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2025年02月19日

Spatial Changes in Basal Ganglia Microstructure in Parkinson's Disease

日 時 2025年02月19日(水) 10:30 より 11:30 まで
講演者 Aviv Mezer先生
講演者所属 Professor, The Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Israel
場 所 生理研1階大会議室(明大寺地区)/Zoom
お問い合わせ先 竹村 浩昌 (htakemur@nips.ac.jp)
要旨
Mapping structural changes in subcortical brain regions is crucial for understanding their functions in both health and disease. We developed a method to quantify microstructure profiles in vivo within a single human brain. Our findings show that spatial profiles in the putamen, caudate, and globus pallidus are consistently reproducible across individuals, clinical conditions, and datasets. Using multiparametric quantitative MRI, we identified distinct, spatially dependent, aging-related changes in water content and iron concentration. In Parkinson’s disease (PD) patients, we observed abnormal profiles in the putamen, particularly in the posterior putamen, which correlate with patients' dopaminergic loss and motor dysfunction.

 
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