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Neural dynamics of multisensory integration for flexible behaviors

Our goal is to clarify the dynamics of brain networks underling flexible cognitive behaviors and decision-making using non-human primates. Furthermore, we investigate the biological basis of cognitive diversity through multisensory integration, which is the origin of the mind and intelligence of primates. We conduct multispecies empirical comparative research mainly focusing on approaches using non-human primate model animals that have higher-order brains, which will enable us to clarify the evolutionary background of the dynamics of brain neural circuits that lead to the complexity and multidimensionality of decision-making and behavioral choice in animals including humans. To achieve these goals, we develop various behavioral paradigms with realistic environment utilizing virtual reality (VR) technology, and perform computational analysis based on large-scale neural activity recordings and neural circuit manipulation applying optogenetics. Through these techniques, we aim to understand the neural dynamics of diverse cognitive behavioral systems from both functional and causal aspects. In particular, we focus on motion systems, spatial navigation systems, balancing system for risk-reward decisions, tracking and avoidance systems, as well as artistic cognition created through flexible integration processing of multisensory inputs and its generating mechanism of impressions and emotions.

Selected publications

*Sasaki R et al. (2024) Science 383(6678):55-61
*Sasaki R et al. (2020) Nat Neurosci 23(8): 1004-1015
*Sasaki & Uka. (2009) Neuron 62(1): 147-157