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2015年01月22日

Heterogeneous spatial origins and functions of astrocytes in the mammalian CNS

日 時 2015年01月22日(木) 14:00 より 15:00 まで
講演者 David Rowitch 教授
講演者所属 The Department of Pediatrics, UCSF School of Medicine / Howard Hughes Medical Institute
お問い合わせ先 分子神経生理 池中一裕 ikenaka@nips.ac.jp (内線:5245)
要旨

この度、新学術で招聘中のFrank Kirchhoff 教授、David Rowitch 教授を招待し 下記の通り、所長招聘セミナーを開催いたします。
皆様多数ご来聴ください。
セミナーは英語で行われます。

Astrocytes are heterogeneous in morphology, marker and gene expression, and physiological properties. Our recent studies have shown that astrocytes are allocated according to a regional/segmental template, and that regionally diverse astrocytes of ventral spinal cord encode distinct gene functions essential for motor neuron survival and sensorimotor circuit integrity. How is such diversity determined? This talk will focus on advances in understanding astrocyte development including the role of neural tube patterning in specification and developmental functions of astrocytes during synaptogenesis, axon path finding and motor neuron survival. We propose that a precise understanding astrocyte development is critical to defining heterogeneity and could lead to a better appreciation for their roles in neurological disease.