生理学研究所 総合生理研究系 生体システム研究部門

業績Publications

  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007
  • 2006
  • 2005
  • 2004
  • 2003
  • 2002

2015

Original paper
Sano H, Murata H, Nambu A (2015) Zonisamide reduces nigrostriatal dopaminergic neurodegeneration in a mouse genetic model of Parkinson's disease. J Neurochemi (in press)
Reviews
Chiken S, Nambu A (2015) Mechanism of Deep Brain Stimulation: Inhibition, Excitation, or Disruption? The Neuroscientist (in press) doi: 10.1177/1073858415581986
Nambu A, Tachibana Y, Chiken S (2015) Cause of parkinsonian symptoms: Firing rate, firing pattern or dynamic activity changes? Basal Ganglia doi: 10.1016/j.baga.2014.11.001
Book chapter in Japanese
佐野裕美、小林和人、南部 篤(2015)大脳基底核による運動制御と病態生理.三品昌美編「分子脳科学:分子から脳機能と心に迫る」 化学同人 pp44-55
南部 篤(2015)強化学習. 里宇明元、牛場潤一(監)神経科学の最前線とリハビリテーション:脳の可塑性と運動. 医歯薬出版 pp31-36

2014

Original paper
Horie M, Watanabe K, Bepari AK, Nashimoto J, Araki K, Sano H, Chiken S, Nambu A, Ono K, Ikenaka K, Kakita A, Yamamura K, Takebayashi H (2014) Disruption of actin-binding domain-containing Dystonin protein causes dystonia musculorum in mice. Eur J Neurosci 40: 3458-3471. DOI: 10.1111/ejn.12711
Reviews
Chiken S, Nambu A (2014) Disrupting neuronal transmission: mechanism of DBS? Front Syst Neurosci 8:33. doi: 10.3389/fnsys.2014.00033
Nambu A, Tachibana Y (2014) Mechanism of parkinsonian neuronal oscillations in the primate basal ganglia: some considerations based on our recent work. Front Syst Neurosci 8:74 doi: 10.3389/fnsys.2014.00074
Book chapter
Nambu A (2014) Functional circuitry of the basal ganglia. Deep Brain Stimulation for Neurological Disorders. Ed. Itakura T, Springer, pp1-11
Nambu A, Chiken S (2014) Mechanism of DBS: Inhibition, Excitation, or Disruption? Deep Brain Stimulation for Neurological Disorders. Ed. Itakura T, Springer, pp13-20
Review in Japanese
橘 吉寿、彦坂 興秀、南部 篤 (2014) 大脳基底核の神経回路と行動選択. Clinical Neuroscience 32: 33-35
佐野 裕美、南部 篤 (2014) 無動、寡動、舞踏運動の病態生理. Clinical Neuroscience 32: 80-82
南部 篤、橘 吉寿 (2014) パーキンソン病と脳のオシレーション. Clinical Neuroscience 32: 768-771
Book chapter in Japanese
南部 篤(2014)大脳皮質と大脳基底核. 標準生理学第8版, 医学書院, pp 342-366
南部 篤(2014)大脳基底核. カンデル神経科学(訳書), メディカル•サイエンス•インターナショナル, pp 963-978

2013

Original paper
Chiken S, Nambu A (2013) High-frequency pallidal stimulation disrupts information flow through the pallidum by GABAergic inhibition. J Neurosci 33: 2268-2280. doi: 10.1523/JNEUROSCI.4144-11.2013.
Sano H, Chiken S, Hikida T, Kobayashi K, Nambu A (2013) Signals through the striatopallidal indirect pathway stop movements by phasic excitation in the substantia nigra. J Neurosci 33: 7583-7594. doi: 10.1523/JNEUROSCI.4932-12.2013.
Sotoyama H, Namba H, Chiken S, Nambu A, Nawa H (2013) Exposure to the cytokine EGF leads to abnormal hyperactivity of pallidal GABA neurons: implications for schizophrenia and its modeling. J Neurochemi 126: 518-528. doi: 10.1111/jnc.12223.
Chen S, Shin D, Watanabe H, Nakanishi Y, Kambara H, Yoshimura N, Nambu A, Isa T, Nishimura Y, Koike Y (2013) Prediction of hand trajectory from electrocorticography signals in primary motor cortex. PLoS One 8(12): e83534. DOI: 10.1371/journal.pone.0083534
Miyachi S, Hirata Y, Inoue K, Lu X, Nambu A, Takada M (2013) Multisynaptic projections from the ventrolateral prefrontal cortex to hand and mouth representations of the monkey primary motor cortex. Neurosci Res 76:141-149. DOI: 10.1016/j.neures.2013.04.004
Reviews
Obeso JA, Guridi J, Nambu A, Crossman A (2013) Motor manifestations and basal ganglia output activity: the paradox continues. Mov Disord 28: 416-418. doi: 10.1002/mds.25358
Takada M, Hoshi E, Saga Y, Inoue KI, Miyachi S, Hatanaka N, Inase M, Nambu A (2013) Organization of two cortico–basal ganglia loop circuits that arise from distinct sectors of the monkey dorsal premotor cortex. Basal Ganglia – An Integrative View. DOI: 10.5772/54822
Takada M, Inoue K, Koketsu D, Kato S, Kobayashi K, Nambu A (2013) Elucidating information processing in primate basal ganglia circuitry: a novel technique for pathway-selective ablation mediated by immunotoxin. Front Neural Circuits 7: 140. doi: 10.3389/fncir.2013.00140
Review in Japanese
南部 篤 (2013) 大脳基底核. 藤永保 (監修) 最新心理学事典 平凡社, pp492-494
南部 篤 (2013) 大脳基底核疾患の病態生理. 辻省次、高橋良輔 (編) パーキンソン病と運動異常 中山書店, pp12-20

2012

Original paper
Inoue KI, Koketsu D, Kato S, Kobayashi K, Nambu A, Takada M (2012) Immunotoxin-mediated tract targeting in the primate brain: selective elimination of the cortico-subthalamic "hyperdirect" pathway. PLoS ONE 7(6): e39149
Takahara D, Inoue KI, Hirata Y, Miyachi S, Nambu A, Takada M, Hoshi E (2012) Multisynaptic projections from the ventrolateral prefrontal cortex to the dorsal premotor cortex in macaques - anatomical substrate for conditional visuomotor behavior. Eur J Neurosci 36: 3365-3375
Shin D, Watanabe H, Kambara H, Nambu A, Isa T, Nishimura Y, Koike Y (2012) Prediction of muscle activities from electrocorticograms in primary motor cortex of primates. PLoS ONE 7(10): e47992
Watanabe H, Sato M, Suzuki T, Nambu A, Nishimura Y, Kawato M, Isa T (2012) Reconstruction of movement-related intracortical activity from micro-electrocorticogram array signals in monkey primary motor cortex. J Neural Eng 9:036006
Bepari AK, Sano H, Tamamaki N, Nambu A, Tanaka KF, Takebayashi H (2012) Identification of optogenetically activated striatal medium spiny neurons by Npas4 expression. PLoS ONE 7(12): e52783 DOI: 10.1371/journal.pone.0052783
Reviews
Nambu A (2012) GABA-B receptor: possible target for Parkinson's disease therapy. Exp Neurol 233: 121-122
Book chapter
Nambu A (2012) Dystonia. Neuroscience in the 21st Century. Eds Pfaff, Springer, vol 2: pp1143-1148
Review in Japanese
南部 篤 (2012) 大脳基底核疾患の病態生理. 臨床神経学 52:1198-1200
知見 聡美、南部 篤 (2012) 大脳基底核の運動制御における抑制性ニューロン. Clinical Neuroscience 30: 1381-1384
Book chapter in Japanese
南部 篤 (2012) モデルマウスの神経活動からジストニアの病態を考える. 長谷川一子 (編) ジストニア2012 中外医学社, pp194-202

2011

Original paper
Saga Y, Hirata Y, Takahara D, Inoue K, Miyachi S, Nambu A, Tanji J, Takada M, Hoshi E (2011) Origins of multisynaptic projections from the basal ganglia to rostrocaudally distinct sectors of the dorsal premotor area in macaques. Eur J Neurosci 33: 285-297
Nishibayashi H, Ogura M, Kakishita K, Tanaka S, Tachibana Y, Nambu A, Kita K, Itakura T (2011) Cortically evoked responses of human pallidal neurons recorded during stereotactic neurosurgery. Mov Disord 26: 469-476
Yumoto N, Lu X, Henry TR, Miyachi S, Nambu A, Fukai T, Takada M (2011) A neural correlate of the processing of multi-second time intervals in primate prefrontal cortex. PLoS ONE 6(4): e19168.
Takara S, Hatanaka N, Takada M, Nambu A (2011) Differential activity patterns of putaminal neurons with inputs from the primary motor cortex and supplementary motor area in behaving monkeys. J Neurophysiol 106: 1203-1217
Nishibayashi H, Nambu A, Tachibana Y, Itakura T (2011) Re; Cortically evoked responses of human pallidal neurons. Mov Disord 26: 2583-2584
Tachibana Y, Iwamuro H, Kita H, Takada M, Nambu A (2011) Subthalamo-pallidal interactions underlying parkinsonian neuronal oscillations in the primate basal ganglia. Eur J Neurosci 34: 1470-1484
Reviews
Nambu A (2011) Somatotopic organization of the primate basal ganglia. Front Neuroanat 5: 26
Nambu A, Chiken S, Shashidharan P, Nishibayashi H, Ogura M, Kakishita K, Tanaka S, Tachibana Y, Kita H, Itakura T (2011) Reduced pallidal output causes dystonia. Front Syst Neurosci 5: 89
Review in Japanese
南部 篤 (2011) 線条体における運動手続き記憶. Clinical Neuroscience 29: 172-176
南部 篤 (2011) 臨床に役立つ大脳基底核の解剖と生理. 神経治療学 28: 19-23
南部 篤 (2011) 大脳基底核における可塑性. Clinical Neuroscience 29: 782-786
南部 篤 (2011) 気になる脳部位 視床下核. 分子精神医学 11: 203-206

2010

Original paper
Hashimoto M, Takahara D, Hirata Y, Inoue KI, Miyachi S, Nambu A, Tanji J, Takada M, Hoshi E (2010) Motor and non-motor projections from the cerebellum to rostrocaudally distinct sectors of the dorsal premotor cortex in macaques. Eur J Neurosci 31: 1402-1413

2009

Original paper
Hatanaka N, Tokuno H, Nambu A, Takada M (2009) Transdural doppler ultrasonography monitors cerebral blood flow changes in relation to motor tasks. Cereb Cortex 19: 820-831.
Book Chapters
Nambu A (2009) Basal ganglia: physiological circuits. In: Squire LR (ed.) Encyclopedia of Neuroscience, volume 2, pp. 111-117. Oxford: Academic Press.
Nambu A (2009) Dynamic model of the basal ganglia functions and movement disorders. In: Nakanish S, Kageyama R, Watababe D (eds.) Systems Biology: The Challenge of Complexity, pp. 91-97. Springer, Tokyo
Nambu A, Hatanaka N, Takara S, Tachibana Y, Takada M (2009) Information processing in the striatum of behaving monkeys. The Basal Ganglia IX. Eds Groenewegen HJ, Voorn P, Berendse HW, Mulder AB, Cools AR, Springer, pp41-48
Iwamuro H, Tachibana Y, Sato N, Nambu A (2009) Organization of motor cortical inputs to the subthalamic nucleus in the monkey. The Basal Ganglia IX. Eds Groenewegen HJ, Voorn P, Berendse HW, Mulder AB, Cools AR, Springer, pp109-117
Takada M, Inoue K, Miyachi S, Okado H, Nambu A (2009) Prevention of calbindin recruitment into nigral dopamine neurons from MPTP-induced degeneration in Macaca fascicularis. The Basal Ganglia IX. Eds Groenewegen HJ, Voorn P, Berendse HW, Mulder AB, Cools AR, Springer, pp377-385
Review in Japanese
南部 篤 (2009) 直接路・間接路・ハイパー直接路の機能. Brain and Nerve 61: 360-372
南部 篤 (2009) 大脳基底核のsomatotopy. Brain and Nerve 61: 1383-1394
南部 篤 (2009) 大脳基底核における興奮性および抑制性アミノ酸による神経伝達. 生体の科学 60: 348-349
南部 篤 (2009) 大脳基底核の機能. Clinical Neuroscience 27: 769-773
知見 聡美、南部 篤 (2010) モデルマウスの神経活動からジストニアの病態を考察する. 実験医学 28(5) 661-666
南部 篤 (2009) 大脳皮質と大脳基底核. 標準生理学第7版 医学書院, pp 354-379

2008

Original paper
Tachibana Y, Kita H, Chiken S, Takada M, Nambu A (2008) Motor cortical control of internal pallidal activity through glutamatergic and GABAergic inputs in awake monkeys. Eur J Neurosci 27: 238-253
Chiken S, Shashidharan P, Nambu A (2008) Cortically evoked long-lasting inhibition of pallidal neurons in a transgenic mouse model of dystonia. J Neurosci 28: 13967-13977
Reviews
Nambu A (2008) Basal ganglia: physiological circuits. New Encyclopedia of Neuroscience

2007

Original paper
Kita H, Chiken S, Tachibana Y, Nambu A (2007) Serotonin modulates pallidal neuronal activity in the awake monkey. J Neurosci 27: 75-83
Lu X, Miyachi S, Ito Y, Nambu A, Takada M (2007) Topographic distribution of output neurons in cerebellar nuclei and cortex to somatotopic map of primary motor cortex. Eur J Neurosci 25: 2374-2382
Kanamatsua T, Otsuki T, Tokuno H, Nambuc A, Takada M, Okamoto K, Watanabe H, Umeda M, Tsukada Y (2007) Changes in the rates of the tricarboxylic acid (TCA) cycle and glutamine synthesis in the monkey brain with hemiparkinsonism induced by intracarotid infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): Studies by non-invasive 13C-magnetic resonance spectroscopy. Brain Res 1181: 142-148.
Reviews
Nambu A (2007) Globus Pallidus internal segment. GABA and the Basal Ganglia: From Molecules to Systems. Prog Brain Res 160. Eds Tepper JM, Abercrombie ED, Bolam JP, Elsevier, Amsterdam pp135-150
Review in Japanese
南部 篤 (2007) 大脳基底核をめぐる6つの問題 Annual Review神経 15-26
Book chapter in Japanese
南部 篤 (2007) 大脳基底核をめぐる6つの問題 Annual Review神経 15-26
南部 篤 (2007) 脳の損傷・病態モデルによる研究:パーキンソン病を中心に ブレイン・マシン・インターフェース 脳と機械をつなぐ,オーム社 pp126-138
南部 篤 (2007) 大脳基底核の神経回路から大脳基底核疾患の病態を理解する 神経変性疾患のサイエンス 南山堂 pp156-169

2006

Original paper
Kita H, Chiken S, Tachibana Y, Nambu A (2006) Origins of GABAA and GABAB receptor mediated responses of globus pallidus induced after stimulation of the putamen in the monkey. J Neurosci 26: 6554-6562
Miyachi S, Lu X, Imanishi M, Sawada K, Nambu A, Takada M (2006) Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex. Neurosci Res 56: 300-308
Review in Japanese
南部 篤 (2006) DBSに神経生理学が寄与できること 臨床脳波 48: 327-336
南部 篤 (2006) 人物往来 佐々木和夫 Clinical Neuroscience 24: 608

2005

Original paper
Miyachi S, Lu X, Inoue S, Iwasaki T, Koike S, Nambu A, Takada M (2005) Organization of multisynaptic inputs from prefrontal cortex to primary motor cortex as revealed by retrograde transneuronal transport of rabies virus. J Neurosci 25: 2547-2556
Kita H, Tachibana Y, Nambu A, Chiken S (2005) Balance of monosynaptic excitatory and disynaptic inhibitory responses of the globus pallidus induced after stimulation of the subthalamic nucleus in the monkey. J Neurosci 25: 8611-8619
Kaneda K, Tachibana Y, Imanishi M, Kita H, Shigemoto R, NambuA, Takada M (2005) Downregulation of metabotropic glutamate receptor 1a in globus pallidus and substantia nigra of parkinsonian monkeys. Eur J Neurosci 22: 3241-3254
Hatanaka N, Tokuno H, Nambu A, Inoue T, Takada M (2005) Input-output organization of jaw movement-related areas in monkey frontal cortex. J Comp Neurol 492: 401-425
Reviews
Nambu A (2005) A new approach to understand the pathophysiology of Parkinson's disease. J Neurol 252 [Suppl 4]: 1-4
Book chapter
Nambu A, Tachibana Y, Kaneda K, Tokuno H, Takada M (2005) Dynamic model of basal ganglia functions and parkinson's disease. The Basal Ganglia VIII. Eds Bolam JP, Ingham CA, Magill PJ, Springer pp307-312
Takada M, Kaneda K, Tachibana Y, Imanishi M, Kita H, Shigemoto R, Nambu A (2005) Down regulation of a metabotropic glutamate receptor in the parkinsonian basal ganglia. The Basal Ganglia VIII. Eds Bolam JP, Ingham CA, Magill PJ, Springer pp255-263
Kita H, Tachibana Y, Nambu A (2005) Glutamatergic and GABAergic control of pallidal activity in monkeys. The Basal Ganglia VIII. Eds Bolam JP, Ingham CA, Magill PJ, Springer pp545-554
Book chapter in Japanese
南部 篤 (2005) 大脳皮質と大脳基底核. 標準生理学第6版 医学書院 pp 359-386
南部 篤 (2005) 定位脳手術のための生理学. 定位脳手術入門 医学書院 pp19-33

2004

Original paper
Tachibana Y, Nambu A, Hatanaka N, Miyachi S, Takada M (2004) Input-output organization of the rostral part of the dorsal premotor cortex, with special reference to the corticostriatal projection. Neurosci Res 48: 45-57
Takada M, Nambu A, Hatanaka N, Tachibana Y, Miyachi S, Taira M, Inase M (2004) Organization of prefrontal outflow toward frontal motor-related areas in macaque monkeys. Eur J Neurosci 19: 3328-3342
Kita H, Nambu A, Kaneda K, Tachibana Y, Takada M (2004) Role of ionotropic glutamatergic and GABAergic inputs on the firing activity of neurons in the external pallidum in awake-monkeys. J Neurophysiol 92: 3069-3084
Book Chapter
Nambu A (2004) A New Dynamic Model of Cortico-Basal Ganglia Loop. Brain Mechanisms for the Integration of Posture and Movement. Prog Brain Res 143. eds Mori S, Stuart DG, Wiesendanger M, Elsevier, Amsterdam, pp461-466
Review in Japanese
南部 篤 (2004) 脳深部刺激療法の作用機序 21, 7 262-269
南部 篤 (2004) 定位脳手術のための生理学 脳神経外科 32: 179-191

2003

Original paper
Akazawa T, Takada M, Nambu A (2003) Activity and distribution patterns of monkey pallidal neurons in response to peripheral nerve stimulation. Neurosci Lett 339: 161-165
Fujiwara-Tsukamoto Y, Isomura Y, Nambu A, Takada M (2003) Excitatory GABA input directly drives seizure-like rhythmic synchronization in mature hippocampal CA1 pyramidal cells. Neuroscience 119: 265-275
Kaneda K, Imanishi M, Nambu A, Shigemoto R, Takada M (2003) Differential expression patterns of mGluRIα in monkey nigral dopamine neurons. Neuroscience 14: 947-950
Hatanaka N, Tokuno H, Hamada I, Inase M, Ito Y, Imanishi M, Hasegawa N, Akazawa T, Nambu A, Takada M (2003) Thalamocortical and intracortical connections of monkey cingulate motor areas. J Comp Nerurol 462: 121-138
Isomura Y, Ito Y, Akazawa T, Nambu A, Takada M (2003) Neural coding of "attention for action" and "response selection" in primate anterior cingulated cortex. J Neurosci 23: 8002-8012
Review in Japanese
南部 篤 (2003) 大脳基底核の動的モデルとパーキンソン病 機能的脳神経外科 42: 44-48
金澤 一郎、南部 篤、谷口 真、服部 信孝、村田 美穂、石井 賢二 (2003) パーキンソン病 (座談会) KINESIS 8: 2-18
南部 篤 (2003) 基底核の機能 BRAIN MEDICAL 15: 248-259

2002

Original paper
Isomura Y, Fujiwara-Tsukamoto Y,Imanishi M, Nambu A, Takada M (2002) Distance-dependent Ni2+-sensitivity of synaptic plasticity in apical dendrites of hippocampal CA1pyramidal cells. J Neurophysiol 87: 1169-1174
Kitano K, Cateau H, Kaneda K, Nambu A, Takada M, Fukai T (2002) Two-state membrane potential transitions of striatal spiny neurons as evidenced by numerical simulations and electrophysiological recordings in awake monkeys. J Neurosci
Kaneda K, Nambu A, Tokuno H, Takada M (2002) Differential processing patterns of motor information via striatopallidal and striatonigral projections. J Neurophysiol 88: 1420-1432
Nambu A, Kaneda K, Tokuno H, Takada N (2002) Organization of corticostriatal motor inputs in monkey putamen. J Neurophysiol 88: 1830-1842
Reviews
Nambu A, Tokuno H, Takada M(2002) Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathway. Neurosci Res 43: 111-117
Book Chapters
Nambu A, Tokuno H, Hamada I, Kita H, Imanishi M, Akazawa T, Ikeuchi Y, Hasegawa N (2002) Excitatorycortical inputs to pallidal neurons through the cortico-subthalamo-pallidal hyperdirect pathway in the monkey. The Basal GangliaVI. eds Graybiel, DeLong MR, Kitai ST, Kluwer Academic/Plenum Publishers, New York, pp217-223
Takada M, Hamada I, Tokuno H, Inase M Ito Y, Hasegawa N, Ikeuchi Y, Imanishi M, Akazawa T, Hatanaka N, Nambu A (2002) Corticostriatal projections from the cingulate motor areas in the macaque monkey. The Basal Ganglia VI. eds Graybiel, DeLong MR, Kitai ST, Kluwer Academic/Plenum Publishers, New York, pp419-428
Yamaji Y, Matsumura M, Kojima J,Tokuno H, Nambu A, Inase M, Imai H, Takada M (2002) Differential reductions in dopaminergic innervation of the motor-related areas of the frontal lobe in MPTP-treated monkeys. The Basal Ganglia VI. eds Graybiel, DeLong MR, Kitai ST, Kluwer Academic/Plenum Publishers, New York, pp159-167
Nambu A, Kaneda K, Tokuno H, Takada M (2002) Partly converging but largely segregated corticostriatal projections from the primary motor cortex and the supplementary motor area. The Basal Ganglia VII. eds Nicholson LFB, Faul RLM, Kluwer Academic/Plenum Publishers, New York, pp147-153
Takada M, Matsumura M, Kojima J, Yamaji Y, Inase M, Tokuno H, Nambu A, Imai H (2002) Protection against nigrostriatal dopamine cell death by pedunculopontine tegmental nucleus lesions. The Basal Ganglia VII. eds Nicholson LFB, Faul RLM, Kluwer Academic/Plenum Publishers, New York, pp67-76
Review in Japanese
高田 昌彦、南部 篤 (2002) 皮質 - 視床下核投射の機能的意義. 脳の科学 24, 437-444
南部 篤 (2002) 大脳基底核の機能 - パーキンソン病理解のために. 臨床リハ 12: 1095-1101
南部 篤 (2002) 大脳基底核の動的モデルとパーキンソン病. 機能的脳神経外科 41: 98-99

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