Director-General Invited Seminar: Helen Mayberg (Icahn School of Medicine at Mount Sinai, USA)
日時
2025年2月21日（金）15:30〜16:30
形式
オンサイトのみ
会場
生理学研究所 明大寺地区実験棟１階 セミナー室A/B
共催
共同利用・共同研究システム形成事業 「学際領域展開ハブ形成プログラム」【スピン生命フロンティア (Spin-L)】
言語
英語
演者
Helen Mayberg
Director, Center of Advanced Circuit Therapeutics
Professor, Neurology, Neurosurgery, Psychiatry, Neuroscience, and AI & Human Health
Mount Sinai Professor of Neurotherapeutics
Icahn School of Medicine at Mount Sinai
タイトル・抄録
Title: Tuning Depression Circuits: Insights from studies of Deep Brain Stimulation
Abstract: Deep Brain Stimulation (DBS), the targeted modulation of discrete neural circuits using implanted electrodes, is an experimental treatment strategy for patients with intractable depression and other neuropsychiatric disorders. While various brain targets are being investigated, progress to optimize and refine DBS to the subcallosal cingulate region (SCC) for depression has continued to evolve and mature, with a growing focus on multimodal readouts to guide clinical decisions over time. Enabled by advances in device technology and supported by animal models, recent studies are now implementing combined multimodal imaging with dense time-series electrophysiological and naturalistic behavioral data to track the trajectory of treatment response and characterize circuit plasticity and repair during acute and chronic stimulation. The use of these complementary perspectives is yielding a more cohesive understanding of disease pathophysiology and DBS mechanisms of actions with implications beyond depression.