業績Publication
2012
- Takaishi M, Fujita F, Uchida K, Yamamoto S, Sawada(Shimizu) M, Hatai(Uotsu) C, Shimizu M, Tominaga M*.
1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.
Molecular Pain. 8:86, 2012, Nov.
PMID:23192000
表紙を飾ります!! =>イメージはこちら
- Uchida K#*, Miura Y#, Nagai M, Tominaga M*.
Isothiocyanates from Wasabia japonica activate transient receptor potential ankyrin 1 channel.
Chem Senses. 37(9):809-818, 2012, Nov.
# equal contribution
PMID:22869685
- Saito S*, Nakatsuka K, Takahashi K, Fukuta N, Imagawa T, Ohta T, Tominaga M*.
Analysis of Transient Receptor Potential Ankyrin 1 (TRPA1) in Frog and Lizard Illuminates Its Nociceptive Heat and Chemical Sensitivities and Coexpression with TRP vanilloid 1 (TRPV1) in Ancestral Vertebrates.
J Biol Chem. 287:30743-54, 2012, Aug.
PMID:22791718
日本語要旨
- Ogawa H, Takahashi K, Miura S, Imagawa T, Saito S, Tominaga M, Ohta T*.
H2S functions as a nociceptive messenger through Transient Receptor Potential Ankyrin 1 (TRPA1) activation.
Neuroscience. 218:335-343, 2012, Aug.
PMID:22641084
- Kitagawa Y*, Miyai A, Usui K, Hamada Y, Deai K, Wada M, Koga Y, Sakata M, Hayashi M, Tominaga M, Matsushita M.
Pharmacological characterization of (3S)-3-(hydroxymethyl)-4-(5-methylpyridin-2-yl)-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide (JTS-653), a novel Transient Receptor Potential Vanilloid 1 antagonist.
J Pharmacol Exp Ther. 342(2):520-528, 2012, Aug
PMID:22588258
- Kashio M, Sokabe T, Shintaku K, Uematsu T, Fukuta N, Kobayashi N, Mori Y, Tominaga M*.
Redox signal-mediated sensitization of Transient Receptor Potential Melastatin 2 (TRPM2) to temperatures affects macrophage functions.
Proc Natl Acad Sci USA. 109(17):6745-6750, 2012, Apr.
日本語要旨
PMID:22493272
NatureAsia websiteで紹介されました。
- Kida N, Sokabe T, Kashio M, Haruna K, Mizuno Y, Suga Y, Nishikawa K, Kanamaru A, Maya Hongo M, Oba A, Tominaga M*.
Importance of transient receptor potential vanilloid 4 (TRPV4) in epidermal barrier function in human skin keratinocytes.
Pflugers Arch Eur J Physiol. 463(5):715-725, 2012, Apr.
PMID:22374181
- Komatsu T#, Uchida K#*, Fujita F, Zhou Y, Tominaga M*.
Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner.
Pflugers Arch Eur J Physiol. 463(4):549-559, 2012, Apr.
# equal contribution
PMID: 22222967
- Nagai K, Saitoh Y, Saito S, Tsutsumi K.
Structure and Hibernation-associated Expression of the Transient Receptor Potential Vanilloid 4 Channel (TRPV4) mRNA in the Japanese Grass Lizard (Takydromus tachydromoides)
Zoolog Sci. 29(3):185-190, 2012, Mar.
PMID:22379986
- Shintaku K, Uchida K, Suzuki Y, Yiming Z, Fushiki T, Watanabe T, Yazawa S, Tominaga M*.
Activation of TRPA1 by a non-pungent capsaicin-like compound, capsiate.
Br J Pharmacol. 165(5):1476-1486, 2012, Mar.
PMID:21883144
- Ohkita M, Saito S, Imagawa T, Takahashi K, Tominaga M, Ohta T*.
Molecular cloning and functional characterization of xenopus tropicalis frog transient receptor potential vanilloid 1 reveals its functional evolution for heat, acid and capsaicin sensitivities in terrestrial vertebrates.
J Biol Chem. 287(4):2388-97, 2012, Jan.
日本語要旨
PMID: 22130664
- Tsunematsu T, Yamanaka A.
The role of orexin/hypocretin in the central nervous system and peripheral
tissues.
Vitam. Horm. 89: 19-33, 2012.
PMID:22640606
Review.
和文著書、和文総説
- 富永真琴: TRPチャネルによる侵害受容機構 日本運動器疼痛学会雑誌 4(1):14-19, 2012.
- 富永真琴: 刺激感受性:温度感受性TRPチャネルの生理機能 日本香粧品学会誌 36(4):1-7, 2012.
- 木田尚子、曽我部隆彰、金丸晶子、富永真琴: 皮膚の温度センサーTRPV4を活性化する化粧品素材の開発 アレルギーの臨床 32(7):659-665, 2012.
- 富永真琴: 侵害受容性疼痛 整形外科 63(8):712-716, 2012.
- 富永真琴: 酸味および辛み受容のメカニズム 香料 No.254:196-202, 2012.
国際会議発表リスト
- M. Tominaga, "Regulation of TRPA1 activity in pathological conditions" The 7th International Conference of Neurons and Brain Diseases, Montreal (Canada), June 2012.
- Saito "Functional evolution of nociceptive receptors TRPA1 and TRPV1 in vertebrates" Annual Meeting of Society for Molecular Biology and Evolution Dublin (Ireland) 2012.
- M. Kashio, "Redox signal-mediated sensitization of Transient Receptor Potential Melastatin 2 (TRPM2) to temperature affects macrophage functions" 4th International Congress on Cell membranes and Oxidative Stress Isparta (Turkey) 2012.
- T. Tsunematsu, "Long time silencing of orexin/ hypocretin neuronal activity using optogenetics in archaerhodopsin-3-expressing transgenic mice" 8th FENS Forum of Neuroscience Barcelona (Spain) 2012.
- M. Tominaga, "Physiological significance of TRPM2 channel and evolutional changes in the structure and function of thermosensitive TRP channels" 2012 International Ion Channel Conference, Jeju (Korea), August 2012.
- Y. Suzuki, "Epithelial TRP channels for maternal-fetal calcium transport" 2012 International Ion Channel Conference, Jeju (Korea), August 2012.
- K. Uchida, "The role of TRPM2 channel in pancreatic b-cell functions" 2012 International Ion Channel Conference, Jeju (Korea), August 2012.
- M. Kashio, "Redox signal mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions" 2012 International Ion Channel Conference, Jeju (Korea), August 2012.
- Y. Zhou, "A novel alternative splicing variant of mouse TRPA1 regulates its channel activity under physiological and pathological conditions" 14th World Congress of Pain, Milan (Italy), August 2012.
- S. Tabuchi, "New model mice for narcolepsy using timing controlled gene expression system in transgenic mice which induces specific ablation of orexin/hypocretin neurons" Neuroscience 2012, (USA), October 2012.
- F. Fujita, "Modal shift of cool sensor TRPM8 by changing ambient temperature and its application to cosmetics" 27th Congress of International Federation of Societies of Cosmetic Chemists, Johannesburg (South Africa), October 2012.
- M. Tominaga, "Molecular mechanisms of nociception through TRPA1 activation" International Conference of Physiological Sciences, Suzhou (China), November 2012.
- T. Tsunematsu, "Optogenetic manipulation of orexin neuronal activity affects sleep/wakefulness state in mice" The 7th Asian Sleep Research Society Congress, Taipei (Taiwan), December 2012
招待講演
- 富永真琴「治療標的としての皮膚のTRPV3,TRPV4」、第85回日本薬理学会年会、京都、2012年3月.
- 山中章弘「オプトジェネティクスを用いたオレキシン神経活動抑制は徐波睡眠を誘導する」、第117回日本解剖学会全国学術集会、甲府、2012年3月.
- 富永真琴「刺激感受性:温度感受性TRPチャネルの生理機能」、第37回日本香粧品学会 、東京、2012年6月.
- M. Tominaga, "Physiological significance of TRPM2 channel and evolutional changes in the structure and function of thermosensitive TRP channels" 2012 International Ion Channel Conference, Jeju (Korea), August 2012.
- 富永真琴「TRPチャネルを介した侵害受容の分子機構」第32回鎮痛薬・オピオイドペプチドシンポジウム、東京、2012年9月.
- 富永真琴「動物におけるカルシウム透過性TRPチャネルを介した環境温度受容」日本植物学会第76回大会、姫路、2012年9月.
- 富永真琴「TRPV1, TRPA1チャネルを介した侵害受容とその制御機構」第42回日本臨床神経生理学会学術大会、東京、2012年11月.
- M. Tominaga, "Molecular mechanisms of nociception through TRPA1 activation" International Conference of Physiological Sciences, Suzhou (China), November 2012.
- 富永真琴「感覚神経に発現する温度感受性TRPチャネルの生理機能」第1回ニューロカンファレンス和歌山、和歌山、2012年12月.
- T. Tsunematsu, "Optogenetic manipulation of orexin neuronal activity affects sleep/wakefulness state in mice" The 7th Asian Sleep Research Society Congress, Taipei (Taiwan), December 2012.
バナースペース
生命創成探究センター
温度生物学研究G
(生理学研究所 細胞生理研究部門)