Research
Elucidation of the Molecular Basis and Physiological Significance of Sensory Function, and the Creation of Novel Pest Control Strategies
We are studying the molecular mechanisms and physiological significance of sensory functions that play a crucial role in the environmental adaptation and survival of organisms. Particularly, our goal is to propose integrated sensory mechanisms by focusing on the functional linkage between receptors such as thermo-sensitive TRP channels and the surrounding lipids. To achieve this, we utilize a variety of methodologies, including behavioral analyses using genetic tools of Drosophila, as well as imaging analyses of neurons and cells. Additionally, we employ electrophysiological analyses using cultured cells, covering a wide range of physiological analyses from genes to behaviors.Furthermore, in addressing sensory dysfunction arising from aging and neurodegenerative diseases such as Alzheimer's disease, we are conducting analyses using Drosophila and mammalian cells to understand the impact of oxidative stress on membrane lipids and receptor functions. We are elucidating mechanisms for sensory dysfunction and developing techniques for the recovery.
Moreover, by exploring and developing unconventional repellents and insecticidal compounds targeting insect sensory receptors and neural functions, we aim to create innovative pest control strategies for the next generation.

The structure and function of sensory receptors are maintained by the surrounding lipids. Lipids are thought to regulate sensory receptors through processes such as the production of metabolites, accumulation of membrane proteins by direct modification and lipid domain, and the propagation of the physicochemical properties of the membrane. However, the complete picture of this interaction remains largely unclear.

We are developing new repellents and insecticides and exploring new approaches to disrupt physiological functions, targeting TRP channels and ion channels in neurons. Additionally, we are seeking modifying substances that can enhance the effects of these compounds.