| 要旨 |
Anatomical microarchitectures (e.g. cytoarchitecture) and functional organizations are heterogeneous across the brain, but the extent to which these anatomical and functional properties are tightly coupled remains unknown. In this talk, I will present our two studies that address this question in cortical and subcortical regions by combining structural MRI, functional MRI and histological data analyses. In the first study, we evaluated anatomical and functional differences between the human lateral geniculate nucleus (LGN) subdivisions (magnocellular and parvocellular) using structural and functional MRI and found that these differences are coupled in the LGN. Based on this, we demonstrated that approximate positions of the LGN subdivisions can be estimated in the living human brain by using non-invasive neuroimaging. In the second study, we investigated the anatomical microarchitecture of face patches, which are a network of cortical regions selectively responsive to images of faces. By developing a method to integrate fMRI and histological data acquired from the same brains, we investigated how the anatomical microarchitecture differs between face patches.
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