| 日 時 | 2023年01月12日(木) 15:00 より 16:00 まで |
|---|---|
| 講演者 | Dr. Ingo Greger |
| 講演者所属 | Programme Leader, Neurobiology Division , MRC, Cambridge, UK |
| 場 所 | 1階会議室 およびZOOM（ハイブリッド） |
| お問い合わせ先 | 深田 正紀(#5873) |
| 要旨 |
AMPA glutamate receptors (AMPARs) mediate fast excitatory neurotransmission throughout the brain, and are central players in various forms of synaptic plasticity that underlies learning. In addition to four core subunits (GluA1-4), an array of auxiliary subunits render AMPAR response properties uniquely versatile, tuned to the needs of a given circuitry. These assemble with the receptor core in various stoichiometries, and in a brain-region specific fashion. Recent cryo-EM structural data, combined with functional studies, have started to shed light on the arrangement of both, core and auxiliary subunits. Hence, despite tremendous versatility, unique to AMPA-type glutamate receptors, organizing principles are beginning to emerge. This information will ultimately allow us to decipher the activation mechanisms underlying synaptic AMPAR responses. In this talk I will discuss our current understanding of AMPAR organization, the differential action of core subunits (GluA1 versus GluA2), and recent insights into its modulation by prominent auxiliary subunits at the level of the receptor and at the synapse. |
