業績Publication
2024
- Guo Z, Murakami M, *Saito K, Kato H, Toriyama M, Tominaga M, Ishii KJ, *Fujita F.
Integrin α5 regulates motility of human monocyte-derived Langerhans cells during immune response.
Exp Dermatol. 33(3):e15021. 2024.
PMID: 38429832.
- Ohnishi K, *Sokabe T, Miura T, Tominaga M, *Ohta A, *Kuhara A.
G protein-coupled receptor-based thermosensation determines temperature acclimatization of Caenorhabditis elegans.
Nat Commun. 15(1):1660. 2024
PMID: 38396085
<プレスリリース(生理研)>
<プレスリリース(ExCELLS)>
- #Ujisawa T, #Lei J, Kashio M, *Tominaga M.
Thermal gradient ring for analysis of temperature-dependent behaviors involving TRP channels in mice.
J Physiol Sci. 74(1):9. 2024.
PMID: 38331738.
#Contributed equally.
<Review>
- *Takayama Y, Tominaga M.
Phosphorylated TRPV1 and ANO1/TMEM16A interaction induced by low concentration of capsaicin or innocuous heat stimulation.
Pain Res. 39: 1-8. 2024.
2023
- Sato Sh, Magaji A, Tominaga M, *Sokabe T.
Avoidance of thiazoline compound depends on multiple sensory pathways mediated by TrpA1 and ORs in Drosophila
Front. Mol. Neurosci. 16:1249715. 2023.
PMID: 38188198
<プレスリリース(生理研)>
<プレスリリース(ExCELLS)>
- Yoshimura A, *Saito S, Saito CT, Takahashi K, Tominaga M, *Ohta T.
Functional analysis of thermo-sensitive TRPV1 in an aquatic vertebrate, masu salmon (Oncorhynchus masou ishikawae).
Biophys Rep. 31:101315. 2023.
PMID: 35898728
- Lei J, Yoshimoto RU, Matsui T, Amagai M, Kido MA, *Tominaga M.
Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice.
Nat Commun. 14(1):4104. 2023.
PMID: 37474531
<プレスリリース(生理研)>
<プレスリリース(ExCELLS)>
- Saito KO, Fujita F, Toriyama M, Utami RA, Guo Z, Myrakami M, Kato H, Suzuki Y, Okada F, Tominaga M, *Ishii KJ.
Roles of TRPM4 in immune responses in keratinocytes and identification
of a novel TRPM4-activating agent.
Biochem. Biophys. Res. Commun. 654: 1-9, 2023.
PMID: 36871485.
- Matsumoto K, Kamide M, Uchida K, Takahata M, Shichiri R, Hida Y, Taniguchi Y, Ohishi A, Tominaga M, Nagasawa K, Kato S.
Transient Receptor Potential Ankyrin 1 in Taste Nerve Contributes to the Sense of Sweet Taste in Mice.
Biol Pharm Bull. 46(7):939-945. 2023.
PMID: 37394645.
- Shimizu T, Fujii T, Hanita K, Shinozaki R, Takamura Y, Suzuki Y, Kageyama T, Kato M, Nishijo H, Tominaga M, *Sakai H.
Polycystic kidney disease 2-like 1 channel contributes to the bitter aftertaste perception of quinine.
Sci Rep. 13(1):4271. 2023.
PMID: 36922541.
- *Otsuka Saito K, Fujita F, Toriyama M, Utami RA, Guo Z, Murakami M, Kato H, Suzuki Y, Okada F, Tominaga M, *Ishii KJ.
Roles of TRPM4 in immune responses in keratinocytes and identification of a novel TRPM4-activating agent.
Biochem Biophys Res Commun. 654:1-9.2023.
PMID: 36871485.
- *Kashio M, *Tominaga M.
Role of novel de novo gain-of-function TRPM3 mutations in a spectrum of neurodevelopmental disorders.
Cell Calcium. 110:102704. 2023.
PMID: 36804759.
<総説>
- Yamanoi Y, Lei J, Takayama Y, Hosogi S, Marunaka Y, *Tominaga M.
TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes.
Commun Biol. 6(1):88.2023
PMID: 36690845
Natre Portfolio Communitiesに「behind the paper」として掲載されました。
<プレスリリース(生理研)>
<プレスリリース(ExCELLS)>
- Atsumi Y, *Toriyama M, Kato H, Nakamura M, Morita A, Takaishi M, Saito K, Tanaka M, Okada F, Tominaga M, *Ishii KJ, *Fujita F.
Anti-Inflammatory Role of TRPV4 in Human Macrophages.
Immunohorizons. 7(1):81-96. 2023
PMID: 36645854.
2022
- Kasahara Y, Narukawa M, Takeuchi A, Tominaga M, Abe K, Asakura T.
Molecular logic of salt taste reception in special reference to transmembrane channel-like 4 (TMC4).
J Physiol Sci. 72(1):31. 2022
PMID: 36451105.
review
- *Sokabe T, Bradshaw HB, Tominaga M, Leishman E, Chandel A, *Montell C.
Endocannabinoids produced in photoreceptor cells in response to light activate
Drosophila TRP channels.
Sci Signal. 15(755):eabl6179. 2022
PMID: 36219683.
<プレスリリース>
- Sugino S, *Inoue K, Kobayashi R, Hirose R, Doi T, Harusato A, Dohi O, Yoshida N, Uchiyama K, Ishikawa T, Takagi T, Yasuda H, Konishi H, Hirai Y, Mizushima K, Naito Y, Tsuji T, Okuda T, Kagawa K, Tominaga M, Itoh Y.
Association Between the Cool Temperature-dependent Suppression of Colonic Peristalsis and Transient Receptor Potential Melastatin 8 Activation in Both a Randomized Clinical Trial and an Animal Model.
J Neurogastroenterol Motil.28(4):693-705. 2022
PMID: 36250375
- *Kashio M, Masubuchi S, Tominaga M.
Protein kinase C (PKC)-mediated phosphorylation of TRPM2 Thr738 counteracts
the effect of cytosolic Ca2+ and elevates the temperature threshold.
J Physiol. 2022 Aug 30. doi: 10.1113/JP283350. Epub ahead of print.
PMID: 36042566.
<プレスリリース>
- *Saito S, Saito CT, Igawa T, Takeda N, Komaki S, Ohta T, Tominaga M.
Evolutionary tuning of TRPA1 underlies the variation in heat avoidance behaviors among frog species inhabiting diverse thermal niches.
Mol Biol Evol 39: msac180. 2022
doi: 10.1093/molbev/msac180. Epub ahead of print.
PMID: 35994363.
<プレスリリース>
- Suito T, Nagao K, Juni N, Hara Y, Sokabe T, Atomi H, *Umeda M.
Regulation of thermoregulatory behavior by commensal bacteria in Drosophila.
Biosci Biotechnol Biochem.86(8):1060-1070. 2022
doi: 10.1093/bbb/zbac087.
PMID: 35671161
- *Suito T, *Nagao K, Kai M, Juni N, Sokabe T, Umeda M.
Measurement of Thermoregulatory Behavior in Drosophila melanogaster.
Behavioral Neurogenetics, Neuromethods, vol 181, 77-91, 2022.
DOI: 10.1007/978-1-0716-2321-3_6
book chapter
- Yoshimura A, *Saito S, Saito CT, Takahashi K, Tominaga M, *Ohta T.
Functional analysis of thermo-sensitive TRPV1 in an aquatic vertebrate, masu salmon (Oncorhynchus masou ishikawae).
Biochem Biophys Rep. 31:101315. 2022
PMID: 35898728
<プレスリリース>
- Nguyen THD, Chapman S, Kashio M, Saito C, Strom T, Yasui M, *Tominaga M.
Single amino acids set apparent temperature thresholds for heat-evoked activation of mosquito transient receptor potential channel TRPA1.
J Biol Chem. 102271. 2022
PMID: 35850302.
<プレスリリース>
- Maruyama K.
Senso-immunology: crosstalk between nociceptive and immune systems.
FEBS J. 289(14):4132-4145. 2022
PMID: 33780155.
review
- Sasajima S, Kondo M, Ohno N, Ujisawa T, Motegi M, Hayami T, Asano S, Asano-Hayami E, Nakai-Shimoda H, Inoue R, Yamada Y, Miura-Yura E, Morishita Y, Himeno T, Tsunekawa S, Kato Y, Nakamura J, Kamiya H, *Tominaga M.
Thermal gradient ring reveals thermosensory changes in diabetic peripheral neuropathy in mice.
Sci Rep. 12(1):9724. 2022
PMID: 35697861
- Nakamura T, Sakamoto J, Okabe K, Taniguchi A, Yamada TG, Nonaka S, Kamei Y, Funahashi A, Tominaga M, Hiroi NF.
Temperature elevation detection in migrating cells.
Optics Contin. 1:1085-1097.2022
<プレスリリース>
- Ujisawa T, Sasajima S, Kashio M, *Tominaga M.
Thermal gradient ring reveals different temperature-dependent behaviors in mice lacking thermosensitive TRP channels.
J Physiol Sci. 72(1):11. 2022
PMID: 35624442
- *Kashio M, *Tominaga M.
TRP channels in thermosensation.
Curr Opin Neurobiol. 75:102591. 2022
PMID: 35728275
review
- *Boudaka A, Tominaga M.
Physiological and Pathological Significance of Esophageal TRP Channels: Special Focus on TRPV4 in Esophageal Epithelial Cells.
Int J Mol Sci. 23(9):4550. 2022
PMID: 35562940
review
- Hiramatsu Y, Suzuki K, Nishida T, Onoda N, Satoh T, Akira S, Ikawa M, Ikeda H, Kamei J, Derouiche S, Tominaga M, Horiguchi Y.
The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model.
mBio. 13(2):e0319721. 2022
Erratum in: mBio. 13(3):e0144622.2022
PMID: 35357202
- Sugisawa E, Kondo T, Kumagai Y, Kato H, Takayama Y, Isohashi K, Shimosegawa
E, Takemura N, Hayashi Y, Sasaki T, Martino MM, Tominaga M, *Maruyama K.
Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia.
Cell Rep. 8;38(10):110462. 2022
PMID: 35263589.
<プレスリリース>
- Derouiche S, Li T, Sakai Y, Uta D, Aoyagi S, *Tominaga M.
Inhibition of TRPV1 and TRPA1 by mosquito and mouse saliva.
Pain. 163(2):299-307, 2022
PMID: 33990108
<プレスリリース>
- Okumo T, Takayama Y, Maruyama K, Kato M, Sunagawa M.
Senso-Immunologic Prospects for Complex Regional Pain Syndrome Treatment.
Front Immunol. 12:786511. 2022
PMID: 35069559
review
英文著書
和文著書、和文総説
- 富永真琴
侵害受容体TRPV1,TRPA1, TRPM3 臨床麻酔「臨時増刊号」2024-3:341-349.
- 曽我部隆彰
「ショウジョウバエから見つかってきた新たな温度受容メカニズム」生物の科学 遺伝78 (2): 112-117. 2024
- 加塩麻紀子
「温度感受性TRPチャネル」生物の科学 遺伝78 (2): 99-104. 2024
- 富永真琴
特集「温度・機械刺激受容の最前線」総論「温度感受性TRPチャネルと機械刺激受容体のpiezoチャネルの発見と研究の進歩」生物の科学 遺伝78 (2): 96-98. 2024
- 加塩麻紀子
温度感受性TRPチャネルによる外界温・体温の受容と生理機能 Medical Science Digest 50 (1): 10-13. 2023
- 富永真琴
Piezoチャネル、TRPチャネルの発見 肥満研究 29 (1):8-12. 2023
- 富永真琴
肝をひやすとは? CLINICAL NEUROSCIENCE 41 (7):975. 2023
- 富永真琴
侵害受容体 TRPV1 麻酔 72: S105-S110. 2023
- 富永真琴
特集「温度応答性と生命現象」 Medical Science Digest 50 (1): 3-5. 2023
- 水藤拓人,長尾耕治郎,梅田眞郷
「昆虫の体温調節行動を司る因子」実験医学 vol.40 No.19 (12月号)(2022)
DOI: 10.18958/7175-00001-0000315-00
- 笹島沙知子、富永真琴
カプサイシンレセプター 糖尿病・内分泌代謝科 55: 617-622, 2022.
- 富永真琴
基礎から学ぶ麻酔科学ノート「TRPV1と侵害受容器」Anet 26(3)22-25, 2022.
- 富永真琴
痒みとTRPチャネル 医学のあゆみ「痒みはどこまでわかったか – 痒み研究の最前線」282 (13): 1115-1119, 2022.
- 富永真琴
Piezoチャネル、TRPチャネルと触覚 医学のあゆみ「五感を科学する」282 (6): 684-688, 2022.
- 富永真琴
David Julius, Ardem Patapoutrian (2021) 温度と触覚の受容体の発見 CLINICAL NEUROSCIENCE 40 (8): 1025-1027, 2022.
- 富永 真琴
「温度感受性TRPチャネル」生化学 94(2) 236-257 (2022)
- 水藤拓人, 曽我部隆彰
「ショウジョウバエの温度選好性を決める温度受容体と制御因子の解析 」
昆虫と自然 57(2) 29-32 2022年1月
- 富永真琴
TRPチャネル、アノクタミン1の機能連関の生理機能と作用物質の有用性 化学工業 73 (7): 444-447, 2022.
- 富永真琴
温度と味(第4節) 「味以外のおいしさの科学」 第2編「食環境とおいしさ」第4章「食の属性とおいしさ」pp.303-308, 2022.
国際会議発表リスト
招待講演
バナースペース
生命創成探究センター
温度生物学研究G
(生理学研究所 細胞生理研究部門)