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  Remodeling of Neuronal Circuits in Development and Recovery,
−In vivo Imaging and Electrophysiological Study-

Remodeling of neuronal circuits takes place during development, learning and recovery after brain damage. The main goal of our research is to understand the regulation of neural circuits remodeling. In details, we are focusing on Glial contribution for the function of neuronal circuits. Glia has been known as a key factor to regulate neural circuits through their physiological function. We are trying to determine their contribution onto the neural circuits in development and learning by visualizing fine structure, controlling activity and analyzing function of neuron and glia in living animals using multi-photon microscopy.

Innovative technology development across fields

The progress of technology has brought about a breakthrough in life science. We contributed to novel technology development through collaborative research across fields. Recently, we revealed neural activity-dependent pH changes in the living brain with single-cell level resolution using a CMOS image sensor which we had newly developed.

 

Transinet acceleration of synaptic plasticity in primary sensory cortex of neuropathic pain model mouse

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Facilitation of spine formation by microglial contact during development

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Typical paper information

*参考文献① Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain. Kim SK, Hayashi H, Ishikawa T, Shibata K, Shigetomi E, Shinozaki Y, Inada H, Roh SE, Kim SJ, Lee G, Bae H, Moorhouse AJ, Mikoshiba K, Fukazawa Y, Koizumi S, Nabekura J. J Clin Invest. 2016 May 2;126(5):1983-97.
*参考文献② Microglia contact induces synapse formation in developing somatosensory cortex. Miyamoto A, Wake H, Ishikawa AW, Eto K, Shibata K, Murakoshi H, Koizumi S, Moorhouse AJ, Yoshimura Y, Nabekura J. Nat Commun. 2016 Aug 25;7:12540.
*参考文献③ CMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain. Horiuchi H, Agetsuma M, Ishida J, Nakamura Y, Cheung DL, Nanasaki S, Kimura Y, Iwata T, Takahashi K, Sawada K, Nabekura J. Nat Commun. 2020 Feb 5;11(1):712.
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