Remodeling of neuronal circuits takes place during development, learning and recovery after brain damage. The main goal of our research is to understand the regulation of neural circuits remodeling. In details, we are focusing on Glial contribution for the function of neuronal circuits. Glia has been known as a key factor to regulate neural circuits through their physiological function. We are trying to determine their contribution onto the neural circuits in development and learning by visualizing fine structure, controlling activity and analyzing function of neuron and glia in living animals using multi-photon microscopy.
The progress of technology has brought about a breakthrough in life science. We contributed to novel technology development through collaborative research across fields. Recently, we revealed neural activity-dependent pH changes in the living brain with single-cell level resolution using a CMOS image sensor which we had newly developed.
Transinet acceleration of synaptic plasticity in primary sensory cortex of neuropathic pain model mouse
Facilitation of spine formation by microglial contact during development
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