f

Research Achievement

2024

Miyazaki Y, Otsuka O, Yamagata Y, Endo T, Sanbo M, Sano H, Kobayashi K, Inahashi H, Kornau H-C, Schmitz D, Prüss H, Meijer D, Hirabayashi M, Fukata Y*, Fukata M*. (*, corresponding authors)
Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity.
Cell Rep (2023)
doi.org/10.1016/j.celrep.2023.113634
PubMed 38194969
f


2023

Lin Chen , Yuko Fukata, Kazuyoshi Murata
In situ cryo-electron tomography: a new method to elucidate cytoplasmic zoning at the molecular level
J Biochem. 2023 Dec 15:mvad102.
doi: 10.1093/jb/mvad102.
PubMed 38102736


Nosková R*, Fukata Y*, Stránecký V, Šaligová J, Bodnárová O, Giertlová M, Fukata M**, Kmoch S** (*, equally contributed; **, corresponding authors)
ADAM22 ethnic-specific variant reducing binding of membrane-associated guanylate kinases causes focal epilepsy and behavioural disorder.
Brain Commun (2023)
doi.org/10.1093/braincomms/fcad295
PubMed 37953841


Zhang X, Kira JI, Ogata H, Imamura T, Mitsuishi M, Fujii T, Kobayashi M, Kitagawa K, Namihira Y, Ohya Y, Maimaitijiang G, Yamasaki R, Fukata Y, Fukata M, Isobe N, Nakamura Y.
Anti-LGI4 Antibody Is a Novel Juxtaparanodal Autoantibody for Chronic Inflammatory Demyelinating Polyneuropathy.
Neurol Neuroimmunol Neuroinflamm. 10:e200081 (2023)
doi: 10.1212/NXI.0000000000200081.
PubMed 36631269

2022

Niki Y, Adachi N, Fukata M, Fukata Y, Oku S, Makino-Okamura C, Takeuchi S, Wakamatsu K, Ito S, Declercq L, Yarosh D B, Mammone T, Nishigori C, Saito N, Ueyama T
S-palmitoylation of tyrosinase at cysteine500 regulates melanogenesis
J Invest Dermatol (2022)
doi: 10.1016/j.jid.2022.08.040
PubMed 36063887


van der Knoop MM*, Maroofian R*, Fukata Y*, van Ierland Y, Karimiani EG, Lehesjoki AE, Muona M, Paetau A, Miyazaki Y, Hirano Y, Selim L, de França M, Fock RA, Beetz C, Ruivenkamp CAL, Eaton AJ, Morneau-Jacob FD, Sagi-Dain L, Shemer-Meiri L, Peleg A, Haddad-Halloun J, Kamphuis DJ, Peeters-Scholte CMPCD, Hiz Kurul S, Horvath R, Lochmüller H, Murphy D, Waldmüller S, Spranger S, Overberg D, Muir AM, Rad A, Vona B, Abdulwahad F, Maddirevula S, Povolotskaya IS, Voinova VY, Gowda VK, Srinivasan VM, Alkuraya FS, Mefford HC, Alfadhel M, Haack TB, Striano P, Severino M, Fukata M**, Hilhorst-Hofstee Y**, Houlden H**.
(*, equally contributed; **, corresponding authors)
Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy.
Brain (2022)
doi: 10.1093/brain/awac116.
PubMed 35373813


Kawai T, Narita H, Konno K, Akter S, Andriani RT, Iwasaki H, Nishikawa S, Yokoi N, Fukata Y, Fukata M, Wiriyasermkul P, Kongpracha P, Nagamori S, Takao K, Miyakawa T, Abe M, Sakimura K, Watanabe M, Nakagawa A, Okamura Y.
Insight into the function of a unique voltage-sensor protein (TMEM266) and its short form in mouse cerebellum
Biochem J (2022)
doi: 10.1042/BCJ20220033
PubMed 35574701


Wirth A, Labus J, Galil DA, Schill Y, Schmidt S,Bunke T, Gorinski N, Yokoi N, Fukata M, Ponimaskin E
Palmitoylation of the small GTPase Cdc42 by DHHC5 modulates spine formation and gene transcription
J Biol Chem (2022)
doi: 10.1016/j.jbc.2022.102048
PubMed 35597282

2021

Fukata Y, Chen X, Chiken S, Hirano Y, Yamagata A, Inahashi H, Sanbo M, Sano H, Goto T, Hirabayashi M, Kornau HC, Prüss H, Nambu A, Fukai S, Nicoll RA, Fukata M.
LGI1-ADAM22-MAGUK configures trans-synaptic nanoalignment for synaptic transmission and epilepsy prevention
Proc Natl Acad Sci USA. 118:e2022580118 (2021)
doi.org/10.1073/pnas.2022580118
PubMed 33397806
f


Yokoi N, Fukata Y*, Okatsu K, Yamagata A,Liu Y, Sanbo M, Miyazaki Y, Goto T, Abe M, Kassai H, Sakimura K, Meijer D, Hirabayashi M, Fukai S, Fukata M*
14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice.
Cell Rep 37:110107 (2021)
doi.org/10.1016/j.celrep.2021.110107
PubMed 34910912
f


Nakamoto C, Goto Y, Tomizawa Y, Fukata Y, Fukata M, Harpsøe K, Gloriam DE, Aoki K, Takeuchi T.
A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro.
Mol Brain 14:173 (2021)
doi.org/10.1186/s13041-021-00882-8
PubMed 34872607
f


Kreye J, Wright SK, van Casteren A, Stöffler L, Machule ML, Reincke SM, Nikolaus M, van Hoof S, Sanchez-Sendin E, Homeyer MA, Gómez CC, Kornau HC, Schmitz D, Kaindl AM, Boehm-Sturm P, Mueller S, Wilson MA, Upadhya MA, Dhangar DR, Greenhill S, Woodhall G, Turko P, Vida I, Garner CC, Wickel J, Geis C, Fukata Y, Fukata M, Prüss H.
Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures
J Exp Med 218:e20210012 (2021)
doi.org/10.1084/jem.20210012
PubMed 34546336


Chen X, Fukata Y, Fukata M, Nicoll R.
MAGUKs are essential, but redundant, in long-term potentiation
Proc Natl Acad Sci USA. 118:e2107585118 (2021)
doi: 10.1073/pnas.2107585118
PubMed 34244435


Fukata Y, Hirano Y, Miyazaki Y, Yokoi N, Fukata M.
Trans-synaptic LGI1-ADAM22-MAGUK in AMPA and NMDA receptor regulation
Neuropharmacology (2021)
doi: 10.1016/j.neuropharm.2021.108628
PubMed 34089731


Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Nakashima S, Shiroshima T, Maeda A, Iwasawa-Okamoto S, Azechi K, Osaka F, Saitoh T, Maenaka K, Shimada T, Fukata Y, Fukata M, Matsumoto J, Nishijo H, Takao K, Tanaka S, Okabe S, Tabuchi K, Uemura T, Mishina M, Mori H, Fukai S.
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
Nat Commun. 2021 12:1848.
doi: 10.1038/s41467-021-22059-6.
PubMed 33758193


2020

Watanabe H, Sano H, Chiken S, Kobayashi K, Fukata Y, Fukata M, Mushiake H, Nambu A.
Forelimb movements evoked by optogenetic stimulation of the macaque motor cortex.
Nat Commun 11:3253 (2020)
doi: 10.1038/s41467-020-16883-5
PubMed 32591505


Oda Y, Sugawara T, Fukata Y, Izumi Y, Otani Y, Higashi T, Fukata M, Furuse M
The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts
J Biol Chem 295:4289-4302 (2020)
doi:10.1074/jbc.RA119.010491
PubMed 32079676


Kornau HC, Kreye J, Stumpf A, Fukata Y, Parthier D, Sammons RP, Imbrosci B, Kurpjuweit S, Kowski AB, Fukata M, Prüss H, Schmitz D.
Human CSF monoclonal LGI1 autoantibodies increase neuronal excitability
Ann Neurol 87(3):405-418 (2020)
doi: 10.1002/ana.25666
PubMed 31900946

2019

Sada R, Kimura H, Fukata Y, Fukata M, Yamamoto H, Kikuchi A.
Dynamic palmitoylation determines microdomain localization of two DKK1 receptors, CKAP4 and LRP6, and regulates DKK1 signaling.
Sci Signaling 12:eaat9519 (2019)
doi: 10.1126/scisignal.aat9519
PubMed 31744930


Cao Y, Qiu T, Kathayat R, Azizi SA, Fukata Y, Fukata M, Rice P, Dickinson BC.
ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5
Nat Chem Biol 15:1232-1240 (2019)
doi: 10.1038/s41589-019-0399-y
PubMed 31740833


Boncompain G, Herit F, Tessier S, Lescure A, Del Nery E, Gestraud P, Staropoli I, Fukata Y, Fukata M, Brelot A, Niedergang F, Perez F.
Targeting CCR5 trafficking to inhibit HIV-1 infection
Science Advances 5:eaax0821 (2019)
doi: 10.1126/sciadv.aax0821
PubMed 31663020


Kanadome T, Yokoi N, Fukata Y, Fukata M.
Systematic Screening of Depalmitoylating Enzymes and Evaluation of Their Activities by the Acyl-PEGyl Exchange Gel-Shift (APEGS) Assay
Methods Mol Biol 2009:83-98 (2019)
doi: 10.1007/978-1-4939-9532-5_7
PubMed 31152397


Hasegawa D, Ohnishi Y, Koyama E, Matsunaga S, Ohtani S, Nakanishi A, Shiga T, Chambers JK, Uchida K, Yokoi N, Fukata Y, Fukata M.
Deleted in colorectal cancer (netrin-1 receptor) antibodies and limbic encephalitis in a cat with hippocampal necrosis
J Vet Intern Med 33:1440-1445 (2019)
doi: 10.1111/jvim.15492
PubMed 30942925

2018

Yamagata A*, Miyazaki Y*, Yokoi N, Shigematsu H, Sato Y, Goto-Ito S, Maeda A, Goto T, Sanbo M, Hirabayashi M, Shirouzu M, Fukata Y, Fukata M**, Fukai S**.
(*, equally contributed; **, corresponding authors)
Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22
Nat Commun 9:1546 (2018)
doi: 10.1038/s41467-018-03947-w
PubMed 29670100
f


Yoshikura N, Kimura A, Fukata M, Fukata Y, Yokoi N, Harada N, Hayashi Y, Inuzuka T, Shimohata T.
Long-term clinical follow-up of a patient with non-paraneoplastic cerebellar ataxia associated with anti-mGluR1 autoantibodies
J Neuroimmunol 319:63-67 (2018)
doi: 10.1016/j.jneuroim.2018.04.001
PubMed 29685291


Fukata M, Yokoi N, Fukata Y.
Neurobiology of autoimmune encephalitis.
Curr Opin Neurobiol 48:1-8 (2018)
doi: 10.1016/j.conb.2017.07.012
PubMed 28829986

2017

Fukata Y, Fukata M.
Epilepsy and synaptic proteins.
Curr Opin Neurobiol, 45:1-8 (2017)
doi: 10.1016/j.conb.2017.02.001
PubMed 28219682


Chen IS, Tateyama M, Fukata Y, Uesugi M, Kubo Y.
Ivermectin activates GIRK channels in a PIP2 -dependent, Gβγ -independent manner and an amino acid residue at the slide helix governs the activation.
J Physiol (2017)
doi: 10.1113/JP274871
PubMed 28715108


Tortosa E, Adolfs Y, Fukata M, Pasterkamp RJ, Kapitein LC, Hoogenraad CC.
Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization.
Neuron 94:809-825 (2017)
doi: 10.1016/j.neuron.2017.04.042
PubMed 28521134


Ogino H, Hisanaga A, Kohno T, Kondo Y, Okumura K, Kamei T, Sato T, Asahara H, Tsuiji H, Fukata M, Hattori M.
Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin.
J Neurosci 37:3181-3191 (2017)
doi: 10.1523/JNEUROSCI.3632-16.2017
PubMed 28213441


Uemura T, Shiroshima T, Maeda A, Yasumura M, Shimada T, Fukata Y, Fukata M, Yoshida T.
In situ screening for postsynaptic cell adhesion molecules during synapse formation.
J Biochem (2017)
doi: 10.1093/jb/mvx030
PubMed 28449070


Cho T, Ishii-Kato A, Fukata Y, Nakayama Y, Iida K, Fukata M, Iida H.
Coupling of a voltage-gated Ca2+ channel homolog with a plasma membrane H+-ATPase in yeast.
Genes to Cells 22:94-104 (2017)
doi: 10.1111/gtc.12458
PubMed 27935186


Sugio S, Tohyama K, Oku S, Fujiyoshi K, Yoshimura T, Hikishima K, Yano R, Fukuda T, Nakamura M, Okano H, Watanabe M1, Fukata M, Ikenaka K, F Tanaka K.
Astrocyte-mediated infantile-onset leukoencephalopathy mouse model.
Glia 65:150-168 (2017)
doi: 10.1002/glia.23084
PubMed 27748972

2016

Fukata Y, Yokoi N, Miyazaki Y, Fukata M.
The LGI1-ADAM22 protein complex in synaptic transmission and synaptic disorders.
Neurosci Res 116:39-45 (2016)
doi: 10.1016/j.neures.2016.09.011.
PubMed 27717669


Yokoi N*, Fukata Y*, Sekiya A, Murakami T, Kobayashi K, Fukata M.
Identification of PSD-95 Depalmitoylating Enzymes.
J Neurosci 36:6431-44 (2016)
doi:10.1523/JNEUROSCI.0419-16.2016
PubMed 27307232
f


Muona M, Fukata Y, Anttonen AK, Laari A, Palotie A, Pihko H, Lönnqvist T, Valanne L, Somer M, Fukata M, Lehesjoki AE.
Dysfunctional ADAM22 implicated in progressive encephalopathy with cortical atrophy and epilepsy.
Neurol Genet 2:e46 (2016)
doi: 10.1212/NXG.0000000000000046
PubMed 27066583


Fukata Y, Murakami T, Yokoi N, Fukata M.
Local Palmitoylation Cycles and Specialized Membrane Domain Organization.
Curr Top Membr 77:97-141 (2016)
doi: 10.1016/bs.ctm.2015.10.003
PubMed 26781831

2015

Lovero KL, Fukata Y, Granger AJ, Fukata M, Nicoll RA.
The LGI1-ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function.
Proc Natl Acad Sci USA. 112:E4129-E4137 (2015)
doi: 10.1073/pnas.1511910112
PubMed 26178195
f


Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, Takahashi N, Iwanari H, Mochizuki Y, Hamakubo T, Imoto K, Meijer D, Watanabe M, Fukata M.
Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.
Nat Med 21:19-26 (2015)
doi:10.1038/nm.3759
PubMed 25485908
Introduced in Lancet Neurology
f f


Fukata M, Sekiya A, Murakami T, Yokoi N, Fukata Y.
Postsynaptic nanodomains generated by local palmitoylation cycles.
Biochem Soc Trans 43:199-204 (2015)
doi: 10.1042/BST20140238
PubMed 25849917


Suzuki M, Murakami T, Cheng J, Kano H, Fukata M, Fujimoto T.
ELMOD2 is anchored to lipid droplets by palmitoylation and regulates adipocyte triglyceride lipase recruitment.
Mol Biol Cell 26:2333-2342 (2015)
doi: 10.1091/mbc.E14-11-1504
PubMed 25904333


Zhu D, Li C, Swanson AM, Villalba RM, Guo J, Zhang Z, Matheny S, Murakami T, Stephenson JR, Daniel S, Fukata M, Hall RA, Olson JJ, Neigh GN, Smith Y, Rainnie DG, Van Meir EG.
BAI1 regulates spatial learning and synaptic plasticity in the hippocampus.
J Clin Invest 125:1497-1508 (2015)
doi: 10.1172/JCI74603
PubMed 25751059

2014

Ohkawa T, Satake S, Yokoi N, Miyazaki Y, Ohshita T, Sobue G, Takashima H, Watanabe O, Fukata Y, Fukata M.
Identification and characterization of GABA(A) receptor autoantibodies in autoimmune encephalitis.
J Neurosci 34:8151-8163 (2014)
doi: 10.1523/JNEUROSCI.4415-13.2014
PubMed 24920620


Kegel L, Jaegle M, Driegen S, Aunin E, Leslie K, Fukata Y, Watanabe M, Fukata M, Meijer D.
Functional phylogenetic analysis of LGI proteins identifies an interaction motif crucial for myelination.
Development 141:1749-1756 (2014)
doi: 10.1242/dev.107995
PubMed 24715463


Gory-Fauré S, Windscheid V, Brocard J, Montessuit S, Tsutsumi R, Denarier E, Fukata Y, Bosc C, Delaroche J, Collomb N, Fukata M, Martinou JC, Pernet-Gallay K, Andrieux A.
Non-microtubular localizations of microtubule-associated protein 6 (MAP6).
PLoS One 9:e114905 (2014)
doi:10.1371/journal.pone.0114905
PubMed 25526643

2013

Ohkawa T, Fukata Y, Yamasaki M, Miyazaki T, Yokoi N, Takashima H, Watanabe M, Watanabe O, Fukata M.
Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors.
J Neurosci 33:18161-18174 (2013)
doi: 10.1523/JNEUROSCI.3506-13.2013
Featured Article
PubMed 24227725
f f


Fukata Y, Dimitrov A, Boncompain G, Vielemeyer O, Perez F, Fukata M.
Local palmitoylation cycles define activity-regulated postsynaptic subdomains
J Cell Biol 202:145-161 (2013)
doi: 10.1083/jcb.201302071
PubMed 23836932
f f


Oku S, Takahashi N, Fukata Y, Fukata M.
In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes
J Biol Chem 288:19816-19829 (2013)
doi: 10.1074/jbc.M112.431676
PubMed 23687301


Zheng B, DeRan M, Li X, Liao X, Fukata M, Wu X.
2-Bromopalmitate analogues as activity-based probes to explore palmitoyl acyltransferases.
J Am Chem Soc 135:7082-7085 (2013)
doi: 10.1021/ja311416v
PubMed 23631516


Kawahara A, Kurauchi S, Fukata Y, Martínez-Hernández J, Yagihashi T, Itadani Y, Sho R, Kajiyama T, Shinzato N, Narusuye K, Fukata M, Luján R, Shigemoto R, Ito I.
Neuronal major histocompatibility complex class I molecules are implicated in the generation of asymmetries in hippocampal circuitry.
J Physiol 591:4777-4791 (2013)
PubMed 23878366

2012

Yokoi N,Fukata M, Fukata Y.
Synaptic plasticity regulated by protein-protein interactions and posttranslational modifications.
Int Rev Cell Mol Biol 297:1-43 (2012)
doi: 10.1016/B978-0-12-394308-8.00001-7
PubMed 22608556


Kusuzawa S, Honda T, Fukata Y, Fukata M, Kanatani S, Tanaka DH, Nakajima K.
Leucine-rich glioma inactivated 1 (Lgi1), an epilepsy-related secreted protein, has a nuclear localization signal and localizes to both the cytoplasm and the nucleus of the caudal ganglionic eminence neurons.
Eur J Neurosci 36:2284-2292 (2012)
doi: 10.1111/j.1460-9568.2012.08129.x
PubMed 22612501


Lu D, Sun HQ, Wang H, Barylko B, Fukata Y, Fukata M, Albanesi JP, Yin HL.
Phosphatidylinositol 4-kinase IIα is palmitoylated by Golgi-localized palmitoyltransferases in cholesterol-dependent manner.
J Biol Chem 287:21856-21865 (2012)
doi: 10.1074/jbc.M112.348094
PubMed 22535966
f


Oku S, Fukata Y, and Fukata M.
DHHC proteins.
Encyclopedia of Signaling Molecules.
Edited by Choi, S., 1st Edition, Springer (2012)
ISBN 978-1-4419-0460-7
Springer

2011

Seppälä EH, Jokinen TS, Fukata M, Fukata Y, Webster MT, Karlsson EK, Kilpinen SK, Steffen F, Dietschi E, Leeb T, Eklund R, Zhao X, Rilstone JJ, Lindblad-Toh K, Minassian BA, Lohi H.
LGI2 truncation causes a remitting focal epilepsy in dogs.
PLoS Genetics 7:e1002194 (2011)
doi: 10.1371/journal.pgen.1002194
PubMed 21829378
PLoS 1002194


Levy AD, Devignot V, Fukata Y, Fukata M, Sobel A, Chauvin S.
Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases.
Mol Biol Cell 22:1930-1942 (2011)
doi: 10.1091/mbc.E10-10-0824
PubMed 21471001

2010

Fukata Y, Fukata M.
Protein palmitoylation in neuronal development and synaptic plasticity.
Nat Rev Neurosci 11:161-175 (2010)
doi: 10.1038/nrn2788.
PubMed 20168314


Fukata Y, Lovero KL, Iwanaga T, Watanabe A, Yokoi N, Tabuchi K, Shigemoto R, Nicoll RA, Fukata M.
Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy.
Proc Natl Acad Sci USA 107:3799-3804 (2010)
doi: 10.1073/pnas.0914537107
PubMed 20133599s
f

2009

Noritake J, Fukata Y, Iwanaga T, Hosomi N, Tsutsumi R, Matsuda N, Tani H, Iwanari H, Mochizuki Y, Kodama T, Matsuura Y, Bredt DS, Hamakubo T, Fukata M
Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95.
J Cell Biol 186:147-160 (2009)
doi: 10.1083/jcb.200903101
PubMed 19596852
f f


Iwanaga T, Tsutsumi R, Noritake J, Fukata Y, Fukata M.
Dynamic protein palmitoylation in cellular signaling.
Prog Lipid Res 48:117-127 (2009)
doi: 10.1016/j.plipres.2009.02.001
PubMed 19233228


Tsutsumi R, Fukata Y, Noritake J, Iwanaga T, Perez F, Fukata M.
Identification of G protein alpha subunit-palmitoylating enzyme.
Mol Cell Biol 29:435-447 (2009)
doi: 10.1128/MCB.01144-08
PubMed 19001095
f


Matsuda N, Lu H, Fukata Y, Noritake J, Gao H, Mukherjee S, Nemoto T, Fukata M, Poo MM.
Differential activity-dependent secretion of brain-derived neurotrophic factor from axon and dendrite.
J Neurosci 29:14185-14198 (2009)
doi: 10.1523/JNEUROSCI.1863-09
PubMed 19906967


Shmueli A, Segal M, Sapir T, Tsutsumi R, Noritake J, Bar A, Sapoznik S. Fukata Y, Orr I Fukata M, Reiner O.
Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity.
EMBO J 29:107-119 (2010)
doi: 10.1038/emboj.2009.325
PubMed 19927128


Mill P, Lee AW, Fukata Y, Tsutsumi R, Fukata M, Keighren M, Porter RM, McKie L, Smyth I, Jackson IJ.
Palmitoylation regulates epidermal homeostasis and hair follicle differentiation
PLoS Genet 5:e1000748 (2009)
doi: 10.1371/journal.pgen.1000748
PubMed 19956733


Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G.
Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.
J Biol Chem 284:3793-3803 (2009)
doi: 10.1074/jbc.M808920200
PubMed 19074428


Greaves J, Prescott GR, Fukata Y, Fukata M, Salaun C, Chamberlain LH.
The hydrophobic cysteine-rich domain of SNAP25 couples with downstream residues to mediated membrane interactions and recognitions by DHHC palmitoyl transferases.
Mol Biol Cell 20:1845-1854 (2009)
doi: 10.1091/mbc.E08-09-0944
PubMed 19158383

2008

Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A.
Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis.
J Neurosci 28:8897-8907 (2008)
doi: 10.1523/JNEUROSCI.2171-08
PubMed 18768683


Greaves J, Salaun C, Fukata Y, Fukata M, Chamberlain LH.
Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein.
J Biol Chem 283:25014-25026 (2008)
doi: 10.1074/jbc.M802140200
PubMed 18596047


Tsutsumi R, Fukata Y, Fukata M.
Discovery of protein-palmitoylating enzymes.
Pflugers Arch 456:1199-1206 (2008)
doi: 10.1007/s00424-008-0465-x
PubMed 18231805

2007

Olsen O, Funke L, Long JF, Fukata M, Kazuta T, Trinidad JC, Moore KA, Misawa H, Welling PA, Burlingame AL, Zhang M, Bredt DS.
Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice.
J Cell Biol 179:151-164 (2007)
PubMed 17923534


Mishima M, Maesaki R, Kasa M, Watanabe T, Fukata M, Kaibuchi K, Hakoshima T.
Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition.
Proc Natl Acad Sci USA 104:10346-10351 (2007)
PubMed 17563362


Yamamoto N, Fukata Y, Fukata M, Yanagisawa K.
GM1-ganglioside-induced Abeta assembly on synaptic membranes of cultured neurons.
Biochim Biophys Acta 1768:1128-1137 (2007)
PubMed 17306220


Wang S, Watanabe T, Noritake J, Fukata M, Yoshimura T, Itoh N, Harada T, Nakagawa M, Matsuura Y, Arimura N, Kaibuchi K.
IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth.
J Cell Sci 120:567-577 (2007)
PubMed 17244649


Tomita S, Shenoy A, Fukata Y, Nicoll RA, Bredt DS.
Stargazin interacts functionally with the AMPA receptor glutamate-binding module.
Neuropharmacology 52:87-91 (2007)
PubMed 16919685

2006

Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M.
Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission.
Science 313:1792-1795 (2006)
PubMed 16990550
f f


Fukata Y, Iwanaga T, Fukata M.
Systematic screening for palmitoyl transferase activity of the DHHC protein family in mammalian cells.
Methods 40:177-182 (2006)
PubMed 17012030


Fang C, Deng L, Keller CA, Fukata M, Fukata Y, Chen G, Lüscher B.
GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses.
J Neurosci 26:12758-12768 (2006)
PubMed 17151279


Fernández-Hernando C, Fukata M, Bernatchez PN, Fukata Y, Lin MI, Bredt DS, Sessa WC.
Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase.
J Cell Biol 174:369-377 (2006)
PubMed 16864653


Hundt M, Tabata H, Jeon MS, Hayashi K, Tanaka Y, Krishna R, De Giorgio L, Liu YC, Fukata M, Altman A.
Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect.
Immunity 24:513-522 (2006)
PubMed 16713970


Fukata Y, Bredt DS, Fukata M.
Protein palmitoylation by DHHC protein family.
The CRC Press: The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology. 81-88 (2006)
PubMed 81-88

2005

Fukata Y, Tzingounis AV, Trinidad JC, Fukata M, Burlingame AL, Nicoll RA, Bredt DS.
Molecular constituents of neuronal AMPA receptor.
J Cell Biol 169:399-404 (2005)
PubMed 15883194


Olsen O, Moore KA, Fukata M, Kazuta T, Trinidad J, Kauer FW, Streuli M, Misawa H, Burlingame AL, Nicoll RA, Bredt DS.
Neurotransmitter release regulated by a MALS-liprin-a presynaptic complex.
J Cell Biol 170:1127-1134 (2005)
PubMed PMC2171538


Arimura N, Ménager C, Kawano Y, Yoshimura T, Kawabata S, Hattori A, Fukata Y, Amano M, Goshima Y, Inagaki M, Morone N, Usukura J, Kaibuchi K.
Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones.
Mol Cell Biol 25: 9973-9984 (2005)
PubMed 16260611


Kimura T, Arimura N, Fukata Y, Watanabe H, Iwamatsu A, Kaibuchi K.
Tubulin and CRMP-2 complex is transported via Kinesin-1.
J Neurochem 93: 1371-1382 (2005)
PubMed 15935053

2004

Fukata M, Fukata Y, Adesnik H, Nicoll RA, Bredt DS.
Identification of PSD-95 Palmitoylating Enzymes.
Neuron 44:987-996 (2004)
PubMed 15603741
f


Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K.
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration.
Dev Cell 6:871-883 (2004)
PubMed 15572129
f


Tomita S, Fukata M, Nicoll RA, Bredt DS.
Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses.
Science 303:1508-1511 (2004)
PubMed 15001777


Noritake J, Fukata M, Sato K, Nakagawa M, Watanabe T, Izumi N, Wang S, Fukata Y, Kaibuchi K.
Positive Role of IQGAP1, an Effector of Rac1, in Actin-Meshwork Formation at Sites of Cell-Cell Contact.
Mol Biol Cell 3:1065-1076 (2004)
PubMed 14699063


Ménager C, Arimura N, Fukata Y, Kaibuchi K.
PIP3 is involved in neuronal polarization and axon formation.
J Neurochem 89:109-118 (2004)
PubMed 15030394


Arimura N, Menager C, Fukata Y, Kaibuchi K.
Role of CRMP-2 in neuronal polarity.
J Neurobiol 58:34-47 (2004)
PubMed 14598368


Nishimura T, Kato K, Yamaguchi T, Fukata Y, Ohno S, Kaibuchi K.
Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity.
Nature Cell Biol 6:328-334 (2004)
PubMed 15048131
f

2003

Fukata M, Nakagawa M, Kaibuchi K.
Roles of Rho-family GTPases in cell polarisation and directional migration
Curr Opin Cell Biol 15:590-597 (2003)
PubMed 14519394


Amano M, Kaneko T, Maeda A, Nakayama M, Ito M, Yamauchi T, Goto H, Fukata Y, Oshiro N, Shinohara A, Iwamatsu A, Kaibuchi K.
Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase.
J Neurochem 87:780-790 (2003)
PubMed 14535960


Nishimura T, Fukata Y, Kato K, Yamaguchi T, Matsuura Y, Kamiguchi H, Kaibuchi K.
CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth.
Nature Cell Biol 5:819-826 (2003)
PubMed 12942088
f

2002

Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K.
Rac1 and Cdc42 Capture Microtubules through IQGAP1 and CLIP-170.
Cell 109:873-885 (2002)
PubMed 12110184
f


Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
Effects of Rho family GTPases on cell-cell adhesion.
Methods Mol Biol 189:121-128 (2002)
PubMed 12094580


Fukata Y, Itoh TJ, Kimura T, Ménager C, Nishimura T, Shiromizu T, Watanabe H, Inagaki N, Iwamatsu A, Hotani H, Kaibuchi K.
CRMP-2 binds to tubulin heterodimers to promote microtubule assembly.
Nature Cell Biol 4:583-591 (2002)
PubMed 12134159


Fukata Y, Kimura T, Kaibuchi K.
Axon specification in hippocampal neurons.
Neuroscience Res 43: 305-315 (2002)
PubMed 12135774


Maeda A, Amano M, Fukata Y, Kaibuchi K.
Translocation of Na(+),K(+)-ATPase is induced by Rho small GTPase in renal epithelial cells.
Biochem Biophys Res Commun 297:1231-1237 (2002)
PubMed 12372419

2001

Fukata M, Kaibuchi K.
Rho-family GTPases in cadherin-mediated cell-cell adhesion.
Nature Reviews Mol Cell Biol 12:887-897 (2001)
PubMed 11733768


Fukata M, Nakagawa M, Itoh N, Kawajiri A, Yamaga M, Kuroda S, Kaibuchi K.
Involvement of IQGAP1, an effector of Rac1 and Cdc42 GTPases, in cell-cell dissociation during cell scattering.
Mol Cell Biol 21:2165-2183 (2001)
PubMed 11238950


Fukata Y, Amano M, Kaibuchi K.
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells.
Trend Pharmacol Sci 22:32-39 (2001)
PubMed 11165670


Nakagawa M, Fukata M, Yamaga M, Itoh N, Kaibuchi K.
Recruitment and activation of Rac1 by the formation of E-cadherin- mediated cell-cell adhesion sites.
J Cell Sci 114:1829-1838 (2001)
PubMed 11329369

2000

Amano M, Fukata Y, Shimokawa H, Kaibuchi K.
Purification and in Vitro Activity of Rho-Associated Kinase.
Methods Enzymol 325:149-155 (2000)
PubMed 11036600


Amano M, Fukata Y, Kaibuchi K.
Regulation and Functions of Rho-Associated Kinase.
Exp Cell Res 261:44-51 (2000)
PubMed 11082274


Izawa T, Fukata Y, Kimura T, Iwamatsu A, Dohi K, Kaibuchi K.
Elongation factor-1 alpha is a novel substrate of rho-associated kinase.
Biochem Biophys Res Commun 278:72-78 (2000)
PubMed 11071857


Kawajiri A, Itoh N, Fukata M, Nakagawa M, Yamaga M, Iwamatsu A, Kaibuchi K.
Identification of a novel beta-catenin-interacting protein.
Biochem Biophys Res Commun 273:712-717 (2000)
PubMed 10873669


Nakamura N, Oshiro N, Fukata Y, Amano M, Fukata M, Kuroda S, Matsuura Y, Leung T, Lim L, Kaibuchi K.
Phosphorylation of ERM proteins at filopodia induced by Cdc42.
Genes Cells 5:571-581 (2000)
PubMed 10947843


Sone M, Suzuki E, Hoshino M, Hou D, Kuromi H, Fukata M, Kuroda S, Kaibuchi K, Nabeshima Y, Hama C.
Synaptic development is controlled in the periactive zones of Drosophila synapses.
Development 127:4157-4168 (2000)
PubMed 10976048


Kandabashi T, Shimokawa H, Miyata K, Kunihiro I, Kawano Y, Fukata Y, Higo T, Egashira K, Takahashi S, Kaibuchi K, Takeshita A.
Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta.
Circulation 101:1319-1323 (2000)
PubMed 10725293

1999

Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
Cell adhesion and Rho small GTPases.
J Cell Sci 112:4491-4500 (1999)
PubMed 10574699


Fukata M, Kuroda S, Nakagawa M, Kawajiri A, Itoh N, Shoji I, Matsuura Y, Yonehara S, Fujisawa H, Kikuchi A, Kaibuchi K.
Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin.
J Biol Chem 274:26044-26050 (1999)
PubMed 10473551


Fukata Y, Oshiro N, Kinoshita N, Kawano Y, Matsuoka Y, Bennett V, Matsuura Y, Kaibuchi K.
Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility.
J Cell Biol 145:347-361 (1999)
PubMed 10209029


Fukata Y, Oshiro N, Kaibuchi K.
Activation of moesin and adducin by Rho-kinase downstream of Rho.
Biophys Chem 82:139-147 (1999)
PubMed 10631797


Kuroda S, Fukata M, Nakagawa M, Kaibuchi K.
Cdc42, Rac1, and their effector IQGAP1 as molecular switches for cadherin-mediated cell-cell adhesion.
Biochem Biophys Res Commun 262:1-6 (1999)
PubMed 10448058


Kawano Y, Fukata Y, Oshiro N, Amano M, Nakamura T, Ito M, Matsumura F, Inagaki M, Kaibuchi K.
Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo.
J Cell Biol 147:1023-1038 (1999)
PubMed 10579722


Hoshino M, Sone M, Fukata M, Kuroda S, Kaibuchi K, Nabeshima Y, Hama C.
Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1.
J Biol Chem 274:17837-17844 (1999)
PubMed 10364228


Kaibuchi K, Kuroda S, Fukata M, Nakagawa M.
Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases.
Curr Opin Cell Biol 11:591-596 (1999)
PubMed 10508646

1998

Fukata Y, Kimura K, Oshiro N, Saya H, Matsuura Y, Kaibuchi K.
Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-kinase and myosin phosphatase.
J Cell Biol 141:409-418 (1998)
PubMed 9548719


Kuroda S, Fukata M, Nakagawa M, Fujii K, Nakamura T, Ookubo T, Izawa I, Nagase T, Nomura N, Tani H, Shoji I, Matsuura Y, Yonehara S, Kaibuchi K.
Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion.
Science 281:832-835 (1998)
PubMed 9694656


Kimura K, Fukata Y, Matsuoka Y, Bennett V, Matsuura Y, Okawa K, Iwamatsu A, Kaibuchi K.
Regulation of the association of adducin with actin filaments by Rho-kinase and myosin phosphatase.
J Biol Chem 273:5542-5548 (1998)
PubMed 9488679


Oshiro N, Fukata Y, Kaibuchi K.
Phosphorylation of Moesin by Rho-associated Kinase (Rho-kinase) Plays a Crucial Role in the Formation of Microvilli-like Structures.
J Biol Chem 273:34663-34666 (1998)
PubMed 9856983


Amano M, Fukata Y, Kaibuchi K.
Regulation of Cytoskeleton and Cell Adhesions by the Small GTPase Rho and Its Targets.
Trend Cardio Med 8:162-168
PubMed 21235928


Amano M, Chihara K, Nakamura N, Fukata Y, Yano T, Shibata M, Ikebe M, Kaibuchi K.
Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase.
Genes Cell 3:177-188 (1998)
PubMed 9619630


Kobayashi K, Kuroda S, Fukata M, Nakamura T, Nagase T, Nomura N, Matsuura Y, Yoshida-Kubomura N, Iwamatsu A, Kaibuchi K.
p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase.
J Biol Chem 273:291-295 (1998)
PubMed 9417078

1997

Fukata M, Kuroda S, Fujii K, Nakamura T, Shoji I, Matsuura Y, Okawa K, Iwamatsu A, Kikuchi A, Kaibuchi K.
Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42.
J Biol Chem 272:29579-29583 (1997)
PubMed 9368021


Kuroda S, Fukata M, Fujii K, Nakamura T, Izawa I, Kaibuchi K.
Regulation of cell-cell adhesion of MDCK cells by Cdc42 and Rac1 small GTPases. Biochem.
Biophys Res Commun 240:430-435 (1997)
PubMed 9388496


Amano M, Chihara K, Kimura K, Fukata Y, Nakamura N, Matsuura Y, Kaibuchi K.
Formation of actin stress fibers and focal adhesions by Rho-kinase.
Science 275:1308-1311 (1997)
PubMed 9036856

1996

Kuroda S, Fukata M, Kobayashi K, Nakafuku M, Nomura N, Iwamatsu A, Kaibuchi K.
Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1.
J Biol Chem 271:23363-23367 (1996)
PubMed 8798539


Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K.
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
Science 273:245-248 (1996)
PubMed 8662509


Amano M, Ito M, Kimura K, Fukata Y, Chihara K, Nakano T, Matsuura Y, Kaibuchi K.
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase).
J Biol Chem 271:20246-20249 (1996)
PubMed 8702756