| 日 時 | 2022年11月18日(金) 13:30 より 14:30 まで |
|---|---|
| 講演者 | Denis Le Bihan |
| 講演者所属 | NeuroSpin, CEA-Saclay, France; NIPS, Okazaki, Japan; Kyoto University Graduate School of Medicine, Kyoto, Japan |
| 場 所 | 生理学研究所（明大寺地区） 1F:セミナー室A・B / Zoomオンライン |
| お問い合わせ先 | 定藤 規弘 (sadato@nips.ac.jp) |
| 要旨 | Diffusion functional MRI (DfMRI) has been shown to more directly reflect neuronal activity than blood oxygenation level dependent (BOLD) MRI which is based on the neurovascular coupling principle. Based on earlier reports that water apparent diffusion coefficient (ADC) decreases in relation to cell swelling it has been hypothesized that the decrease water diffusion observed during neural evoked responses would originate from changes occurring in a membrane bound layer of structured water molecules likely at the dendritic spine level. Interestingly, a recently introduced fMRI method (DIANA) was also shown to be directly reflecting neuronal activation and inhibition (firing of action potentials) with a very high temporal resolution through changes in water relaxation times (T2). Although the exact mechanisms remain unclear at this stage both DIANA and DfMRI point out to the important role of membrane bound water in neuronal function. |
