Probes for correlated microcopies, advances in instrumentation and analysis, will be shown involving light, x-ray, electron and ion imaging methods. Use of these methods - in various combinations - are providing researchers with a powerful arsenal of tools and technologies for obtaining multiscale and multimodal data, from the level of molecules to whole organs - from milliseconds to life spans. This talk will highlight projects in which development and application of new contrasting methods and imaging instruments have allowed us to observe important relationships between cellular, subcellular and molecular constituents of cells in nervous systems.