc- tural study of mitochondria in type IIb muscle fibers. J Vet Med Sci 83:1764-1771. doi: 10.1292/jvms.21-0408.
35. Horiuchi H, Parajuli B, Komiya H, Ogawa Y, Jin S, Takahashi K, Azuma YT, Tanaka F, Suzumura A, Takeuchi H (2021)
Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation.
Front Immunol 12:615898. doi: 10.3389/fimmu.2021.615898.
36. Sano F, Shigetomi E, Shinozaki Y, Tsuzukiyama H, Saito K, Mikoshiba K, Horiuchi H, Cheung DL, Nabekura J,
Sugita K, Aihara M, Koizumi S (2021) Reactive astrocyte-driven epileptogenesis is induced by microglia
initially activated following status epilepticus. JCI Insight 6(9):e135391. doi: 10.1172/jci.insight.135391.
37. Cheung DL, Cooke MJ, Goulton CS, Chaichim C, Cheung LF, Khoshaba A, Nabekura J, Moorhouse AJ (2021)
Global transgenic upregulation of KCC2 confers enhanced diazepam efficacy in treating sustained seizures.
Epilepsia(in press, epub Nov 17). doi: 10.1111/epi.17097.
38. Tanaka M, Shigetomi E, Parajuli B, Nagatomo H, Shinozaki Y, Hirayama Y, Saito K, Kubota Y, Danjo Y, Lee JH,
Kim SK, Nabekura J, Koizumi S (2021) Adenosine A2B receptor down-regulates metabotropic glutamate receptor 5
in astrocytes during postnatal development. Glia 69(11): 2546-2558. doi: 10.1002/glia.24006.
39. Koizumi S, Shigetomi E, Sano F, Saito K, Kim SK, Nabekura J (2022) Abnormal Ca
2+ Signals in Reactive Astrocytes
as a Common Cause of Brain Diseases. Int J Mol Sci 23(1):149 (epub Dec 23, 2021). doi: 10.3390/ijms23010149.
40. Nishio N, Hayashi K, Ishikawa AW, Yoshimura Y (2021) The role of early visual experience in the development of
spatial-frequency preference in the primary visual cortex. J Physiol 599(17):4131-4152. doi: 10.1113/JP281463.
41.Kimura R, Yoshimura Y (2021) The contribution of low contrast – preferring neurons to information representation
in the primary visual cortex after learning. Sci Adv 7(48):eabj9976. doi: 10.1126/sciadv.abj9976.
42. Yamaguchi K, Otomo K, Kozawa Y, Tsutsumi M, Inose T, Hirai K, Sato S, Nemoto T, Uji-i T (2021)
Adaptive Optical Two-photon Microscopy for Surface profiled Living Biological Specimens.
ACS Omega 6:438-447. doi: 10.1021/acsomega.0c04888
43. Kitrungrotsakul T, Iwamoto Y, Takemoto S, Yokota H, Ipponjima S, Nemoto T, Lin L, Tong R, Li J, Chen Y-W (2021)
Accurate and fast mitotic detection using an anchor-free method based on full-scale connection with
recurrent deep layer aggregation in 4D microscopy images. BMC Bioinformatics 22: 91, doi:10.1186/s12859-021-04014-w.
44. Kitrungrotsakul T, Han X-H, Iwamoto Y, Takemoto S, Yokota H, Ipponjima S, Nemoto T, Xiong W, Chen Y-W (2021).
A Cascade of 2.5D CNN and Bidirectional CLSTM Network for Mitotic Cell Detection in 4D Microscopy Image.
IEEE/ACM Trans Comput Biol Bioinform 18(2): 396-404. doi: 10.1109/TCBB.2019.2919015.
45. Takahashi T, Zhang H, Otomo K, Okamura Y, Nemoto T (2021) Protocol for constructing
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65. Zubair M, Murris SR, Isa K, Onoe H, Koshimizu Y, Kobayashi K, Vanduffel W, Isa T (2021)
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66. Koshimizu Y, Isa K, Kobayashi K, Isa T (2021) Double viral vector technology for selective manipulation of
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67. Ota K, Oisi Y, Suzuki T, Ikeda M, Ito Y, Ito T, Uwamori H, Kobayashi K, Kobayashi M, Odagawa M, Matsubara C,
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68. Miya K, Keino-Masu K, Okada T, Kobayashi K, Masu M (2021) Expression of heparan sulfate endosulfatases in
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70. Matsumura T, Sato T, Abe T, Sanjo H, Katagiri K, Kimura H, Fujii T, Tanaka H, Hirabayashi M, Ogawa T (2021)
Rat in vitro spermatogenesis promoted by chemical supplementations and oxygen-tension control.
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基礎生物学研究所 NIBB 2020
1. Kaori Nakazawa, Yuichi Shichino, Shintaro Iwasaki,
Nobuyuki Shiina (2020) Implications of RNG140 (caprin2)-mediated
translational regulation in eye lens differentiation. The Journal of Biological Chemistry 295(44):15029-15044.
doi: 10.1074/jbc.RA120.012715.
2. Takamasa Mizoguchi, Michi Fukada, Miku Iihama, Xuehui Song, Shun Fukagawa, Shuhei Kuwabara, Shuhei Omaru,
Shin-ichi Higashijima, Motoyuki Itoh (2020) Transient activation of the Notch-her15.1 axis plays an important role
in the maturation of V2b interneurons. Dvelopment 147(16) doi: 10.1242/dev.191312.
3. Yuto Uemura, Kagayaki Kato, Koichi Kawakami, Yukiko Kimura, Yoichi Oda and Shin-ichi Higashijima (2020)
Neuronal Circuits That Control Rhythmic Pectoral Fin Movements in Zebrafish. Journal of Neuroscience 40(35):6678-6690.
doi: 10.1523/JNEUROSCI.1484-20.2020.
4. Chie Satou, Rachael L. Neve, Hassana K. Oyibo, Estelle Arn Bouldoires, Takuma Mori, Shinichi Higashijima,
Georg B. Keller, Rainer W. Friedrich (2021) A viral toolbox for conditional and transneuronal gene expression
in zebrafish. bioRxiv. doi: 10.1101/2021.03.25.436574.
5. Nodoka Kanazawa, Mayuko Goto, Yumi Harada, Chiaki Takimoto, Yuuka Sasaki, Tamaki Uchikawa, Yasuhiro Kamei,
Megumi Matsuo, Shoji Fukamachi (2020) Changes in a Cone Opsin Repertoire Affect Color-Dependent Social Behavior
in Medaka but Not Behavioral Photosensitivity. Frontiers in Genetics 11. doi: 10.3389/fgene.2020.00801.
6. Akiko Kondow, Kiyoshi Ohnuma, Yasuhiro Kamei, Atsushi Taniguchi, Ryoma Bise, Yoichi Sato, Hisateru Yamaguchi,
Shigenori Nonaka, Keiichiro Hashimoto (2020) Light‐sheet microscopy‐based 3D single‐cell tracking reveals a correlation
between cell cycle and the start of endoderm cell internalization in early zebrafish development. Development,
Growth & Differentiation 62(July 8):495-502. doi: 10.1111/dgd.12695.
7. Chih-Wei Zeng, Yasuhiro Kamei, Shuji Shigenobu, Jin-Chuan Sheu, Huai-Jen Tsai (2021) Injury-induced
Cavl-expressing cells at lesion rostral side play major roles in spinal cord regeneration.
Open Biology 11(2):200304-200304. doi: 10.1098/rsob.200304.
8. Yuko Watanabe, Kazuho Okuya, Yuki Takada, Masato Kinoshita, Saori Yokoi, Shinichi Chisada, Yasuhiro Kamei,
Hideki Tatsukawa, Naoyuki Yamamoto, Hideki Abe, Hisashi Hashimoto, Kiyotaka Hitomi (2020) Gene disruption of medaka
(Oryzias latipes) orthologue for mammalian tissue-type transglutaminase (TG2) causes movement retardation.
The Journal of Biochemistry 168(3):213-222. doi: 10.1093/jb/mvaa038.
9. Gembu Abe, Toshinori Hayashi, Keigo Yoshida, Takafumi Yoshida, Hidehiro Kudoh, Joe Sakamoto, Ayumi Konishi,
Yasuhiro Kamei, Takashi Takeuchi, Koji Tamura, Hitoshi Yokoyama (2020) Insights regarding skin regeneration in
non-amniote vertebrates: Skin regeneration without scar formation and potential step-up to a higher level of regeneration.
Seminars in cell & developmental biology 100:109-121. doi: 10.1016/j.semcdb.2019.11.014.
10. Magdalena K. Sznurkowska, Edouard Hannezo, Roberta Azzarelli, Lemonia Chatzeli, Tatsuro Ikeda, Shosei Yoshida,
Anna Philpott, Benjamin D. Simons (2020) Tracing the cellular basis of islet specification in mouse pancreas.
Nature Communications. doi: 10.1038/s41467-020-18837-3
11. David J. Jörg, Yu Kitadate, Shosei Yoshida, Benjamin D. Simons (2021) Stem Cell Populations as Self-Renewing
Many-Particle Systems. Annual Review of Condensed Matter Physics 12(1). doi: 10.1146/annurev-conmatphys-041720-125707.
12.C A Rezende-Melo, A L Caldeira-Brant, A L Drumond-Bock, G M Buchold, G Shetty, F R C L Almeida, M M Matzuk, K Hara,
S Yoshida, M L Meistrich, H Chiarini-Garcia (2020) Spermatogonial asynchrony in Tex14 mutant mice lacking intercellular
bridges. Reproduction 160(2):205-215. doi: 10.1530/rep-20-0118.
13. Shosei Yoshida (2020) Mouse Spermatogenesis Reflects the Unity and Diversity of Tissue Stem Cell Niche Systems.
Cold Spring Harbor Perspectives in Biology 12(12). doi: 10.1101/cshperspect.a036186.
14. Okada K, Takada S (2020) The second pharyngeal pouch is generated by dynamic remodeling of endodermal epithelium
in zebrafish. Development 147(24):dev194738. doi: 10.1242/dev.194738
15. Hiraki Sakuta, Chia-Hao Lin, Takeshi Y Hiyama, Takashi Matsuda, Katsushi Yamaguchi, Shuji Shigenobu, Kenta Kobayashi,
Masaharu Noda (2020) SLC9A4 in the organum vasculosum of the lamina terminalis is a [Na+] sensor for the control of water
intake. Pflugers Archiv : European journal of physiology. doi: 10.1007/s00424-020-02389-y.
16. Hiraki Sakuta (2020) Nax-positive glial cells in the organum vasculosum laminae terminalis produce epoxyeicosatrienoic
acids to induce water intake in response to increases in [Na+] in body fluids. Neuroscience Research 154:45-51. doi: 10.1016/j.neures.2019.05.006.
17. Sakai Y, Hatta M, Furukawa S, Kawata M, Ueno N, Maruyama S (2020) Environmental factors explain spawning day
deviation from full moon in the scleractinian coral Acropora. Biology Letters 16(1). doi: 10.1098/rsbl.2019.0760.
18. Takehana Yusuke, Zahm Margot, Cabau Cedric, Klopp Christophe, Roques Celine, Bouchez Olivier, Donnadieu Cecile,
Barrachina Celia, Journot Laurent, Kawaguchi Mari, others (2020) Genome sequence of the euryhaline Javafish medaka,
Oryzias javanicus: a small aquarium fish model for studies on adaptation to salinity. G3: Genes, Genomes,
Genetics 10(3):907-915 doi: 10.1534/g3.119.400725.
19. Yingshu Li, Yongjie Liu, Hang Yang, Ting Zhang, Kiyoshi Naruse, Qiang Tu (2020) Dynamic transcriptional and
chromatin accessibility landscape of medaka embryogenesis. Genome Research. doi: 10.1101/gr.258871.119
20. Usami M. F., Arata M., Shi D., Oka S., Higuchi Y., Tissir F., Takeichi M., Fujimori T. (2021)
Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multi-ciliated cells.
J Cell Sci. 134(4) doi: 10.1242/jcs.257006.
21. Noriyuki Kinoshita, Yutaka Hashimoto, Naoko Yasue, Makoto Suzuki, Ileana M. Cristea, Naoto Ueno (2020)
Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway
during Embryogenesis. CELL REPORTS 30(11):3875+ doi:10.1016/j.celrep.2020.02.074.
22. Noriyuki Kinoshita, Takamasa S Yamamoto, Naoko Yasue, Toshihiko Fujimori, Naoto Ueno (2020) Force-dependent remodeling
of a tight junction protein ZO-1 is regulated by phase separation. bioRxiv doi: 10.1101/2020.10.04.323436.
生理学研究所 NIPS 2020
1. Kaneko N, Nakamura S, Sawamoto K (2020) Effects of interferon-alpha on hippocampal neurogenesis and
behavior in common marmosets. Mol Brain 13:98. doi: 10.1186/s13041-020-00639-9.
2. Akter M, Kaneko N, Herranz-Perez V, Nakamura S, Oishi H, Garcia-Verdugo JM, Sawamoto K (2020) Dynamic
Changes in the Neurogenic Potential in the Ventricular- Subventricular Zone of Common Marmoset during
Postnatal Brain Development. Cerebral Cortex 30:4092-4109. doi: 10.1093/cercor/bhaa031
3. Kumar D, Koyanagi I, Carrier-Ruiz A, Vergara P, Srinivasan S, Sugaya Y, Kasuya M, Yu TS, Vogt KE,
Muratani M, Ohnishi T, Singh S, Teixeira CM, Cherasse Y, Naoi T, Wang SH, Nondhalee P, Osman BAH,
Kaneko N, Sawamoto K, Kernie SG, Sakurai T, McHugh TJ, Kano M, Yanagisawa M, Sakaguchi M (2020)
Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation.
Neuron 107:552-565.e10. doi:10.1016/j.neuron.2020.05.008.
4. Sawada M, Matsumoto M, Narita K, Kumamoto N, Ugawa S, Takeda S, Sawamoto K (2020) Invitro Time-lapse
Imaging of Primary Cilium in Migrating Neuroblasts. Bio-protocol 10:e3823. doi:10.21769/BioProtoc.3823.
5. Oda Y, Sugawara T, Fukata Y, Izumi Y, Otani T, Higashi T, Fukata M, Furuse M (2020) The extracellular domain
of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular
contacts. J Biol Chem 295:4289-4302. doi: 10.1074/jbc.RA119.010491.
6. Hempstock W, Sugioka S, Ishizuka N, Sugawara T, Furuse M. Hayashi H (2020) Angulin-2/ILDRl, a tricellular
tight junction protein, does not affect water transport in the mouse large intestine. Sci Rep 10:10374. doi:
10.1038/s41598-020-67319-5.
7. Nagatake T, Yan-Chun Z, Ito T, Itoh M, Kometani K, Furuse M, Saika A, Node E, Kunisawa J, Minato N,
Hamazaki Y (2021) Selective expression of claudin-5 in thymic endothelial cells regulates the blood-thymus
barrier and T-cell export. Int Immunol (33(3):171-182). doi: 10.1093/intimm/dxaa069.
8. Sugisawa E, Takayama Y, Takemura N, Kondo T, Hatakeyama S, Kumagai Y, Sunagawa M, Tominaga M,
Maruyama K (2020) RNA sensing by gut Piezol is essential for systemic serotonin synthesis. Cell 182 (3):
609-624. doi: 10.1016/j.cell.2020.06.022.
9. Feng X, Takayama Y, Ohno N, Kanda H, Dai Y, Sokabe T, Tominaga M (2020) Increased TRPV4 expression
in non-myelinating Schwann cells is associated with demyelination after sciatic nerve injury. Communs Biol 3:
716. doi: 10.1038/s42003-020-01444-9.
10. Ashina K, Kobayashi K, Derouiche S, Hamabata T, Nakamura T, Nagata N, Tominaga M, Murata T (2021)
5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid accelerates the healing of colitis by inhibiting transient
receptor potential vanilloid 4-mediated signaling. FASEB J (35(4):e21238). doi: 10.196/fj.20193207RRR.
11. Shimoda K, Nishimura A, Sunggip C, Ito T, Nishiyama K, Kato Y, Tanaka T, Tozaki-Saitoh H, Tsuda M,
Nishida M (2020) Modulation of P2Y6R expression exacerbates pressure overload-induced cardiac remodeling
in mice. Sci Rep 10(1):13926. doi: 10.1038/s41598-020-70956-5.
12. Nishiyama K, Toyama C, Kato Y, Tanaka T, Nishimura A, Nagata R, Mori Y, Nishida M (2021) Deletion of
TRPC3 or TRPC6 fails to attenuate the formation of inflammation and fibrosis in nonalcoholic steatohepatitis.
Biol Pharm Bull 44(3):431-436. doi: 10.1248/bpb.b20-00903.
13. Guo T, Tanaka T, Matsumoto M, Kaneko K, Unzai T, Ogino Y, Aotani D, Kusakabe T, Iwakura H, Miyazawa
T, Sawamoto K, Minokoshi Y, Masuzaki H, Inagaki N, Nakao K (2020) A combination of dietary fat intake
and nicotine exposure enhances CBl endocannabinoid receptor expression in hypothalamic nuclei in male mice.
Neurosci Lett 714(1):134550. doi: 10.1016/j.neulet.2019.134550.
14. Minokoshi Y, Nakajima KI, Okamoto S (2020) Homeostatic versus hedonic control of carbohydrate selection.
J Physiol 598(18):3831-3844. doi: 10.1113/JP280066.
15. Minokoshi Y (2020) Neural control of homeostatic feeding and food selection. "New insights into metabolic
syndrome" (ed Takada A), IntechOpen. doi: 10.5772/intechopen.93413.
16. 箕越靖彦(2020) 炭水化物嗜好性の恒常的・快楽的調節機． Current Therapy 38(8): 68-76.
17. 箕越靖彦(2020) 空腹感と満腹感．“摂食と健康の科学（シリーズ＜栄養と疾病の科学＞ 1)" （高田明和編），朝倉書店， pp.
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18. Koseki H, Miyata H, Shimo S, Ohno N, Mifune K, Shimano K, Yamamoto K, Nozaki K, Kasuya H, Narumiya
S, Aoki T (2020) Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress,
Determine Intracranial Aneurysm Formation. Transl Stroke Res 11:80-92. doi: 10.1007 /s12975-019-0690-y.
19. Otani Y, Ohno N, Cui J, Yamaguchi Y, Baba H (2020) Upregulation of large myelin protein zero leads to
Charcot-Marie-Tooth disease-like neuropathy in mice. Commun Biol 3:121. doi: 10.1038/s42003-020-0854-z.
20. Sampilvanjil A, Karasawa T, Yamada N, Komada T, Higashi T, Baatarjav C, Watanabe S, Kamata R, Ohno
N, Takahashi M (2020) Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells. Am J
Physiol Heart Circ Physiol 318:H508-H518. doi: 10.1152/ajpheart.00559.2019.
21. Oka M, Shimo S, Ohno N, Imai H, Abekura Y, Koseki H, Miyata H, Shimizu K, Kushamae M, Ono I, Nozaki K,
Kawashima A, Kawamata T, Aoki T (2020) Dedifferentiation of smooth muscle cells in intracranial aneurysms
and its potential contribution to the pathogenesis. Sci Rep 10:8330. doi: 10.1038/s41598-020-65361-x.
22. Yamada N, Karasawa T, Wakiya T, Sadatomo A, Ito H, Kamata R, Watanabe S, Komada T, Kimura H,
Sanada Y, Sakuma Y, Mizuta K, Ohno N, Sata N, Takahashi M (2020) Iron overload as a risk factor for
hepatic ischemia-reperfusion injury in liver transplantation: Potential role of ferroptosis. Am J Transplant
20:1606-1618. doi: 10.1111/ajt.15773.
23. Shimo S, Saitoh S, Nguyen HB, Thai TQ, Ikutomo M, Muramatsu K, Ohno N (2020) Sodium-glucose cotransporter
(SGLT) inhibitor restores lost axonal varicosities of the myenteric plexus in a mouse model of
high-fat diet-induced obesity. Sci Rep 10:12372. doi: 10.1038/s41598-020-69256-9.
24. Morita R, Onuma TA, Manni L, Ohno N, Nishida H (2020) Mouth opening is mediated by separation of
dorsal and ventral daughter cells of the lip precursor cells in the larvacean, Oikopleura dioica. Dev Genes Evol
230:315-327. doi: 10.1007 /s00427-020-00667-4.
25. Miyata T, Hagiwara D, Hodai Y, Miwata T, Kawaguchi Y, Kurimoto J, Ozaki H, Mitsumoto K, Takagi H,
Suga H, Kobayashi T, Sugiyama M, Onoue T, Ito Y, Iwama S, Banno R, Matsumoto M, Kawakami N, Ohno N,
Sakamoto H, Arima H (2020) Degradation of Mutant Protein Aggregates within the Endoplasmic Reticulum
of Vasopressin Neurons. iScience 23:101648. doi: 10.1016/j.isci.2020.101648.
26. Okamoto S, Sohn J, Tanaka T, Takahashi M, Ishida I, Yamauchi K, Koike M, Fujiyama F, Hioki H (2020)
Overlapping Projections of Neighboring Direct and Indirect Pathway Neostriatal Neurons to Globus Pallidus
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