HOME >  Research >  Division of Homeostatic Development

Research

Division of Homeostatic Development

WebSite

Member

  Remodeling of Neuronal Circuits in Development and Recovery,
−In vivo Imaging and Electrophysiological Study-

Remodeling of neuronal circuits takes place during development, learning and recovery after brain damage. The main goal of our research is to understand the regulation of neural circuits remodeling. In details, we are focusing on glial contribution for the function of neuronal circuits. Glia has been known as a key factor to regulate neural circuits through their physiological function. We are trying to determine their contribution onto the neural circuits in development and learning by visualizing fine structure, controlling activity, recording specific synaptic transmissions and analyzing function of neurons and glias in both in living animals using multi-photon microscopy and in vitro electrophysiology.

Innovative technology development across fields

The progress of technology has brought about a breakthrough in life science. We contributed to novel technology development through collaborative research across fields. Recently, we revealed neural activity-dependent pH changes in the living brain with single-cell level resolution using a CMOS image sensor which we had newly developed.

 

CMOS-based ion image sensor revealed neuronal activity dependent pH changes in the living brain

2021nabekura-1.jpg

 

Pain circuit reorganization with activated astrocytes as a therapeutic approach

2021nabekura-2.jpg

 

Typical paper information

*参考文献① Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain. Kim SK, Hayashi H, Ishikawa T, Shibata K, Shigetomi E, Shinozaki Y, Inada H, Roh SE, Kim SJ, Lee G, Bae H, Moorhouse AJ, Mikoshiba K, Fukazawa Y, Koizumi S, Nabekura J. J Clin Invest. 2016 May 2;126(5):1983-97.
*参考文献② Microglia contact induces synapse formation in developing somatosensory cortex. Miyamoto A, Wake H, Ishikawa AW, Eto K, Shibata K, Murakoshi H, Koizumi S, Moorhouse AJ, Yoshimura Y, Nabekura J. Nat Commun. 2016 Aug 25;7:12540.
*参考文献③ CMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain. Horiuchi H, Agetsuma M, Ishida J, Nakamura Y, Cheung DL, Nanasaki S, Kimura Y, Iwata T, Takahashi K, Sawada K, Nabekura J. Nat Commun. 2020 Feb 5;11(1):712.
Researchers List

Introduce a researcher of NIPS.