業績Publication
2016
- Yamamoto A, Takahashi K, Saito S, Tominaga M, Ohta T.*
Two different avian cold-sensitive sensory neurons: Transient receptor potential melastatin 8 (TRPM8)-dependent and -independent activation mechanisms.
Neuropharmacology 111: 130-141, 2016. Dec
PMID:27590914
- Gupta R, Saito S*, Mori Y, Itoh SG, Okumura H, Tominaga M*.
Structural basis of TRPA1 inhibition by HC-030031 utilizing species-specific differences.
Sci Rep. 6, Article number: 37460, 2016 Nov.
PMID: 27874100
- Peng G#, Kashio M#, Li T, Dong X, Tominaga M, Kadowaki T*.
TRPA1 Channels in Drosophila and Honey Bee Ectoparasitic Mites Share Heat Sensitivity and Temperature-Related Physiological Functions
Front. Physiol., 05 October 2016
PMID:27761115
#These authors have contributed equally to this work.
- Sun W, Uchida K*, Takahashi N, Iwata Y, Wakabayashi S, Goto T, Kawada T, Tominaga M*.
Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes.
Pflugers Arch. 468(9):1527-40, 2016. Sep.
PMID:27318696
- Kaimoto T, Hatakeyama Y, Takahashi K, Imagawa T, Tominaga M, Ohta T.
Involvement of transient receptor potential A1 channel in algesic and analgesic actions of the organic compound limonene.
Eur. J. Pain 20: 1155-1165, 2016. Aug
PMID:27030509
- Zhong J#, Amina S#, Liang M#, Akther S, Yuhi T, Nishimura T, Tsuji C, Tsuji
T, Liu H-X, Hashii M, Furuhara K, Yokoyama S, Yamamoto Y, Okamoto H, Zhao
YJ, Lee HC, Tominaga M, Lepatina O, Higashida K*.
Cyclic ADP-ribose and heat regulate oxytocin release via CD38 and TRPM2 in the hypothalamus during social or psychological stress in mice.
Front. Neurosci. 10: 304, 2016.
PMID:27499729
- Mihara H, Suzuki N, Boudaka AA, Muhammad JS, Tominaga M, Tabuchi Y, Sugiyama T
Transient receptor potential vanilloid 4-dependent calcium influx and ATP
release in mouse and rat gastric epithelia.
World J Gastroenterol. 22(24):5512-5519, 2016. Jun.
PMID:27350729
- Dong X#, Kashio M#, Peng G, Wang X, Tominaga M, Kadowaki T*.
Isoform-specific modulation of the chemical sensitivity of conserved TRPA1 channel in the major honeybee ectoparasitic mite, Tropilaelaps ercedesae.
# equal contribution
Open Biol. 6(6), 2016, Jun.
PMID:27307515
- Okuda H, Noguchi A, Kobayashi H, Kondo D, Harada KH, Youssefian S, Shioi H, Kabata R, Domon Y, Kubota K, Kitano Y, Takayama Y, Hitomi T, Ohno K, Saito Y, Asano T, Tominaga M, Takahashi T*, Koizumi A*.
Infantile Pain Episodes Associated with Novel Nav1.9 Mutations in Familial Episodic Pain Syndrome in Japanese Families
PLoS One. 25;11(5):e0154827, 2016, May
PMID:27224030
- Yoshida A, Furube E, Mannari T, Takayama Y, Kittaka H, Tominaga M, Miyata S*.
TRPV1 is crucial for proinflammatory STAT3 signaling and thermoregulation-associated pathways in the brain during inflammation.
Sci Rep. 18;6:26088, 2016, May
PMID:27188969
- Saito S*, Ohkita M, Saito CT, Takahashi K, Tominaga M, Ohta T*.
Evolution of Heat Sensors Drove Shifts in Thermosensation between Xenopus Species Adapted to Different Thermal Niches
J. Biol. Chem. 20;291(21):11446-59, 2016,May.
PMID:27022021
日本語要旨;生理研研究報告
- Takaishi M, Uchida K, Suzuki Y, Matsui H, Shimada T, Fujita F*, Tominaga M*.
Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8.
J. Physiol. Sci. 66(2):143-155, 2016, Mar.
PMID:26645885
- Sun W, Uchida K*, Suzuki Y, Zhou Y, Kim M, Takayama Y, Takahashi N, Goto T, Wakabayashi S, Kawada T, Iwata Y, Tominaga M*.
Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue
EMBO Rep. 17(3):383-399,2016, Mar.
PMID:26882545
日本語要旨
- Uchida, K.#*, Demirkhanyan, L.#, Asuthkar, S., Cohen, A., Tominaga, M., Zakharian, E.*
Stimulation dependent gating of TRPM3 channel in a planar lipid bilayer
# equal contribution
FASEB J. 30(3):1306-1316, 2016, Mar.
PMID:26655382
日本語要旨
- Demirkhanyan L, Uchida K, Tominaga M, *Zakharian E.
TRPM3 gating in planar lipid bilayers defines peculiar agonist specificity.
Channels (Austin). 10(4):258-60, 2016 Jul.
PMID:26901668
autocommentary
和文著書、和文総説
- 富永真琴,“わさびで「つーん」とするのはなぜですか?” Clinical Neuroscience 34, 483(2016).
- 富永真琴,“温度感受性TRP チャネルと脳機能” 日本神経精神薬理学雑誌 36, 37-41(2016).
- 富永真琴,“温度感受性TRP チャネルと亜鉛による制御” 亜鉛栄養治療 7, 14-19(2016).
- 富永真琴,“辛み感覚とTRP チャネル/anoctamin 1 の機能連関” 日本味と匂学会雑誌23, 111-117(2016).
国際会議発表リスト
- E. Kurganov, "Extracellular Ca2+ is required in the heat-evoked activation
of green anole TRPA1" Advances & Breakthroughs in Calcium Signaling,
Honolulu (USA), April 2016.
- S. Derouiche, "Functional interaction between TRPV4 and anoctamin
1 in salivary and lacrimal glands" Advances & Breakthroughs in
Calcium Signaling, Honolulu (USA), April 2016.
- Y. Suzuki, "Involvement of TRPM7 in the intercellular junction formation
in mouse urothelium" Advances & Breakthroughs in Calcium Signaling,
Honolulu (USA), April 2016.
- M. Tominaga, "Functional interaction between TRP channels and anoctamin1" 6th Oxidative Stress, Calcium Signaling
and TRP Channels World Congress, Isparta (Turkey), May 2016.
- M. Tominaga, "Involvement of the Interaction between TRP Channels and Anoctamin1 in the Pungent Sensation" 17th
International Symposium on Olfaction and Taste (ISOT2016) Satellite Symposium, Tokyo (Japan), June 2016.
- Y. Takayama, "TRPV1-ANO1 interaction enhances HOT taste?" 17th International Symposium on Olfaction and Taste
(ISOT2016), Yokohama (Japan), June 2016.
- W. Sun, "Absence of TRPV2 impaired BAT thermogenesis in mice" 17th International Symposium on Olfaction and
Taste (ISOT2016), Yokohama (Japan), June 2016.
- S. Saito, "Evolutionary trajectory of a heat sensor TRPV1 in clawed frogs inferred from multispecies comparison and
ancestral protein reconstruction" Society for Molecular Biology and Evolution Conference 2016, Gold Coast (Australia),
July 2016.
- M. Tominaga, "Functional interaction between TRPV4 and anoctamin1 causes water efflux in choroid plexus epithelial
cells" Physiology2016, Dublin (Ireland), July 2016.
- Y. Takayama, "Interaction of transient receptor potential vanilloid 1 and anoctamin 1 in primary sensory neurons"
Physiology2016, Dublin (Ireland), July 2016.
- M. Tominaga, "Pungent sensation through TRP channels in the oral cavity" 27th Annual Meeting of the European
Chemoreception Research Organization(ECRO2016), Athens (Greece), September 2016.
- M. Tominaga, "Ion channels and channelopathies for acute and chronic pain" International Association for the Study of
Pain (IASP2016), Yokohama (Japan), September 2016.
- M. Tominaga, "Basic Mechanisms / Neurobiology Acute and Chronic Pain" International Association for the Study of
Pain (IASP2016), Yokohama (Japan), September 2016.
- Y. Takayama, "Interaction of TRPV1 and ANO1 in DRG neurons" International Association for the Study of Pain
(IASP2016), Yokohama (Japan), September 2016.
- R. Gupta, "Structural basis for TRPA1 inhibition by HC-030031 utilizing species-specific differences" International
Symposium on Regulation of Cell Functions by Transient Receptor Potential Channels, Landwirtschaft (Germany),
September 2016.
- H. Kittaka, "The molecular mechanism of itch and the involvement of TRP channels" 26th International Symposium of
Itch, Tokyo (Japan), October 2016.
- H. Kittaka, "Identification of the molecular target of crotamiton, an anti-itch agent" Neuroscience2016, San Diego
(USA), November 2016.
- S. Saito, "Evolutionary changes in thermoTRP channels contributed
to species diversity in thermal nociception in vertebrates" Joint
Meeting of the 22nd International Congress of Zoology & the 87 Meeting
of the Zoological Society of Japan, Onnason & Ginowan (Japan), November
2016.
- M. Tominaga, "Structural basis for inhibition of wasabi receptor TRPA1 by HC-030031" The 15th International
Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, Fukuoka (Japan), December 2016.
招待講演
- 富永真琴「温度生物学と温度感受性TRP チャネル」,第2 回山梨医学フォーラム,山梨,2016 年6 月.
- 富永真琴「温度感受性TRP チャネルを介した温度感知メカニズム」,日本睡眠学会第20 回睡眠科学研究講座,
東京,2016 年7 月.
- 富永真琴「温度感受性TRP チャネルと亜鉛による制御」,第13 亜鉛栄養治療研究会,大阪,2016 年8 月.
- 富永真琴「口の中で辛みと温度を感じるメカニズム」,第24 回「脳の世紀」シンポジウム,東京,2016 年9 月.
- 富永真琴「温度感受性TRP チャネルの構造と機能」,日本脳神経外科学会第75 回学術総会,福岡,2016 年
10 月.
- 富永真琴「TRP チャネルを介した痒み・痛み刺激感知機構」,第68 回日本皮膚科学会西部支部学術大会,米子,
2016 年11 月.
- 富永真琴「温度感受性TRP チャネルの生理機能と創薬標的としての意義」,第38 回生体膜と薬物の相互作用
シンポジウム,名古屋,2016 年11 月.
バナースペース
生命創成探究センター
温度生物学研究G
(生理学研究所 細胞生理研究部門)