Section of Brain Function Information


Imaging structure and function relationship of human and non-human primate brain by ultra-high field MRI

Magnetic resonance (MR) is an excellent technique for non-invasive observation of biological structure, function, metabolism, and molecular dynamics. Section of Brain Function Information at Supportive Center for Brain Research assists functional and structural measurements of the brain and body of human and non-human primates through the high (3 tesla) and ultra-field field (7 tesla) MRIs. Our laboratory also develops fundamental techniques such as measurement methods, analysis methods, a range of applications, and safety verification.
Furthermore, we will promote research on the relationship between the structure and function of the human brain using MRI and MRS (MR spectroscopy), and develop new measurement methods to collect biological parameters. We also participate in multicenter clinical studies to elucidate diseases by various neuroimaging and promote the investigation of endophenotypes and biomarkers of psychiatric disorders based on the analysis of large-scale imaging data. In addition to developing post process and analysis methods, we train researchers who can make fully utilize the high and ultra-high field MRI in their research.


MRI systems operated by the National Institute for Physiological Sciencies (7-tesla ultra-high field MRI: Siemens Magnetom 7T, state-of-the-art 3-tesla high-performance gradient MRI: Siemens Magnetom Cima.X, 3-tesla 2-pair simultaneous measurement MRI (hyperscanning MRI): Siemens Magnetom Verio x2). Functional (FC) and structural (SC) brain connectivity mapping by functional MRI (fMRI) and diffusion MRI (dMRI). Layer-fMRI for cortical laminar resolution obtained by 7T MRI.

Selected publications

*Schijven D, Postema MC, Fukunaga M et al. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium. Proc Natl Acad Sci U S A. 120, e2213880120 (2023)
*Goda N, Hasegawa T, Koketsu D et al., Cerebro-cerebellar interactions in nonhuman primates examined by optogenetic functional magnetic resonance imaging. Cereb Cortex Commun 3, tgac022 (2022)
*Maruyama S, Fukunaga M, Sugawara SK et al., Cognitive control affects motor learning through local variations in GABA within the primary motor cortex. Sci Rep 11, 18566 (2021)
*Yamamoto T, Fukunaga M, Sugawara SK et al., Quantitative evaluations of geometrical distortion corrections in cortical surface‐based analysis of high‐resolution functional mri data at 7T. J Magn Reson Imaging. 53, 1220 (2021)
*Fukunaga M, Li TQ, van Gelderen P et al., Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast. Proc Natl Acad Sci U S A. 107, 3834 (2010)