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Neural Development & Regeneration

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Mechanisms and functional significance of neurogenesis in the postnatal brain
Endogenous regenerative mechanisms of injured brain and new therapies for brain diseases

New neurons and glial cells are continuously generated throughout life, not only at the embryonic and neonatal stages. Recent studies using experimental animals indicate that several regions of the adult brain have the capacity to regenerate injured neural tissues. In collaboration with researchers at other laboratories in NIPS, we have been studying the mechanisms for cell migration and regeneration in the postnatal brain. Our group aims to study the endogenous repair mechanisms in the brain and develop a new strategy to promote neuronal and glial cell regeneration after injury.

 

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Fig.1. Newborn neurons (green) generated by neural stem cells (blue) migrate along radial glial fibers (red) towards the injured brain tissue and differentiate into mature neurons (Jinnou et al., Cell Stem Cell 2018).
 

 

 

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Fig.2. The regulatory mechanism involving Filopodium-like lateral protrusion (FLP) formation links neuronal migration termination and the initiation of differentiation, contributing to the positioning and functions of new neurons in the postnatal olfactory bulbs (Sawada et al., EMBO J 2018).
 

Typical paper information

* M. Sawada, et al., PlexinD1 signaling controls morphological changes and migration termination in newborn neurons. EMBO J e97404 (2018)
* H. Jinnou, et al., Radial glial fibers promote neuronal migration and functional recovery after neonatal brain injury. Cell Stem Cell 22: 128-137 (2018)
* T. Fujioka, et al., β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain EBioMedicine 16: 195-203 (2017)
* N. Kaneko et al., Mechanisms of neuronal migration in the adult brain. J Neurochem 141: 835–847 (2017)
* H. Ota, et al., Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA. Nat Commun 5: 4532 (2014)
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