A longstanding goal in neuroscience is to achieve a complete understanding of the central nervous system, from the brain as a whole all the way down to individual neurons and synapses. A fundamental challenge in achieving this goal is bridging knowledge gaps impeded by the difficulty in integrating experimental measurements across different scales, for example between computations in local circuits and communication across brain areas. In the mammalian neocortex, cortico-cortical connections formed by long-range projection neurons across different areas are essential for higher cognitive function.  I will present the development of new technologies that enable simultaneous recordings of identified long-range projection neurons across cortical areas.  Using the mouse tactile whisker sensorimotor system as a model, I will describe the application of such methods for dissecting the role of long-range networks in the neocortex during sensory-guided decision making.

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