National Institute for Physiological Sciences Takemura Lab Sensory & Cognitive Brain Mapping
National Institutes of Natural Sciences National Institute for Physiological SciencesNational Institutes of Natural Sciences National Institute for Physiological Sciences

Seminars

Closed

Director-General Invited Seminar: Helen Mayberg (Icahn School of Medicine at Mount Sinai, USA)

Date and Time

Februrary 21st, 2025 (Fri), 15:30-16:30

Format

Onsite only

Venue

Seminar Room A/B, 1st floor, National Institute for Physiological Sciences

Co-Host

Frontiers of Life Sciences [Spin-L]

Language

English

Speaker

Helen Mayberg

Director, Center of Advanced Circuit Therapeutics

Professor, Neurology, Neurosurgery, Psychiatry, Neuroscience, and AI & Human Health

Mount Sinai Professor of Neurotherapeutics

Icahn School of Medicine at Mount Sinai

Title and Abstract

Title: Tuning Depression Circuits: Insights from studies of Deep Brain Stimulation


Abstract: Deep Brain Stimulation (DBS), the targeted modulation of discrete neural circuits using implanted electrodes, is an experimental treatment strategy for patients with intractable depression and other neuropsychiatric disorders. While various brain targets are being investigated, progress to optimize and refine DBS to the subcallosal cingulate region (SCC) for depression has continued to evolve and mature, with a growing focus on multimodal readouts to guide clinical decisions over time. Enabled by advances in device technology and supported by animal models, recent studies are now implementing combined multimodal imaging with dense time-series electrophysiological and naturalistic behavioral data to track the trajectory of treatment response and characterize circuit plasticity and repair during acute and chronic stimulation. The use of these complementary perspectives is yielding a more cohesive understanding of disease pathophysiology and DBS mechanisms of actions with implications beyond depression.