業績Publication
2014
- Yamaoka M, Maeda N*, Takayama Y, Sekimoto R, Tsushima Y, Matsuda K, Mori T, Inoue K, Nishizawa H, Tominaga M, Funahashi T, Shimomura I.
Adipose hypothermia in obesity and its association with period homolog 1, insulin sensitivity, and inflammation in fat.
PLoS One. 14;9(11):e112813, 2014, Nov.
PMID:25397888
- Banzawa N, Saito S, Imagawa T, Kashio M, Takahashi K, Tominaga M, Ohta T*.
Molecular Basis Determining Inhibition/Activation of Nociceptive Receptor TRPA1: A Single Amino Acid Dictates Species-specific Actions of the Most Potent Mammalian TRPA1 Antagonists.
J Biol Chem. 289(46):31927-31939, 2014, Nov
PMID:25271161
- Uchida K*, Tominaga M*.
The role of TRPM2 in pancreatic β-cells and the development of diabetes.
Cell Calcium. 56:332-339, 2014, Nov.
PMID:25084624
Review,査読有
- Kurganov E, Zhou Y, Saito S, Tominaga M*.
Heat and AITC Activate Green Anole TRPA1 in a Membrane-Delimited Manner.
Pflugers Arch - Eur J Physiol. 466:1873-1884, 2014, Oct.
PMID:24385018
- Yoshida M, Dezaki K, Uchida K, Kodera S, Lam NV, Ito K, Rita RS, Yamada H, Shimomura K, Ishikawa SE, Sugawara H, Kawakami M, Tominaga M, Yada T, Kakei M*.
Involvement of cAMP-EPAC-TRPM2 activation in glucose- and incretin-induced insulin secretion.
Diabetes 63(10):3394-3403, 2014, Oct.
PMID:24824430
- Okada Y*, Shirai K, Reinach PS, Kitano-Izutani A, Miyajima M, Flanders KC, Jester JV, Tominaga M, Saika S.
TRPA1 is required for TGF-β signaling and its loss blocks inflammatory fibrosis in mouse corneal stroma.
Lab Invest. 94(9):1030-1041, 2014, Sep.
PMID:25068659
- Yamawaki H, Mihara H, Suzuki N, Nishizono H, Uchida K, Watanabe S, Tominaga M, Sugiyama T*.
Role of transient receptor potential vanilloid 4 activation in indomethacin-induced intestinal damage.
Am J Physiol Gastrointest Liver Physiol. 1;307(1):G33-40. 2014, Jul.
PMID:24789205
- Mizuno H, Suzuki Y*, Watanabe M, Sokabe T, Yamamoto T, Hattori R, Gotoh M, Tominaga M*.
Potential role of transient receptor potential (TRP) channels in bladder cancer cells.
J Physiol Sci. 64(4):305-314, 2014, July.
PMID:24849279
- Miyamoto T, Mochizuki T*, Nakagomi H, Kira S, Watanabe M, Takayama Y, Suzuki Y, Koizumi S, Takeda M, Tominaga M*.
Functional role for Piezo1 in stretch-evoked Ca2+ influx and ATP release in urothelial cell cultures.
J Biol Chem. 289(23):16565-16575, 2014, Jun.
PMID:24759099
- Takayama Y, Shibasaki K, Suzuki Y, Yamanaka A, Tominaga M*.
Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1.
FASEB J. 28(5):2238-2248, 2014, May.
日本語要旨
PMID:24509911
- Shibasaki K*, Ikenaka K, Tamalu F, Tominaga M, Ishizaki Y.
A novel subtype of astrocytes expressing TRPV4 regulates neuronal excitability via release of gliotransmitters.
J Biol Chem.289(21):14470-14480, 2014, May.
表紙を飾りました!
PMID:24737318
- Tabuchi S, Tsunematsu T, Black SW, Tominaga M, Maruyama M, Takagi K, Minokoshi Y, Sakurai T, Kilduff TS, Yamanaka A.
Conditional Ablation of Orexin/Hypocretin Neurons: A New Mouse Model for the Study of Narcolepsy and Orexin System Function.
J Nerosci. 34(19):6495-6509, 2014, May.
PMID:24806676
- Sato A, Sokabe T, Kashio M, Yasukochi Y, Tominaga M, Shiomi K*.
Embryonic thermosensitive TRPA1 determines transgenerational diapause phenotype of the silkworm, Bombyx mori.
PNAS. 111(13):E1269-1255, 2014, Apr.
日本語要旨
PMID:24639527
- Saito S*, Banzawa N, Fukuta N, Saito CT, Takahashi K, Imagawa T, Ohta T, Tominaga M*.
Heat and noxious chemical sensor, chicken TRPA1, as a target of bird repellents and identification of its structural determinants by multispecies functional comparison.
Mol Biol Evol 31(3):708-722, 2014, Mar.
日本語要旨
PMID: 24398321
- Terada Y, Horie S, Takayama H, Uchida K, Tominaga M, Watanabe T.
Activation and Inhibition of Thermosensitive TRP Channels by Voacangine, an Alkaloid Present in Voacanga africana, an African Tree.
J Nat Prod. 77(2):285-297, 2014, Feb.
PMID:24484240
- Hirai T, Enomoto M*, Kaburagi H, Sotome S, Yoshida-Tanaka K, Ukegawa M,
Kuwahara H, Yamamoto M, Tajiri M, Miyata H, Hirai Y, Tominaga M, Shinomiya K, Mizusawa H, Okawa A, Yokota T*.
Intrathecal AAV serotype 9-mediated delivery of shRNA against TRPV1 attenuates thermal hyperalgesia in a mouse model of peripheral nerve injury.
Mol. Ther. 22(2):409-419, 2014, Feb.
PMID:24322332
- Takaishi M, Uchida K, Fujita F*, Tominaga M*.
Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity.
J Physiol. Sci. 64(1):47-57, 2014, Jan.
PMID:24122170
和文著書、和文総説
- 富永真琴,“TRPチャネルと疼痛”ファインケミカル 43(1),6-11, 2014
- 富永真琴,“TRPチャネルの新たな役割” 脳21 17(2),39-43, 2014
- 富永真琴,“脳内温度・浸透圧の感知メカニズムとその破綻” 脳内環境-維持機構と破綻がもたらす疾患研究 136-141,2014
- 加塩麻紀子,富永真琴,“レドックス・センサーTRPチャネルと炎症” 臨床免疫・アレルギー 62(6),619-653,2014
国際会議発表リスト
- S.Saito, "Molecular basis for the specific differences in heat receptor
TRPV1 related to thermal adaptation in Xenopus species" SMBE2014 annual meeting of Society for Molecular Biology
and Evolution, San Juan(Puerto Rico) June 2014.
- M. Tominaga, "A pain-enhancing mechanism through interaction between TRP channels and anoctamines" 9th International Conference for Neurons and Brain Disease, Madrid (Spain), July 2014.
- H. Kittaka, " Involvement of lysophosphatidic acid-evoked activation of TRPA1 and TRPV1 in peripheral itch sensation in mice" 24th International Symposium of Itch, Tokyo (Japan), August 2014.
- M. Tominaga, "Functional Regulation of TRPM5 and TRPA1" The 11th International Symposium on Molecular and Neural Mechanisms of taste and Olfactory Perception, Fukuoka (Japan), October 2014.
- M. Tominaga, "Functional Interaction between TRP channels and Anoctamin1" The 12th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, Fukuoka (Japan), November 2014.
- Y. Takayama, "A pain-enhancing mechanism through TRPA1-ANO1 interaction, and its inhibition effect by drag" Neuroscience2014, Washington D.C. (USA), November 2014.
- M. Tominaga, "Molecular mechanisms for detecting noxious stimuli in the peripheral nerve endings" New Directions in Pain Neuroscience, Osaka (Japan), December 2014.
招待講演
- 富永真琴「温度感受性TRPチャネルの生理機能」、第51回日本小児外科学会学術大会、大阪、2014年5月.
- 富永真琴「TRPチャネルと痛覚を含む口腔内感覚」、第56回歯科基礎医学会学術大会、福岡、2014年9月.
- 富永真琴「温度感受性TRPチャネルの生理機能」、横浜北部消化器病研究会、横浜、2014年10月.
- 富永真琴「温度感受性チャネル・機械刺激感受性チャネルの生理機能」、第87回日本泌尿器科学学会山梨地方会サテライトシンポジウム、山梨、2014年11月.
バナースペース
生命創成探究センター
温度生物学研究G
(生理学研究所 細胞生理研究部門)