Remodeling of neuronal circuits takes place during development, learning and recovery after brain damage. The main goal of our research is to understand the regulation of neural circuits remodeling. In details, we are focusing on glial contribution for the function of neuronal circuits. Glia has been known as a key factor to regulate neural circuits through their physiological function. We are trying to determine their contribution onto the neural circuits in development and learning by visualizing fine structure, controlling activity, recording specific synaptic transmissions and analyzing function of neurons and glias in both in living animals using multi-photon microscopy and in vitro electrophysiology.
The progress of technology has brought about a breakthrough in life science. We contributed to novel technology development through collaborative research across fields. Recently, we revealed neural activity-dependent pH changes in the living brain with single-cell level resolution using a CMOS image sensor which we had newly developed.
CMOS-based ion image sensor revealed neuronal activity dependent pH changes in the living brain
Pain circuit reorganization with activated astrocytes as a therapeutic approach
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